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  • cidofovir
  • Among these, cidofovir, an acyclic nucleotide-phosphonate analogue of deoxycytosine-monophosphate, has been employed with various outcomes, alone or in combination with mirtazapine, an agonist of serotonin-receptor-2A (5HT2AR) blocking the JCV entry into glial cells. (springer.com)
  • dCTP
  • For pol β, the insertion of dCTP was preferred opposite the dG-FAF adduct in a single nucleotide gap assay consistent with 19 F NMR data. (uri.edu)
  • Surface plasmon resonance binding kinetics revealed that pol β binds tightly with DNA in the presence of correct dCTP, but the adduct weakens binding with no nucleotide specificity. (uri.edu)
  • gene
  • 5-Methyl-2'-deoxycytosine, the most common epigenetic marker of DNA in eukaryotic cells, plays a key role in gene regulation and affects various cellular processes such as development and carcinogenesis. (uni-konstanz.de)
  • different
  • In certain embodiments of the invention, each different type of nucleotide 218 is distinguishably labeled with a bulky group and each incorporated nucleotide 218 is identified by the changes in mass and/or surface stress of the structure 116, 212 upon incorporation of the nucleotide 218 . (google.com)
  • upon
  • In contrast, dG-FAF adduct at the replication fork for the Kfexo − complex adopts a mix of the major and minor groove conformers with minimal effect upon the addition of non-hydrolysable nucleotides. (uri.edu)