Cell ProliferationCell DivisionSignal TransductionCells, CulturedCell LineCell Line, TumorApoptosisPhosphorylationCalciumDose-Response Relationship, DrugMice, Inbred C57BLEnzyme InhibitorsTumor Suppressor Protein p53TransfectionProtein BindingMice, KnockoutPlant ExtractsGene Expression RegulationEnzyme ActivationMolecular Sequence DataTime FactorsCell CycleTranscription, GeneticRats, Sprague-DawleyMutationCell DifferentiationKineticsBinding SitesRNA, MessengerBromodeoxyuridineCell SurvivalCell MovementBlotting, WesternImmunohistochemistryLymphocyte ActivationReverse Transcriptase Polymerase Chain ReactionTumor Cells, CulturedRNA, Small InterferingProliferating Cell Nuclear AntigenDown-RegulationGene Expression Regulation, NeoplasticKi-67 AntigenFlow CytometryTranscription FactorsEpithelial CellsCell Growth ProcessesT-LymphocytesGene ExpressionMice, TransgenicUp-RegulationFibroblastsRNA InterferenceDNA-Binding ProteinsStem CellsCyclin D1Base SequenceMice, Inbred BALB CMice, NudeProto-Oncogene Proteins c-aktThymidineCell Cycle ProteinsMuscle, Smooth, VascularDNACell CountModels, BiologicalCyclin-Dependent Kinase Inhibitor p27Amino Acid SequenceProtein-Serine-Threonine KinasesProto-Oncogene ProteinsCell Transformation, NeoplasticNuclear ProteinsRecombinant ProteinsExtracellular Signal-Regulated MAP KinasesGene Knockdown TechniquesCyclin-Dependent Kinase Inhibitor p21PhenotypeGene Expression Regulation, DevelopmentalMAP Kinase Signaling SystemGrowth InhibitorsCell AdhesionHyperplasiaMyocytes, Smooth MuscleAntineoplastic AgentsDisease Models, AnimalMitogen-Activated Protein Kinase 3Proto-Oncogene Proteins c-mycMitogensG1 PhaseTrans-ActivatorsPhosphatidylinositol 3-KinasesMitogen-Activated Protein KinasesMitogen-Activated Protein Kinase 1Promoter Regions, GeneticBreast NeoplasmsTumor Suppressor ProteinsTransforming Growth Factor betaInterleukin-2Membrane ProteinsS PhaseMitosis