18-Hydroxy-11-deoxycorticosterone (also known as 18-OH-DOC, 18,21-dihydroxyprogesterone, and 18,21-dihydroxypregn-4-ene-3,20-dione) is an endogenous steroid and a mineralocorticoid. (wikipedia.org)
In humans, 18-OH-DOC is a weak mineralocorticoid. (wikipedia.org)
Excessive secretion of 18-OH-DOC can cause mineralocorticoid excess syndrome, although these cases are very rare. (wikipedia.org)
Numerous aldosterone precursors, including deoxycorticosterone and 18-hydroxycorticosterone, have mineralocorticoid activity and may produce or exacerbate features typical of mineralocorticoid hypertension when present in excessive amounts in various pathologic states. (medscape.com)
The accumulation of the cortisol precursor 11-deoxycorticosterone can activate mineralocorticoid receptors which may lead to hypokalemia, edema, or hypertension. (drugbank.com)
Aldosterone2
Deoxycorticosterone (DOC) is a C-21 (21 carbon atoms) steroid hormones synthesized in the zona fasciculata (ZF) and zona glomerulosa (ZG) of the adrenal gland and is a precursor for the synthesis of cortisol and aldosterone (see the image below). (medscape.com)
Deoxycorticosterone (DOC) is a C-21 (21 carbon atoms) steroid hormone synthesized in zona fasciculata (ZF) and zona glomerulosa (ZG) of the adrenal gland and is a precursor for the synthesis of cortisol and aldosterone (see the image below). (medscape.com)
Progesterone1
Deoxycorticosterone (DOC) is produced from progesterone under the effect of 21-hydroxylase (other name: 21-hydroxyprogesterone). (medscape.com)
Hypertension1
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension: Erratum. (bvsalud.org)
Symptoms1
6 Patients should be monitored for these symptoms as they are evidence of elevated 11-deoxycorticosterone levels, and for symptoms such as hirustism, acne, and hypertrichosis which may be suggestive of excessive circulating androgen levels. (drugbank.com)