Dengue virus antigen. Medical search. Frequent questions

However, children and young adults remain at increased risk for progression to dengue hemorrhagic fever and dengue shock syndrome, particularly during repeat infection with a new DV serotype. (marshfieldlabs.org)
Hemostatic defects in dengue hemorrhagic fever. (microbiologyresearch.org)
With additional clinical validation, the method could provide a means to distinguish between primary and secondary infections and identify those at risk for developing dengue hemorrhagic fever or shock syndrome. (genomeweb.com)
Dengue virus, an arthropod-borne RNA virus of the Flaviviridae family, has 4 serotypes that cause dengue fever or dengue hemorrhagic fever in humans. (cdc.gov)
Severe dengue was previously known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) [ 8 ]. (hindawi.com)
Severe manifestations (dengue hemorrhagic fever and dengue shock syndrome) are rare, but may be fatal. (cdc.gov)
Dengue hemorrhagic fever is defined as acute onset of fever with nonspecific symptoms. (cdc.gov)
The definition for dengue shock syndrome follows all of the above criteria for dengue hemorrhagic fever and also includes hypotension or narrow pulse pressure (less than 20 mm Hg). (cdc.gov)
More symptoms are seen when the dengue progresses into one of its severe forms: Dengue Shock Syndrome and Dengue Hemorrhagic Fever. (nextoptimalmaleenhancement.net)
The symptoms of hemorrhagic fever are similar to dengue fever but the former is more severe. (nextoptimalmaleenhancement.net)
Dengue can also cause potentially fatal hemorrhagic fever with a bleeding tendency and shock. (msdmanuals.com)
Treatment is symptomatic and, for dengue hemorrhagic fever, includes meticulously adjusted intravascular volume replacement. (msdmanuals.com)
In 2007, 28,181 cases were reported in Paraguay, 55 were classified as dengue hemorrhagic fever and seven of them died. (bvsalud.org)

Though uncommon, false-positive nonstructural protein 1 (NS1) results may occur in individuals with active infection due to other flaviviruses, including West Nile virus and yellow fever virus. (marshfieldlabs.org)
Following dengue infection, the incubation period varies from 3 to 7 days, and while some infections remain asymptomatic, the majority of individuals will develop classic dengue fever. (marshfieldlabs.org)
The presence of dengue nonstructural protein 1 (NS1) antigen is consistent with acute-phase infection with dengue virus. (marshfieldlabs.org)
The NS1 antigen is typically detectable within 1 to 2 days following infection and up to 9 days following symptom onset. (marshfieldlabs.org)
NS1 antigen may also be detectable during secondary dengue virus infection, but for a shorter duration of time (1-4 days following symptom onset). (marshfieldlabs.org)
The absence of dengue NS1 antigen is consistent with the lack of acute-phase infection. (marshfieldlabs.org)
The activation of autophagy and ER stress during infection enhances virus reproduction. (wikipedia.org)
This study describes the susceptibility to dengue virus infection of a monocytic cell line at different states of differentiation. (microbiologyresearch.org)
Infectious virus titres increased in undifferentiated U937 cells following infection with clinical isolates but only when the cells were infected via their Fc receptors. (microbiologyresearch.org)
Once differentiated, cells were susceptible to infection either with virus alone or with virus-antibody complexes. (microbiologyresearch.org)
Infection was cytolytic and virus was released into the supernatant fluid. (microbiologyresearch.org)
Increased blood vessel permeability, which occurs in dengue haemorrhagic fever and dengue shock syndrome patients, has been correlated with secondary heterotypic infections and has been postulated to arise from antibody-enhanced infection of monocytes. (microbiologyresearch.org)
Infection enhancement of dengue type 2 virus in the human U-937 monocyte line by antibodies to Flavivirus cross-reactive determinants. (microbiologyresearch.org)
The immune response to dengue virus infection is a well-coordinated balancing act. (nature.com)
New research shows that an imbalanced response - driven partially by the productive infection of antigen-presenting cells - is associated with progression to severe disease. (nature.com)
The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
1) describe the epidemiology, clinical manifestation, management and prevention of Zika virus disease, 2) discuss diagnostic testing for Zika virus infection and interpretation of test results, 3) articulate the importance of early recognition and reporting of cases, 4) state the recommendations for pregnant women and possible Zika virus exposure, and 5) discuss evaluation of infants with microcephaly and relationship of Zika in microcephaly. (cdc.gov)
The World Health Organization recommends that the vaccine only be given to persons with confirmed prior dengue virus infection. (cdc.gov)
In May 2019, Dengvaxia® was approved by the U.S. Food and Drug Administration (FDA) in the United States for use in children 9-16 years old living in an area with endemic dengue with laboratory confirmed prior dengue virus infection. (cdc.gov)
Should 3-doses of Dengvaxia ® be administered routinely to persons 9-16 years of age with laboratory-confirmed previous dengue infection and living in endemic areas to prevent virologically confirmed dengue, hospitalizations and severe dengue? (cdc.gov)
The Tufts team set out to develop and test a Simoa-based dengue test hoping that the digital platform might be able to more sensitively detect anti-dengue antibodies, opening up the possibility of detecting the disease earlier after infection. (genomeweb.com)
Overall, the results suggest that Simoa may be able to detect dengue infection at a much earlier stage of infection as compared to ELISAs, the authors wrote. (genomeweb.com)
Monkeypox virus is a viral infection caused by monkeypox virus (MPXV). (boat-bio.com)
Salmonella Typhoid Antigen Rapid Test Kit: A Breakthrough in Rapid Diagnosis of Typhoid Typhoid is a disease caused by a bacterial infection of Salmonella typhi, which is spread by contaminated foo. (boat-bio.com)
Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. (microbiologyresearch.org)
Following infection with one serotype, subsequent infection with a different serotype increases a person's risk of severe dengue and death. (paho.org)
Because of the clinical course, on day plus 1, physicians suspected a possible dengue virus infection. (cdc.gov)
A serum sample test showed a weak positive result for dengue virus by using IgM and IgG antibody tests, and a strong positive result for dengue virus nonstructural protein-1, or NS1, antigen, demonstrating acute dengue virus infection. (cdc.gov)
Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. (hindawi.com)
Knowledge about the pathogenesis of dengue infection is limited, but both viral and immune host factors appear to be associated with severe illness [ 26 ]. (hindawi.com)
Approximately 100 million people get sick from infection, and 40,000 die from severe dengue. (cdc.gov)
Detection of ongoing/recent dengue virus infection by both molecular (RT-PCR) and serological methods (IgM) was available in 15/19 participating laboratories. (who.int)
Serum IgM antibodies can be detected from dengue patients as early as three to five days after the onset of fever and generally persist for 30 - 90 days, although detectable levels may be present eight months post-infection. (ncnsd.org)
The IgM cut-off is set to detect IgM levels characteristic of current dengue infection. (ncnsd.org)
1997). Commercial Assays for the Serological Diagnosis of Dengue Infection. (ncnsd.org)
Lam, K., et al (2000) Evaluation of a Capture Screening Enzyme-Linked Immunosorbent Assay for Combined Determination of Immunoglobulin M and G Antibodies Produced during Dengue Infection. (ncnsd.org)
Sang, C., et al (1998) Evaluation of a Commercial Capture Enzyme-Linked Immunosorbent Assay for Detection of Immunoglobulin M and G Antibodies Produced during Dengue Infection. (ncnsd.org)
Infection with dengue virus does not increase the risk of foetal malformation or deformity. (nextoptimalmaleenhancement.net)
Viral antigens - NS1 protein appears before antibodies during acute infection. (healthcarentsickcare.com)
Chikungunya transmission mirrors dengue as Aedes aegypti and Aedes albopictus mosquitoes spread infection through bites. (healthcarentsickcare.com)
Virus antibodies - IgM indicates recent infection while IgG signals past exposure. (healthcarentsickcare.com)
Dengue virus infection has emerged as marker in clinical practice ( 11 ). (who.int)
Dengue is an acute disease currently considered a re-emerging infection, whose main vector is Aedes aegypti. (bvsalud.org)
A reduction in platelet number or function can occur through a variety of mechanisms, including autoimmune destruction, spleen sequestration, bone marrow infiltration by tumor cells, infection (e.g. dengue fever), and adverse drug reaction. (bvsalud.org)
Z ported human infections indicated that clinical characteris- ika virus (ZIKV) is a mosquito-transmitted virus in the tics of infection with ZIKV included fever, headache, mal- family Flaviviridae and genus Flavivirus . (folkhalsomyndigheten.se)

Concurrent evaluation for the NS1 antigen alongside testing for IgM- and IgG-class antibodies to DV (DENGM / Dengue Virus Antibody, IgG and IgM, Serum) provides optimal diagnostic potential for both early and late dengue disease. (marshfieldlabs.org)
This antibody was raised against Dengue virus 2 Envelope protein, which may cross react with Envelope protein of Dengue virus 3 but does not recignize with Envelope protein of JEV. (genetex.com)
Dengue virus Envelope protein antibody detects Dengue virus Envelope protein protein at cytoplasm by immunohistochemical analysis. (genetex.com)
Green: Dengue virus Envelope protein stained by Dengue virus Envelope protein antibody (GTX127277) diluted at 1:1000. (genetex.com)
Non-infected (-) and infected (+) BHK-21 whole cell extracts (5 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with Dengue virus Envelope protein antibody (GTX127277) diluted at 1:25000. (genetex.com)
According to the group, currently used ELISAs for anti-dengue antibody detection suffer from a lack of sensitivity in the first few days of illness, when antibodies against the disease may be present at too low a concentration to be detected. (genomeweb.com)
Since a plant-derived antibody cocktail to Ebola virus in 2014 had been shown to be effective 5 , more studies and cases have been reported. (nature.com)
Using state-of-the-art antibody technologies we have developed streamlined, high-throughput single B-cell PCR cloning technology to isolate natural disease-fighting antibodies directly from virus-infected patient blood samples. (a-star.edu.sg)
The SIgN Antibody Platform designs, develops and engineers human antibodies, including bispecific monoclonal antibodies that can bind two different types of antigen at one time. (a-star.edu.sg)
Blacksell, S. et al (2007) Evaluation of the Panbio dengue virus nonstructural 1 antigen detection and immunoglobulin M antibody enzyme-linked immunosorbent assays for the diagnosis of acute dengue infections in Laos. (ncnsd.org)
In recent years various immunoenzymatic systems have been developed immunoassay for the diagnosis of dengue, including the M antibody captureELISA (MAC ELISA). (bvsalud.org)
The aim of this cross-sectional observational study was to compare the MAC ELISA test developed at the Instituto de Investigaciones en Cienciad de la Salud(IICS) using antigens supplied by the Instituto Pedro Kouri (IPK) of Cuba and Evandro Chagas of Brazil with a commercial kit of M antibody capture ELISA for dengue virus (Focus Diagnostics Inc. Cypress, CA, USA). (bvsalud.org)

Dengue virus (DENV) is the cause of dengue fever. (wikipedia.org)
33 Antigen detection assays are not available for MVEV, but have been used for JEV and Dengue fever virus. (mja.com.au)
11 It is also possible that prior immunisation with yellow fever virus or JEV vaccine may induce cross-reactive antibodies. (mja.com.au)
Zika virus is a single-stranded RNA virus in the genus flavivirus, family flaviviridae that is closely related to dengue, yellow fever, Japanese encephalitis and West Nile viruses. (cdc.gov)
NEW YORK (GenomeWeb) - A team from Tufts University has published a proof of concept demonstrating that Quanterix's digital ELISA technology, Simoa, may allow more sensitive detection of the host immune response to dengue fever than other current methods. (genomeweb.com)
Dengue fever, a mosquito-borne viral disease, has been on the rise over the past 50 years, mainly in Southeast Asia. (heolabs.com)
Since the early clinical manifestations caused by dengue fever are similar to those of respiratory infectious diseases, coupled with the fact that the relevant vaccine has not yet been approved for. (boat-bio.com)
Dengue fever is currently one of the most important mosquito-borne diseases that affect humans. (unicamp.br)
Symptomatic infections vary from a mild, flu-like illness known as dengue fever (DF) to a life-threatening form called severe dengue (SD) [ 8 ]. (hindawi.com)
The Panbio dengue IgM Capture ELISA is for the qualitative detection of IgM antibodies to dengue antigen in serum, as an aid in the clinical laboratory diagnosis of patients with clinical symptoms consistent with dengue fever. (ncnsd.org)
Assay (ELISA) and MRL Dengue Fever Virus Immunoglobulin M Capture ELISA for Diagnosis of Dengue Virus Infections in Southeast Asia. (ncnsd.org)
Dengue fever is a disease spread by the vector called Aedes mosquito, which breeds on still water that gets collected especially after the end of the summer. (nextoptimalmaleenhancement.net)
Dengue is also known as the break-bone fever and typically occurs in tropical regions. (nextoptimalmaleenhancement.net)
Dengue is mainly characterized by sudden fever accompanied by severe headaches, joint and muscle pains, nausea, vomiting, skin rash and nose or gum bleeding. (nextoptimalmaleenhancement.net)
This is a severe complication of dengue fever . (nextoptimalmaleenhancement.net)
But in some cases, symptoms of dengue fever resolve and signs of circulatory failure develop which can rapidly progress to severe shock, which can then lead to death within 12-24 hours. (nextoptimalmaleenhancement.net)
The signs and symptoms of Dengue fever and DHF in Pregnancy is similar to that in the non-pregnant patient. (nextoptimalmaleenhancement.net)
Dengue fever can affect the unborn baby. (nextoptimalmaleenhancement.net)
People of all age group suffer from dengue fever. (nextoptimalmaleenhancement.net)
Clinical diagnosis of dengue fever can be difficult as the signs and symptoms of dengue fever are similar to that of a viral fever, malaria or typhoid fever. (nextoptimalmaleenhancement.net)
Tests done to confirm a diagnosis of dengue fever include a serum or autopsy tissue sample, which is taken to identify the virus. (nextoptimalmaleenhancement.net)
Dengue viruses are spread by bites of infected Aedes aegypti and Aedes albopictus mosquitoes which also transmit chikungunya, yellow fever and Zika virus. (healthcarentsickcare.com)
Chikungunya fever is caused by the chikungunya virus, an alphavirus from the Togaviridae family transmitted between humans by Aedes mosquitoes. (healthcarentsickcare.com)
Dengue fever usually results in abrupt onset of high fever, headache, myalgias, arthralgias, and generalized lymphadenopathy, followed by a rash that appears with a recurrent fever after an afebrile period. (msdmanuals.com)
50-100 million cases of dengue fever brate hosts of dengue virus in nature cessed by multiplex polymerase chain and 500 000 of dengue haemorrhagic are humans and several species of Asian reaction (PCR) in which the presence fever (DHF) reported annually ( 4 ). (who.int)
Infectious disease outbreaks like dengue, HIV, chikungunya, Hepatitis and yellow fever is common in developing countries like Pakistan. (edu.pk)
2.2 Transmission of haemorrhagic fever viruses. (who.int)
Valley fever, dengue haemorrhagic fever, Crimean-Congo haemorrhagic fever and Ebola haemorrhagic fever. (who.int)
There are 14 distinct viruses associated with haemorrhagic fever in humans. (who.int)
Results of laboratory tests revealed severe thrombocytopenia and a careful history disclosed dengue fever as the cause. (bvsalud.org)
thrombocytopenia, platelet disorder, dengue fever. (bvsalud.org)
Though most of these manifestations are noted on ocular mucosa like conjunctiva, sclera, there have been reports of dengue fever presenting as small vesicles on soft palate, erythema and crusting of lips and tongue 5 . (bvsalud.org)
Here we report a case of thrombocytopenia associated with dengue fever, which showed only oral manifestations, thus highlighting the significance of recognizing the oral signs. (bvsalud.org)
Patient had suffered from dengue fever six months before, for which she had undergone blood transfusion, as per her previous medical reports. (bvsalud.org)
Based on the clinical examination, hematological disorder due to dengue fever was chiefly considered, while differential diagnoses included oral squamous cell carcinoma of tongue and buccal mucosa and other infections like influenza, measles, rubella and bacterial sepsis. (bvsalud.org)
The A aegypti mosquito is a known transmitter of dengue fever and yellow fever. (medscape.com)

For the full text of the recommendations, see Dengue Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2021 . (cdc.gov)
For more information, see Laboratory Testing Requirements for Vaccination with Dengvaxia Dengue Vaccine . (cdc.gov)
Recombinant domains of the E protein are used as well-defined antigens in the serological detection of antibodies directed against dengue virus and as immunogens in vaccine candidates. (wikipedia.org)
A vaccine to prevent dengue (CYD-TDV, Dengvaxia®) is licensed and available in 20 countries for people ages 9-45 years old. (cdc.gov)
The US Advisory Committee on Immunization Practices (ACIP) Dengue Vaccine Work Group reviewed Dengvaxia ® safety and efficacy data in a systematic literature review in 2018. (cdc.gov)
Virus-like particles (VLPs) enable the construction of promising platforms in the field of vaccine development. (nature.com)
It is clear that an effective vaccine against Covid-19 is crucial if we are to beat this virus. (pasteur.fr)
This has provided hope for the design of a universal vaccine able to prime against diverse influenza virus strains and subtypes. (mdpi.com)
To date, there is no effective vaccine or specific antiviral therapy for dengue. (hindawi.com)
The virus can cause acute, subacute, or chronic disease and there is currently no vaccine or specific drug against the virus. (meridianbioscience.com)
Virology group is also trying to lay the foundation for the development of an effective therapeutic vaccine for HPV, Dengue, and HIV. (edu.pk)
A Phase I Study to Determine the Safety and Immunogenicity of the Candidate Zika Virus (ZIKV) Vaccine ChAdOx1 Zika in Healthy Adult Volunteers. (who.int)
Adenovirus vectored vaccine, Zika virus vaccine, Dengue virus vaccine). (who.int)

In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
Dengue viruses (DENV) transmitted by Aedes aegypti mosquitoes present a growing public health challenge (Shepard et al. (cdc.gov)
There are 4 dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4), all of which circulate globally, with most endemic coun-tries reporting circulation of all 4 serotypes in recent years. (cdc.gov)
In this study, the role of the His residue at position 39 in the M protein (M39) of dengue virus type 2 (DENV-2) in the virus life cycle was investigated. (microbiologyresearch.org)
Mutations encoding basic (Arg), non-polar (Leu and Pro) and uncharged polar (Asn, Gln and Tyr) amino acids at M39 were introduced into a DENV-2 genomic-length cDNA clone and their effects on virus replication were examined. (microbiologyresearch.org)
The four dengue serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) circulate throughout the Americas, and in some countries simultaneously. (paho.org)
for the detection of dengue virus (DENV) in Aedes aegypti. (unicamp.br)
aegypti with the NS1 rapid test kit in our dengue cluster investigation further illustrates its potential use for surveillance of DENV in wild mosquito populations. (unicamp.br)
BACKGROUND: Aedes albopictus and Aedes aegypti are known for their potential as vectors of dengue (DENV) and chikungunya (CHIKV) viruses. (bvsalud.org)
We investigated whether expression of the Zika virus (ZIKV) and dengue virus (DENV) protease induced alterations in the cellular lipid profile, and subsequently whether co-expression of these proteases with VLP constructs was able to improve VLP yield. (bvsalud.org)
The Dengue virus complex (DENV), formed by four serotypes, constitutes the most important arbovirus affecting humans. (bvsalud.org)
It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
Dengue is an arthropod-borne disease caused by the Dengue virus (DENV) [ 1 ]. (hindawi.com)
DENV is an enveloped, single-stranded, positive-strand RNA virus, member of the genus Flavivirus in the Flaviviridae family. (hindawi.com)
Nevertheless, the involved DENV type and the host genetic makeup may explain some differences in clinical manifestations observed, since genetic polymorphisms appear to provide protection or predispose to more severe forms of dengue [ 27 ]. (hindawi.com)
Dengue is a rapidly spreading mosquito-borne viral disease caused by one of four dengue virus serotypes (DENV 1-4). (healthcarentsickcare.com)
Laboratory testing with a rapid conducted at that time showed that 6.1% of the residents assay suggested that a dengue virus (DENV) was the caus- in nearby regions of Uganda had specifi c antibodies to ative agent. (folkhalsomyndigheten.se)
aegypti ), implicating these species as likely lin (Ig) M-capture ELISA with DENV antigen confi rmed epidemic or enzootic vectors ( 3 - 5 ). (folkhalsomyndigheten.se)

In the study, published this week online as an accepted manuscript in the Journal of Clinical Microbiology , the Tufts group described their development of a Simoa-based assay to detect type 2 anti-dengue IgG and IgM and compared its sensitivity to two commercially available ELISA kits for the two antibodies. (genomeweb.com)
In their study, the Tufts team first measured the Simoa assay's sensitivity, as well as those of two ELISA kits for dengue detection, using serial dilutions of dengue type 2-positive plasma. (genomeweb.com)
In contrast, the IgG Simoa was able to detect anti-dengue IgG at 1:10,000,000 dilution, making it 1,000 times more sensitive than the EuroImmun IgG ELISA kit. (genomeweb.com)
Similarly, the IgM Simoa was able to detect anti-dengue IgM at 10,000 times higher dilution than the EuroImmun IgM ELISA kit. (genomeweb.com)
Detection of IgM antibodies to dengue virus by ELISA is a valuable procedure, particularly in second and subsequent infections where the occurrence of complications is high. (ncnsd.org)
This data has been extracted from the Dengue IgM Capture and Dengue IgG Capture ELISA Instructions for Use. (ncnsd.org)
2015 we analysed the serum samples of 140 patients with a suspicion of dengue, using ELISA and multiplex polymerase chain reaction. (who.int)
Les échantillons de sérum de 140 patients susceptibles d'avoir contracté le virus de la dengue ont été analysés entre mai et octobre 2015 à l'aide du test ELISA et de l'amplification en chaîne par polymérase multiplexe. (who.int)
En los últimos años se han desarrollado diferentes sistemas inmunoenzimáticos para el diagnóstico del dengue, entre ellos el ELISA de captura de IgM (MAC ELISA). (bvsalud.org)
El objetivo de este estudio observacional analítico de corte transverso fu ecomparar la prueba del MAC ELISA desarrollada en el Instituto de Investigaciones en Ciencias de la Salud (IICS) utilizando antígenos suministrados por el Instituto Pedro Kouri(IPK) de Cuba y el Evandro Chagas de Brasil, con el kit comercial ELISA IgM por capturapara virus del dengue (Focus Diagnostics Inc. Cypress, CA, USA). (bvsalud.org)

Methods: Nineteen national-level public health laboratories performed routine dengue diagnostic assays on a proficiency testing panel consisting of two modules: one containing commercial serum samples spiked with cultured dengue viruses for the detection of nucleic acid and non-structural protein 1 (NS1) (Module A) and one containing human serum samples for the detection of anti-dengue virus antibodies (Module B). A review of logistics arrangements was also conducted. (who.int)

The case-fatality ratio for severe dengue is 10% or higher when untreated but can be reduced to less than 1% with good clinical management. (cdc.gov)
Age, co-morbidities, host genetics, and virus strain are risk factors for severe dengue with heterotypic secondary infections being the most prominent factor associated with severe dengue (Wilder-Smith et al. (cdc.gov)
Protection against virologically confirmed dengue, severe dengue, and hospitalization for dengue. (cdc.gov)
The harms considered critical outcomes were serious adverse events, hospitalizations, severe dengue and deaths. (cdc.gov)
Key research interests are the immunology of infectious disease including severe bacterial infections, Zika virus and Chikungunya virus. (imperial.ac.uk)
The illness can evolve to severe dengue, characterized by shock, respiratory distress, severe bleeding, and/or serious organ impairment. (paho.org)
The disease can evolve into severe dengue, characterized by shock, shortness of breath, severe bleeding and / or complications in the organs. (paho.org)
In pregnancy infections with dengue virus is not more severe as compared to a non-pregnant patient as in the case, for instance, of malaria. (nextoptimalmaleenhancement.net)
The disease is characterized by severe joint pain and shares some clinical signs with dengue and Zika. (meridianbioscience.com)
Some people develop severe dengue characterized by fluid leakage, bleeding, and organ impairment. (healthcarentsickcare.com)
A pregnant woman can pass the dengue virus to her fetus during pregnancy or around the time of birth, although the rate of vertical transmission appears low (see World Health Organization [WHO]: Dengue and severe dengue ). (msdmanuals.com)
Some of these viruses cause relatively mild illnesses, while others can cause severe, life-threatening disease. (who.int)

Dengue shock syndrome could also lead to an organ dysfunction because of low blood pressure. (nextoptimalmaleenhancement.net)

RT-PCR tests are available for early dengue diagnosis, but serological methods are more cost effective and easily available making them attractive, especially in dengue endemic countries. (genomeweb.com)
Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
We recommend testing of recent travelers returning from areas to which dengue virus is endemic before allowing such donations. (cdc.gov)
Dengue is endemic to the tropical regions of the world in latitudes from about 35 ° north to 35 ° south. (msdmanuals.com)
10 years living in areas where dengue is endemic. (msdmanuals.com)

Dengue virus (DV) is a globally distributed flavivirus with 4 distinct serotypes (DV-1, -2, -3, -4) and is primarily transmitted by the Aedes aegypti mosquito, found throughout the tropical and subtropical regions of over 100 countries. (marshfieldlabs.org)
Until a few hundred years ago, dengue virus was transmitted in sylvatic cycles in Africa, Southeast Asia and South Asia between mosquitoes of the genus Aedes and nonhuman primates, with rare emergences into human populations. (wikipedia.org)
The global spread of dengue virus, however, has followed its emergence from sylvatic cycles and the primary lifecycle now exclusively involves transmission between humans and Aedes mosquitoes. (wikipedia.org)
Dengue virus is transmitted by species of the mosquito genus Aedes. (wikipedia.org)
In the Americas, Aedes aegypti is the mosquito vector that is the main source of dengue transmission. (paho.org)
The causative agents, enveloped single-strand RNA viruses from the genus Flavivirus with 4 serotypes, are transmitted by the bite of Aedes mosquitoes. (msdmanuals.com)
Aedes mosquitoes may acquire the virus when they feed on humans during this period. (msdmanuals.com)
El dengue es una enfermedad aguda grave considerada actualmente como infección reemergente, cuyo vector principal es el Aedes aegypti. (bvsalud.org)

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8(+) T cell response. (expasy.org)

Discussion: This first round of external quality assessment of dengue diagnostics was successfully conducted in national-level public health laboratories in the WHO Western Pacific Region, revealing good proficiency in both molecular and serological testing. (who.int)
Detection mostly relies on serological tests that confirm the presence of IgM or IgG antibodies to the virus, or, during the early stage, direct detection is possibly by RT-qPCR. (meridianbioscience.com)

Expression of cloned envelope protein genes from the flavivirus tick-borne encephalitis virus in mammalian cells and random mutagenesis by PCR. (microbiologyresearch.org)
Reference Dengue is a mosquito-borne disease caused by a flavivirus. (msdmanuals.com)

Over one hundred vaccines using varied approaches including protein subunit, viral vector, RNA, DNA, inactivated virus, attenuated virus, and virus like particles (VLPs) platforms are in clinical trials. (nature.com)
These protein subunits can assemble into virus particles without viral RNA genome in mammalian cells to study virus-cell entry 2 and to develop vaccines 3 . (nature.com)
Dengue is the most important reemerging mosquito-borne viral disease worldwide. (hindawi.com)
Dengue and chikungunya are viral diseases transmitted by infected mosquitoes. (healthcarentsickcare.com)
Viral RNA via RT-PCR - Confirms active virus. (healthcarentsickcare.com)
ABSTRACT Dengue is one of the most important arthropod-borne viral diseases. (who.int)
Dengue virus is transmitted to was approved by the Ethics Committee borne viral diseases worldwide ( 1 ). (who.int)
Our work relates to eight main themes which consist of the Establishment of assays/methods to study viruses, Studies on Virus Genome characterization, variability, Genotyping/ Serotyping, Studies on viral genes/proteins and their role in disease outcome using Bioinformatics tools, Virus Prevalence and Molecular Epidemiology, Studies on Anti-viral therapy: role of various viral & host factors in treatment response rates and Studies on Virus association with other abnormal conditions/Diseases. (edu.pk)

Additionally, coinfection with and lack of rapid tests for Zika virus and chikungunya complicate matters in real-world infections. (wikipedia.org)
Current estimates indicate that as many as 390 million infections occur each year, and many dengue infections are increasingly understood to be asymptomatic or subclinical. (wikipedia.org)
Test kit is used for the rapid detection of monkeypox virus antigens in human specimens,making it a valuable tool in the early diagnosis and control of monkeypox infections. (boat-bio.com)
current estimates indicate 390 million dengue virus infections and 96 million clinically apparent cases in 2010. (cdc.gov)
Evidence from animal models shows that T cells can provide heterosubtypic protection and are crucial for immune control of influenza virus infections. (mdpi.com)
Vazquez, S., et al (2007) Evaluation of immunoglobulin M and G capture enzyme-linked immunosorbent assay Panbio kits for diagnostic dengue infections. (ncnsd.org)
Overview of Arbovirus, Arenavirus, and Filovirus Infections Arbovirus (arthropod-borne virus) is defined as any virus that is transmitted to humans and/or other vertebrates by certain species of blood-feeding arthropods, mostly insects (flies and mosquitoes). (msdmanuals.com)

Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines. (mdpi.com)
Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)

Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate form. (microbiologyresearch.org)

Groen, J., et al (2000) Evaluation of Six Immunoassays for Detection of Dengue Virus-Specific Immunoglobulin M and G Antibodies. (ncnsd.org)

It is transmitted by the bite of a mosquito infected with one of the four serotypes of dengue virus. (paho.org)
We determined the frequency of different serotypes of dengue virus to highlight its hyperendemicity in Rawalpindi, Pakistan. (who.int)

Serologic testing for the presence of IgM and IgG antibodies to dengue virus is recommended in such cases. (marshfieldlabs.org)

Antigen Peptide Dengue Polyprotein - HLA-B*07:02 (APTRVVAAEM) - AA 1697 - 1706 (Serine protease NS3) for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxity or proliferation assays. (jpt.com)

To confirm the diagnosis your doctor will test your blood for the presence of dengue virus. (nextoptimalmaleenhancement.net)

trypsin-sensitive virus receptors and trypsin-resistant immune complex receptors. (microbiologyresearch.org)
Moreover, VLPs offer interesting biotechnological advantages as they can serve as scaffolds for presenting heterologous antigens capable of inducing immune responses against other infectious diseases. (nature.com)
ArD 14701 antigen gave positive results with the following immune fluids: West Nile, Usutu and Dengue 3. (cdc.gov)
Find your antigen peptide and select the connected PepMix™ Peptide Pool and MHC Multimer for efficient immune monitoring, mapping of T cell epitopes or development of immunotherapy and vaccines. (jpt.com)

Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, all of which can cause the full spectrum of disease. (wikipedia.org)
Questions are limited to clinicians who would like information related to Zika virus disease. (cdc.gov)
We also use combinatorial phage display technology to discover antibodies against human disease antigens, including cytokines and tumor markers on cancer stem cells. (a-star.edu.sg)
PAHO/WHO provides advice and technical support for dengue prevention and control based on a regional strategy adopted by PAHO / WHO member States in 2016, called the " Strategy for arboviral disease prevention and control " (CD55.R6). (paho.org)
Incidence of dengue has increased many fold in the past 50 years and has expanded to areas that were previously free from the disease. (who.int)
Since VHF share symptoms with many other diseases, positive identification of the disease relies on laboratory evidence of the viruses in the bloodstream, such as detection of antigens and antibodies or isolation of the virus from the body. (who.int)

Performed hands on RT-PCR for Dengue virus antigen detection on 30 serum samples for the same]. (kokilabenhospital.com)
Ninety two coded serum samples wererandomly selected from patients who attended the IICS with suspected dengue, respecting their confidentiality. (bvsalud.org)

Objective: Accurate laboratory testing is a critical component of dengue surveillance and control. (who.int)
Study of Clinicomicrobiological cases of Dengue with a comparative study of its laboratory diagnostic methods at a tertiary care centre of Navi Mumbai, Year 2010-2012. (kokilabenhospital.com)
Genes and antigens of parasites : a laboratory manual, the proceedings of a course held at the Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil, 14 November-17 December, 1983 / organized and edited by Carlos M. Morel. (who.int)

Ribavirin (already established as therapy for hepatitis C virus, which is also in the Flaviviridae family) was used in a study of 153 Indian children with JEV encephalitis, but did not indicate any benefit compared with placebo. (mja.com.au)

The majority of those were excluded as describing different live attenuated dengue vaccines or not including primary trial data. (cdc.gov)
Although the assembled VLPs do not have S protein spikes, they could be developed as formulations that can improve the immunogenicity of vaccines including S antigens, and further could be used as platforms that can carry S antigens of concern for various mutations. (nature.com)
Borne Encephalitis or Dengue virus vaccines). (who.int)

Our firm has strived to establish a extremely efficient and stable employees crew and explored an effective excellent command method for Hcv Core-Ns3-Ns5 Fusion Antigen, Jev Igm Rapid Test Kit , Mycobacterium Tuberculosis Rapid Test Kit , Chagas Fra Antigen , Lyme Osp-C Antigen . (boat-bio.com)

the only exception is the four dengue viruses, which may circulate continually among humans. (who.int)

The objective of this programme was to assess dengue diagnostic proficiency among national-level public health laboratories in the World Health Organization (WHO) Western Pacific Region. (who.int)
Further comprehensive diagnostic testing for dengue virus and other priority pathogens in the Region will be assessed during future rounds. (who.int)

In Gabon where outbreaks of both viruses have occurred, there is no vector control program targeting these arboviruses. (bvsalud.org)
This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. (hindawi.com)
There is currently no specific treatment for dengue, and vector control and vaccination are the only effective methods to prevent future outbreaks. (who.int)

Dengue incidence has increased in the Americas over the past four decades, from 1.5 million cumulative cases in the 1980s to 16,2 million in the decade 2010-2019. (paho.org)
more recently, dengue incidence has increased in Central and South America. (msdmanuals.com)

This same study identified 47 strains of dengue virus. (wikipedia.org)

Monoclonal antibodies to Sindbis virus glycoprotein El can neutralize, enhance infectivity, and independently inhibit haemag-glutination or haemolysis. (microbiologyresearch.org)

the main vector of dengue, has proved highly difficult to control, and continues to expand its geographic range. (cdc.gov)
is the vector mosquito for dengue and is widely distributed in the Americas. (paho.org)
Only Canada and continental Chile are free from dengue and its vector. (paho.org)

181B potentially associated with Zika virus (ZIKV) has highlighted the urgent need to identify individuals infected with ZIKV. (who.int)
Zika virus (ZIKV) is a mosquito-borne fl avivirus fi rst studies in the absence of epidemics ( 6 - 8 ). (folkhalsomyndigheten.se)

We assessed predominantly pediatric patients in Vietnam with dengue and other febrile illness 3 months after acute illness. (researchgate.net)

In this study the potential of the kit for field surveillance of infected dengue vectors, which are epidemiologically important, has been demonstrated. (unicamp.br)

Anatomy7

Organisms33

Diseases5

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes13

Disciplines and Occupations1

Information Science3

Health Care4

Geographicals2

Hemorrhagic fever13

Infection45

Antibody12

Fever36

Vaccine13

DENV18

ELISA10

Anti-Dengue1

Severe12

Shock syndrome1

Endemic5

Aedes8

Serotype1

Serological2

Flavivirus2

Viral8

Infections7

Clinical2

Recombinant1

Detection of dengue virus1

Serotypes of dengue virus2

Antibodies to dengue virus1

Assays1

Presence of dengue1

Immune4

Disease6

Serum samples2

Laboratory3

Flaviviridae1

Vaccines3

Fusion Antigen1

Humans1

Diagnostic2

Outbreaks3

Incidence has increased2

Strains1

Monoclonal1

Vector3

ZIKV2

Febrile1

Vectors1