Denv disease severity. Medical search. Frequent questions

Dengue is caused by four closely related viruses (DENV-1-4), and a person can be infected with each serotype for a total of four infections during their lifetime. (cdc.gov)
After an infection with one DENV serotype, antibodies induced are type specific and cross-react with other DENV serotypes ( 4 ). (cdc.gov)
P = .007) but was absent for DENV-1, in accordance with the serotype-dependent OAS3 activity found in the functional study. (nih.gov)
Patients with the DENV-1 serotype were more prone to present with several clinical and laboratory features as compared with DENV-4 patients, including spontaneous bleeding ( P = 0.03), intense abdominal pain ( P = 0.004), neurological symptoms ( P = 0.09), and thrombocytopenia ( P = 0.01). (biomedcentral.com)
DENV-4 was the predominant serotype, followed by DENV-1, in a large outbreak of dengue in central Brazil. (biomedcentral.com)
Disease with a serotype appears to provide life long immunity against reinfection with that serotype but not against the others (4). (healthyguide.info)
5 Droxinostat 5 6 Importantly severe disease including Droxinostat DHF is much more likely among individuals who have already recovered from a primary infection and are experiencing a secondary infection with a different serotype (4). (healthyguide.info)
Three serotypes DENV-1 2 and 3 are currently endemic throughout Brazil with the four serotype emerging (9). (healthyguide.info)
In 2013, dengue serotype-3 virus (DENV-3) re-emerged in the South Pacific after 18 years, causing concurrent outbreaks in several Pacific island countries. (who.int)
Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. (broadinstitute.org)
Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia. (broadinstitute.org)
OSAKA, JAPAN & CAMBRIDGE, MASS.--( Business Wire / Korea Newswire ) August 23, 2022 -- Takeda (TSE:4502/NYSE:TAK) today announced the company's dengue vaccine, QDENGA® (Dengue Tetravalent Vaccine [Live, Attenuated]) (TAK-003), was approved by the Indonesia National Agency for Drug and Food Control, Badan Pengawas Obat dan Makanan (BPOM), for the prevention of dengue disease caused by any serotype in individuals six years to 45 years of age. (newswire.co.kr)
In Indonesia, QDENGA is indicated for the prevention of dengue disease caused by any dengue virus serotype in individuals six years to 45 years of age and should be administered subcutaneously as a 0.5 mL dose at a two-dose (0 and 3 months) schedule pursuant to approved dosing regimen. (newswire.co.kr)
DENV-2 was the most prevalent serotype in several outbreaks in the Americas [ 6 ] and was epidemiologically classified as the most relevant serotype worldwide due to its association with the highest number of intense outbreaks, followed in sequence by DENV-3, DENV-1, and DENV-4 [ 25 ]. (hindawi.com)
Each individual DENV serotype triggers a distinctive host immune response and has been responsible for dengue epidemics [7-10]. (enmd-2076.com)
Additionally, contamination with one DENV serotype leads to the development of lifelong immunity toward?that particular strain?but no cross-protective immunity towards other serotypes [5]. (enmd-2076.com)
Following an infection with one DENV serotype, the antibodies induced are type-specific and also cross-reactive with other DENV sero-types (Wilder-Smith et al. (cdc.gov)
(5, 6, 8) In Hodeidah, 29% (116/400) of patients with dengue- like illnesses were reported to be infected with DENV, predominantly of serotype 2. (who.int)

Dengue is an acute infectious disease caused by infection with any one of four serotypes of dengue virus (DENV 1-4), which are transmitted by Aedes mosquitoes [ 1 ]. (biomedcentral.com)
The disease is caused by four distinct dengue virus serotypes (DENV 1-4) that are transmitted primarily by the female Aedes aegypti mosquito, with Aedes albopictus as a secondary vector. (biomedcentral.com)
Dengue is a debilitating disease spread through the bite of an Aedes mosquito that carries DENV. (biomedcentral.com)
The Global Dengue & Aedes -Transmitted Diseases Consortium (GDAC) considers the published results of Part 1 to be an important and incremental development after the results of Sanofi Pasteur's Dengvaxia®, which was found to have an increased risk of hospitalized and severe dengue in vaccine recipients who were dengue seronegative prior to vaccination. (gdac-dengue.org)
GDAC is an international consortium that seeks to promote the development and implementation of innovative and synergistic approaches for prevention and control of dengue and other diseases transmitted by Aedes mosquitoes. (gdac-dengue.org)
Dengue is caused by dengue virus (DENV), a virus which can be transmitted by Aedes mosquitos. (pasteur-kh.org)
Na última década houve um aumento da incidência do dengue que reflete a ampla distribuição do Aedes Aegypti no território nacional, e uma elevação de casos graves da doença que tem sido atribuída à recirculação dos sorotipos DENV 1 e 2. (sbmt.org.br)
São identificados também os fatores de risco ambientais associados à infecção pelo DENV e verificada a distribuição espacial e temporal das formas imaturas e adultas de Aedes aegypti e sua relação com os casos de dengue, pela captura de mosquitos nos domicílios dos casos febris e arredores. (sbmt.org.br)
It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
Both diseases, together with Zika and yellow fever, are transmitted by mosquitoes of the Aedes genus, whose two most widespread species are Aedes aegypti and Aedes albopictus . (arbocat.cat)
In summary, the presence of Aedes albopictus mosquitoes in Catalunya has opened up the possibility of an Aedes -borne disease outbreak triggered by an imported case, that is, the arrival of an infected person travelling from an endemic country. (arbocat.cat)
Although dengue, chikungunya and Zika are not the only arboviral threats posed by global warming and globalization in Southern Europe , ArboCat currently focuses on modelling the risk of outbreaks in Catalunya of these three diseases transmitted by the Aedes albopictus mosquito species because they represent the most serious and dramatic emergency we may have to deal with. (arbocat.cat)
Recently, the number of Aedes aegypti foci has increased in west of Santa Catarina, south Brazil, which has increased concern regarding mosquito-borne disease outbreaks such as dengue fever, Zika virus, and chikungunya. (geneticsmr.com)
Dengue viruses (DENV) transmitted by Aedes aegypti mosquitoes present a growing public health challenge (Shepard et al. (cdc.gov)
Dengue and chikungunya in our backyard: preventing Aedes mosquito-borne diseases. (medscape.com)
Aedes mosquitoes are vectors of serious (re)-emerging viral diseases such as dengue, chikungunya and Zika. (who.int)
The global burden of Aedes -borne diseases is on the rise, leading to huge outbreaks emerging in different parts of the world. (who.int)
Moreover, DENV in Hodeidah was co-circulating with chikungunya virus, which is also transmitted by Aedes mosquitoes. (who.int)
(10) The current upheaval in the country has contributed to the emergence of Aedes -transmitted diseases, including dengue, as a result of health system collapse and damage, humanitarian crisis and internal population displacement. (who.int)

The National Notifiable Diseases Surveillance System received notifications for 7,875 cases of disease transmitted by mosquitoes during the 2011-12 season (1 July 2011 to 30 June 2012). (health.gov.au)
Sentinel chicken, mosquito surveillance, viral detection in mosquitoes and climate modelling are used to provide early warning of arboviral disease activity in Australia. (health.gov.au)
Surveillance for exotic mosquitoes at the border continues to be a vital part of preventing the spread of mosquito-borne diseases to new areas of Australia. (health.gov.au)
The only known natural hosts for DENV are humans and mosquitoes. (biomedcentral.com)
strong class="kwd-title" Keywords: thrombopoietin receptor agonists, thrombocytopenia, dengue, immune thrombocytopenic purpura Introduction and background Dengue is an infectious, arboviral disease of humans transmitted by mosquitoes [1]. (enmd-2076.com)
They are transmitted through blood-feeding insects such as mosquitoes and ticks, and include viruses such as chikungunya virus (CHIKV), dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), yellow fever virus (YFV), and eastern equine encephalitis virus (EEEV). (encyclopedia.pub)

While several lines of evidence suggest a protective role of T cells against disease associated with Dengue virus (DENV) infection, their potential contribution to immunopathology in the acute phase of DENV infection remains controversial, and it has been hypothesized that the more severe form of the disease (dengue hemorrhagic fever, DHF) is associated with altered T cell responses. (mdpi.com)

Dengue is endemic throughout the tropics and subtropics, with an estimated 3.8 billion persons (95% confidence interval [CI]: 3.5 billion-4.1 billion), or approximately 53% of the global population, living in areas suitable for DENV transmission ( 3 ). (cdc.gov)
2016). DENV is endemic throughout the tropics and sub-tropics, with an estimated 3.8 (95% confidence interval [CI] 3.5-4.1) billion people (roughly 53% of the global population) living in areas that are suitable for DENV transmission with the vast majority in Asia, followed by Africa and the Americas (Messina et al. (cdc.gov)

In 2013, an estimated 58 million symptomatic DENV infections (95% CI: 24 million-122 million) and 13,586 deaths occurred worldwide (95% CI: 4,200-34,700), resulting in a total annual cost of $8.9 billion (95% CI: $3.7 billion-$19.7 billion) in direct medical and nonmedical costs and indirect costs associated with time lost because of illness, care, or death ( 1 , 2 ). (cdc.gov)
In addition, virtually all (100%) sec- uring 1977, Cuba experienced a nationwide outbreak ondary DENV-2 infections in the 1997 Santiago de Cuba of dengue fever (DF). (cdc.gov)
More than 500,000 cases outbreak were clinically overt in marked contrast to pri- caused by a dengue 1 virus (DENV-1) of Southeast Asian mary DENV-2 infections, of which only 3.0% produced origin were reported ( 1 , 2 ). (cdc.gov)
DENV-2 infections. (cdc.gov)
Serum samples were first tested for dengue to DENV-2 illnesses after DENV-1 infections in human immunoglobulin G (IgG) by an ELISA inhibition method volunteers ( 14 ). (cdc.gov)
Vaccine-associated enhanced diseases (VAED) are modified presentations of clinical infections affecting individuals exposed to a wild-type pathogen after having received a prior vaccination for the same pathogen [1] . (cov19longhaulfoundation.org)
Four antigenically and genetically distinct DENV serotypes (DENV1-4) have been described to co-circulate around the world and cause human infections [ 4 ]. (biomedcentral.com)
Despite that, there is no clinically approved antiviral for treatment of dengue virus (DENV) infections. (biomedcentral.com)
Despite the advancement of today's drugs discovery and development, no effective anti-dengue drug has been approved for treatment of DENV infections with meticulous fluid management remaining the mainstay of treatment. (biomedcentral.com)
Importantly, two complementary animal models demonstrated enhanced CHIKV infections in the presence of sub-neutralizing levels of anti-CHIKV antibodies, with severe disease outcome and increase lethality. (datexis.com)
The severity of the disease varies from asymptomatic infections to life-threatening dengue hemorrhagic fever (DHF). (healthyguide.info)
Vaccine development has been challenging by the need for vaccines conferring strong protection against all four serotypes to avoid the elevated risk of severe disease associated with secondary infections (12). (healthyguide.info)
Taken together, the findings underscore the importance of the viral load and DENV infections for the occurrence of microcephaly. (healingpoint.in)
Zika virus and DENV infections are interesting in their own right. (healingpoint.in)
The disease is endemic in more than 100 countries, 1 and it is estimated that 390 million dengue infections occur annually. (who.int)
Too few DENV-4 infections were seen to draw any conclusion. (gdac-dengue.org)
With the increasing number of dengue virus infections imported into Germany, knowledge about the different phases of the disease and possible complications is essential for the treatment of patients. (biomedcentral.com)
The outcomes of infection by any of the DENV types range from asymptomatic, subclinical to symptomatic infections [ 4 - 7 ]. (hindawi.com)
90%) for identification of primary DENV infections. (hindawi.com)
In Brazil, the three main arbovirus infections related to this vector in terms of case number and severity are dengue fever, chikungunya, and more recently, the Zika virus ( Marcondes and Ximenes, 2015 ). (geneticsmr.com)
2019). Global estimates for 2013 suggest a total of 58 million symptomatic DENV infections (95% CI 24-122) and 13,586 fatal cases occurred (95% CI 4200-34,700), resulting in a total annual global cost of $8.9 billion (95% CI 3.7-19.7) (Shepard et al. (cdc.gov)

The development of a suitable infection system with primary human cells and an in vivo model allows the study of antibody enhancement in clinically important viruses, such as the recently emerged Zika virus (ZIKV), which infection is enhanced with cross-reactive anti-DENV antibodies33. (datexis.com)
Flaviviruses, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), Dengue virus (DENV), and West Nile virus (WNV), are important arthropod-borne pathogens that present an immense global health problem. (biomodul.de)
The Zika virus and genomic studies of it have opened fascinating windows into our knowledge of the infectious disease and its relevance in the context of emerging outbreaks. (healingpoint.in)
In another recent study in the same journal, researchers again used primate models to suggest that preexisting antibodies against DENV could worsen the severity of congenital Zika. (healingpoint.in)
As mentioned above, the main diseases transmitted by this vector are yellow fever, dengue, chikungunya and Zika. (arbocat.cat)
The mosquito-borne flaviviruses dengue and zika cause endemic or pandemic disease and long-term sequelae across over 40% of the world's population and there are no broadly licensed vaccines for either. (uvm.edu)

NAMAC assists in the detection, management and control of real or potential outbreaks of arboviruses or malaria and provides advice on the risk of these diseases or exotic vectors being imported from overseas. (health.gov.au)
Dengue became a notifiable disease on 1 September 1989 in China, partly in response to outbreaks of dengue fever, with cases of dengue hemorrhagic fever being reported sequentially in Hainan, Guangxi, Fujian, Zhejiang, and Yunnan provinces during the 1980s. (biomedcentral.com)
Dengue virus serotypes 1, 2 and 4 (DENV-1, -2 and -4) have been co-circulating in Venezuela for at least the past 10 years, causing minor or major outbreaks of dengue fever (DF) and DHF/DSS. (ox.ac.uk)
The disease has of late been in the headlines with multiple outbreaks in the last few years in multiple Indian states, including, more recently, Kerala and Karnataka. (healingpoint.in)
BACKGROUND: Late relapsing hepatitis after yellow fever (LHep-YF) during the convalescent phase of the disease has been described during recent yellow fever (YF) outbreaks in Brazil. (stanford.edu)
The ongoing global pandemic caused by coronavirus disease 2019 (COVID-19) has once again demonstrated the significance of the Coronaviridae family in causing human disease outbreaks. (preprints.org)
In Yemen, one of the poorest and least developed countries afflicted with vector- borne diseases (VBDs), dengue cases and outbreaks attributed to dengue virus serotypes 2 and 3 have been reported from Hodeidah city in the west and Al-Mukalla city in the east, respectively. (who.int)

The four dengue virus serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) all circulate globally, and most countries where dengue is endemic have reported circulation of all four serotypes. (cdc.gov)
Integrated vector control and surveillance remain the principle strategies for disease prevention and control in endemic regions, as no vaccine or specific medical treatment are yet available. (biomedcentral.com)
ABSTRACT Visceral leishmaniasis (VL) has shown endemic pattern and epidemic episodes in urban and rural areas, however, there are still gaps in knowledge with regards to disease transmission. (scielo.br)
Hence, in a dengue-endemic area with multiple co-circulating DENV serotypes, there is a probability of sequential contamination from two, three, or even four serotypes throughout the life of a person [4]. (enmd-2076.com)
There are 4 dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4), all of which circulate globally, with most endemic coun-tries reporting circulation of all 4 serotypes in recent years. (cdc.gov)

Both DENV-2 viruses, from 1981 and 1997, belong to antibodies against dengue virus in 44.46% of the popula- the same genotype. (cdc.gov)
Title : Guidelines for plaque-reduction neutralization testing of human antibodies to dengue viruses Corporate Authors(s) : National Center for Zoonotic, Vector-Borne and Enteric Diseases (U.S.) Published Date : June 2008 Source : Viral immunology. (cdc.gov)
An antibody-based test would be complicated because antibodies produced by the infection can cross-react with those of the dengue (DENV), yellow fever, and West Nile viruses. (healingpoint.in)

The clinical outcome was the severity of cases: dengue, dengue with warning signs, and severe dengue. (biomedcentral.com)
Our findings contribute to the understanding of clinical differences and immune status related to the serotypes DENV-1 and DENV-4 in central of Brazil. (biomedcentral.com)
According to the disease progression, there are three clinical phases: the initial febrile phase from 1 to 3 days after the onset of symptoms, followed by the critical phase (4-7 days), and recovery or death. (biomedcentral.com)
We evaluated the utility of anti-DENV IgM in urine to identify dengue cases among AFI patients enrolled in a clinical study. (cdc.gov)
5 days post-illness onset [DPO]) and late (6-14 DPO) in the clinical course was associated with dengue severity. (cdc.gov)
There was no difference in the proportion with urine anti-DENV IgM positivity between severity groups late in the clinical course. (cdc.gov)
CONCLUSION: While detection of urine anti-DENV IgM lacked adequate diagnostic sensitivity, it is a highly specific marker for laboratory-positive dengue, and its presence early in the clinical course may distinguish those with more severe disease. (cdc.gov)
In order to recognize vaccine associated disease enhancement, it is therefore necessary to have a clear understanding of the clinical presentation and usual course of the natural disease. (cov19longhaulfoundation.org)
Infection with DENV causes a wide spectrum of clinical manifestations ranging from undifferentiated fever, classical dengue fever to severe sometimes fatal manifestation characterized by plasma leakage with or without haemorrhage [ 3 ]. (biomedcentral.com)
When wild-type mice and other non-human primates were used as the animal model for DENV infection, clinical isolates of DENVs showed a low level or lack of viral replication and clinical disease [ 7 ]. (biomedcentral.com)
Their unpredictable disease severity, unusual clinical features, and severe neurological manifestations underscore an urgent need for antiviral interventions. (biomodul.de)
Both clinical outcomes were attributed to modulation of DENV-mediated viral load-independent MC degranulation. (gla.ac.uk)
Out of these cases, 96 million individuals experience clinical symptoms of varying severity. (pidjournal.com)
While there has been no definitive association of the distinct DENV types with clinical course of disease, there are reports suggesting that DENV-2 and DENV-3 cause severe disease more frequently than the other serotypes and that DENV-4 causes a milder illness [ 23 , 24 ]. (hindawi.com)
Nevertheless, the involved DENV type and the host genetic makeup may explain some differences in clinical manifestations observed, since genetic polymorphisms appear to provide protection or predispose to more severe forms of dengue [ 27 ]. (hindawi.com)
Clinical disease varies from a mild, undifferentiated febrile illness to severe disease with shock, hemorrhage and/or severe organ impairment such as hepatitis and encephalitis. (cdc.gov)

Severity of disease is markedly increased when infec- vector-control programs stopped transmission of dengue tion with dengue virus type 2 (DENV-2) follows infection viruses. (cdc.gov)
Asian DENV-2 viruses were not neutralized dur- ized with DHF, 12 of whom died. (cdc.gov)
The potential for vaccination against SARS-CoV-2 to be associated with disease enhancement is of theoretical concern, given similar observations with other respiratory viruses in general, and in animal models of highly pathogenic coronaviruses in particular [14] . (cov19longhaulfoundation.org)
Intro Dengue viruses (DENV) are the most common mosquito-borne RNA viruses worldwide, classified serologically into four antigenically unique types (DENV-1C4). (thinkbeforeyouclickca.org)
To gain a better understanding of the nature of the current epidemic, the complete sequence was determined of the envelope (E) gene of 15 Venezuelan DENV-3 viruses isolated during 2000 and 2001 from patients presenting with different disease severity. (ox.ac.uk)
Dengue computer virus Dengue computer virus (DENV) is usually a single-stranded ribonucleic acid (RNA) virus belonging to the family Flaviviridae, which includes the Yellow Fever virus, West Nile computer virus, and around 70 other viruses [1,4]. (enmd-2076.com)

It is responsible for chikungunya fever (CHIKF), a disease characterized by the presence of incapacitating arthralgia3. (datexis.com)

Serum was tested for DENV RNA and anti-DENV IgM. (cdc.gov)
RESULTS: Urine anti-DENV IgM sensitivity and specificity were 47.4% and 98.5%, respectively, when compared with serum anti-DENV IgM ELISA results, and 29.7% and 91.1% when compared with serum rRT-PCR results. (cdc.gov)
In additional experiments, mice were pretreated i. p with 100 L anti-DENV-3 polyclonal antiserum or control serum, 60 min before inoculation of the adapted DENV-3. (thinkbeforeyouclickca.org)
The anti-DENV serum utilized was kindly given by Dr. Ricardo Galler from Departamento de Bioqumica e Biologia Molecular do Instituto Oswaldo Cruz-Fiocruz, RJ, Brazil [34]. (thinkbeforeyouclickca.org)
Serum was from Rhesus monkeys inoculated subcutaneously within the AZ5104 anterior surface of the remaining forearm with 0,5 ml of Rabbit Polyclonal to MAP3K7 (phospho-Thr187) the viral suspension comprising 105 PFU of the DENV-3 H87 (13 dpi) [34]. (thinkbeforeyouclickca.org)
Geraniin seemed to provide a protective effect on infected BALB/c mice liver when given at 24 h pre- and 24 h post-infection as liver damage was observed to be very mild even though a significant reduction of DENV-2 RNA load in serum was not observed in these two treatment groups. (biomedcentral.com)
However, when administered at 72 h post-infection, severe liver damage in the form of necrosis and haemorrhage had prevailed despite a substantial reduction of DENV-2 RNA load in serum. (biomedcentral.com)

The DENV genome is about 11000 bases of positive-sense, single-stranded RNA (ssRNA) that codes for three structural proteins (capsid protein C, membrane protein M, envelope protein E) and seven nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). (wikipedia.org)
DENV is an enveloped, single-stranded, positive-strand RNA virus, member of the genus Flavivirus in the Flaviviridae family. (hindawi.com)

BACKGROUND: Dengue is an important arboviral disease with about 100 million dengue cases per year, of which, ~5% result in severe disease. (cdc.gov)
SARS-CoV-2 progressed to a global pandemic with substantial consequences due to its high infectivity and transmissibility, and its ability to cause both a severe respiratory illness, and a systemic disease with fatal consequences for vulnerable populations. (cov19longhaulfoundation.org)
Our meta-analysis identified children, secondary infection, diabetes and renal disease(s) as important predictors of severe dengue. (biomedcentral.com)
Mice deficient for each of these molecules presented more severe disease manifestation and improved viral replication. (thinkbeforeyouclickca.org)
Consequently, we describe a model of DENV-3 illness in immunocompetent mice that shows to be an interesting tool to study hostCvirus relationships and mechanisms mediating safety or those associated with severe disease manifestation. (thinkbeforeyouclickca.org)
Common disease manifestations range from asymptomatic to moderate febrile illness, with a smaller proportion of patients who progress to severe illness characterized by hemorrhage, shock and death [ 4 ]. (biomedcentral.com)
Geraniin was found to be effective in reducing DENV-2 RNA load when administered at 72 h post-infection while earlier administration could prevent severe liver damage caused by DENV-2 infection. (biomedcentral.com)
This absence has hindered research on dengue, especially on how the viral and host factors contributed to the severe forms of this disease [ 6 ]. (biomedcentral.com)
Although all five patients who died from the disease were females, it is inconclusive if sex is a significant risk factor for severe disease. (pidjournal.com)
Likewise, the patient's age has no association with the progression to severe disease. (pidjournal.com)
Dengue can manifest in various ways, ranging from a mild febrile illness to a severe, potentially fatal disease. (pidjournal.com)
The numbers of recipients who developed severe disease were too small to draw any conclusions about preventing severe disease. (gdac-dengue.org)
The immunopathology of the disease remains largely unknown and there are no biomarkers that can either predict severe outcome after infection or immunoprotection after natural infection or vaccination. (pasteur-kh.org)
In March 2020, the World Health Organization declared coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2, to be a pandemic. (preprints.org)

The etiologic agents of dengue fever and dengue hemorrhagic fever (DF/DHF) are four serotypes: dengue virus (DENV)-1, DENV-2, DENV-3, and DENV-4, part of the dengue complex of the genus Flavivirus [ 1 ]. (biomedcentral.com)
The four serotypes of DENV (DENV-1, DENV-2, DENV-3 and DENV-4) belong to the genus Flavivirus and the family Flaviviridae [ 1 ]. (biomedcentral.com)
Dengue virus (DENV) is an arbovirus (arthropod-transmitted virus) from the Flavivirus family and is one of the leading causes of mosquito-borne diseases worldwide. (pidjournal.com)
There are four antigenically PSI distinct dengue computer virus serotypes, known as DENV-1, DENV-2, DENV-3, and DENV-4, belonging to the genus Flavivirus [4-5]. (enmd-2076.com)
DENV are members of the genus Flavivirus , within the family Flaviviridae . (cdc.gov)

This is a Brighton Collaboration Case Definition of the term "Vaccine Associated Enhanced Disease" to be utilized in the evaluation of adverse events following immunization. (cov19longhaulfoundation.org)
Vaccine-associated enhanced respiratory (VAERD) disease refers to disease with predominant involvement of the lower respiratory tract. (cov19longhaulfoundation.org)
However, a case fatality rate that ranges from 0.5% to nearly 20% depending on age and other risk factors, and the understanding that SARS-CoV-2 is now a well-adapted human pathogen that will continue to cause disease in susceptible populations, makes the development of an effective vaccine a global priority. (cov19longhaulfoundation.org)
We aim to improve vaccination strategies for vaccine-preventable diseases and identify novel biomarkers of severity or treatment response. (pasteur-kh.org)

The natural history of coronavirus infectious disease caused by SARS-CoV-2 (COVID-19), is yet to be fully described. (cov19longhaulfoundation.org)
There is an ongoing fear of an outbreak and contracting the disease, experiencing the physical setbacks dengue can cause as well as the potential financial impacts," said Dr. Anggraini Alam, Sp.A(K), pediatric infectious disease consultant. (newswire.co.kr)

Dengue is an arboviral infection caused by a dengue virus (DENV) belonging to the Flaviviridae family. (biomedcentral.com)
Dengue virus was isolated in 1943 in Japan (DENV 1) and 1945 in Hawaii (DENV 2) for the first time as a member of the family of Flaviviridae . (biomedcentral.com)

There are four distinct but antigenically related types or serotypes of DENV (DENV-1 to DENV-4). (hindawi.com)

Human cases of arbovirus infection and malaria are monitored using the National Notifiable Diseases Surveillance System (NNDSS). (health.gov.au)

The adaptive immune response that develops with infection by any DENV provides long-term immunity to the homologous virus and short-lived protection against heterologous DENV. (cdc.gov)
Infection by any of the 4 dengue virus (DENV) serotypes can result in a spectrum of disease severity. (nih.gov)
Members of NAMAC have expertise in virus and disease surveillance, epidemiology, virology, vector ecology, vector control and quarantine, and represent agencies with a substantial interest in this area. (health.gov.au)
Dengue virus (DENV) is the cause of dengue fever. (wikipedia.org)
Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, all of which can cause the full spectrum of disease. (wikipedia.org)
The dengue virus (DENV) serotypes were identified in 243 cases. (biomedcentral.com)
In some experiments, the suspension of the adapted DENV-3 disease was UV-irradiated (exposure of virus stock for 15 min to a UV light producing irradiation mainly at 365 nm) or warmth inactivated (56C for 1 h) before inoculation of mice. (thinkbeforeyouclickca.org)
This was observed for rabies virus23, influenza virus24, dengue virus (DENV)25,26, Ross River virus (RRV)27, human immunodeficiency virus (HIV)28 and Marburg virus29. (datexis.com)
The first recorded outbreak due to DENV-3 in Venezuela dates to 1964 and the virus then seems to have disappeared. (ox.ac.uk)
Previous phylogenetic studies revealed that the DENV-3 circulating during the 1960s Latin American outbreak was a genotype V virus. (ox.ac.uk)
The disease is caused by a computer virus organized in four specific but carefully related and co-circulating serotypes: DENV-1 DENV-2 DENV-3 and DENV-4 (3). (healthyguide.info)
Immunocompetent, interferon (alpha and beta) receptor one knockout (KO), AnxA1 KO, and formyl peptide receptor 2 (FPR2) KO mice were infected with dengue virus (DENV) and treated with the AnxA1 mimetic peptide Ac2-26 for analysis. (gla.ac.uk)
The virus isolation rate was only (4.5%: 1/22) from all patient sera, serotyping showed the presence of DENV-3 serotypes. (unair.ac.id)
Therefore, health education about dengue virus infection should always done to all community for understanding to prevent this disease. (unair.ac.id)
Dengue fever is a viral infection that is spread through the bite of a mosquito infected with one of the four strains of dengue virus (DENV). (giggles.co.in)
Dengue is an arthropod-borne disease caused by the Dengue virus (DENV) [ 1 ]. (hindawi.com)
I was also involved in other projects regarding SARS-CoV-2 variants and disease severity in infants (DOI 10.3389/fmed.2022.896352), Rift Valley fever virus epidemiology in humans and animals in Kenya (DOI 10.1371/journal.pgph.0000505), and dengue virus evolution in Africa (ongoing Ph.D. candidate mentorship). (stanford.edu)
Mpox, previously known as monkeypox, is a zoonotic disease caused by the mpox virus. (news-medical.net)
The 4 dengue virus serotypes were DENV-1, DENV-2, DENV-3, and DENV-4. (clinicaltrials.gov)
The dengue virus serotypes are DENV-1, DENV-2, DENV-3 and DENV-4. (clinicaltrials.gov)
4) Transcriptional profiling of DENV virus infection (Joint College of Medicine/Engineering Biomedical Engineering grant with Donna Rizzo and John Hanley from UVM and Sam Scarpino from Northeastern). (uvm.edu)
Dengue is one of the most common mosquito-borne diseases in the world, and a person can get infected by one of the four serotypes of the virus named DENV-1, DENV-2, DENV-3, and DENV-4. (smb.org)

Dengue is a vector-borne viral disease considered to be a global public health issue due to an increasing incidence and its potential to cause epidemics and/or continuous viral circulation in most urban areas in tropical and subtropical regions of the world. (biomedcentral.com)
The Brazilian Surveillance System registered at least four dengue epidemics in 2002, 2008, 2010, and 2013, with a predominance with a predominance of the serotypes DENV-3, DENV-2, DENV-1 and DENV-4 in each year, respectively. (biomedcentral.com)
This study also confirms previous reports showing that the DENV-3 strain currently circulating in the Americas is related to the strain that caused DHF epidemics in Sri Lanka and India in 1989-1991 (genotype III). (ox.ac.uk)
Afraid of infection, uninfected individuals may spontaneously protect themselves against infectors in varying degrees, depending on the severity of epidemics. (smb.org)
We introduce a mathematical model formulated by differential equations to describe the severity of epidemics and group-precaution levels relying on the severity level during the epidemics. (smb.org)
In turn, the severity change of epidemics leads to the evolution of the group-precaution level. (smb.org)
Considering the time lag in responding to the severity change of epidemics, we further extend our model, which is a system of delay differential equations. (smb.org)
(3, 4) Emerging dengue epidemics in the Middle East in the past two decades raise concerns about the widespread emergence of the disease in this politically unstable region, with reports of dengue fever/ dengue hemorrhagic fever and deaths from the countries of the Arabian Peninsula, including Yemen. (who.int)

Some NS1 ELISA has low sensitivity for DENV-4 and it has contributed to the failure of reporting epidemiological data concerning DENV-4 cases in Brazil [ 21 , 22 ]. (hindawi.com)

When standardized for age, case-fatality rates for persons related to the time-dependent changes in severity of dis- who had been infected with DENV-1 during 1977-1979 ease found with secondary dengue infection. (cdc.gov)
Secondary infection was more predominant among DENV-4 cases (80.0%) compared with DENV-1 cases (62.3%) ( P = 0.03). (biomedcentral.com)

Dengue offers escalated in geographic distribution and disease severity to become the most common arboviral illness of humans. (thinkbeforeyouclickca.org)
Dengue is the most common vector-borne viral disease of humans. (gdac-dengue.org)
feeds almost exclusively on humans and is therefore the more efficient disease spreader, making it the main culprit for the huge burden posed by these diseases in tropical regions. (arbocat.cat)

The National Arbovirus and Malaria Advisory Committee (NAMAC) provides expert technical advice on arboviruses and malaria to the Australian Health Protection Principal Committee (AHPPC) through the Communicable Diseases Network of Australia (CDNA). (health.gov.au)

14 Unité de Génétique Fonctionnelle des Maladies Infectieuses, Department Genome and Genetics Centre National de la Recherche Scientifique, URA3012, Paris, France Systems Biology of Diseases Unit, Faculty of Science. (nih.gov)

In 1997, an Asian genotype DENV-2, closely related that heterologous neutralizing antibody titers are inversely to the 1981 strain, entered Cuba and circulated in the correlated with severity of a second infection. (cdc.gov)

Evidence of previous dengue infection, such as detection of anti-DENV immunoglobulin G with a highly specific serodiagnostic test, will be required for eligible children before vaccination. (cdc.gov)

Dengue is one of the most common vector-borne diseases of public health importance globally. (who.int)
Ticks are the carriers of several vector-borne diseases worldwide. (smb.org)

Dengue is a mosquito-borne viral disease that afflicts millions of individuals worldwide every year. (nih.gov)
Dengue fever, a mosquito-borne viral disease, is a rapidly emerging public health problem in Ecuador and throughout the tropics. (biomedcentral.com)
Dengue is a mosquito-borne viral disease that poses a significant global public health threat, with prevalence in over 125 countries. (newswire.co.kr)
Dengue is the most important reemerging mosquito-borne viral disease worldwide. (hindawi.com)

Urine was tested for anti-DENV IgM, and its sensitivity and specificity to detect sera laboratory-positive dengue cases were calculated. (cdc.gov)

But amidst the coronavirus disease of 2019 pandemic, it was reported that in 22 countries where dengue fever is prevalent, there was a reduction of around 16% in its occurrence, according to data, and we might see an upsurge in cases postpandemic. (pidjournal.com)
The coronavirus disease 2019 (COVID-19) pandemic caused an unprecedented global emergency. (news-medical.net)

We investigated the impact of variants of interferon-regulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection. (nih.gov)
While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti-DENV-1 activity. (nih.gov)

Here, we describe the phenotype of illness of immunocompetent mice with an adapted DENV-3 strain. (thinkbeforeyouclickca.org)

Centers for Disease Control and Prevention. (cdc.gov)

This information can be used to guide implementation of a One Health approach that involves human health, animal health, environmental, and other relevant partners in developing strategies for preparedness, response, and control to current and future coronavirus disease threats. (preprints.org)

To calculate disease titer, plaque assays were carried out in LLC-MK2 cells as AZ5104 explained below. (thinkbeforeyouclickca.org)

In this study, geraniin extracted from the rind of Nephelium lappaceum was shown to inhibit the replication of DENV-2 in both in vitro and in vivo experiments. (biomedcentral.com)
Knockdown of OSBPL10 expression in THP-1 cells by two shRNAs followed by DENV2 infection tests led to a significant reduction in DENV replication, being a direct functional proof that the lower OSBPL10 expression profile in Africans protects this ancestry against dengue disease. (hal.science)

The presence of DENV-2 was confirmed when viral antigens were detected in focal areas of the damaged liver, thus making it an ideal model to investigate the pathogenesis of dengue disease and henceforth the anti-dengue potentials of natural compounds. (biomedcentral.com)

Host immune responses contribute to dengue's pathogenesis and severity, yet the possibility that failure in endogenous inflammation resolution pathways could characterise the disease has not been contemplated. (gla.ac.uk)
The Immunology Unit researches the human host immune response to infectious diseases of high prevalence in Cambodia. (pasteur-kh.org)

Immunopathogenesis of dengue disease is also poorly recognized, in part, due to of the absence of appropriate animal models of illness. (thinkbeforeyouclickca.org)
In addition, we demonstrate that IFN- production is essential for the sponsor to deal with DENV-3 illness in a manner similar to that shown previously for DENV-2. (thinkbeforeyouclickca.org)
Hence, reduced IFN- production during DENV-3 illness was associated with diminished NOS2 manifestation and Nitric oxide production. (thinkbeforeyouclickca.org)
Whilst the absence of AnxA1 or its receptor FPR2 aggravated illness in infected mice, treatment with AnxA1 agonistic peptide attenuated disease manifestationsatteanuated the symptoms of the disease. (gla.ac.uk)

An EWS incorporates environmental data (e.g., climate, altitude, sea surface temperature), epidemiological surveillance data, and other social-ecological data in a spatiotemporal prediction model that generates operational disease risk forecasts, such as seasonal risk maps. (biomedcentral.com)
Using disease modeling, epidemiological, and phylogenetic analysis, we study the genomic evolution and transmission dynamics of H5N1 avian influenza A after 2020. (stanford.edu)

In addition, the effect of Ac2-26 on DENV-induced MC degranulation was assessed in vitro and in vivo. (gla.ac.uk)

NAMAC provides an annual report that describes the epidemiology of mosquito-borne diseases of public health in Australia. (health.gov.au)
This report describes the epidemiology of mosquito-borne diseases of public health importance in Australia during the season 1 July 2011 to 30 June 2012. (health.gov.au)
Getahun A, Batikawai A, Nand D, Khan S, Sahukhan A, Faktaufon D. Dengue in Fiji: epidemiology of the 2014 DENV-3 outbreak. (who.int)

Anatomy12

Organisms16

Diseases65

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment74

Psychiatry and Psychology7

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20192

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