• Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase, converting it to deoxycytidine monophosphate (dCMP), a DNA precursor. (wikipedia.org)
  • Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis. (bvsalud.org)
  • The deoxyribonucleoside salvage pathway with the rate-limiting enzyme deoxycytidine kinase (dCK) captures extracellular deoxyribonucleosides for use in intracellular deoxyribonucleotide metabolism . (bvsalud.org)
  • Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. (genetex.com)
  • Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. (genetex.com)
  • Cytidine deaminase (CDA) and deoxycytidine monophosphate deaminase (DCTD), deoxycytidine kinase (dCK), 5'-nucleotidase and human equilibrative nucleoside transporter (hENT1) participate in the regulation of cellular nucleotide and nucleoside pools and also in the metabolism of therapeutically significant nucleoside and nucleotide analogs including cytarabine that is commonly used for the treatment of diverse hematological malignancies. (imtm.cz)
  • One to 30 microliters (microl) of styrene -oxide were reacted with 0.5 milligram calf thymus DNA, 2'- deoxyguanosine-3'-monophosphate (dGp), 2'-deoxyadenosine-3'- monophosphate (dAp), 2'-deoxycytidine-3'-monophosphate (dCp), or 2'- deoxythymidine-3'-monophosphate (dTp) in a Tris/hydrochloric-acid buffer, pH 7.5, at 37 degrees-C for about 15 hours. (cdc.gov)
  • Therefore, a series of 5-substituted analogs of 2'-deoxycytidine 5'-(alpha-P-borano)triphosphates (dCTPalphaB) were synthesized with the hope of increasing the nuclease resistance of deoxycytosine residues and thereby enhancing the deoxycytosine band intensities. (duke.edu)
  • These dCTP analogs contain a boranophosphate modification at the alpha-phosphate group in 2'-deoxycytidine 5'-triphosphate (dCTP) as well as a 5-methyl, 5-ethyl, 5-bromo or 5-iodo substitution for the 5-hydrogen of cytosine. (duke.edu)
  • Results of our coexpression analysis demonstrated that PTTG family genes were positively correlated with thiamine triphosphate (TTP), deoxycytidine triphosphate (dCTP) metabolic, glycolysis, gluconeogenesis, and cell-cycle related pathways. (medsci.org)
  • Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. (wikipedia.org)
  • Scholars@Duke publication: Synthesis of 5-substituted 2'-deoxycytidine 5'-(alpha-P-borano)triphosphates, their incorporationinto DNA and effects on exonuclease. (duke.edu)
  • 5-(Hydroxymethyl)-2′-deoxycytidine (5-hmdC), 5-(formyl)-2′-deoxycytidine (5-fodC), and 5-(carboxyl)-2′-deoxycytidine (5-cadC) are intermediates in the DNA demethylation pathway and can act as biomarkers. (wikipedia.org)
  • To better understand Dicer function, and the potential mechanisms by which RNAi contributes to pluripotency, short RNA expression was profiled from 4 ES cell libraries: 2 made from a Dicer-conditional ES cell line before and several months after deletion of Dicer, and 2 made before and 5 days after demethylation of J1 ES cells with 5-aza-deoxycytidine. (nih.gov)
  • It can also be used as a precursor for 5-aza-2′-deoxycytidine, a treatment for MDS patients. (wikipedia.org)
  • Combining UHRF1 knockdown with 5-aza-deoxycytidine treatment resulted in restoration of P16 levels compared to controls siRNA samples. (liverpool.ac.uk)
  • We showed strong evidence that Keap1 expression is regulated by its promoter methylation, as KEAP1 expression was restored following 5-aza-deoxycytidine treatment. (liverpool.ac.uk)
  • The induction of MAGE-1, -2, -3, and -4 gene expression in eight colorectal carcinoma cell lines also was examined by use of a demethylating agent, 5-Aza- 2'-deoxycytidine (DAC). (elsevierpure.com)
  • 2. Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells. (nih.gov)
  • 5. Clofarabine exerts antileukemic activity against cytarabine-resistant B-cell precursor acute lymphoblastic leukemia with low deoxycytidine kinase expression. (nih.gov)
  • 12. Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase. (nih.gov)
  • 16. Activation of deoxycytidine kinase by various nucleoside analogues. (nih.gov)
  • Relationship between deoxycytidine kinase (DCK) genotypic variants and fludarabine toxicity in patients with follicular lymphoma. (cdc.gov)
  • dFdCTP is also known to incorporate into RNA and competes with deoxycytidine triphosphate (dCTP) for the binding site of POLA and POLE. (medscape.com)
  • Emtricitabine must be converted intracellularly to its triphosphate form, which then competes with deoxycytidine 5'-triphosphate for incorporation into the developing viral DNA strand. (antimicrobe.org)
  • dFdC) is a pyrimidine analogue of deoxycytidine that has antitumor activity against various solid tumors, including pancreatic cancer, non-small-cell lung cancer, breast cancer and ovarian cancer. (medscape.com)
  • Messenger RNA formation: resistance to inhibition by 3'-deoxycytidine. (uchicago.edu)
  • Deoxycytidine prevents or delays (but does not reverse) the cytotoxic activity. (nih.gov)
  • An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 5-Fluoro-2'-deoxycytidine (10356-76-0). (nih.gov)
  • Effects of 5-Fluoro-2'-deoxycytidine in Mouse Lymphoma. (nih.gov)
  • Of these 11 cell lines, nine showed re-expression of the gene after treatment with 5-aza-2'-deoxycytidine, a DNA demethylation agent. (cdc.gov)
  • During the last 10 years, three European phase II studies were performed to investigate the treatment of elderly patients with myelodysplastic syndrome (MDS) with low-dose 5-aza-2'-deoxycytidine (decitabine, DAC). (nih.gov)