• MUC5B, the predominate mucin in the mouth and female genital tract, has been shown to significantly reduce attachment and biofilm formation of Streptococcus mutans , a bacteria with the potential to form cavities. (wikipedia.org)
  • Similar effects of MUC5B and other mucins have been demonstrated with other pathogens, such as Candida albicans , Helicobacter pylori , and even HIV . (wikipedia.org)
  • The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis , which may be important in maintaining mucosal barriers. (wikipedia.org)
  • A recently identified human mucin gene is MUC21 , previously known as chromosome 6 open reading frame 205. (wikipedia.org)
  • Mature mucins are composed of two distinct regions: The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. (wikipedia.org)
  • N-linked oligosaccharides are also found on mucins, but in less abundance than O-linked sugars. (wikipedia.org)
  • Two membrane mucins, MUC1 and MUC4 have been extensively studied in relation to their pathological implication in the disease process. (wikipedia.org)
  • Fusion of the vesicles to the plasma membrane causes release of the mucin, which as it exchanges Ca 2+ for Na + expands up to 600 fold. (wikipedia.org)
  • Although some mucins are membrane -bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane , most mucins are secreted as principal components of mucus by mucous membranes or are secreted to become a component of saliva . (wikipedia.org)