AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
beta-Transducin Repeat-Containing ProteinsSKP Cullin F-Box Protein LigasesProteasome Endopeptidase ComplexUbiquitin-Protein LigasesProteolysisPropylene GlycolF-Box ProteinsUbiquitinationUbiquitinCell Cycle ProteinsCell LineMolecular Sequence DataProtein BindingHeLa CellsMutationNuclear ProteinsPhosphorylationAmino Acid SequenceSignal TransductionDNA-Binding ProteinsTranscription FactorsBiodegradation, EnvironmentalCells, CulturedKineticsCysteine EndopeptidasesUbiquitinsRNA, MessengerMultienzyme ComplexesBase SequenceTime FactorsEndoplasmic Reticulum-Associated DegradationModels, BiologicalHydrolysisProtein Processing, Post-TranslationalCell Line, TumorProtein TransportTranscription, GeneticBlotting, WesternCarrier ProteinsApoptosisCalciumGene Expression RegulationRecombinant ProteinsRecombinant Fusion ProteinsEnzyme ActivationEndoplasmic ReticulumMice, Inbred C57BLMembrane ProteinsBinding SitesSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiaeSubstrate SpecificityMice, KnockoutProteinsPeptide HydrolasesRNA StabilityRNA, Small InterferingHydrogen-Ion ConcentrationBacterial ProteinsAutophagyDown-RegulationHEK293 CellsEscherichia coliCysteine Proteinase InhibitorsEnzyme InhibitorsFibroblastsProteasome InhibitorsDose-Response Relationship, DrugCell NucleusRNA InterferenceTemperatureTumor Suppressor Protein p53Protein StabilityPlasmidsCell MembraneEndopeptidasesEndocytosisElectrophoresis, Polyacrylamide GelImmunoblottingProtein-Serine-Threonine KinasesTumor Cells, CulturedImmunoprecipitationCattleProtease InhibitorsBiological TransportOxidation-ReductionNF-kappa BSequence Homology, Amino AcidCytoplasmReverse Transcriptase Polymerase Chain ReactionProtein Structure, TertiaryPromoter Regions, GeneticLiverPeptide FragmentsLigasesCell CyclePeptidesI-kappa B ProteinsCloning, MolecularCytosol
Lysosomal degradationProteasomalUbiquitination and degradationPathwayExtracellular matrixUbiquitin ligaseAutophagyEnzymeInduces lysosomalMediatesPhosphorylationSedimentsMetastasisEndocytosisLysosomesMechanismMethodologyColorectal cancerIncreasesPromotesInteractionRegulatesInhibitorsProteasomeBehaviorInternalizationOxygenReceptorFindingsMacrophagesTime-dependentChemicalVacuoleCharacteristicsTemperatureSoilEnzymesHeavily dependentApoptosisDominantDemonstrateTissuesTranscriptionNuclearProgressionStronglyActivationResultsAreasGeneExposureContentFamilyRequiresHighlyProcess
Lysosomal degradation3
  • During autophagy, phagophores capture portions of cytoplasm and form double-membrane autophagosomes to deliver cargo for lysosomal degradation. (rupress.org)
  • Here, we found that PAR1 activation induces lysosomal degradation of Src. (tmu.edu.tw)
  • We show that PAR1 activation triggers endocytosis-dependent lysosomal degradation of Src in both human embryonic kidney 293 and human umbilical vein endothelial cells. (tmu.edu.tw)
Proteasomal3
  • Our findings reveal that TLR2/NADPH oxidase-mediated Txnip proteasomal degradation facilitates pro-inflammatory cytokine production during GAS infection. (frontiersin.org)
  • Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT 1A receptor via phosphorylation Biochemical and Biophysical Research Communications , 510 (3), 370-375. (elsevierpure.com)
  • Cysteine-specific ubiquitination protects the peroxisomal import receptor Pex5p against proteasomal degradation. (ruhr-uni-bochum.de)
Ubiquitination and degradation2
Pathway2
  • Destruction of BOA via hydroxylated molecules presents a new pathway for BOA degradation without accumulation of 2-aminophenoxazinone. (unicatt.it)
  • By acting on this neuroprotective pathway, 24-OHC favors tau protein clearance by triggering tau ubiquitination and subsequently its degradation through the ubiquitin-proteasome system. (unito.it)
Extracellular matrix3
  • This is accompanied by increased, VAMP3-dependent secretion of MT1-MMP, enhanced degradation of extracellular matrix, and increased cell invasion. (nature.com)
  • The degradation of articular cartilage in osteoarthritis (OA) is the result of an imbalance in the construction (anabolism) and the degradation (catabolism) of the extracellular matrix. (lu.se)
  • This gradual degradation of extracellular matrix creates cartilage damage. (lu.se)
Ubiquitin ligase3
  • We previously identified the E3 ubiquitin ligase IDOL as a sterol-dependent regulator of the LDL receptor (LDLR). (kent.ac.uk)
  • Here we report the identification and biochemical and structural characterization of an E2-E3 ubiquitin ligase complex for LDLR degradation. (kent.ac.uk)
  • Silencing Txnip prompted TLR2-mediated inducible nitric oxide synthase (iNOS)/NO, TNF-α, and IL-6 production whereas the blockage of Txnip degradation by pharmacologically inhibiting the HECT E3 ubiquitin ligase with heclin and AMP-dependent protein kinase with dorsomorphin effectively reduced such effects. (frontiersin.org)
Autophagy3
  • The legislation of autophagy is normally complicated but could be grouped buy Pimobendan (Vetmedin) into three main stages: initiation, maturation and, degradation (10). (careersfromscience.org)
  • Autophagy is a highly conserved and lysosome-dependent bulk degradation process. (hindawi.com)
  • Autophagy stimulus-dependent role of the small GTPase Ras2 in peroxisome degradation. (ruhr-uni-bochum.de)
Enzyme3
  • This enzyme participates in caprolactam degradation. (wikipedia.org)
  • The second studied enzyme is LPMO, which is a copper dependent enzyme used for the degradation of polysaccharides, such as cellulose and chitin. (lu.se)
  • [ 4 ] Lysyl oxidase, a copper-dependent enzyme, is important in the synthesis and cross-linking of elastin and collagen. (medscape.com)
Induces lysosomal1
  • Thus chloroquine induces lysosomal stress and provokes a p53-dependent cell death that does not require caspase-mediated apoptosis. (jci.org)
Mediates1
  • The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. (kent.ac.uk)
Phosphorylation4
  • This was consistent with IkappaBalpha phosphorylation and degradation, yet TNF-alpha-induced NF-kappaB DNA binding was only 30-40% greater than for IL-1beta. (nih.gov)
  • We studied here phosphorylation of 5-HT 1A R by cyclin-dependent kinase 5 (Cdk5), a neuron-specific membrane-bound Ser/Thr kinase that is activated by binding of the p35 Cdk5 activator. (elsevierpure.com)
  • The phosphorylation stimulated the degradation of 5-HT 1A R by the proteasome, resulting in neutralization of the inhibitory action of 5-HT 1A R on intracellular cAMP concentration. (elsevierpure.com)
  • These results suggest that Cdk5-p35 modulates 5-HT signaling through phosphorylation-dependent degradation of 5-HT lA R. (elsevierpure.com)
Sediments2
  • In this study, frequency-dependent magnetic susceptibility ( χ fd% ) was combined with the chemical content of sediments for an assessment of mangrove ecosystem degradation. (allenpress.com)
  • In this work, effects of microplastics (polypropylene and polystyrene) at four concentrations (0.2-10%, w/w) on di-n-butyl phthalate (DBP) degradation in offshore sediments were investigated. (unboundmedicine.com)
Metastasis1
  • m(6)A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation. (nih.gov)
Endocytosis1
  • Blocking agonist-induced endocytosis of PAR1 by inhibition of dynamin activity suppresses PAR1-induced degradation of Src. (tmu.edu.tw)
Lysosomes1
  • Src is associated and trafficked together with activated PAR1 to early endosomes and then sorted to lysosomes for degradation. (tmu.edu.tw)
Mechanism2
  • The presence of the two different sizes should favor and uncover electrochemical Ostwald ripening as a degradation mechanism, that is, the growth of larger particles in the Pt/C catalyst at the expense of the smaller particles via the formation of ionic metal species. (au.dk)
  • Even when released, they remain largely membrane associated due to their hydrophobic nature and can be taken up by cells via a high-affinity uptake mechanism [ 23 ], which is followed by their enzymatic degradation. (degruyter.com)
Methodology2
  • The degradation rate at the end of the forecasting period, eighth year, is computed using a robust principal component analysis (RCPA) based methodology. (researchgate.net)
  • Dependent on sampling methodology. (who.int)
Colorectal cancer1
  • Chloroquine-induced cell death in primary MEFs and human colorectal cancer cells was dependent upon p53, but not upon the p53 modulators Atm or Arf. (jci.org)
Increases2
  • The rate of degradation increases with decreasing pH. (rxlist.com)
  • first author Binggui Sun and colleagues found gene dose-dependent increases in CatB activity in the CysC-deficient animals. (alzforum.org)
Promotes1
  • These results confirm the prediction that spinal presynaptic Fbxo3-dependent Fbxl2 ubiquitination promotes the subsequent RIM1α/Ca V 2.2 cascade in SNL-induced neuropathic pain. (jneurosci.org)
Interaction2
  • This interaction triggeredproteasomal degradation of FLIPS, which promoted activation of caspase-8 and apoptosis. (edu.au)
  • The thickness of the cartilage is mainly dependent on the interaction between collagen and aggrecan. (lu.se)
Regulates1
  • In studies during the early 1990's, Gregg Semenza identified, and then in 1995 purified and cloned, a transcription factor that regulates these oxygen-dependent responses. (nobelprize.org)
Inhibitors1
Proteasome2
  • Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest. (bvsalud.org)
  • Our results demonstrate that MPP(+) induces cell cycle arrest independently of its mitochondrial toxicity or the p53 status of the target cells , but rather through the proteasome - and phosphatidylinositol 3-Akt- glycogen synthase kinase -3beta-dependent cyclin D1 degradation. (bvsalud.org)
Behavior3
  • Their phase fraction, that is, the ratio of smaller- to larger-size population, however, exhibits a depth-dependent behavior. (au.dk)
  • The level of SP immunoreactivity was associated with motor behavior degradation. (cdc.gov)
  • However, the ideal temperature for heat application depends on the thermal behavior of each material, such as glass transition (T g ) and initial degradation temperatures. (bvsalud.org)
Internalization1
  • However, Src activity is neither required for agonist-induced PAR1 internalization nor required for Src degradation upon PAR1 activation. (tmu.edu.tw)
Oxygen3
  • post-trans-lational and oxygen-sensitive degradation. (nobelprize.org)
  • a covalent modification that is itself dependent on oxygen. (nobelprize.org)
  • degradation in the presence (aerobic) and absence (anaerobic) of oxygen has been reported. (cdc.gov)
Receptor2
  • The activation of Toll-like receptor 2 (TLR2) initiated Txnip degradation, while no further Txnip degradation was observed in TLR2-deficient bone marrow-derived macrophages. (frontiersin.org)
  • The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor. (ruhr-uni-bochum.de)
Findings2
  • These findings specifically demonstrate that intermittent chloroquine use effectively prevents cancer in mouse models of 2 genetically distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia, suggesting that agents targeting lysosome-mediated degradation may be effective in cancer prevention. (jci.org)
  • These findings suggest that 24-OHC contributes to tau degradation through the up-regulation of the SIRT1/PGC1α/Nrf2 axis. (unito.it)
Macrophages1
  • Caspase-8-dependent apoptosisof infected macrophages, which requires activation of the mitogen-activated protein (MAP) kinase p38, lowers the spreadof mycobacteria. (edu.au)
Time-dependent3
  • 6 ] checked the effect of moisture conditions on the time-dependent behaviour of Inada granite. (hindawi.com)
  • The experimental and theoretical results have shown that the time-dependent behaviours of rocks are seriously affected by water [ 7 , 8 ]. (hindawi.com)
  • Effect of time dependent phenomena and ageing on. (tudelft.nl)
Chemical2
  • Chemical and physical degradation under coupled loading conditions. (tudelft.nl)
  • study highlights the relevance of social support to chemical dependents as a factor of better social performance, thus providing contributions to new research on the area. (bvsalud.org)
Vacuole1
  • Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner. (ruhr-uni-bochum.de)
Characteristics1
  • Then a three-dimensional finite difference analysis was executed on expressway tunnel portal areas while considering tunnel excavation and the moisture degradation effects on creep characteristics of surrounding rocks. (hindawi.com)
Temperature3
  • High temperature chemistry impacts emissions and material dependent surface degradation, which impacts friction and hence efficiency. (imperial.ac.uk)
  • A moderate weight loss began at around 270 ºC for all materials, which represented the initial degradation temperature. (bvsalud.org)
  • Regarding the heat treatment itself, it was concluded that the effective temperature for heat treatment is material dependent. (bvsalud.org)
Soil1
  • A high soil degradation rate didn't help. (org.in)
Enzymes1
  • The eCB system is comprised of eCBs, anandamide, and 2-arachidonoyl glycerol, their cannabinoid-1 and cannabinoid-2 receptors (CB 1 and CB 2 , respectively), and the enzymes involved in their biosynthesis and degradation. (degruyter.com)
Heavily dependent1
  • Currently security of our food supply is heavily dependent on our ability to pay for food imports and on reliable shipping services both to the RMI and within our islands group. (who.int)
Apoptosis3
  • Chloroquine treatment enhanced markers of both macroautophagy and apoptosis in MEFs but ultimately impaired lysosomal protein degradation. (jci.org)
  • Interestingly, chloroquine-induced cell death was not dependent on caspase-mediated apoptosis, as neither overexpression of the antiapoptotic protein Bcl-2 nor deletion of the proapoptotic Bax and Bak affected chloroquine-induced MEF death. (jci.org)
  • A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and cells become necrotic. (bmj.com)
Dominant3
  • Dominant negative (NIK) repressed TNF-alpha and IL-1beta-induced kappaB-dependent transcription by approximately 60% and approximately 35%, respectively. (nih.gov)
  • Significant positive correlation was observed between the total relative abundances of dominant DBP-degraders and DBP degradation percentage. (unboundmedicine.com)
  • The results indicated that the changes in DBP degradation percentage were related to both DBP bioavailability and the total relative abundances of dominant DBP-degraders. (unboundmedicine.com)
Demonstrate1
  • Finally, the lack of correlation between DNA binding and transcriptional activation plus the fact that PP1 and genistein both inhibited kappaB-dependent transcription without affecting DNA binding activity demonstrate the existence of regulatory steps downstream of NF-kappaB DNA binding. (nih.gov)
Tissues1
  • The degradation of the cartilage (and other tissues in the joint) is slow, and therefore it is sometimes said that OA is a degenerative disease. (lu.se)
Transcription1
  • 10 ng/ml) induced kappaB-dependent transcription equally. (nih.gov)
Nuclear1
  • This was not explained by degradation of IkappaBbeta, IkappaBepsilon, or p105 nor nuclear translocation of NF-kappaB. (nih.gov)
Progression1
  • That is, RIM1α-facilitated Ca V 2.2 expression plays a role in the downstream signaling of Fbxo3-dependent Fbxl2 ubiquitination/degradation to promote spinal plasticity underlying the progression of nociceptive hypersensitivity following neuropathic injury. (jneurosci.org)
Strongly1
  • The stability of esomeprazole sodium in aqueous solution is strongly pH dependent. (rxlist.com)
Activation3
  • NADPH oxidase-regulated NF-κB activation and pro-inflammatory activation were induced and accompanied by Txnip degradation during GAS infection. (frontiersin.org)
  • Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. (nih.gov)
  • These data reveal an imprecise relationship between IKK activation, IkappaBalpha degradation, and NF-kappaB DNA binding, suggesting the existence of additional mechanisms that regulate NF-kappaB activation. (nih.gov)
Results1
  • The results of a depth-dependent degradation suggest that employing a depth-dependent catalyst design can be used for future improvement of catalyst stability. (au.dk)
Areas2
  • The stability of our food supply at the national level is dependent on the resilience of the food supply system (comprising domestic production and imports) to shocks - such as food price spikes, climatic disasters (droughts, cyclones, storm surges etc.), outbreaks of pest/ diseases, and also to longer-term trends - including downturns in the global economy, changing climatic conditions and labor migration from rural areas. (who.int)
  • Specimen collection and transportation should be appropriate to minimize bias though specimen degradation in rural and remote areas. (who.int)
Gene1
  • Therapeutically these data are important as inhibition of the NIK-IKK-IkappaBalpha cascade may not produce equivalent reductions in NF-kappaB-dependent gene expression. (nih.gov)
Exposure2
  • The response is exposure dependent (HRHF>LRNF) and tissue dependent (epitenon>endotenon). (cdc.gov)
  • The tissue response is also dependent upon duration of task exposure. (cdc.gov)
Content1
  • During the first stage of cartilage degradation, the aggrecan content in the cartilage decreases. (lu.se)
Family1
  • We identified the UBE2D family (UBE2D1-4) as E2 partners for IDOL that support both autoubiquitination and IDOL-dependent ubiquitination of the LDLR in a cell-free system. (kent.ac.uk)
Requires2
  • Spinal plasticity, a key process mediating neuropathic pain development, requires ubiquitination-dependent protein turnover. (jneurosci.org)
  • The microkinetic analysis of heterogeneous systems leading to surface degradation and/or deposit formation currently requires either experimentally derived sticking coefficients or major computational expense (e.g. ab initio, density functional or plane wave methods). (imperial.ac.uk)
Highly1
  • Fish is a very important component of our diet and is vital to food security, particularly in the outer- islands where people are highly dependent on fish for daily nutrition. (who.int)
Process2