Denv specific monoclonal antibodies. Medical search. Frequent questions

Furthermore, levels of neutralising antibody, ACE2 blocking activity, and spike-specific IgA measured prior to BTI also correlated with the duration of infection. (bvsalud.org)
JNJ-1802 exerts picomolar to low nanomolar in vitro antiviral activity, a high barrier to resistance and potent in vivo efficacy in mice against infection with any of the four DENV serotypes. (bvsalud.org)
Finally, we demonstrate that the small-molecule inhibitor JNJ-1802 is highly effective against viral infection with DENV-1 or DENV-2 in non-human primates. (bvsalud.org)
Relationship between Trimester-Specific ZIKV Infection Risk and Microcephaly in Bahia, Brazil. (atmire.com)
Control BHK cells (uninfected) and Virus (DENV 1,2) infection BHK cells were fixed in 4% PFA, permeabilized with PBS containing 0.1% Triton X-100. (leadgenebio.com)
Virus infection C636 cell lysates were stained with mouse anti-DENV M monoclonal antibody at 1:1000 dilution. (leadgenebio.com)
The suboptimal antibodies can result from natural infection or from vaccination. (wikipedia.org)
In ADE, antiviral antibodies promote viral infection of target immune cells by exploiting the phagocytic FcγR or complement pathway. (wikipedia.org)
The process of phagocytosis is accompanied by virus degradation, but if the virus is not neutralized (either due to low affinity binding or targeting to a non-neutralizing epitope), antibody binding may result in virus escape and, therefore, more severe infection. (wikipedia.org)
Natural infection and the attenuated vaccine induce antibodies that enhance the update of the homologous virus and H1N1 virus isolated several years later, demonstrating that a primary influenza A virus infection results in the induction of infection enhancing antibodies. (wikipedia.org)
Infection induces the production of neutralizing homotypic immunoglobulin G (IgG) antibodies that provide lifelong immunity against the infecting serotype. (wikipedia.org)
B cells manufacture antibodies which are exquisitely tailored protein tools critical to controlling infection. (uvm.edu)
Alternatively, activated B cells can develop into memory B cells that persist long after infection to provide an institutional memory of those manufactured antibodies to facilitate their rapid remanufacture (or improvement) to protect against a subsequent pathogen encounter. (uvm.edu)
His goal is to develop novel immune metrics and specific antibody tools that can be used to advance vaccine development and to understand host-pathogen interactions during viral infection or vaccination. (uvm.edu)
4) Transcriptional profiling of DENV virus infection (Joint College of Medicine/Engineering Biomedical Engineering grant with Donna Rizzo and John Hanley from UVM and Sam Scarpino from Northeastern). (uvm.edu)
Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. (microbiologyresearch.org)
Considering the calamity of ZIKV infection, there is an urgent need to develop rapid detection methods for ZIKV along with DENV, which shares common clinical symptoms with ZIKV. (frontiersin.org)
hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection. (fsu.edu)
Dengue virus (DENV) infection is one of the most widespread mosquito-borne viral infections. (shengsci.com)
Liver injury is commonly observed in severe DENV infection, and the present study aimed to examine the efficacy of crocetin treatment in an immunocompetent mouse model of DENV infection exhibiting liver injury. (shengsci.com)
These VOCs have shown variable escape from antibody responses and have been shown to trigger qualitatively different antibody responses during infection. (bvsalud.org)
We further isolated an antibody from Beta infection which targeted the N417 site, enabling cross-neutralization of Beta, Delta+, and Omicron, all of which possess this residue. (bvsalud.org)
The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
however, a new model using high doses of DENV has recently been shown to develop hemorrhagic signs after infection. (mdpi.com)
Dengue is an acute infectious disease caused by infection with any one of four serotypes of dengue virus (DENV 1-4), which are transmitted by Aedes mosquitoes [ 1 ]. (biomedcentral.com)
Here we have shown that a mannoside glycolipid conjugate (MGC) bearing a trimannose head with a saturated lipid chain inhibited DENV productive infection. (cnrs.fr)

The overlapping epidemiology and immunologic cross-reactivity between ZIKV and dengue virus (DENV) pose complex challenges to vaccine design, given the potential for antibody-dependent enhancement of disease. (bvsalud.org)
Therefore, classification of ZIKV-specific antibody targets is of notable value. (bvsalud.org)
From a ZIKV-infected rhesus macaque, we identify ZIKV-reactive B cells and isolate potent neutralizing monoclonal antibodies (mAbs) with no cross-reactivity to DENV. (bvsalud.org)
We group these mAbs into four distinct antigenic groups targeting ZIKV-specific cross-protomer epitopes on the envelope glycoprotein. (bvsalud.org)
These results provide key insights into ZIKV-specific antigenicity and have implications for ZIKV vaccine, diagnostic, and therapeutic development. (bvsalud.org)
We have been using structure-guided protein engineering to develop novel immunogens that elicit DENV and ZIKV protective antibody responses. (einsteinmed.edu)
Zika virus (ZIKV) and dengue virus (DENV) are closely related flaviviruses primarily transmitted by Aedes mosquitoes. (biomedcentral.com)
s ubalbatus could be a vector for ZIKV and DENV or not. (biomedcentral.com)
were fed with blood meal containing ZIKV or DENV-2. (biomedcentral.com)
At 4, 7, 10, 14, and 21 days post-inoculation (dpi), the infections of ZIKV or DENV-2 in the midguts, ovaries and salivary glands were detected and quantified by RT-PCR and RT-qPCR. (biomedcentral.com)
were reared in artificial urine containing ZIKV or DENV-2. (biomedcentral.com)
Zika virus (ZIKV) and dengue virus (DENV) share a lot of similarities being both phylogenetically closely related, share the same insect vector passage for reaching the host, affinity for the same carbohydrate. (biomedcentral.com)

During the Louis antigens, prepared on Vero cells and inactivated by last 3 years, no further DENV isolates have been reported betapropiolactone (Sigma-Aldrich, St Quentin Fallavier, on the island. (cdc.gov)
Two DENV-1 isolates form Brasília (Federal District, Brazil), were identified using polyclonal and monoclonal antibody-assay. (unb.br)
Genomic RNA of those isolates (DF01 e DF02) were amplified using specific primer pairs for DENV-1 by RT-PCR. (unb.br)
Setthapramote C, Pitaksajjakul P, Sasaki T, Ikuta K, Ramasoota P. Validation of Neutralizing Human Mnonoclonal Antibodies Against all Four Dengue virus serotype of Clinical Isolates. (mahidol.ac.th)
This study aims to improve the development of immunodiagnostic methods for dengue virus (DENV) detection through the production and characterization of 22 monoclonal antibodies (mAbs) against Brazilian isolates of DENV-1, -2 and -3. (fiocruz.br)
To our knowledge, these are the first monoclonal antibodies raised against Brazilian DENV isolates, and they may be of special interest in the development of diagnostic assays, as well as for basic research. (fiocruz.br)
RESEARCH virus was recovered by culturing 140 µL of acute-phase 2001, 95% of isolates were DENV-1. (cdc.gov)

Dr. Ralph Baric (above) and his team showed how antibodies from Dengue fever survivors can be used to fight Zika. (unc.edu)
The Baric team conducted research that showed how antibodies from patients who survived Dengue fever can be used to fight the Zika virus now. (unc.edu)
We wanted to know how these pre-existing Dengue antibodies in the human population were likely to interact with the Zika virus," Swanstrom says. (unc.edu)
The antibody derived from Dengue survivors, EDE 1, neutralized the Zika virus in cell cultures, creating a protective effect. (unc.edu)
A therapeutic treatment using these antibodies would protect pregnant women and others from contracting the Zika virus if they came in contact with it. (unc.edu)
3) Defining B cell memory to Dengue and Zika and developing potent neutralizing antibodies (CDC and NIH, Collaboration with A. De Silva, University of North Carolina, Chapel Hill). (uvm.edu)
Cross-reactive dengue virus-derived monoclonal antibodies to Zika virus envelope protein: Panacea or Pandora's box? (biomedcentral.com)

Accompanying the change in the relative proportions of with flavivirus-, dengue-, or serotype-specific monoclonal dengue virus serotypes recovered from patients in the antibodies (23,24). (cdc.gov)
Dengue virus (DENV) is an arbovirus (arthropod-transmitted virus) from the Flavivirus family and is one of the leading causes of mosquito-borne diseases worldwide. (pidjournal.com)
Dengue virus (DENV), a mosquito-borne flavivirus, causes severe and potentially fatal symptoms in millions of infected individuals each year. (cnrs.fr)

Green: Dengue virus Envelope protein stained by Dengue virus Envelope protein antibody (GTX127277) diluted at 1:1000. (genetex.com)

Cells were stained with mouse anti-DENV M monoclonal antibody (1:400) followed by secondary antibodies (goat anti-Mouse IgG-iFluor 488, 1:400, green) and cell nuclei were stained with Hoechst 33342 (Blue). (leadgenebio.com)

Dengue is caused by dengue virus (DENV), a virus which can be transmitted by Aedes mosquitos. (pasteur-kh.org)

Characterization of Human Monoclonal Antibodies (HuMAbs) with Neutralizing and Enhancing Activities to Four Serotypes of Dengue Virus. (mahidol.ac.th)

These variable mutations also influence the cross-reactivity of the antibody response mounted by individuals infected with each of these variants. (bvsalud.org)
We show that Beta and Delta infections resulted in antibody responses that were more cross-reactive than the original D614G variant, but they had differing patterns of cross-reactivity. (bvsalud.org)

Dengue virus (DENV) is the most prevalent mosquito-borne virus worldwide, causing ~390 million infections annually. (berkeley.edu)
Author Summary Dengue is definitely a mosquito-borne disease caused by one of four AZ5104 serotypes of (DENV-1-4). (thinkbeforeyouclickca.org)
Intro Dengue viruses (DENV) are the most common mosquito-borne RNA viruses worldwide, classified serologically into four antigenically unique types (DENV-1C4). (thinkbeforeyouclickca.org)

The SJ25C1 antibody and the HIB19 monoclonal antibody recognize overlapping epitopes. (thermofisher.com)
ADE may occur because of the non-neutralizing characteristic of an antibody, which binds viral epitopes other than those involved in host-cell attachment and entry. (wikipedia.org)
It may also happen when antibodies are present at sub-neutralizing concentrations (yielding occupancies on viral epitopes below the threshold for neutralization), or when the strength of antibody-antigen interaction is below a certain threshold. (wikipedia.org)
This study sought to understand the antibody responses elicited by different SARS-CoV-2 variants and to define shared epitopes. (bvsalud.org)
The discovery of antibodies which target escape mutations common to multiple variants highlights conserved epitopes to target in future vaccines and therapeutics. (bvsalud.org)

When the antibodies were tested against the four DENV serotypes, different reactivity patterns were identified: group-specific, subcomplex specific (DENV-1, -3 and -4 and DENV-2 and -3) and dengue serotype-specific (DENV-2 or -3). (fiocruz.br)

Therapeutic Human MAbs against 4 serotypes of DENV. (mahidol.ac.th)
The mAbs include IgG2bκ, IgG2aκ and IgG1κ isotypes, and most were raised against the envelope or the pre-membrane proteins of DENV. (fiocruz.br)
The use of monoclonal antibodies (mAbs) as therapeutics (immunotherapy) has been highly successful for oncology and other indications, but application of mAbs to viral immunotherapy is only now emerging. (einsteinmed.edu)
mAbs offer an advantage of being highly specific, with little adverse effects. (einsteinmed.edu)
After the fourth immunization, four hybridoma lines (18G10, 9G4, 23F4 and 22A10) secreting anti-WDV CP MAbs were acquired through four time cell fusions, antibody specificity and level of sensitivity analyses, and cell limiting dilution cloning. (thetechnoant.info)

In additional experiments, mice were pretreated i. p with 100 L anti-DENV-3 polyclonal antiserum or control serum, 60 min before inoculation of the adapted DENV-3. (thinkbeforeyouclickca.org)
The anti-DENV serum utilized was kindly given by Dr. Ricardo Galler from Departamento de Bioqumica e Biologia Molecular do Instituto Oswaldo Cruz-Fiocruz, RJ, Brazil [34]. (thinkbeforeyouclickca.org)
Serum was from Rhesus monkeys inoculated subcutaneously within the AZ5104 anterior surface of the remaining forearm with 0,5 ml of Rabbit Polyclonal to MAP3K7 (phospho-Thr187) the viral suspension comprising 105 PFU of the DENV-3 H87 (13 dpi) [34]. (thinkbeforeyouclickca.org)
Using an indirect enzyme-linked immunosorbent assay (ELISA) for SARS-CoV-2's RBD, we screened serum from wild and domestic animals for the presence of antibodies against SARS-CoV-2's RBD. (bvsalud.org)
Surprisingly prepandemic feline serum samples submitted to the University of Tennessee Veterinary Hospital were â ¼50% positive for anti-SARS RBD antibodies. (bvsalud.org)
Two receptor antibodies (angiotensin II type 1 receptor antibodies and alpha-2B adrenergic receptor) and serum levels of IL-6/IL-8 can distinguish individuals with PCVS from vaccinated individuals who did not develop PCVS. (discovermednews.com)
Brain-derived neurotrophic factor measurements in mouse serum and plasma using a sensitive and specific enzyme-linked immunosorbent assay. (ebsco.com)

In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)

Santé des Armées [IMTSSA]) tropical virology laboratory and specific binding was demonstrated by using a peroxi- in Marseille to identify the etiologic agent. (cdc.gov)
Projects are highly interdisciplinary and involve aspects such as phage display, structure-based protein design, bispecific antibody engineering, structural biology, virology, and cancer biology. (einsteinmed.edu)

The clones obtained with DENV-1 subgenomic fragments used in this study, were transferred into lowcopy plasmid modified for the possible construction of an infectious cDNA clone. (unb.br)
Mutations encoding basic (Arg), non-polar (Leu and Pro) and uncharged polar (Asn, Gln and Tyr) amino acids at M39 were introduced into a DENV-2 genomic-length cDNA clone and their effects on virus replication were examined. (microbiologyresearch.org)

Then, the NS1 epitope targeted by these antibodies will be mapped to elucidate the residues involved in cell surface binding. (berkeley.edu)
Keadsanti S, Setthapramote S, Pitaksajjakul P, Sasaki T, Ikuta K, Yamanaka A, Konishi E, Ramasoota P. Epitope Mapping of Neutralizing Human Monoclonal Antibody against Dengue virus using Escape Mutant Strategy. (mahidol.ac.th)
Thus, we have identified a novel antibody which targets a shared epitope found on three distinct VOCs, enabling their cross-neutralization. (bvsalud.org)

Participants that were nucleocapsid seropositive prior to their BTI had significantly higher levels of binding and functional antibodies to the spike protein, shorter median duration of infections, and lower median peak viral loads compared to seronegative participants. (bvsalud.org)
In people who have contracted Dengue virus, antibodies generated by the body in response to serial infections may be protective or, under some circumstances, actually may promote more severe disease symptoms. (unc.edu)

Here we present JNJ-1802-a highly potent DENV inhibitor that blocks the NS3-NS4B interaction within the viral replication complex. (bvsalud.org)
Here, we aimed to develop a potent SARS-CoV-2 antibody w. (biomedcentral.com)

Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which binding of a virus to suboptimal antibodies enhances its entry into host cells, followed by its replication. (wikipedia.org)
Humanized mouse models can sustain DENV replication and show some signs of disease, but further development is needed to validate the immune response. (mdpi.com)

We found three recombination events among all DENV examined sequences, one of the new full length genome described here was apparently recombinant. (unb.br)
Our analysis of full genome sequences samples of DENV-1 population geographically structured and with low-diversity in Latin American has yielded strong evidence of relatively pervasive recombination. (unb.br)

By studying plasma from individuals infected with either the original D614G, Beta, or Delta variants, we showed that the Beta and Delta variants elicit antibody responses that are overall more cross-reactive than those triggered by D614G. (bvsalud.org)
To probe this further, we isolated monoclonal antibodies from a Beta-infected individual with plasma responses against Beta, Delta+, and Omicron, which all possess the N417 residue. (bvsalud.org)

Four antigenically distinct serotypes, DENV types 1 to 4, exist (3). (cdc.gov)

Non-structural protein 1 (NS1) is the only protein secreted from DENV-infected cells and plays a role in pathogenesis through induction of barrier dysfunction of human endothelial cells. (berkeley.edu)
In my research, I seek to identify specific DENV NS1 regions that are required for binding to human endothelial cells and to investigate whether blocking these binding sites prevents NS1-induced pathogenesis. (berkeley.edu)
My experimental approach includes testing a panel of anti-NS1 monoclonal antibodies to determine which antibodies prevent NS1 binding to human pulmonary microvascular endothelial cells (HPMEC). (berkeley.edu)

The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. (thermofisher.com)

Their high binding specificity and affinity make them comparable to antibodies, but they are superior regarding a longer shelf life, simple production and chemical modification, in addition to low toxicity and immunogenicity. (encyclopedia.pub)

We focus on developing new therapeutics by protein engineering that may have features that are not possible with conventional (natural) antibodies. (einsteinmed.edu)
Understanding antibodies targeting escape mutations, such as K417N, which repeatedly emerge through convergent evolution in SARS-CoV-2 variants, may aid in the development of next-generation antibody therapeutics and vaccines. (bvsalud.org)

Development of a rapid lateral flow assay for detection of anti-coccidioidal antibodies. (ebsco.com)

Titration curve of anti-DENV M antibody in ELISA. (leadgenebio.com)
2018) Valoración de un nuevo ensayo quimioluminiscente en comparación con ELISA en la detección de IgG contra el virus de la hepatitis E. Revista de la Sociedad Andaluza de Microbiología y Parasitología Clínica. (vircell.com)
Correlations between three ELISA protocols measurements of RTS,S/AS01-induced anti-CSP IgG antibodies. (ebsco.com)

DENV-3 was dase-labeled goat anti-human IgG conjugate. (cdc.gov)

Pitaksajjakul P, Benjathummarak S, Hananatachai H, Fujiyama K, Misaki R, Sasaki T, Ikuta K, Ramasoota P. Cloning and expression of recombinant IgG of neutralizing human monoclonal antibody against dengue virus. (mahidol.ac.th)
In some experiments IL-18 was neutralized by daily i.p. injection of 1mg/kg of recombinant human being IL-18BP per animal (hIL-18 bp), starting 1 hour after DENV-3 inoculation and enduring until day time 6 after disease inoculation. (thinkbeforeyouclickca.org)

Flow cytometry analysis of CD19 was performed by staining Raji CD19 Knock out cells with 0.25 µg Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ (Product # 12-4714-82, yellow histogram) or 0.25 µg CD19 Monoclonal Antibody (HIB19), PE, eBioscience™ (Product # 12-0199-42, blue histogram). (thermofisher.com)
Applications Tested: This HIB19 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
After interaction with a virus, the antibodies bind Fc receptors (FcR) expressed on certain immune cells or complement proteins. (wikipedia.org)
Essentially, the virus "deceives" the process of phagocytosis of immune cells and uses the host's antibodies as a Trojan horse. (wikipedia.org)
He studied how naïve B cells that do not yet make antibodies, become activated (in part by CD4+ T cells) to scale up and develop into antibody-producing cellular factories such as plasmablasts and plasma cells. (uvm.edu)
It showed remarkable cell promiscuity, being active in human skin dendritic cells, hepatoma cell lines and Vero cells, and was active against all four DENV serotypes, with an IC50 in the low micromolar range. (cnrs.fr)

We recently described the interaction between non-structural proteins NS3 and NS4B as a promising target for the development of pan-serotype dengue virus (DENV) inhibitors3. (bvsalud.org)

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated. (thermofisher.com)

This antibody was raised against Dengue virus 2 Envelope protein, which may cross react with Envelope protein of Dengue virus 3 but does not recignize with Envelope protein of JEV. (genetex.com)
Dengue virus Envelope protein antibody detects Dengue virus Envelope protein protein at cytoplasm by immunohistochemical analysis. (genetex.com)
Non-infected (-) and infected (+) BHK-21 whole cell extracts (5 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with Dengue virus Envelope protein antibody (GTX127277) diluted at 1:25000. (genetex.com)

Description: The HIB19 monoclonal antibody reacts with human CD19, a 95 kDa transmembrane glycoprotein. (thermofisher.com)

We isolated an N417-dependent antibody, 084-7D, which showed similar neutralization breadth to the plasma. (bvsalud.org)

In some experiments, the suspension of the adapted DENV-3 disease was UV-irradiated (exposure of virus stock for 15 min to a UV light producing irradiation mainly at 365 nm) or warmth inactivated (56C for 1 h) before inoculation of mice. (thinkbeforeyouclickca.org)

Here, we describe the phenotype of illness of immunocompetent mice with an adapted DENV-3 strain. (thinkbeforeyouclickca.org)
Consequently, we describe a model of DENV-3 illness in immunocompetent mice that shows to be an interesting tool to study hostCvirus relationships and mechanisms mediating safety or those associated with severe disease manifestation. (thinkbeforeyouclickca.org)

Their recognition by specific host receptors called pattern recognition receptors (PRR) induces a strong inflammatory response to kill the pathogen. (elifesciences.org)
Chemokine receptors that are specific for CC CHEMOKINES. (lookformedical.com)
A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)

Os clones obtidos com fragmentos genômicos de DENV-1 utilizados no estudo, foram transferidos para um vetor modificado para o possível desenvolvimento de cDNA infeccioso. (unb.br)

ADE is mainly mediated by IgG antibodies, but IgM and IgA antibodies have also been shown to trigger it. (wikipedia.org)

We demonstrate that upon hitting a host cell, motile Pseudomonas aeruginosa induce a specific gene expression program. (elifesciences.org)

We have used phage display to dissect critical determinants underlying specific protein-protein and protein-antibody interactions. (einsteinmed.edu)

DENV-1 was isolated during this epidemic, while lated in Martinique 2 years earlier. (cdc.gov)

More recently we seek to understand how norovirus, a family of viruses for which there is no vaccine and causes significant gastrointestinal illness (vomiting and diarrhea) and hospitalization can skew the infant antibody response towards those that may not offer protection. (uvm.edu)

Development of Monoclonal Antibodies specific to Foot and Mouth Disease Virus using phage display and hybridoma techniques. (mahidol.ac.th)
This work also directly led to the development of a new antibody (Nirsevimab) that can protect premature infants after one dose for an entire winter season against respiratory syncytial virus (RSV). (uvm.edu)

Dois isolados brasilienses (Distrito Federal, Brasil) de DENV-1 foram identificados em testes utilizando anticorpo policlonal e monoclonal. (unb.br)

In combination with clinical symptoms and radiographic findings, antibody-b. (ebsco.com)

Benjathummarak S, Setthapramote C, Sasaki T, Ikuta K, Ramasoota P, Pitaksajjakul P. Cloning and Expression of A scFv Antibody Generated from Neutralizing Human Monoclonal Antibody against Dengue virus. (mahidol.ac.th)

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