• Both endogenous and exogenous glucocorticoids are known to cause psychosis and depression, implying that neurogenesis in the dentate gyrus may play an important role in modulating symptoms of stress and depression. (wikipedia.org)
  • Translational studies show that the key consequences of stress exposure on the hippocampus are suppression of neurogenesis in the dentate gyrus (DG) and dendritic remodeling in the cornu ammonis (CA), particularly the CA3 subfield. (pnas.org)
  • Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used medications for mood and anxiety disorders, and adult neurogenesis in the dentate gyrus has been shown to be involved in the behavioral effects of SSRIs in mice. (bibsys.no)
  • Much more attention has been paid to neurogenesis in the dentate gyrus than in the other areas. (wikipedia.org)
  • Most lateral views of the dentate gyrus may appear to suggest a structure consisting of just one entity, but medial movement may provide evidence of the ventral and dorsal parts of the dentate gyrus. (wikipedia.org)
  • It covers more poorly expressed degenerative changes of nerve cells in the area of dentate gyrus and glial proliferation occurs mainly in the blood vessel zone, where infiltration of microglia cells is observed. (nih.gov)
  • Hormonal regulation of cell production Gould and her colleagues found that the ovarian steroid estrogen enhances cell proliferation in the dentate gyrus of the adult rat. (wikipedia.org)
  • Also and conversely, steroid hormones of the adrenal glands were found to inhibit cell proliferation in the dentate gyrus but do so indirectly via an NMDA receptor-dependent mechanism. (wikipedia.org)
  • Running increases cell proliferation and neurogenesis in adult mouse dentate gyrus. (wikipedia.org)
  • Electroconvulsive seizure-induced gene expression profile of the hippocampus dentate gyrus granule cell layer. (nih.gov)
  • To better understand the molecular changes that may be necessary for the clinical effectiveness of ECS we have combined the technologies of gene expression profiling using cDNA microarrays with T7-based RNA amplification and laser microdissection to identify regulated genes in the dentate gyrus granule cell layer of the hippocampus. (nih.gov)
  • Many theories of hippocampal function assume that area CA3 of hippocampus is capable of performing rapid pattern storage, as well as pattern completion when a partial version of a familiar pattern is presented, and that the dentate gyrus (DG) is a preprocessor that performs pattern separation, facilitating storage and recall in CA3. (nih.gov)
  • Chen said that this neurotransmitter, called GABA (gamma-aminobutyric acid), was found in deformed cells called "reactive astrocytes" in a structure in the core of the brain called the dentate gyrus , whose structure is the gateway to hippocampus, an area of the brain that is critical for learning and memory. (thefreedictionary.com)
  • The dentate gyrus is thought to contribute to the formation of new episodic memories, the spontaneous exploration of novel environments, and other functions. (wikipedia.org)
  • The dentate gyrus is thought to contribute to the formation of memories, and to play a role in depression. (wikipedia.org)
  • More than any other cell type in the brain studied so far, dentate granule cells require hormone levels to be within the physiological range. (uva.nl)
  • Conversely, prolonged exposure of animals to a high level of corticosterone suppresses neurogenesis and presumably makes dentate granule cells more vulnerable to delayed cell death. (uva.nl)
  • These corticosteroid effects on dentate cell and network function are translated into behavioral consequences, in health and disease. (uva.nl)
  • Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the 'irritable mossy cell' hypothesis," Journal of Physiology , vol. 524, no. 1, pp. 117-134, 2000. (hindawi.com)
  • The principal cell type of the dentate gyrus is the granule cell. (wikipedia.org)
  • The dentate granule cell has an elliptical cell body with a width of approximately 10 μm and a height of 18μm. (wikipedia.org)
  • University of Alabama at Birmingham researchers have proposed a model that resolves a seeming paradox in one of the most intriguing areas of the brain-the dentate gyrus. (medicalxpress.com)