Density lipoprotein receptor that binds. Medical search. Frequent questions

The LDLR gene provides instructions for making a protein called a low-density lipoprotein receptor. (medlineplus.gov)
Some LDLR gene mutations reduce the number of low-density lipoprotein receptors produced within cells. (medlineplus.gov)
Low-density lipoprotein receptor (LDLR) is member of a family of endocytic receptors that internalize various extracellular ligands for their further intracellular degradation. (nih.gov)
In order to map the binding region of LDLR for FVIII, we expressed the extracellular ligand-binding domain of LDLR (a cluster of seven complement-type repeats (CRs)), and its overlapping fragments, using the baculovirus expression system. (nih.gov)
Initially, we tested the binding of the LDLR cluster with plasma-derived FVIII and receptor-associated protein (RAP), a folding chaperone for LDLR. (nih.gov)
Results showed that the binding curves of the expressed LDLR cluster and the commercial full-length LDLR were indeed comparable indicating a relevant structure of expressed fragments. (nih.gov)
Next, both RAP and FVIII were tested for binding to the overlapping LDLR fragments and found to bind to the same pattern of the fragments. (nih.gov)
The results indicate that both RAP and FVIII bind to multiple sites on LDLR constituting the same core region within LDLR exodomain. (nih.gov)
Dr. Levine's group has shown that ApoE, which is made by macrophages in the lung, binds to low density lipoprotein receptors (LDLR) that are expressed by ciliated airway epithelial cells. (nih.gov)
A cell surface receptor called the low-density lipoprotein receptor (LDLR) is responsible for binding ApoE. (acsh.org)
The low-density lipoprotein receptor (LDLR) is the major cholesterol-carrying lipoprotein of plasma, acting to regulate cholesterol homeostasis in mammalian cells. (embl.de)
The present invention relates to compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), including its interaction with the low density lipoprotein receptor (LDLR). (justia.com)
They reported that these knockout mice showed increased hepatic LDLR protein (but not mRNA), increased clearance of circulating lipoproteins and reduced plasma cholesterol levels. (justia.com)
APOE associated to the LVP allows the initial virus attachment to cell surface receptors such as the heparan sulfate proteoglycans (HSPGs), syndecan-1 (SDC1), syndecan-1 (SDC2), the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type I (SCARB1) (PubMed:12970454, PubMed:12356718, PubMed:12913001, PubMed:28404852, PubMed:22767607). (proteopedia.org)
Repatha binds to PCSK9 and inhibits circulating PCSK9 from binding to the low-density lipoprotein (LDL) receptor (LDLR), preventing PCSK9-mediated LDLR degradation and permitting LDLR to recycle back to the liver cell surface. (salesandmarketingnetwork.com)
RNA sequencing of the scalp skin from IFAP-affected individuals revealed a dramatic reduction in transcript levels of low-density lipoprotein receptor (LDLR) and of keratin genes known to be expressed in the outer root sheath of hair follicles. (uni-koeln.de)

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. (wikipedia.org)
Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. (wikipedia.org)
SREBF1 has been shown to interact with: CREB-binding protein, DAX1 LMNA, and TWIST2. (wikipedia.org)
1. Identification of a zinc finger protein that binds to the sterol regulatory element. (nih.gov)
7. Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein. (nih.gov)
9. Transcriptional modulators affect in vivo protein binding to the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase promoters. (nih.gov)
11. Sterol regulatory element-binding protein-1a binds to cis elements in the promoter of the rat high density lipoprotein receptor SR-BI gene. (nih.gov)
14. Sterol regulatory element-binding protein-2 negatively regulates low density lipoprotein receptor-related protein transcription. (nih.gov)
15. Yin yang 1 protein negatively regulates high-density lipoprotein receptor gene transcription by disrupting binding of sterol regulatory element binding protein to the sterol regulatory element. (nih.gov)
16. Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element. (nih.gov)
17. A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. (nih.gov)
18. The physiological role of sterol regulatory element-binding protein-2 in cultured human cells. (nih.gov)
19. Red 25, a protein that binds specifically to the sterol regulatory region in the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (nih.gov)
The time fVIII remains in the circulation may be prolonged by simultaneous blocking the receptors, which are low-density lipoprotein receptor-related protein (LRP) and cell-surface heparan sulfate proteoglycans (HSPGs). (nih.gov)
Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. (embl.de)
The PCSK9 protein controls the number of low-density lipoprotein (LDL) receptors, which are proteins on the surface of cells. (zoeharcombe.com)
The PCSK9 protein breaks down LDL receptors before they reach the cell surface, so that more cholesterol can remain in the bloodstream (Ref 2). (zoeharcombe.com)
In addition, as low‑density lipoprotein receptor‑related protein 6 (LRP6) is a receptor of DKK‑1 and DKK‑2 and their interaction on the cell surface inhibits Wnt/β‑catenin signaling, it was examined whether the exogenous DKK‑3 protein affects LRP6‑mediated Wnt/β‑catenin signaling. (spandidos-publications.com)
The first of these is the canonical Wnt/β-catenin pathway ( 5 ), in which Wnt3a, a member of the Wnt ligands, binds to a frizzled receptor and the corresponding co-receptor of low-density lipoprotein receptor-related protein 6 (LRP6). (spandidos-publications.com)
Canonical Wnt signaling is initiated by the binding of Wnt proteins to their receptors, low-density lipoprotein-related protein 5 and 6 (LRP5/6) and frizzled proteins, leading to phosphatidylinositol (4,5)bisphosphate (PtdIns(4,5)P2) production, signalosome formation, and LRP phosphorylation. (harvard.edu)
We previously reported that autoantibodies (autoAbs) to the main epitope on CD69 reacted to its homologous amino acid sequence in low-density-lipoprotein-receptor-related protein 2 (LPR2), a multiligand receptor for protein reabsorption. (biomedcentral.com)
Interestingly, the amino acid sequence of this main epitope (EKNLYWI) is highly homologous to a part (EKRLYWI) of low-density-lipoprotein-receptor-related protein 2 (LRP2). (biomedcentral.com)
Hematoxylin and eosin staining of various fat depots showed that increased adipocyte size caused by HFD intake was markedly reduced and correlated with reduced mRNA levels of lipogenesis genes, including sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and CCAAT/enhancer binding protein alpha, and increased uncoupling protein 1 levels. (springer.com)
Several mediators are involved in lipid metabolism, including sterol regulatory element-binding protein-1c (SREBP-1c) and CCAAT/enhancer binding protein alpha (C/EBPα), which are important transcription factors involved in the regulation of lipogenic gene mRNA expression. (springer.com)
SREBF1 encodes sterol regulatory element-binding protein 1 (SREBP1), which promotes the transcription of lipogenes involved in the biosynthesis of fatty acids and cholesterols. (uni-koeln.de)
When SARS-CoV-2 invades the body, the spike protein on the virus binds to a receptor on the host cell known as ACE2. (iflscience.com)
PAI-1 promoted the migration of microglial cells in culture via the low-density lipoprotein receptor-related protein (LRP) 1/Janus kinase (JAK)/signal transducer and activator of transcription (STAT)1 axis. (biomedcentral.com)
PAI-1 plays a dual role in the regulation of cell migration through differential interactions with its binding partners such as uPA, tPA, vitronectin, and low-density lipoprotein receptor-related protein (LRP)1. (biomedcentral.com)
Since cholesterol is not water soluble, it binds itself to protein receptors in the blood stream to travel around the body, forming lipoproteins. (curejoy.com)
and low-density lipoproteins (LDL), with less protein than cholesterol. (curejoy.com)
Calcium-binding may be crucial for numerous protein-protein interactions. (expasy.org)
Transforming growth factor β-1 binding protein (TGF-B1-BP) (14 out of 16 or 18 copies). (expasy.org)
In health, Wnt binds to the N-terminal extracellular domain rich in cysteine of the Frizzled (FZD) protein receptor [ 3 ]. (oncotarget.com)

citation needed] The proteins encoded by this gene are transcription factors that bind to a sequence in the promoter of different genes, called sterol regulatory element-1 (SRE1). (wikipedia.org)
Proteins produced from these genes are essential for the normal function of low-density lipoprotein receptors. (medlineplus.gov)
20. Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins. (nih.gov)
Our data shed some light on the role of SR-F1 in efferocytosis, through its capacity to bind C1q and CRT, two proteins involved in this process. (frontiersin.org)
ER resident proteins contain a retrieval signal, the COOH-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL), 1 which binds to a membrane receptor in the cis -Golgi region and returns them to the ER. (rupress.org)
Made as secreted glycoproteins, Wnt proteins exert their biologic effects by binding to at least two membrane receptors, namely the frizzled and low-density lipoprotein receptor related proteins. (biomedcentral.com)
Many of these proteins require calcium for their biological function and a calcium-binding site has been found to be located at the N-terminus of some EGF-like domains [ 8 ]. (expasy.org)
Proteins that are known or that are predicted to contain calcium-binding EGF-like domains are listed below. (expasy.org)
Frizzled (FZD) proteins, a family of Wnt receptors, are involved in carcinogenesis in different organs. (oncotarget.com)

In the current study, we identify a 23-amino acid fragment of TFPI (TFPIc23) localized to the C-terminus, which mediates binding to the VLDL receptor. (johnshopkins.edu)
The scavenger receptor SR-F1 binds to and mediates the internalization of a wide range of ligands, and is involved in several immunological processes. (frontiersin.org)
Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. (curehunter.com)
ApoE mediates cholesterol metabolism by binding various receptors. (nih.gov)
Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). (drugbank.com)

The TFPIc23 peptide inhibits endothelial cell proliferation through an apoptotic mechanism and blocks vessel outgrowth in the in vitro assays, and this activity is mediated through interaction with the VLDL receptor. (johnshopkins.edu)
Clopidogrel selectively inhibits adenosine diphosphate (ADP) binding to platelet receptors and subsequent ADP-mediated activation of GP llb/llla complex, thereby inhibiting platelet aggregation. (medscape.com)
The PAI-vitronectin complex binds to the Arg-Gly-Asp motif of αv integrins and inhibits the integrin-mediated cell migration [ 28 - 33 ]. (biomedcentral.com)
Upon oral administration, ibcasertib binds to and inhibits the activity of aurora B, VEGFRs, c-kit and PDGFRs, which may result in a decrease in the proliferation of tumor cells that overexpress these kinases. (nih.gov)
In addition, this agent binds to the CD40 antigen present on the surfaces of tumor cells, which induces antibody-dependent cytotoxicity (ADCC), and eventually inhibits the proliferation of CD40-expressing tumor cells. (nih.gov)
Upon antibody/antigen binding and internalization, opadotin binds to and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor cell apoptosis. (nih.gov)
Upon administration, luvixasertib selectively binds to and inhibits the activity of Mps1. (nih.gov)

High-Density Lipoprotein Transport Through Aortic Endothelial Cells Involves Scavenger Receptor BI and ATP-Binding Cassette Transporter G1. (uzh.ch)
Mouse MARCO is a type II transmembrane glycoprotein belonging to the class A scavenger receptor family. (rndsystems.com)

Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. (embl.de)
The small molecule modulators of PCSK9 function can be used therapeutically to lower LDL-cholesterol levels in blood, and can be used in the prevention and/or treatment of cholesterol and lipoprotein metabolism disorders, including familial hypercholesterolemia, atherogenic dyslipidemia, atherosclerosis, and, more generally, cardiovascular disease (CVD). (justia.com)

These fragments were then purified using diafiltration, affinity and size exclusion chromatography and tested for the binding using surface plasmon resonance (SPR). (nih.gov)
The acidic residues between the fourth and sixth cysteines are important for high-affinity binding of positively charged sequences in LDLR's ligands. (embl.de)
β -Caryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid agonist of type 2 receptors (CB2-R). It isn't psychogenic due to the absence of an affinity to cannabinoid receptor type 1 (CB1). (mdpi.com)
1. A simple technique of 'rosette' formation by low-density-lipoprotein-coated erythrocytes around human lymphoblastoid cells, stimulated to generate specific high affinity low-density lipoprotein receptors, is described. (portlandpress.com)
2. Rosette formation is specific for high-affinity surface binding alone and the properties of the low-density lipoprotein receptors defined by it are identical with those found by using 125 I-labelled low-density lipoprotein binding at 4°C. (portlandpress.com)

SR-F1 is now viewed as a multifaceted receptor ( 9 ), which can bind and mediate cell internalization of a wide range of endogenous and exogenous ligands, suggesting key roles in immune responses and tissue homeostasis. (frontiersin.org)
Class 4, in which defective internalization alleles alter the concentration of normal receptors in clathrin-coated pits for internalization by the hepatocyte. (medscape.com)

The receptors bind to particles called low-density lipoproteins (LDLs), which are the main carriers of cholesterol in the blood. (zoeharcombe.com)
In the blood, cholesterol is transported in lipoprotein particles, where the low-density lipoprotein (LDL) cholesterol (LDL-C) is considered "bad" cholesterol, while HDL-cholesterol (HDL-C) is known as "good" cholesterol. (justia.com)
PAI-1 inhibited microglial engulfment of zymosan particles in a vitronectin- and Toll-like receptor 2/6-dependent manner. (biomedcentral.com)

Both saturated fats and trans fats tend to block low-density lipoprotein (LDL) receptors, thus preventing the uptake of LDL from the bloodstream. (longdom.org)
When the scientists blocked the SR-B1 cholesterol receptor in the cells, it slowed down the uptake of the virus. (iflscience.com)
The resulting inhibition causes a reduction in transferrin-bound iron uptake in a variety of cell types, suggesting that HFE is involved in the regulation of iron uptake by TFR1, possibly by limiting the amount of iron released from transferrin. (diff.org)

Lipid and lipoprotein abnormalities are extremely common in the general population and are regarded as a highly modifiable risk factor for cardiovascular disease, due to the influence of cholesterol on atherosclerosis. (justia.com)
Plasma apoprotein and lipoprotein lipid levels in vegetarians. (nih.gov)

Hypercholesterolemia results when low-density lipoprotein receptors are unable to remove cholesterol from the blood effectively. (medlineplus.gov)
Mutations in the LDL receptor gene cause familial hypercholesterolemia. (embl.de)
Dyslipidemia is elevation of plasma cholesterol (hypercholesterolemia) and/or triglycerides (TGs) or a low high-density lipoprotein (HDL) level that contributes to the development of atherosclerosis. (justia.com)

In order to be internalized, the receptor-ligand complex must first cluster into clathrin-coated pits. (embl.de)
The fifth domain is the cytoplasmic tail that directs the receptor to clathrin-coated pits. (embl.de)

Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9)-low density lipoprotein receptor interaction with injectable monoclonal antibodies or small interfering RNA lowers plasma low density lipoprotein-cholesterol, but despite nearly 2 decades of effort, an oral inhibitor of PCSK9 is not available. (nih.gov)
This antitumor mechanism may involve the very low density lipoprotein (VLDL) receptor because the in vitro antiproliferative activity of TFPI is mediated through interaction with the VLDL receptor. (johnshopkins.edu)
Interestingly, the extracellular domain of SR-F1 engages in a heterophilic trans-interaction with SREC-II and SR-F1/SREC-II heterodimerization has been suggested to suppress the ligand binding properties of SR-F1 ( 7 ). (frontiersin.org)
Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. (nih.gov)

The statins are highly effective in reducing low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides, and they also increase high-density lipoprotein cholesterol (HDL-C) levels. (medscape.com)
In addition, flaxseed oil supplementation significantly decreased serum total cholesterol, triglyceride and low-density lipoprotein (LDL) cholesterol levels while significantly increasing the HDL cholesterol levels compared to HFD feeding alone. (longdom.org)
Other study measures included exploratory analyses of non-high-density lipoprotein cholesterol, apolipoprotein B, total cholesterol, Lipoprotein(a), triglycerides, high-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and apolipoprotein A-1 levels, as well as cardiovascular events of interest. (industryintel.com)

The haem-haemopexin complex binds to its specific receptor CD91 and is endocytosed. (diff.org)
The haemoglobin-haptoglobin complex binds to a specific receptor. (diff.org)

By removing LDLs from the bloodstream, these receptors play a critical role in regulating cholesterol levels. (medlineplus.gov)
Scavenger receptors were first defined by their ability to bind and induce metabolization of modified low density lipoproteins (LDLs) such as acetylated LDL (AcLDL) and oxidized LDL (OxLDL) ( 8 ). (frontiersin.org)

This element is a decamer (oligomer with ten subunits) flanking the LDL receptor gene and other genes involved in, for instance, sterol biosynthesis. (wikipedia.org)
5. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. (nih.gov)

Other mutations disrupt the receptors' ability to remove low-density lipoproteins from the bloodstream. (medlineplus.gov)
Mutations in any of these genes prevent cells from making functional receptors or alter the receptors' function. (medlineplus.gov)
Numerous familial hypercholestorolemia mutations of the LDL receptor alter the calcium coordinating residue of LDL-A domains or other crucial scaffolding residues. (embl.de)
Class 2a mutations impede altogether the transport of the receptor from the endoplasmic reticulum to the Golgi apparatus. (medscape.com)
Class 2b mutations lead a fractional obstruction of receptor transport from the endoplasmic reticulum to the Golgi apparatus. (medscape.com)

Our data demonstrate that this VLDL receptor-binding fragment of the TFPI molecule has apoptotic, antiangiogenic, and antitumor activity and suggests a possible mechanism whereby TFPI can regulate angiogenesis and tumor growth independently of its anticoagulant activity. (johnshopkins.edu)

A stable THP-1 cell line overexpressing SR-F1 was generated and C1q was shown to bind more strongly to the surface of SR-F1 overexpressing macrophages, with C1q/SR-F1 colocalization observed in some membrane areas. (frontiersin.org)
In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. (drugbank.com)

The LDL receptor binds LDL and transports it into cells by acidic endocytosis. (embl.de)

3. Common double- and single-stranded DNA binding factor for a sterol regulatory element. (nih.gov)
This process requires cleavage of SREBP1 by site-1-protease (S1P) and S2P and subsequent translocation into the nucleus where it binds to sterol regulatory elements (SRE). (uni-koeln.de)

E1/E2 heterodimer binds host apolipoproteins such as APOB and APOE thereby forming a lipo-viro-particle (LVP) (PubMed:25122793, PubMed:29695434, PubMed:24838241). (proteopedia.org)

therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C115970 Ibcasertib An orally available, small molecule inhibitor of select serine-threonine kinases, including aurora kinase B (aurora B), vascular endothelial growth factor receptors (VEGFRs), stem cell factor receptor (c-KIT), and platelet-derived growth factor receptors (PDGFRs), with potential antineoplastic activity. (nih.gov)

All membrane-bound splice variants showed receptor activity toward fluorescent AcLDL when expressed transiently in COS-1 cells ( 10 ). (frontiersin.org)

LRP2 (also designated as megalin or gp330) is one of the superfamily of low-density-lipoprotein receptors (LDLRs) [ 7 , 8 ]. (biomedcentral.com)

E1/E2 heterodimer binding on CD81 activates the epithelial growth factor receptor (EGFR) signaling pathway (PubMed:22855500). (proteopedia.org)

The number of LDL receptors on the surface of liver cells determines how quickly cholesterol is removed from the bloodstream. (zoeharcombe.com)

Wnt signaling serves an important role in disease development processes in adults ( 4 ), triggering at least two, perhaps three, pathways that employ Wnt receptors of the frizzled seven transmembrane classes. (spandidos-publications.com)

We identified two different binding regions on SR-F1: the N-terminal moiety interacts with C1q and CRT whereas the C-terminal moiety binds AcLDL. (frontiersin.org)
Upon administration of anvatabart opadotin, the antibody moiety targets and binds to HER2 on tumor cells. (nih.gov)

Class 2, which involves defective transport alleles that disrupt normal folding of the receptor and cause either breakdown in transfer to the cell surface or successful transport of truncated, mutated receptors. (medscape.com)
3. Preliminary observations suggest that specific surface binding of low-density lipoprotein is shown by some, but not all, lymphoid cell lines, is independent of certain other surface receptors and is unrelated to whether the cells originate from B or T cells. (portlandpress.com)
4. Loss of low-density lipoprotein surface receptors on lymphoid cell lines (as with other surface receptors) may occur simply from prolonged culture rather than as a result of genetically mediated familial abnormality. (portlandpress.com)
therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C121217 Cifurtilimab A proprietary, non-fucosylated monoclonal antibody directed against the cell surface receptor CD40 with potential immunostimulatory and antineoplastic activities. (nih.gov)
Upon intravenous administration, cifurtilimab binds to CD40 on a variety of immune cell types, triggering both cellular proliferation and activation of antigen-presenting cells (APCs), which activates B-cells and T-cells, and enhances the immune response against tumor cells. (nih.gov)
HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. (nih.gov)

Lactoferrin binds to LRP or RHL -1 and is endocytosed and targeted to the lysosomes for degradation. (diff.org)

More hydrophobic or amphophilic photosensitizers such as disulfonated ZnPcS 2 are preferentially transported by lipoproteins, which are taken up directly by tumor cells, whereas hydrophilic photosensitizers such as tetrasulfonated AlPcS 4 are transported largely by albumin and deposited mainly in the vascular stroma of tumors ( 8 ). (snmjournals.org)
Binds to dendritic cells (DCs) via C1QR1, resulting in down-regulation of T-lymphocytes proliferation (PubMed:11086025, PubMed:17881511). (proteopedia.org)
Specifically, hormone-releasing enteroendocrine cells which express a host of receptors activated by these bacterial metabolites. (bvsalud.org)

Indeed, ele- ments of the RISK pathway, including PI3K, Akt, eNOS, and ad- enosine receptors have also been shown to be involved in IPo (Fig. 3). (researchgate.net)
Regarding the regulation of the Wnt/β‑catenin signaling pathway, exogenous DKK‑1 and DKK‑2 are reported to inhibit Wnt signaling by binding the associated effectors. (spandidos-publications.com)
A receptor-mediated pathway for cholesterol homeo- stasis. (nih.gov)

If those measures are not sufficient for glycemic control, patients may be prescribed oral antihyperglycemic drugs, injectable glucagon -like peptide-1 (GLP-1) receptor agonists, insulin , or a combination of these drugs. (msdmanuals.com)

8. Serum response element-like sequences of the human low density lipoprotein receptor promoter: possible regulation sites for sterol-independent transcriptional activation. (nih.gov)
Dr. Levine's group has extended these findings to asthmatics, where they have shown that increased serum levels of high-density lipoproteins and apoA-I are associated with less severe airflow obstruction. (nih.gov)

Regulation of plasma cholesterol lipoprotein receptors. (nih.gov)

When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). (t3db.ca)

The activity of EGCG against SARS-CoV-2 has been attributed, at least in part, to disrupting binding to its receptor, angiotensin-converting enzyme 2 (ACE2) 10 , 11 . (nature.com)
However, HCoV-OC43 does not bind the ACE2 receptor (a proposed target of EGCG against SARS-CoV-2 10 , 11 ), suggesting the involvement of alternative or additional antiviral mechanisms against CoVs, which are still unknown. (nature.com)

The association of plasma high-density lipoprotein cholesterol with dietary intake and alcohol consumption. (nih.gov)

Class 5, where defective recycling alleles inhibit dissociation of the receptor and the ligand, thus interrupting recycling of the receptor. (medscape.com)

Specific fVIII residues that mediate binding to these receptors have been identified and are potential mutagenesis targets for an improved fVIII. (nih.gov)

Chemokines that regulate monocyte/macrophage trafficking (MIF, MCP-1) and pattern-recognition receptors that bind chitin (chitinases) and oxidized low-density lipoprotein (CD68) were also increased following isocyanate -albumin exposure. (cdc.gov)

Insulin stimulation of SREBP-1c is mediated by liver X receptor (LXR) and mTORC1. (wikipedia.org)

These receptors play a vital role in regulating blood cholesterol levels. (zoeharcombe.com)
Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. (nih.gov)

We produced recombinant SR-F1 ectodomain and fragments deleted from the last 2 or 5 C-terminal epidermal growth factor-like modules and investigated their role in the binding of acetylated low density lipoprotein (AcLDL), complement C1q, and calreticulin (CRT). (frontiersin.org)

6. Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1. (nih.gov)

Anatomy25

Organisms13

Diseases18

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes47

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Health Care1

LDLR16

Protein33

Proteins9

Mediates5

Inhibits7

Scavenger receptor2

Metabolism2

Affinity5

Internalization2

Particles3

Uptake3

Lipid2

Hypercholesterolemia3

Clathrin-coated pits2

Interaction4

Total cholesterol3

Complex binds2

LDLs2

Gene2

Mutations5

VLDL1

Macrophages2

Endocytosis1

Sterol regulatory2

ApoE1

Endothelial1

Showed receptor activity1

LRP21

Epithelial1

Bloodstream1

Transmembrane1

Moiety2

Cell6

Lysosomes1

Cells3

Pathway3

Injectable1

Serum2

Regulation1

Similarity1

ACE22

High-density1

Inhibit1

Mediate1

Macrophage1

Insulin1

Levels2

Complement1

Transcription1