Dengue virus wolbachia. Medical search. Frequent questions

This paper examines the effect of larval nutrition on the susceptibility of Wolbachia infected Aedes aegypti mosquitoes to dengue virus infection. (worldmosquitoprogram.org)
Background: Wolbachia pipientis is a common endosymbiotic bacterium of arthropods that strongly inhibits dengue virus (DENV) infection and transmission in the primary vector, the mosquito Aedes aegypti. (johnshopkins.edu)
Dengue virus (DENV) belongs to the Flaviviridae family and has 4 serotypes (DENV-1 to DENV-4) ( 7 ) that cause human disease through transmission by infected female mosquitoes, mainly Aedes mosquitoes. (cdc.gov)
NCEZID staff are working with partners in Puerto Rico to release male mosquitoes with Wolbachia bacteria to evaluate how effective the technique is in reducing Aedes aegypti mosquitoes. (cdc.gov)
Wolbachia suppresses the ability of the virus to replicate in dengue-carrying Aedes aegypti mosquitoes and cause infections when they bite humans. (aljazeera.com)
The virus and associated mosquitoes - Aedes aegypti and Aedes albopictus, or the yellow fever and Asian tiger mosquitoes - are not only booming in endemic countries, they're also pushing into higher altitudes and latitudes. (channelnewsasia.com)
It turns out that Wolbachia prevents these viruses from reproducing in Aedes aegypti mosquitoes that spread them. (phys.org)
Oxitec has found a way to genetically manipulate Aedes aegypti , the mosquito species mainly responsible for transmitting Dengue and yellow fever viruses to humans. (real-agenda.com)
Outbreaks of Dengue virus occur primarily in areas where Aedes aegypti and sometimes Aedes albopictus mosquitoes live and breed. (real-agenda.com)
A team at University of Texas Austin has developed a new method for identifying whether a mosquito is of the Aedes aegypti species, which is responsible for transmitting Zika, dengue and other deadly diseases. (mongabay.com)
The low-cost, 3D-printed portable toolbox identifies a pair of genes in a crushed-up mosquito that reveal whether the insect is Aedes aegypti and whether it has been exposed to the Wolbachia bacterium, which prevents the spread of diseases carried by the mosquito. (mongabay.com)
DIY Diagnostics , a team of researchers based at University of Texas at Austin, has been investigating how the Wolbachia bacterium can be used to suppress the load of dangerous viruses transmitted to humans by one of the most notorious mosquito species, Aedes aegypti . (mongabay.com)
The diagnostic tool uses a 3D-printed box, a smartphone camera and a simple chemical test to determine whether a mosquito is Aedes aegypti and whether it has been exposed to the Wolbachia bacterium. (mongabay.com)
One strand of my recent work has examined the potential public health benefits of Wolbachia, a novel biological control to reduce the ability of Aedes aegypti mosquitoes to transmit dengue. (imperial.ac.uk)
Cases have been reported in Florida, where there are known colonies of Aedes aegypti, a dengue-carrying mosquito. (sciencedaily.com)
Researchers at the University of Wisconsin-Madison have confirmed that a benign bacterium called Wolbachia pipientis can completely block transmission of Zika virus in Aedes aegypti , the mosquito species responsible for passing the virus to humans. (scienceblog.com)
While not typically found in the Aedes aegypti mosquito - the species that also transmits dengue, chikungunya and yellow fever viruses - O'Neill discovered in the early 1990s that Wolbachia could be introduced to the mosquito in the lab and would prevent the mosquitoes from transmitting dengue virus. (scienceblog.com)
Zika virus belongs to the same family as dengue virus and Aliota and Osorio - with co-authors Stephen Penaido at SVM and Ivan Dario Velez, at the Universidad de Antioquia in Medellin, Colombia - asked whether Wolbachia -harboring Aedes aegypti may also be effective against Zika virus. (scienceblog.com)
We saw reduced vector competence in Aedes aegypti with Wolbachia ," says Osorio, defined as the intrinsic ability of an insect to support the development or replication of a pathogen like a virus and then transmit it. (scienceblog.com)
The World Mosquito Program aims to spread Wolbachia among Aedes aegypti mosquitoes, a tropical mosquito that is a host for dengue, yellow fever, and other viruses. (gatesnotes.com)
Researchers released batches of Aedes aegypti mosquitoes carrying the w AlbB strain of Wolbachia into the wild, in six different sites in greater Kuala Lumpur with high levels of dengue transmission. (gla.ac.uk)
The researchers released adult Aedes aegypti mosquitoes infected with Wolbachia bacteria in three areas near to suitable mosquito habitat in Cairns, Queensland. (ist.ac.at)
2017): Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes aegypti. (ist.ac.at)
Large-scalereleases and establishment of wMel Wolbachia in Aedes aegypti mosquitoes throughout the Cities of Bello, Medellı´n and Itagu¨ı´, Colombia. (mvcac.org)
The introduction of the naturally occurring wMel Wolbachia strain into Aedes aegypti mosquitoes has been shown to reduce the ability of the mosquitoes to transmit dengue and other viruses. (mvcac.org)
The Aedes aegypti mosquitoes that most commonly spread dengue have been resistant to insecticides, which have fleeting results even in the best-case scenario. (mystateline.com)
It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
Tiny, pesky and deadly, Aedes aegypti mosquitoes are super at spreading disease, including dengue, chikungunya and Zika virus. (usf.edu)
Researchers from the Johns Hopkins Malaria Research Institute at the Johns Hopkins Bloomberg School of Public Health have made an important finding about Aedes aegypti mosquitoes-;one that could one day lead to better methods for reducing the mosquito-to-human transmission of dengue, yellow fever, Zika, and other harmful and sometimes deadly viruses. (news-medical.net)
Hospitals are struggling to treat dengue, a viral disease that spreads through the bite of the Aedes aegypti mosquito. (theconversation.com)
Dengue is an urban-centric disease spread by the Aedes mosquitoes that bite during the day. (theconversation.com)
The Wolbachia bacteria exist naturally in about 60% of insect species, just not in the Aedes aegypti mosquito. (whnt.com)
Dengue, a viral fever, is transmitted by Aedes species of mosquitoes. (healthy-americans.com)
Aedes mosquitoes thrive in warm and humid environments, so definitely climate change and rising temperatures and also extreme weather events are helping extend their habitat range," said Dr. Gabriela Paz-Bailey, chief of the dengue branch at the division of vector-borne diseases at the U.S. National Center for Emerging and Zoonotic Infectious Diseases. (healthy-americans.com)
Wolbachia dapat melumpuhkan virus dengue dalam tubuh nyamuk aedes aegypti, penyebab demam berdarah dengue (DBD). (lensabali.com)
Nyamuk aedes aegypti yang membawa wolbachia dan kawin dengan nyamuk aedes aegypti yang tidak mengandung wolbachia akan melumpuhkan virus dengue sehingga tidak akan menular ke manusia dan penularan DBD bisa ditekan. (lensabali.com)
All of the mosquitoes in the NEA are Aedes aegypti, according to Undark , which is a type that may infect humans with viruses like dengue. (interestingengineering.com)
Aedes aegypti mosquitos no longer readily transmit the dengue virus to humans when infected with Wolbachia. (interestingengineering.com)
In intervention areas, this has so far resulted in sharp declines in Aedes aegypti numbers in the wild as well as significantly less dengue virus. (interestingengineering.com)
Hussain, M, Bradshaw, T., Lee, M. & Asgari, S. (2022) The involvement of atlastin in dengue virus and Wolbachia infection in Aedes aegypti and its regulation by aae-miR-989. (insect-host-pathogen.org)
Bishop, C., Hussain, M., Hugo, L.E. & Asgari, S. (2022) Analysis of Aedes aegypti microRNAs in response to Wolbachia w AlbB infection and their potential role in mosquito longevity. (insect-host-pathogen.org)
Dai, Z., Etebari, K. & Asgari, S. (2022) N6-methyladenosine modification of the Aedes aegypti transcriptome and its alteration upon dengue virus infection in Aag2 cell line. (insect-host-pathogen.org)
Leitner, M., Etebari, K. & Asgari, S. (2022) Transcriptional response of Aedes aegypti mosquito cells to dengue virus at early stages of infection. (insect-host-pathogen.org)
S. (2021) Transcriptional response of Wolbachia to dengue virus infection in the mosquito Aedes aegypti cells. (insect-host-pathogen.org)
Bishop, C. & Asgari, S. (2021) Altered gene expression profile of Wolbachia pipientis w AlbB strain following transinfection from its native host Aedes albopictus to Aedes aegypti cells. (insect-host-pathogen.org)
The wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. (edu.au)
2 The most important dengue vector in the Western Pacific Region is Aedes aegypti ( Stegomyia aegypti ), which is predominately found in densely populated urban areas. (who.int)
Dengue outbreaks have also been associated with Aedes albopictus , particularly in China, 3 and several other Aedes species found in South Pacific countries and areas may also be competent dengue vectors. (who.int)

The endosymbiont Wolbachia pipientis is being released into populations of the mosquito vector of dengue, Zika, chikungunya and yellow fever viruses throughout the tropics. (grantome.com)
mosquitoes against pathogens is being released into the tropics as a possible means for limiting human infections with dengue, Zika and other viruses transmitted by the mosquito. (grantome.com)
These mosquitoes spread viruses including dengue, Zika, and chikungunya. (cdc.gov)
Ever since the discovery that the mosquito-transmitted Zika virus can cause serious birth defects, policy makers have been trying to figure out what to do to stop the spread of this horrible virus. (cei.org)
Globally, vector-borne illnesses-from malaria to dengue to Zika-present major health threats, particularly in less developed nations, where people reside in homes that are open to the environment, such as huts and homes without screened windows. (cei.org)
Studies have also shown the Wolbachia method can be effective in preventing the transmission of Zika, chikungunya, yellow fever and other mosquito-borne illnesses, researchers said. (aljazeera.com)
This capability could be used to enhance ongoing efforts that use Wolbachia to fight dengue fever and Zika virus. (phys.org)
The ability to genetically engineer Wolbachia could lead to inserting genes that cause the bacteria to produce traits that increase the effectiveness of usingWolbachia against dengue and Zika viruses. (phys.org)
Although portable tools and "biopesticides" such as Wolbachia are currently effective, adaptive dengue and Zika viruses will likely evolve past these tactics just as they have for countless other methods. (mongabay.com)
such as dengue, Zika and yellow fever, and has already caught on as an effective approach to combating such infectious diseases. (mongabay.com)
A second major current personal research interest is the epidemilogy and control of major mosquito-borne diseases, notably malaria (working with Azra Ghani ) and 'flaviviruses' - a family of viruses which includes dengue, yellow fever and Zika. (imperial.ac.uk)
Matthew Aliota, a scientist at the UW-Madison School of Veterinary Medicine (SVM) and first author of the paper - published today (July 1, 2016) in the journal Scientific Reports - says the bacteria could present a "novel biological control mechanism," aiding efforts to stop the spread of Zika virus. (scienceblog.com)
There are not yet any approved Zika virus vaccines or antiviral medications, and ongoing mosquito control strategies have not been adequate to contain the spread of the virus. (scienceblog.com)
They were also interested in studying the mechanisms behind Zika virus infection and transmission in mosquitoes. (scienceblog.com)
In the study, the team infected mice with Zika virus originally isolated from a human patient and allowed mosquitoes from Medellin to feed on the mice either two or three days after they were infected. (scienceblog.com)
The mosquitoes were either harboring the same strain of the Wolbachia bacteria (called wMel) used in field studies or were Wolbachia -free and the mice had levels of virus in their blood similar to humans infected with Zika virus. (scienceblog.com)
An additional group of mosquitoes, both wild-type and Wolbachia -infected, was allowed to feed instead from a membrane containing sheep's blood spiked with a high concentration of Zika virus, per other standard laboratory studies. (scienceblog.com)
Four, seven, 10 and 17 days after the mosquitoes fed on Zika-virus-infected blood the researchers tested them for Zika virus infection, assessed whether the virus had disseminated - or spread to other tissues in the mosquito, and examined whether the virus made its way to the mosquito saliva, where it must be present to be transmitted. (scienceblog.com)
They found that mosquitoes carrying Wolbachia were less likely to become infected with Zika virus after feeding on viral blood, and those that were infected were not capable of transmitting the virus in their saliva. (scienceblog.com)
Mosquitoes with Wolbachia were less capable of harboring Zika virus, and though they do get infected with Zika, it is to a lesser extent than wild-type mosquitoes. (scienceblog.com)
Previous studies have shown that the Wolbachia method is effective in preventing transmission of Zika, chikungunya, and yellow fever, among others. (thecherawchronicle.com)
Here's how they do it: The mosquitoes being produced in this factory carry bacteria called Wolbachia that block them from transmitting dengue and other viruses, such as Zika , chikungunya and yellow fever , to humans. (gatesnotes.com)
Wolbachia is a naturally occurring bacteria and what it does is stops the ability of the mosquito to transmit various viruses to people, viruses like Dengue, Chikungunya, and Zika that cause devastating diseases around the world. (neb.com)
The w AlbB strain of Wolbachia is also effective for blocking transmission of other viruses including Zika, chikungunya, and yellow fever. (gla.ac.uk)
These releases were undertaken under operational conditions with the aim of rapidly scaling the intervention in response to the Zika virus crisis. (mvcac.org)
Since vaccines aren't readily available for most mosquito-borne illnesses - those developed for chikungunya, dengue and Zika virus are still in the trial stage - we need other tools to fight them. (usf.edu)
mosquitoes transmit 'arthropod-borne' or 'arbo-' viruses including dengue virus, yellow fever virus, Zika virus, chikungunya virus, and Mayaro virus. (news-medical.net)
CN) - Health officials in Colombia reported the first deaths connected to the Zika virus, after three infected people in Colombia died from a disease that attacks the nervous system researchers believe is linked to Zika. (courthousenews.com)
This disease, known as Guillain-Barre syndrome, causes paralysis and has led to five deaths, including three patients who had been diagnosed with the Zika virus. (courthousenews.com)
The confirmation that the dead also had Zika is the latest development in a week that has been dominated by fear of the virus and the discovery of additional risks and side effects. (courthousenews.com)
The transmission of Zika through kissing is particularly concerning with the start of Carnival on Friday, the same day as discoveries that virus is active in urine and saliva were made. (courthousenews.com)
Researchers in Australia are attempting to breed mosquitoes and injecting their eggs with Wolbachia bacteria, which inhibit Zika, dengue fever, and other types of flavivirus. (courthousenews.com)
These include studying its suspected link to microcephaly, the possible transmission of the virus via reproductive fluids and modifying existing research to test pregnant women and infants for Zika. (courthousenews.com)
This bacteria prevents the insects from being able to transmit blood-borne viruses like dengue, Zika, chikungunya, and yellow fever. (goodable.co)
In Puerto Rico, chikungunya, dengue, and Zika viruses have each caused large outbreaks during 2010-2022. (cdc.gov)
Both the main vectors transmit not only dengue virus but also other closely related arboviruses such as chikungunya and Zika viruses. (who.int)
Since late 2013, a few countries in the Pacific have reported concurrent outbreaks of dengue, chikungunya and Zika virus disease. (who.int)

Previous trials involving Wolbachia - commonly found in fruit flies and other insects - also showed positive results in reducing dengue cases, researchers said. (aljazeera.com)

Recently scientists have managed to use Wolbachia bacteria to control outbreaks of dengue fever. (wikipedia.org)
Releasing these infected mosquitoes has resulted in the wild mosquito population becoming infected, lowering the incidence of dengue fever. (wikipedia.org)
Sturmer, J. (2014) Researchers want Wolbachia-infected mosquitoes unleashed on Townsville in bid to eradicate dengue fever. (wikipedia.org)
The fight against dengue fever has taken a significant leap forward with the emergence of a groundbreaking innovation: the use of Wolbachia bacteria to control transmission. (expresshealthcaremgmt.com)
Dengue fever infections dropped dramatically in an Indonesian study where a bacteria was introduced into disease-carrying mosquitoes, offering hope in the battle against an illness that sickens millions annually around the world. (aljazeera.com)
Take dengue - sometimes known as "break-bone fever", which gives you some idea of its symptoms - which has exploded over the past few decades. (channelnewsasia.com)
Australian research scientists have developed a strategy for fighting Dengue fever, a viral disease spread by mosquitoes that affects more than 50 million people annually and causes fever and crippling joint and muscle pain-and in some cases even death. (real-agenda.com)
Dengue fever is on the rise worldwide and spreading faster than any other insect-borne viral disease. (real-agenda.com)
Dengue infection typically causes high fever, crushing headache, severe pain behind your eyes, rash, and excruciating pain in your joints and spine, which is why it's sometimes called "break bone fever. (real-agenda.com)
Dr. Renu Daval-Drager of the World Health Organization says some cases of Dengue can be fatal, particularly the more serious Dengue hemorrhagic fever. (real-agenda.com)
Dengue fever is a disease contracted by mosquitoes. (ugm.ac.id)
With the theme ASEAN Communities United against Dengue Fever , member countries were trying to increase awareness on preventive efforts to tackle the disease. (ugm.ac.id)
Adi Utarini believed that the results of the research would be a reference for minimising dengue fever case in the country. (ugm.ac.id)
Yudiria Amelia, said dengue fever cases in the city had reduced in May with just 40 cases compared to the same period of last year with 350 cases. (ugm.ac.id)
In spite of the decrease, dengue fever control has to keep running," she said. (ugm.ac.id)
Related to the decreasing cases, her office and EDP Yogyakarta would do a study to know the impact of the release of Wolbachia mosquito at a great scale towards the decrease of dengue fever case. (ugm.ac.id)
From this recruitment we would obtain comparison of dengue fever case in the areas that are released with Wolbachia," she said. (ugm.ac.id)
Michael Chew, Infection and Immunobiology Portfolio Manager at Wellcome said: "These findings mark important progress in the future of dengue fever control. (gla.ac.uk)
More than 2.5 billion people live in areas afflicted by dengue fever, a mosquito-borne viral disease that is increasing at alarming rates in tropical and subtropical countries. (ist.ac.at)
Included within the series are papers on orbiviruses transmitted by Culicoides, lesser known viruses transmitted by mosquitoes including Cache Valley, Everglades, Jamestown Canyon, and LaCrosse, and recently discovered viruses transmitted by ticks including Bourbon, Heartland, Colorado tick fever, and Powassan. (mvcac.org)
TEGUCIGALPA, Honduras (AP) - For decades, preventing dengue fever in Honduras has meant teaching people to fear mosquitoes and avoid their bites. (mystateline.com)
When you come down with a case of dengue fever, it's often akin to getting the worst case of influenza you can imagine," said Conor McMeniman, a mosquito researcher at Johns Hopkins University. (mystateline.com)
Symptomatic infections vary from a mild, flu-like illness known as dengue fever (DF) to a life-threatening form called severe dengue (SD) [ 8 ]. (hindawi.com)
Severe dengue was previously known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) [ 8 ]. (hindawi.com)
Currently, a vaccine is available for yellow fever virus. (news-medical.net)
Explainer: what is dengue fever? (theconversation.com)
Dengue fever was found to be the main cause . (theconversation.com)
Cases of a 'mystery fever' in Uttar Pradesh were mostly due to dengue. (theconversation.com)
Cases of dengue fever, a mosquito-borne viral illness that can be fatal, are surging around the world. (healthy-americans.com)
What is dengue fever and why is it becoming more widespread? (healthy-americans.com)
The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia. (virology.ws)
In Indonesia, for instance, the not-for-profit World Mosquito Program achieved a 77% reduction in dengue fever cases and an 86% reduction in people presenting at hospital for medical treatment of dengue fever after releasing five million Wolbachia infected mosquito eggs in Yogyakarta. (sandpipercomms.com)
This genus includes also the West Nile virus, Tick-borne Encephalitis Virus, Yellow Fever Virus, and several other viruses which may cause encephalitis. (denguevirusnet.com)
DENV causes a wide range of diseases in humans, from a self limited Dengue Fever (DF) to a life-threatening syndrome called Dengue Hemorrhagic Fever (DHF) or Dengue Shock Syndrome (DSS) . (denguevirusnet.com)
Dengue fever is not only deadly, it is painful-it has also defied the efforts of scientists seeking a cure, or even a treatment. (edu.au)
A group of children in Brazil are helping to combat dengue fever by breeding mosquitoes that are infected with Wolbachia bacteria. (goodable.co)
Dengue fever (DF) and dengue haemorrhagic fever (DHF) are on the increase in Asia and the Pacific. (who.int)

Nowadays, about 140 countries deal with outbreaks of dengue regularly. (channelnewsasia.com)

In Yogyakarta, Eliminate Dengue Project (EDP) Yogyakarta team has used natural Wolbachia bacteria to inhibit the spread of dengue virus in the mosquito. (ugm.ac.id)
Researchers led by Jorge Osorio, a UW-Madison professor of pathobiological sciences, and Scott O'Neill of the the Eliminate Dengue Program (EDP) and Monash University in Melbourne, Australia, are already releasing mosquitoes harboring the Wolbachia bacterium in pilot studies in Colombia, Brazil, Australia, Vietnam and Indonesia to help control the spread of dengue virus. (scienceblog.com)
A new paper published by researchers from the Doherty Institute and other collaborators in Australia and Vietnam has found that a bacteria used to slow the spread of dengue virus in mosquitoes works better in wild than in the lab. (edu.au)

As further research and field trials continue, we can look forward to a future with significantly reduced dengue infections and the improved well-being of communities worldwide. (expresshealthcaremgmt.com)
Infections requiring hospitalisation also fell by 86 percent in Wolbachia-treated areas of Yogyakarta, a city on Java island where the experiment was conducted, researchers said. (aljazeera.com)
The trial involved releasing Wolbachia into the mosquito population across specific parts of Yogyakarta to measure how it affected the incidence of infections among three to 45-year-olds. (aljazeera.com)
Researchers estimated that on average, 23 percent of those who have not yet been infected become infected by dengue every year, corresponding to roughly 228,000 infections per year in Chennai alone. (sciencedaily.com)
She currently leads a translational programme of dengue research in OUCRU-Vietnam, including pathogenesis studies, innovative technology for monitoring critically ill patients, physiology studies of severe dengue infections as well as clinical trials of novel therapeutics. (imperial.ac.uk)
Release of virus-blocking Wolbachia -infected mosquitoes is an emerging disease control strategy that aims to control dengue and other arboviral infections. (biomedcentral.com)
mosquitoes are effective vectors of arborviruses because they can sustain significant infections with these viruses without suffering costs to their overall ability to reproduce-;what biologists call 'fitness. (news-medical.net)
Data from the federal health ministry suggests more than 100,000 dengue infections and 90 deaths were reported in the country from January to October. (theconversation.com)
Dengue infections occur cyclically, peaking every alternate year. (theconversation.com)
Since the initial presentation of dengue and COVID infections are similar, they can be misdiagnosed, leading to catastrophic, including fatal, consequences. (theconversation.com)
This study which involved targeting enzymes in biosynthetic pathways of the parasitic worms' endosymbiont (Wolbachia), has proven to be an alternative therapeutic option leading to the discovery of new drugs, which will help facilitate the elimination of parasitic infections. (bvsalud.org)
A team of researchers affiliated with several institutions in Vietnam and Australia has found that introducing a strain of bacteria known to infect mosquitoes in the wild was more effective in reducing dengue infections than bacteria introduced in the lab. (edu.au)
Testing the idea in the lab showed the mosquitoes were 68 percent less likely to become infected with dengue after sipping infected blood from human patients than were mosquitoes without wMel bacterial infections. (edu.au)
Dengue is a growing public health threat, causing approximately 400 million infections annually. (cdc.gov)

Each year there are around 90 million symptomatic cases of dengue, with severe disease in around 1% of cases, including life-threatening hemorrhage or shock syndrome. (gla.ac.uk)
Knowledge about the pathogenesis of dengue infection is limited, but both viral and immune host factors appear to be associated with severe illness [ 26 ]. (hindawi.com)
Nevertheless, the involved DENV type and the host genetic makeup may explain some differences in clinical manifestations observed, since genetic polymorphisms appear to provide protection or predispose to more severe forms of dengue [ 27 ]. (hindawi.com)
mosquitoes lacking the Ago2 gene, the siRNA pathway is impaired, arborvirus infection becomes more severe, and the mosquitoes' ability to transmit these viruses drops sharply-;as they sicken, feed less, and often die within days. (news-medical.net)
Dengue causes a wide spectrum of disease, ranging from asymptomatic infection to severe flu-like symptoms. (theconversation.com)
Severe dengue infection, though less common, can be accompanied by any number of complications including severe bleeding, organ impairment and plasma leakage from the blood into surrounding tissue. (theconversation.com)
The risk of death is higher if severe dengue is not managed properly. (theconversation.com)
About 5 percent of people who get sick will progress to what's called severe dengue, which causes plasma, the protein-rich fluid component of blood, to leak out of blood vessels. (healthy-americans.com)
Severe dengue has a mortality rate of between 2 and 5 percent in people whose symptoms are treated. (healthy-americans.com)
Severe dengue may go untreated because patients live far from medical care or can't afford it, or because hospitals are overwhelmed with cases during an outbreak. (healthy-americans.com)
Approximately 22,000 people die from severe dengue each year. (sandpipercomms.com)
Mortality is highest during the initial period of the outbreak or epidemic, and increasing numbers of severe dengue cases overwhelm health facilities. (who.int)

Nigeria and Ghana have provisionally approved a new malaria vaccine developed by scientists at the University of Oxford, and Japanese drugmaker Takeda Pharmaceutical's dengue shot is being steadily rolled out around the world. (channelnewsasia.com)
There is no vaccine to prevent or medicine to treat chikungunya virus infection. (sciencedaily.com)
To date, there is no effective vaccine or specific antiviral therapy for dengue. (hindawi.com)
One dengue vaccine is approved by the Food and Drug Administration for individuals between six and 16 who have had prior dengue infection. (news-medical.net)
Efforts to create a vaccine for dengue have been made since the 1920s. (sandpipercomms.com)
Complexities with manufacturing a safe and effective vaccine that can work against all four dengue serotypes have been difficult to overcome. (sandpipercomms.com)
A safe and effective vaccine against dengue would make a significant impact on the burden of disease. (sandpipercomms.com)
In the absence of a vaccine, vector control is the mainstay for dengue prevention and control. (who.int)
Given the lack of a dengue vaccine, control of dengue depends on vector control. (who.int)
In June 2021, the Advisory Committee on Immunization Practices recommended the first dengue vaccine (CYD-TDV) for children aged 9-16years with a previous dengue infection, living in endemic areas, such as Puerto Rico (PR). (cdc.gov)
As the COVID-19 pandemic affected vaccine intention worldwide, we assessed dengue vaccine intention before (pre-COVID) and after (post-COVID) COVID-19 vaccine availability among participants enrolled in the Communities Organized to Prevent Arboviruses (COPA) cohort to prepare for dengue vaccine implementation in PR. (cdc.gov)
We used logistic regression models to evaluate changes in dengue vaccine intention by interview timing and participant characteristics. (cdc.gov)
Post-COVID, dengue vaccine intention in adults increased for themselves from 73.4% to 84.5% (adjusted odds ratio (aOR)=2.27, 95%CI:1.90-2.71) and relative to their children from 75.6% to 85.5% (aOR=2.21, 95%CI:1.75-2.78). (cdc.gov)
Among all participants, groups with higher dengue vaccine intention included those who reported previous year influenza vaccine uptake and those who reported being frequently bitten by mosquitos, compared to those who did not. (cdc.gov)
The primary reasons for vaccine hesitancy were concerns with side effects and not believing in vaccines, which should be considered during educational strategies prior to dengue vaccine implementation. (cdc.gov)
In general, dengue vaccine intention is high in PR and has increased after COVID-19 vaccine availability, potentially due to increased awareness of vaccine importance during the COVID-19 pandemic. (cdc.gov)
Willingness to receive the COVID-19 vaccine was associated with a later interview date, higher household income, previous COVID-19 diagnosis among household members, COVID-19 risk perception, influenza vaccine uptake, dengue vaccine intention, and general positive perceptions of vaccines. (cdc.gov)
These findings can aid the targeting of vector-control interventions and the planning for dengue vaccine implementation. (cdc.gov)
Dengue is a growing international public health problem for which a licensed vaccine, therapeutic drugs, and effective vector control programs are lacking. (cdc.gov)

This experiment shows the exciting breakthrough that wolbachia can be: a new safe, sustainable and effective approach to dengue control - just what the international community needs," said Professor Cameron Simmons of the World Mosquito Program at the World Mosquito Program. (thecherawchronicle.com)
The World Mosquito Program is releasing mosquitoes that contain Wolbachia. (neb.com)
This emerging strategy for battling dengue was pioneered over the last decade by the nonprofit World Mosquito Program, and it is being tested in more than a dozen countries. (mystateline.com)
The mosquitoes come from eggs, produced in a World Mosquito Program bio factory to carry the bacteria Wolbachia, which interrupts the transmission of dengue. (whnt.com)
Kampanye metode Wolbachia di Kota Denpasar itu merupakan program kolaborasi Pemerintah Kota Denpasar dengan World Mosquito Program (WMP) dan Save the Children Indonesia untuk mencegah DBD di Kota Denpasar. (lensabali.com)
Sementara itu anggota Komisi IX DPR I Ketut Kariyasa Adnyana menyampaikan pencegahan DBD berkoordinasi dengan World Mosquito Program (WMP) menguji coba metode Wolbachia yang sudah dilakukan di Yogyakarta serta mampu menurunkan 88 persen kasus DBD. (lensabali.com)
Senior Project Manager Save the Children Indonesia untuk World Mosquito Program (WMP) Bali Man Magilan menyampaikan dengan adanya metode Wolbachia ini diharapkan mampu melindungi masyarakat dari DBD. (lensabali.com)

The dengue virus belongs to the Flaviviridae family, with four closely related but distinct strains - DENV-1, DENV-2, DENV-3, and DENV-4. (theconversation.com)
The co-evolution of CifA-CifB pairs may account in part for the incompatibility patterns documented in insects infected with different Wolbachia strains, but the molecular mechanisms remain elusive. (bvsalud.org)
These four subtypes are different strains of dengue virus that have 60-80% homology between each other. (denguevirusnet.com)
Parry, R., de Malmanche, H. & Asgari, S. (2021) Persistent Spodoptera frugiperda rhabdovirus infection in Sf9 cells is not restricted by Wolbachia w MelPop-CLA and w AlbB strains and is targeted by the RNAi machinery. (insect-host-pathogen.org)

Wolbachia bacteria inhibit dengue virus replication by hijacking gene expression in mosquitoes, Australian researchers have found. (abc.net.au)
Using a strain of the bacteria Wolbachia , which inhibit mosquitoes from transmitting viruses to humans, researchers at the Universities of Glasgow and Melbourne and the Institute for Medical Research in Malaysia were successfully able to reduce cases of dengue at sites in Kuala Lumpur. (gla.ac.uk)
These include Release of Insects Carrying a Dominant Lethal system and Wolbachia , an endosymbiotic bacterium, to inhibit dengue virus in the vector. (who.int)

As a result, these mosquitoes are unable to transmit the dengue virus to humans, effectively breaking the cycle of transmission. (expresshealthcaremgmt.com)

We have evidence our Wolbachia method is safe, sustainable and dramatically reduces incidence of dengue. (aljazeera.com)
This intervention forms the basis of an epidemiological study to assess the impact of operational deployment of wMel Wolbachia on the reduction of the incidence of notified dengue cases and virologically-confirmed dengue. (mvcac.org)
The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. (hindawi.com)
Dengue incidence rate ratio in Wolbachia-treated versus untreated cluster. (ina-registry.org)
Dengue incidence during the dry season accounted for 63% of variability in epidemic magnitude. (cdc.gov)
Analyses from Southeast Asia have demonstrated multiannual oscillations in dengue incidence ( 8 - 10 ), which have been variably associated with macroclimatic weather cycles (exemplified by the El Niño Southern Oscillation) in different settings and with changes in population demographics in Thailand ( 11 ). (cdc.gov)
Knowledge of spatial and temporal patterns in dengue incidence at a subnational level is relevant for 2 main reasons: it can provide insights into the biological and ecologic mechanisms that drive transmission, and it might facilitate predictions of the magnitude, timing, and location of future dengue epidemics. (cdc.gov)

By releasing mosquito larvae infected with Wolbachia into five dengue-endemic cities in Indonesia, the Ministry of Health has initiated a long-term treatment strategy that promises to measurably reduce the burden of dengue. (expresshealthcaremgmt.com)
With nations in South America battling some of the worst outbreaks of mosquito-borne disease in decades, the case of a British woman who caught dengue while on holiday in France last summer has sparked warnings about similar outbreaks in countries where insect-carried pestilence hasn't previously been endemic. (channelnewsasia.com)
In the 1970s, dengue was endemic in nine countries. (channelnewsasia.com)
Although dengue rarely occurs in the continental United States, it is endemic in Puerto Rico and in many popular tourist destinations in Latin America, Southeast Asia and the Pacific islands. (sciencedaily.com)
Outside Puerto Rico and other territories where the disease is endemic, there are about 550 dengue cases each year in the United States , but they are imported by travelers who were infected abroad and passed the disease along to their close contacts. (healthy-americans.com)
One casualty is dengue, which is endemic in the ASEAN region. (sandpipercomms.com)
Wolbachia programmes in dengue-endemic areas have seen good results over the years. (sandpipercomms.com)
The dynamics of dengue in disease-endemic areas are characterized by strong seasonality and multiannual epidemic peaks ( 3 ), with substantial interannual and spatial heterogeneity in the magnitude of seasonal epidemics ( 4 ). (cdc.gov)
As in many dengue-endemic settings, the dengue surveillance system in Vietnam relies on passive reporting of clinically diagnosed dengue in hospitalized patients. (cdc.gov)

Special mosquitoes are being bred to fight dengue. (mystateline.com)
Tens of millions of disease-ridden mosquitoes are being bred inside plastic boxes by Singapore's National Environment Agency (NEA) to fight dengue. (interestingengineering.com)

the vector, reducing or eliminating its ability to transmit viruses. (grantome.com)
Mosquitoes are a vector for the virus that causes dengue. (wikipedia.org)
We evaluated the effectiveness of a community-based intervention for dengue vector control in Ouagadougou, the capital city of Burkina Faso. (cdc.gov)
The World Health Organization (WHO) has stated that effective vector control measures are critical to achieving and sustaining reduction of disease attributable to dengue ( 14 ). (cdc.gov)
Common dengue vector control measures, which are typically community-driven in tandem with health promotion campaigns, include use of insecticide-treated materials ( 15 ) or water storage tanks ( 16 ) and elimination of breeding sites or use of larvicides ( 17 ). (cdc.gov)
Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. (hindawi.com)
This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. (hindawi.com)
The replacement approach contrasts with suppression strategies with Wolbachia , sterile insect techniques, or conventional vector control tools, which likely need ongoing application. (biomedcentral.com)
These viruses may spread to humans from nonhuman reservoirs, but most arboviral diseases are not transmissible by humans, perhaps because the typical viremia is inadequate to infect the arthropod vector. (msdmanuals.com)
The primary goal of vector control activities is to reduce vector population density to levels that are believed to correlate with a lower dengue transmission risk. (who.int)
In this paper we describe dengue vector surveillance and control practices in the Western Pacific Region and provide a perspective for future dengue control. (who.int)
While insufficient to accurately predict the risk of human infection, dengue vector surveillance employs several entomological indicators that have been developed to assess the risk of outbreaks occurring. (who.int)
5,6 A model employing all three parameters of dengue transmission, vector density, human cases and vector infection rate, would probably be the most accurate in determining outbreak thresholds for early outbreak prediction. (who.int)
Vector control is the primary tool available for dengue prevention and control. (cdc.gov)
In Vietnam, vector control is pursued through a targeted approach of low-volume space spraying of households around clusters of reported dengue cases. (cdc.gov)

A third of the global burden of dengue is in India. (theconversation.com)
The global distribution and burden of dengue. (who.int)
The heaviest burden of dengue is in the Asia Pacific countries, where about 1800 million people are at risk of infection. (who.int)

According to the World Health Organization (WHO), there are an estimated 390 million cases of dengue each year , with ASEAN bearing the highest burden. (sandpipercomms.com)
The Western Pacific Region reported cases of dengue in more than 30 countries and territories. (who.int)

However, there is evidence that DENV can be transmitted vertically from mother to progeny, and this may help the virus persist in nature in the absence of regular human transmission. (johnshopkins.edu)
We examined the effect of Wolbachia infection on the prevalence of DENV infection, and viral load in the ovaries. (johnshopkins.edu)
Interestingly, regardless of the method of infection, Wolbachia infection strongly reduced DENV load in the ovaries. (johnshopkins.edu)
There was a trend towards lower rates in the presence of Wolbachia, with overall maximum likelihood estimate of infection rates of 5.04 per 1000 larvae for mosquitoes without Wolbachia, and 1.93 per 1000 larvae for Wolbachia-infected mosquitoes, after DENV injection. (johnshopkins.edu)
Conclusions: Our data support the idea that vertical transmission of DENV is rare in nature, even in the absence of Wolbachia. (johnshopkins.edu)
Nevertheless, the low prevalence of disseminated DENV infection and lower DENV load in the ovaries supports the hypothesis that the presence of Wolbachia in Ae. (johnshopkins.edu)
Dengue is an arthropod-borne disease caused by the Dengue virus (DENV) [ 1 ]. (hindawi.com)
DENV is an enveloped, single-stranded, positive-strand RNA virus, member of the genus Flavivirus in the Flaviviridae family. (hindawi.com)
Dengue is caused by Dengue virus (DENV), a mosquito-borne flavivirus. (denguevirusnet.com)
DENV is an single stranded RNA positive-strand virus of the family Flaviviridae, genus Flavivirus. (denguevirusnet.com)
DENV is a 50-nm virus enveloped with a lipid membrane (see figure 1). (denguevirusnet.com)
aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. (edu.au)

Martha Ocampo drops a capsule of mosquito eggs into a jar of water as directed by a Doctors Without Borders volunteer, as part of a program to help prevent the spread of dengue, in Tegucigalpa, Honduras, Wednesday, Aug. 23, 2023. (mystateline.com)
Edgard Boquín, a project leader working with Doctors Without Borders, holds a glass jar filled with mosquitoes before their release in neighborhoods rife with dengue, in a facility in Tegucigalpa, Honduras, Tuesday, Aug. 22, 2023. (whnt.com)

With the successful implementation of Wolbachia in Indonesia, this groundbreaking innovation in dengue prevention holds immense promise for the global fight against this debilitating disease. (expresshealthcaremgmt.com)
Dengue is the most rapidly spreading mosquito-borne disease in the world with more than 50 million cases globally every year, including about eight million in Indonesia. (aljazeera.com)
Infecting and spreading mosquitoes with Wolbachia has been successfully field tested in Australia, Brazil, Columbia, Indonesia and Vietnam. (phys.org)
The randomized controlled trial conducted in Yogyakarta, Indonesia, found that Wolbachia -carrying mosquitoes reduced the number of dengue cases in the city by 77 percent and dengue hospitalizations by 86 percent . (gatesnotes.com)

We have distributed mosquito with Wolbachia to almost half of the areas of Yogyakarta city," said EDP's main researcher, Prof. Adi Utarini, to journalists on Friday (8/6) at Fortakgama UGM room. (ugm.ac.id)
Using costing data from existing Wolbachia releases, previous dynamic model-based estimates of Wolbachia effectiveness, and a spatially explicit model of release and surveillance requirements, we predicted the costs and effectiveness of the ongoing programme in Yogyakarta City and three new hypothetical programmes in Yogyakarta Special Autonomous Region, Jakarta, and Bali. (biomedcentral.com)

Results of the three-year study, published in the New England Journal of Medicine this week, found that infecting dengue-carrying mosquitoes with a harmless bacteria called Wolbachia led to a 77 percent drop in human cases. (aljazeera.com)
Another promising tool is a bacteria called Wolbachia . (channelnewsasia.com)
The mosquitoes Enriquez unleashed in his El Manchen neighborhood - an area rife with dengue - were bred by scientists to carry bacteria called Wolbachia that interrupt transmission of the disease. (mystateline.com)

A bacterium called Wolbachia that ?vaccinates? (grantome.com)
Explore our story timeline, which all started with a bacterium called Wolbachia . (worldmosquitoprogram.org)

Our study showed that well-planned, evidence/community-based interventions that control exposure to dengue vectors are feasible and effective in urban settings in Africa that have limited resources. (cdc.gov)
Mosquitos infected with the bacteria Wolbachia are significantly worse vectors for dengue virus, and are therefore a promising tool in fighting the disease, but how to establish and spread Wolbachia in an urban mosquito population is unclear. (ist.ac.at)

aegypti mosquitoes that contained wMel Wolbachia, were undertaken across the cities of Bello, Medellı´n and Itagu¨ı´ in Colombia. (mvcac.org)
In studies on communities along the U.S. southern border in areas where the aegypti mosquito is well established, researchers found that there were as many or sometimes even more of the mosquitoes on the Texas side, but far fewer dengue cases there than on the Mexican side. (healthy-americans.com)

Many human viruses utilise or suppress ubiquitin and ubiquitin-like pathways during infection, enhancing their replication. (gla.ac.uk)
For instance, Wolbachia modulates the replication of viruses or parasites. (datadryad.org)
Replication of all positive-stranded RNA viruses occurs in close association with virus-induced intracellular membrane structures. (denguevirusnet.com)

Hantavirus Infection Hantaviridae are a family of enveloped single-stranded RNA viruses, which consists of at least 4 serotypes with 9 viruses causing 2 major, sometimes overlapping, clinical syndromes: Hemorrhagic. (msdmanuals.com)
Other features of the disease include its epidemiological patterns, including hyper-endemicity of multiple dengue virus serotypes in many countries and the alarming impact on both human health and the global and national economies. (who.int)

They found that Wolbachia infected mosquitoes had significantly reduced dengue virus infection rates across all three diets‚ suggesting that the effectiveness of Wolbachia in disrupting dengue virus infection is unlikely to be compromised by varied larval nutrition in field settings. (worldmosquitoprogram.org)

However, dengue continues to be a neglected disease in this region, often eclipsed by the substantial burden of malaria ( 12 ). (cdc.gov)
She has clinical academic experience in a variety of tropical diseases, including Chagas disease, malaria and dengue, having worked in northern Australia, Kenya, Tanzania and Honduras. (imperial.ac.uk)

Note: This important study shows the establishment of the wMel Wolbachia and the companion paper shows the reduction of dengue in the treated cities. (mvcac.org)
Early entomological data and modelling analyses have suggested promising outcomes, and wMel Wolbachia releases are now ongoing or planned in 12 countries. (biomedcentral.com)
The researchers settled on wMel, a Wolbachia bacteria strain that prior research has shown to be harmless to mosquitoes but reduces their susceptibility to the dengue virus. (edu.au)

In a WHO press conference at the start of April about the worrying dengue and chikungunya (a related virus spread by the same mosquitoes) epidemics there, Raman Velyayudhan, head of the WHO global programme on the control of neglected tropical diseases, said that trend could continue around the world this year. (channelnewsasia.com)

Dengue is the most important reemerging mosquito-borne viral disease worldwide. (hindawi.com)
Dengue is a mosquito-borne viral disease of public health significance that has rapidly spread in all regions of WHO in recent years. (who.int)

Scientists have manipulated Wolbachia so it blocks the growth of virus inside the mosquito. (wikipedia.org)
Scientists believe the virus is responsible for a host of brain defects in developing fetuses, including microcephaly, and has contributed to an uptick in cases of a neurological disorder called Guillain-Barre syndrome. (scienceblog.com)
Previously, scientists have carried out successful mosquito releases using a different strain of the Wolbachia bacteria, but while this strain was effective in some conditions, it did not appear to be suitable for use in the very hot conditions experienced in equatorial countries such as Malaysia. (gla.ac.uk)
Scientists have learned that infecting these mosquitoes with Wolbachia stymies their ability to pick up dengue and other viruses. (usf.edu)
But scientists say dengue will continue to spread to places that haven't experienced it before. (healthy-americans.com)
Because of that lack of progress, scientists have been looking for ways to reduce the number of mosquitoes that carry the virus in human populated areas. (edu.au)

Wolbachia are maternally inherited endosymbionts that infect nearly half of all arthropod species. (nature.com)
Once Wolbachia infect a host arthropod, it wraps itself in a layer of the arthropod's membrane. (phys.org)
It can be made to infect human tissue culture cells in the laboratory but these laboratory systems are very artificial and do not predict the actual ability of Wolbachia to infect an actual human being. (real-agenda.com)
Suppression efforts have mainly focused on mosquito control, but an international, non-profit research collaboration, the Eliminate Dengue Program, is trialing a new approach: harnessing bacteria that infect mosquitoes and so reduce their capacity to transmit viruses. (ist.ac.at)

Mosquitoes transmit numerous arboviruses including dengue and chikungunya virus (CHIKV). (datadryad.org)

With more than half the world's population at risk of contracting dengue, the World Health Organization is paying close attention to the mosquito releases in Honduras, and elsewhere, and it is poised to promote the strategy globally. (mystateline.com)

Instead of working to eliminate mosquitoes the program encourages the release of mosquitoes infected with the bacteria Wolbachia, which interrupts the transmission of dengue. (mystateline.com)

In Malaysia alone, over 100,000 dengue cases were reported in 2016, with an annual cost estimated at $175 million. (gla.ac.uk)
Singapore, too, has used Wolbachia mosquitoes since 2016 as part of a multi-faceted approach to fighting dengue. (sandpipercomms.com)
NEA researchers in Singapore have released male mosquitoes carrying the Wolbachia parasite since 2016. (interestingengineering.com)

That is one of the surprise discoveries made by a pair of Vanderbilt biologists when they sequenced the genome of a virus that attacks Wolbachia, a bacterial parasite that has successfully infected not only black widow spiders but more than half of all arthropod species, which include insects, spiders and crustaceans. (phys.org)
In our research Wolbachia-infected insects are feeding on our researchers all the time and there is no sign of any human illness associated with insect Wolbachia. (real-agenda.com)
Wolbachia can be found in up to 60 percent of insects around the world, including butterflies and bees. (scienceblog.com)
Wolbachia is a genus of maternally inherited intracellular endosymbiotic bacteria belonging to the order Rickettsiales and is estimated to be distributed in ca. 44% of arthropods, and 66% of insects, and also shows mutualistic symbiosis in nematodes [ 1 , 2 , 3 ]. (biomedcentral.com)
For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protein for masculinization and dosage compensation in lepidopteran insects. (bvsalud.org)
Cytoplasmic incompatibility (CI) results when Wolbachia bacteria-infected male insects mate with uninfected females, leading to embryonic lethality. (bvsalud.org)
City officials said on Friday that they had been trapping and testing mosquitoes in the neighborhood where the case was reported and had not found any further insects with the virus . (healthy-americans.com)
Arbovirus (arthropod-borne virus) is defined as any virus that is transmitted to humans and/or other vertebrates by certain species of blood-feeding arthropods, mostly insects (flies and mosquitoes) and arachnids (ticks). (msdmanuals.com)

Dung Phung, the lead scientist on the project, said that currently dengue prevention and control is mostly reactive, limiting the effectiveness of measures to combat its spread. (channelnewsasia.com)
Community participation and interagency collaboration are required for effective and sustainable dengue prevention and control. (who.int)

A study publishing on 30th May 2017 in the open access journal PLOS Biology by Michael Turelli from University of California, Davis in collaboration with Nick Barton from the Institute of Science and Technology (IST Austria) and colleagues from Scott O'Neill's "Eliminate Dengue Program" demonstrates that over time, strategic releases may allow mosquitoes infected with the dengue-suppressing bacteria to spread across large cities. (ist.ac.at)

Only one in four dengue cases are symptomatic. (healthy-americans.com)

Collaborating with Christl Donnelly and with the Eliminate Dengue initiative which is developing Wolbachia, we have estimated the potential impact of Wolbachia on dengue transmission and are now studying spatial spread of Wolbachia after initial release. (imperial.ac.uk)
As Wolbachia is essential for the development, reproduction, and survival of filarial worms, we spatially explored how Wolbachia interacts with the worm's reproductive system by performing a spatial characterization using Spatial Transcriptomics (ST) across a posterior region containing reproductive tissue and developing embryos of adult female Brugia malayi worms. (bvsalud.org)
We provide a proof-of-concept for miniature-ST to explore spatial gene expression patterns in small sample types, demonstrating the method's ability to uncover nuanced tissue region expression patterns, observe the spatial localization of key B. malayi - Wolbachia pathway genes, and co-localize the B. malayi spatial transcriptome in Wolbachia tissue regions, also under antibiotic treatment. (bvsalud.org)
Refining the global spatial limits of dengue virus transmission by evidence-based consensus. (who.int)

There are not yet any vaccines to prevent infection with dengue virus. (sciencedaily.com)

Public health authorities should continue adopting a multi-tiered approach to dengue prevention. (sandpipercomms.com)

However, researchers claim Wolbachia bacterium is completely benign to humans. (real-agenda.com)
The researchers, reporting July 16 in PLOS Neglected Tropical Diseases , tested blood samples from 1,010 people across 50 locations in Chennai, a city with over 6 million people in South India, and found that nearly all of them had been exposed to dengue and 44 percent had been exposed to chikungunya. (sciencedaily.com)
Now, this international team of researchers has shown that the wAlbB strain of Wolbachia is stable and effective, even in daily peak temperatures of 36 degrees and higher, as commonly experienced in areas of Malaysia where dengue is prevalent. (gla.ac.uk)
The researchers tracked the spread of Wolbachia through mosquito populations over two years by trapping and testing them for the bacteria. (ist.ac.at)
The researchers found that Wolbachia-infected mosquitoes spread at about 100-200 meters per year in the larger sites, but there was little evidence of such spread in the smaller area even after two years. (ist.ac.at)
In this new effort, the researchers looked at the possibility of introducing a bacteria strain that infects dengue-carrying mosquitoes, but not in a way that will lead to resistance. (edu.au)
Amid the fear, researchers across the world doing research to better understand, treat and prevent the virus. (courthousenews.com)

With these tools, she is studying 1) the emergence and spread of the tick-borne Powassan virus, 2) the impact of dengue virus genetic diversity on control tools such as the virus-inhibiting Wolbachia bacterium, and 3) the identification and characterization of emerging West Nile virus variants. (yale.edu)

A recent study in three black fly species in the genus Simulium found differential Wolbachia prevalence among species, suggesting host-specific interactions 16 . (nature.com)
Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. (bvsalud.org)
It is not part of the International Committee on Taxonomy of Viruses classification of viruses (ie, it is not a species, genus, or family), which is based on the nature and structure of the viral genome. (msdmanuals.com)
The term arbovirus (arthropod-borne virus) describes a virus that is transmitted by certain species of arthropods. (msdmanuals.com)

I'm interested in how viruses engage with these pathways with respect to cellular antiviral immunity, to develop novel avenues for therapeutic intervention. (gla.ac.uk)
There are no antiviral therapies for any of these viruses. (news-medical.net)

The Australian nonprofit is taking a different tack, raising mosquitoes infected with Wolbachia bacteria. (usf.edu)

The filarial endosymbiont, Wolbachia, has emerged as an attractive therapeutic target for filariasis elimination, due to the dependence of the filaria on this endosymbiont for survival. (bvsalud.org)

The case in Pasadena is a rare locally acquired case of dengue in the United States. (healthy-americans.com)

One such project is E-Dengue in Vietnam, designed to help health systems prepare for dengue outbreaks up to two months in advance by collating local data. (channelnewsasia.com)

It's important to note that Wolbachia does not pose any threat to humans-it solely impacts the mosquitoes, making it an environmentally friendly approach that preserves the delicate balance of our ecosystems. (expresshealthcaremgmt.com)
Q: Can humans be infected with Wolbachia bacteria? (expresshealthcaremgmt.com)
A: Wolbachia renders mosquitoes that carry the dengue virus sterile, preventing them from transmitting the virus when they bite humans. (expresshealthcaremgmt.com)
Wolbachia is an insect bacterium that has not been detected living inside humans or any other vertebrates. (real-agenda.com)
The major difference for humans lies in subtle differences in the surface proteins of the different dengue subtypes. (denguevirusnet.com)
In their paper published in Proceedings of the National Academy of Sciences, the group outlines experiments they have been conducting in Vietnam meant to reduce the number of humans infected with the dengue virus, and what they found as a result. (edu.au)

Most filarial worms evolved a mutualistic association with endosymbiotic bacteria Wolbachia. (bvsalud.org)

When Wolbachia infects mosquitoes, the mosquitoes' ability to transmit Dengue virus is almost completely blocked. (real-agenda.com)
This toolkit can also determine whether a mosquito has been exposed to the Wolbachia bacteria, which infects mosquitoes and prevents them from transmitting dangerous pathogens. (mongabay.com)

Our groundbreaking Wolbachia method can prevent disease. (worldmosquitoprogram.org)
Get the facts on Wolbachia , mosquito-borne disease and where we work. (worldmosquitoprogram.org)
Latest research papers and publications on mosquito-borne disease control using the Wolbachia method. (worldmosquitoprogram.org)
With time, the sterilizing effect of Wolbachia will become apparent, significantly reducing the mosquito-borne disease burden in the long run. (expresshealthcaremgmt.com)
In 1999, the West Nile virus appeared in New York City, and since then, it has caused nearly 2,000 deaths and more than 20,000 cases of serious and debilitating neuroinvasive disease. (cei.org)
The work of my group on these viruses includes assessment of disease burden, understanding how transmission intensity varies geographically and seasonally, and modelling the optimal use of current and novel interventions. (imperial.ac.uk)
Surprisingly, almost none of the people who had been exposed to dengue reported having been infected by it, either because they weren't properly diagnosed with the disease or because they didn't show symptoms. (sciencedaily.com)
And what's remarkable about the Wolbachia mosquitoes is that once enough of them are released to offer disease protection, it's a solution that's self-sustaining. (gatesnotes.com)
Instead of making mosquitoes more resistant to the viruses, the discovery opens a possible path for making mosquitoes more susceptible and less tolerant to virus infection, which would impair their ability to transmit disease. (news-medical.net)
mosquitoes don't get sick when they are infected by these viruses-;our findings effectively solve this mystery and suggest a potential new mosquito-based disease control strategy that merits further study. (news-medical.net)
Although the full global burden of the disease is uncertain, the initiation of activities to record all dengue cases partly explains the sharp increase in the number of cases reported in recent years. (who.int)

Anatomy7

Organisms65

Diseases11

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes37

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Health Care8

Geographicals8

Aedes48

Zika37

Reducing dengue cases1

Fever37

Outbreaks of dengue1

Spread of dengue virus3

Infections14

Severe12

Vaccine19

World Mosquito Program7

Strains4

Inhibit3

Transmit the dengue virus to humans1

Incidence7

Endemic9

Fight dengue2

Vector15

Burden of dengue3

Cases of dengue2

DENV12

20232

Indonesia4

Yogyakarta2

Bacteria called3

Bacterium called2

Vectors2

Aegypti2

Replication3

Serotypes2

Significantly reduced dengue1

Malaria2

WMel3

Worrying dengue and chikungunya1

Viral disease2

Scientists6

Infect4

Chikungunya virus1

Risk of contra1

Transmission of dengue1

20163

Insects8

Prevention and control2

Eliminate Dengue Program1

Symptomatic1

Spatial4

Infection with dengue1

Approach to dengue1

Researchers7

Impact of dengue1

Species4

Antiviral2

Mosquitoes infected1

Endosymbiont1

Case of dengue1

Prepare for dengue1

Humans6

Endosymbiotic1

Infects mosquitoes2

Disease11