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  • Dose-Dense Chemot
  • Dose-dense chemotherapy (DDC) is a concept of chemotherapy administration that is being used more and more. (oncolink.org)
  • Dose-Dense Chemotherapy (DDC) aims to achieve maximum tumor kill by increasing the rate of chemotherapy delivery, not by increasing dosage (which is the theory behind many stem cell transplant protocols ). (oncolink.org)
  • While previous research has evaluated the use of various forms of "dose dense" chemotherapy, this is the first major controlled study to show a clear survival benefit for women with node-positive breast cancer. (innovations-report.com)
  • It is too soon to determine whether a dose dense chemotherapy regimen with filgrastim should be the new standard of care," said Jeffrey Abrams, the oncologist in charge of breast cancer treatment trials at NCI. (innovations-report.com)
  • In addition to improved disease-free survival, the study indicated that dose dense chemotherapy may also lead to higher overall survival rates. (innovations-report.com)
  • densities
  • LDL consists of several subclasses of particles with different sizes and densities, including large buoyant (lb) and intermediate and small dense (sd) LDLs. (hindawi.com)
  • Patients
  • The patients with this disease show signs of abnormal dense granules and melanosomes which can cause prolonged bleeding and albinism . (wikipedia.org)
  • Chediak-Higashi syndrome is an autosomal recessive disorder where patients platelets are have a deficient amount of dense granules. (wikipedia.org)
  • Patients and mice with dense granule deficiency have a harder time forming a hemostatic plug and therefore have a longer bleed time. (wikipedia.org)
  • The dose dense regimen was made tolerable for patients because of the drug filgrastim, which helps prevent neutropenia, a serious complication of chemotherapy. (innovations-report.com)
  • Among patients on the dose dense regimens, disease-free survival was 82 percent after four years, compared to 75 percent for those who received conventional therapy. (innovations-report.com)
  • Since frequent administration of chemotherapy can result in a condition called neutropenia, a decline in the number of a certain type of white blood cells, the researchers administered filgrastim to patients on the dose dense regimens. (innovations-report.com)
  • After three years, 92 percent of patients on the dose dense therapy were alive, compared to 90 percent of those on the conventionally administered regimens. (innovations-report.com)
  • Side effects were found to be no more severe among patients on the dose dense regimens than among those on the conventional treatments, and patients on the dose dense regimens suffered fewer cases of neutropenia. (innovations-report.com)
  • This prospective observational study seeks to demonstrate the ability to meet nutritional needs of a calorically dense enteral formula in critically ill patients. (bioportfolio.com)
  • dynamical
  • We find that growth and expansion of a dense colony of cells leads to a dynamical transition from an isotropic disordered phase to a nematic phase characterized by orientational alignment of rod-like cells. (pnas.org)
  • Here, we have performed high-pressure experiments and first-principles theoretical calculations to investigate the stability, structure, and dynamical properties of dense CO 2 . (pnas.org)
  • women
  • Researchers tested both dose dense and conventional chemotherapy regimens in 1,973 women with node-positive primary breast cancer and no other metastases. (innovations-report.com)
  • I have urged you to consider what it might be like to learn that you, your mother,sister,spouse or friend is dense breasted & see if you can empathize with women who only learn that after their mastectomy, chemo & radiation. (ibabuzz.com)
  • electrons
  • The dense granules' matrix is dense with electrons that allow them to be detected through whole mount electron microscopy . (wikipedia.org)
  • Graphene is the densest two-dimensional material, with unique mechanical and electronic properties and having some electrons moving with near-light velocities and behaving as if they had zero mass. (stonybrook.edu)
  • Carbon
  • DIME weapons consist of a carbon fiber casing filled with a mixture of explosive and very dense microshrapnel, consisting of very small particles (1-2 mm) or powder of a heavy metal. (wikipedia.org)
  • A recent study shows that becoming denser has a more extensive impact on forests' ability to bind carbon dioxide than has previously been assumed. (helsinki.fi)
  • According to the study, published in the PLoS ONE science journal , forests in many countries bind an increasing amount of carbon dioxide as they become denser. (helsinki.fi)
  • Forests that become denser bind carbon dioxide effectively. (helsinki.fi)
  • Carbon recovery can be expanded by protecting forest areas and allowing commercial forests to grow dense, says head of the research team Aapo Rautiainen from the Faculty of Biological and Environmental Sciences at the University of Helsinki. (helsinki.fi)
  • A shared characteristic of both the investigated areas is that the growing stock that became denser resulted in a substantially more extensive increase in the forests' carbon storage than the square area change. (helsinki.fi)
  • Now Zhu, Oganov and their colleagues propose three new structures of carbon, which should be more than 3 percent denser than diamond. (stonybrook.edu)
  • Structural polymorphism in dense carbon dioxide (CO 2 ) has attracted significant attention in high-pressure physics and chemistry for the past two decades. (pnas.org)
  • times
  • The resulting material was about 3 times as dense as natural wood, and about 11 times as stiff and strong - making it potentially useful for high-strength engineering applications. (nature.com)
  • HP claims to have made a chip design breakthrough that could result in integrated circuits up to eight times denser than those currently in production. (theregister.co.uk)
  • IBM's eDRAM cell is twice as dense as any announced 22nm embedded SRAM cell - including the world's smallest 22-nanometer memory cell announced by IBM in August 2008 - and up to four times as dense as any comparable 32nm embedded SRAM in the industry. (cdrinfo.com)
  • proteins
  • Dense granules are similar to lysosomes with an acidic pH and even some lysosomal proteins like CD63 . (wikipedia.org)
  • The calcium from a dense granule accounts for the majority of the calcium within the platelets and plays a role in the binding of different proteins. (wikipedia.org)
  • There are a number of proteins that are within the dense granule membrane. (wikipedia.org)
  • significantly
  • The researchers found that two dose dense regimens provided significantly higher disease-free survival rates than two regimens using conventional dosing, and that efficacy did not differ between the two dose dense regimens. (innovations-report.com)
  • made
  • In this paper, we present a taxonomy of dense, two-frame stereo methods designed to assess the differ-ent components and design decisions made in individual stereo algorithms. (microsoft.com)
  • plasma
  • Broadened Lyman-$alpha$ x-ray lines from neon X and argon XVIII radiators, which are immersed in a hot, dense deuterium or deuterium-tritium plasma, are discussed. (unt.edu)
  • The Dense Medium Plasma (DMP) technology is a highly efficient AOT for treatment of VOCs in extracted groundwater. (sbir.gov)
  • make
  • Scientists have tried to devise processes that make wood denser, to obtain materials suitable for high-strength applications, but with limited success. (nature.com)
  • However
  • The origin of these dense granules is still unknown, however, it is thought that may come from the mechanism involving the endocytotic pathway . (wikipedia.org)
  • However, the secretion of dense granules occurs along with platelet activation. (wikipedia.org)
  • study
  • We study the iterative solution of dense linear systems that arise from boundary element discretizations of the electrostatic integral equation in magnetoencephalography (MEG). (mendeley.com)
  • The purpose of this randomized controlled study using a crossover design is to investigate the main effect of portion size and food type (low-energy dense vs. high-energy dense) on caloric. (bioportfolio.com)