• The Deoxynucleotide Triphosphates (dNTPS) Market size is estimated to grow at a CAGR of 7.26% between 2023 and 2028. (technavio.com)
  • What will be the size of the Deoxynucleotide Triphosphates dNTPS Market During the Forecast Period? (technavio.com)
  • Deoxynucleotide triphosphates dNTPS are used in labs for a myriad of applications, including DNA sequencing. (technavio.com)
  • Additionally, the deoxynucleotide triphosphates (dNTPS) market is observing a rising demand from the pharmaceutical and biotechnology sectors owing to the increasing commercial approval of oligonucleotide therapies by authorities such as the US FDA and EMA. (technavio.com)
  • Thus, the growing commercial availability of oligonucleotide therapies is expected to positively impact the growth of the global deoxynucleotide triphosphates (dNTPS) market during the forecast period. (technavio.com)
  • Variation in regulatory standards and compliances globally is among the primary challenges faced by vendors in the global deoxynucleotide triphosphates (dNTPS) market. (technavio.com)
  • Deoxynucleotide triphosphate triphosphyohydrolyases (dNTPases) play a critical role in cellular survival and DNA replication through the proper maintenance of cellular dNTP pools by hydrolyzing dNTPs into deoxynucleosides and inorganic triphosphate (PPPi). (biorxiv.org)
  • SAM domain and HD domain containing protein 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that inhibits retroviruses by depleting intracellular deoxynucleotide triphosphates (dNTPs) in non-cycling myeloid cells. (oncotarget.com)
  • This RNA-dependent DNA polymerase, with the assistance of reverse transcription primers, deoxynucleotides (dNTPs: dATP, dTTP, dGTP and dCTP) and enzyme cofactors, catalyzes the synthesis of cDNA from its respective target RNA sequence. (stratech.co.uk)
  • dNTPs or deoxynucleotide triphosphates are the "building blocks" for DNA. (meridianbioscience.com)
  • The SpinOUT™ PCR columns are spin format desalting columns that have the ability to remove salts, radioisotpes, dyes, primers and deoxynucleotides (dNTPs) for nucleic acids following PCR. (gbiosciences.com)
  • The Deoxynucleotide (dNTP) Solution Set contains 0.25 ml of each 100 mM ultrapure nucleotide as four separate solutions (dATP, dCTP, dGTP and dTTP). (neb.com)
  • AGS can also be caused by defects of SAMHD1, a 3' exonuclease and deoxynucleotide (dNTP) triphosphohydrolase. (nih.gov)
  • Each deoxynucleotide solution (dATP, dCTP, dGTP, dTTP) is provided in a separate vial at 100 mM. (biotium.com)
  • Cells containing high concentrations of deoxynucleotides are unable to properly repair single-strand DNA breaks. (nih.gov)
  • Inhibition of this enzyme by the diphosphate nucleoside causes a reduction in the concentrations of deoxynucleotides, including dCTP. (globalrph.com)
  • dGTP inhibits ribonucleotide reductase, which is needed for synthesis of deoxynucleotides. (medscape.com)
  • We suggest some implications of these results for the mechanism of sequence-specific DNA recognition, DNA structure, and the evolution of the deoxynucleotide synthesis pathways. (caltech.edu)
  • Inhibitor of deoxynucleotide synthesis. (medscape.com)
  • Since 2-chloro-2΄-deoxy- β -D-adenosine is resistant to deamination by adenosine deaminase and there is little deoxynucleotide deaminase in lymphocytes and monocytes, 2-CdAMP accumulates intracellularly and is subsequently converted into the active triphosphate deoxynucleotide, 2-chloro-2΄-deoxy- β -D-adenosine triphosphate (2-CdATP). (nih.gov)
  • The enzyme deoxynucleotide 3′-phosphatase (EC 3.1.3.34) catalyzes the reaction a 2′-deoxyribonucleoside 3′-phosphate + H2O = a 2′-deoxyribonucleoside + phosphate This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. (wikipedia.org)
  • Mutant deoxynucleotide carrier is associated with congenital microcephaly. (medlineplus.gov)
  • Reaction of Cyclopent(c,d)pyrene-3,4-epoxide with DNA and Deoxynucleotides. (epa.gov)
  • It is postulated that cells with high deoxycytidine kinase and low deoxynucleotidase activities will be selectively killed by 2-chloro-2΄-deoxy- β -D-adenosine as toxic deoxynucleotides accumulate intracellularly. (nih.gov)
  • The Phusion High-Fidelity PCR Kit contains a sufficient supply of Phusion High-Fidelity DNA Polymerase, Phusion HF and GC Buffers, deoxynucleotides, magnesium chloride, DMSO, and DNA size standard to perform 50 reactions (small) or 200 reactions (large). (neb.com)
  • We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces replication stress by downregulating the regulatory subunit RRM2 of ribonucleotide reductase, perturbing deoxynucleotide triphosphate (dNTP) supply. (nature.com)
  • Iacobazzi V, Ventura M, Fiermonte G, Prezioso G, Rocchi M, Palmieri F. Genomic organization and mapping of the gene (SLC25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC). (medlineplus.gov)
  • The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals. (medlineplus.gov)
  • Results for Reference: Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA. (neb.com)