• The expression of transforming growth factor‑β/Smad pathway proteins, α‑smooth muscle actin (α‑SMA), collagen I and collagen III was observed in fibrotic livers using western blot analysis. (spandidos-publications.com)
  • Local alterations in collagen density were clearly seen, allowing us to obtain three-dimensional information regarding the organization of the mammary stroma, such as radiating collagen fibers that could not have been obtained using classical histological techniques. (biomedcentral.com)
  • The presentation of these tumor-associated collagen signatures allowed us to identify pre-palpable tumors and see cells at the tumor-stromal boundary invading into the stroma along radially aligned collagen fibers. (biomedcentral.com)
  • Mammary glands from mice that underwent abrupt involution exhibited denser stroma, altered collagen composition, higher inflammation and proliferation, increased estrogen receptor α and progesterone receptor expression compared to those that underwent gradual involution. (biomedcentral.com)
  • Symptoms of cardiac amyloidosis are a combination of heart failure and amyloid deposition in various other organs. (wikipedia.org)
  • Deposition of amyloid into other organs makes the diagnosis of cardiac amyloidosis difficult as these extracardiac manifestations mask the diagnosis. (wikipedia.org)
  • Extracardiac manifestations include: Macroglossia Periorbital bruising Loss of the third and fourth heart sound Thromboembolisms Symmetric sensory neuropathy (such as bilateral carpal tunnel) Postural hypotension (secondary to autonomic neuropathy) Nephrotic syndrome (secondary to free light chain damage to the kidneys/deposition of amyloid in the kidneys) The general cause of cardiac amyloidosis is the misfolding of a specific protein precursor depending on the amyloidosis type. (wikipedia.org)
  • The aim of this narrative review is to summarize contemporary evidence on the use of circulating cardiac biomarkers of heart failure (HF) and to identify a promising biomarker model for clinical use in personalized point-of-care HF management. (annlabmed.org)
  • This increase in stiffness strongly correlated with an increase in necrosis, which reveals a potential link between tumor hypoxia and ECM deposition and stiffness. (ibecbarcelona.eu)
  • Imaging of the tumor-stromal interface in live tumor tissue ex vivo was performed with multiphoton laser-scanning microscopy (MPLSM) to generate multiphoton excitation (MPE) of endogenous fluorophores and second harmonic generation (SHG) to image stromal collagen. (biomedcentral.com)
  • Consistent with this observation, primary tumor explants cultured in a randomly organized collagen matrix realigned the collagen fibers, allowing individual tumor cells to migrate out along radially aligned fibers. (biomedcentral.com)
  • However, a lack of clinical biomarkers to predict response represents a critical unmet need to identify potential responders and dissect resistance mechanisms to personalize immunotherapy and combinatorial therapy. (elifesciences.org)
  • We focus on the benefits and drawbacks of biomarker-guided assistance in daily clinical management of patients with HF. (annlabmed.org)
  • Organ coefficients, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), hexadecenoic acid (HA), laminin (LN), procollagen type III (PCIII), hydroxyproline (Hyp), glutathione (GSH‑Px), malondialdehyde (MDA), superoxide dismutase (SOD) and transforming growth factor β1 (TGF‑β1) levels were measured in rats with hepatic fibrosis. (spandidos-publications.com)
  • These excessive depositions disturb the normal structure of the hepatic lobule, resulting in misdirected blood flow through the liver, thereby impairing normal organ functioning. (spandidos-publications.com)
  • BACKGROUND: Choosing the appropriate antipsychotic drug (APD) treatment for patients with schizophrenia (SCZ) can be challenging, as the treatment response to APD is highly variable and difficult to predict due to the lack of effective biomarkers. (inra.fr)
  • As a result, molecular gatekeepers also can uncover molecular linkages between coverage biomarkers along with wellness outcomes that could rather be hidden simply by complicated interactions within direct proportions.With the current economic research isoxanthanol has been looked at for treatment of monosodium iodoacetate (MIA)-induced arthritis (OA) within vivo. (sirna-library.com)
  • Amyloid deposition in the heart causes restrictive diastolic heart failure that progresses to systolic heart failure. (wikipedia.org)
  • yet, zero direct association ended up being found between virtually any exposure biomarkers and get older from menarche. (sirna-library.com)
  • Previous studies have indicated the association between treatment response and genetic and epigenetic factors, but no effective biomarkers have been identified. (inra.fr)
  • In addition, we provide clear information on the role of alternative biomarkers and future directions with the aim of improving the predictive ability and reproducibility of multiple biomarker models and advancing genomic, transcriptomic, proteomic, and metabolomic evaluations. (annlabmed.org)
  • He is a member of the Stem Cell Network Centre of Excellence (past member of the Stem Cell Policy Committee and Research Management Committee and current Sub-chair of the Training and Education Committee), and a member of the AllerGen Network Centre of Excellence (Research Management Committee and Co-Chair of the Biomarkers Program). (ubc.ca)
  • In particular, local cell invasion was found predominantly to be oriented along certain aligned collagen fibers, suggesting that radial alignment of collagen fibers relative to tumors facilitates invasion. (biomedcentral.com)
  • 14. Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment. (nih.gov)
  • 17. Differential motile response of human malignant mesothelioma cells to fibronectin, laminin and collagen type IV: the role of beta1 integrins. (nih.gov)
  • This is a retrospective study of immunohistochemical markers of early fibrosis including laminin and fibronectin, collagen deposition and lipocyte activation in hepatic biopsies of 36 psoriatic patients treated with methotrexate for one to five years, at an average dose of 20 mg/week. (nih.gov)
  • Expression of laminin, fibronectin, collagens III and IV increased significantly and progressively over baseline values after cumulative doses of 1.5 +/- 0.25 g (n = 20) and 3 +/- 0.5 g methotrexate, respectively. (nih.gov)
  • During fibrosis, there is excessive deposition of ECM, of which FN is one of the major components. (nih.gov)
  • 15. Laminin deposition to type IV collagen enhances haptotaxis, chemokinesis, and adhesion of hepatoma cells through beta1-integrins. (nih.gov)
  • Biopsies before initiation of methotrexate (n = 36) showed minimal immunohistochemical expression of desmin, transforming growth factor alpha, matrix proteins, and collagen. (nih.gov)
  • Increases in desmin, smooth muscle actin and collagen type I also occurred but the changes were less consistent. (nih.gov)
  • Treatment with 3D6 antibody induced clearance of vascular Aβ that was spatially and temporally associated with a transient increase in microhemorrhage and in capillary Aβ deposition. (nih.gov)
  • 2. Epidermal growth factor and laminin receptors contribute to migratory and invasive properties of gliomas. (nih.gov)
  • [ 54 ] Mesenchymal cells also have been implicated clinically in tumor progression with clinical observations demonstrating that elevated levels of FN, type IV collagen or laminin within the stroma are associated with an invasive phenotype and poor prognosis. (medscape.com)
  • Extracardiac manifestations include: Macroglossia Periorbital bruising Loss of the third and fourth heart sound Thromboembolisms Symmetric sensory neuropathy (such as bilateral carpal tunnel) Postural hypotension (secondary to autonomic neuropathy) Nephrotic syndrome (secondary to free light chain damage to the kidneys/deposition of amyloid in the kidneys) The general cause of cardiac amyloidosis is the misfolding of a specific protein precursor depending on the amyloidosis type. (wikipedia.org)
  • Immunohistochemical quantification of matrix proteins and collagens type III and IV may be early, sensitive and dose responsive markers of methotrexate hepatotoxicity which progress with increasing cumulative doses of methotrexate. (nih.gov)
  • With regard to the pathological consequences, C1q deposition is associated with the activation of the classical pathway of the C. Excessive C activation can cause angiogenetic factor imbalance and an impaired invasion of the decidua by trophoblasts, thus leading to incorrect placentation [ 5 , 9 ]. (explorationpub.com)
  • [ 49 ] Increased matrix deposition by CAFs leads to ECM cross-linking and, together with the high interstitial pressure caused by the expanding tumor mass, CAFs cause tumor-induced stromal stiffening thereby facilitating tumor invasion and metastases. (medscape.com)
  • 8. Integrin alpha3beta1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells. (nih.gov)
  • Impaired or Absent ADA function results in the deposition from the dangerous metabolites adenosine, 2deoxyadenosine and deoxyadenosine triphosphate (dATP). (siamtech.net)
  • Elevated intracellular uptake of 2deoxyadenosine accompanied by phosphorylation by deoxycytidine kinase results in deposition of deoxyadenosine triphosphate (dATP) which inhibits ribonucleotide reductase, stopping regular DNA fix and synthesis [5]. (siamtech.net)
  • This is due to the amount of time that it takes to accumulate the amyloid depositions being longer in the Senile variant. (wikipedia.org)