• Development of dengue vaccines began in the 1920s, but was hindered by the need to create immunity against all four dengue serotypes. (wikipedia.org)
  • In May 2019, Dengvaxia was approved in the United States as the first vaccine approved for the prevention of dengue disease caused by all dengue virus serotypes (1, 2, 3 and 4) in people ages nine through 16 who have laboratory-confirmed previous dengue infection and who live in endemic areas. (wikipedia.org)
  • Dengvaxia is a chimeric vaccine made using recombinant DNA technology by replacing the PrM (pre-membrane) and E (envelope) structural genes of the yellow fever attenuated 17D strain vaccine with those from the four dengue serotypes. (wikipedia.org)
  • A candidate vaccine (Sanofi Pasteur, Swiftwater, PA, USA) containing all 4 DENV serotypes is in advanced clinical testing. (cdc.gov)
  • The first observation was that a single dose of 4 live-attenuated chimeric DENVs given subcutaneously at a single site failed to raise type-specific protective immunity against the 4 DENV serotypes, and 2) doses 2 and 3 of the Sanofi Pasteur vaccine given to children over a 1-year period failed to improve efficacy outcomes. (cdc.gov)
  • There are 4 dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4), all of which circulate globally, with most endemic coun-tries reporting circulation of all 4 serotypes in recent years. (cdc.gov)
  • The 4 dengue serotypes are serologically and genetically distinct, although they share several of their structural antigens. (cdc.gov)
  • QDENGA® (TAK-003) is a dengue vaccine that is based on a live-attenuated dengue serotype 2 virus, which provides the genetic "backbone" for all four dengue virus serotypes and is designed to protect against any of these serotypes. (newswire.co.kr)
  • GMTs of neutralizing antibodies for each of the 4 dengue serotypes were measured by microneutralization test 50% [MNT50]. (clinicaltrials.gov)
  • The 4 dengue virus serotypes were DENV-1, DENV-2, DENV-3, and DENV-4. (clinicaltrials.gov)
  • Seropositivity rates were assessed for the four dengue serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. (clinicaltrials.gov)
  • The dengue virus serotypes are DENV-1, DENV-2, DENV-3 and DENV-4. (clinicaltrials.gov)
  • Seropositivity for multiple dengue serotypes was summarized in the following categories: tetravalent and at least trivalent. (clinicaltrials.gov)
  • Several decades of dengue vaccine research have shown how challenging it is to develop a highly efficacious vaccine that protects against all four dengue serotypes (DENV-1-4) for people of all ages. (ntu.edu.sg)
  • Dengue fever is caused by four different serotypes of the dengue virus, and recovery from one serotype does not provide immunity against the others. (thaimedicalnews.com)
  • The prevalence of these serotypes varies geographically, making dengue a complex challenge to combat. (thaimedicalnews.com)
  • Takeda Pharmaceuticals' QDENGA is a tetravalent vaccine designed to provide protection against all four serotypes of the dengue virus. (thaimedicalnews.com)
  • The vaccine is based on a live-attenuated dengue serotype 2 virus, which serves as the genetic "backbone" for all four serotypes. (thaimedicalnews.com)
  • Achieving uniform protection across all dengue virus serotypes is a complex task, and ensuring equitable access to the vaccine, particularly in low-resource settings, is crucial. (thaimedicalnews.com)
  • Infection by one of the four dengue virus serotypes has been shown to confer lasting protection against homotypic re-infection, but only transient protection against a secondary heterotypic infection. (medicofem.com)
  • Due to these dengue-specific complexities, vaccine development focuses on the generation of a tetravalent vaccine aimed at providing long-term protection against all virus serotypes. (medicofem.com)
  • There are four serotypes of the virus that cause dengue - DENV-1, DENV-2, DENV-3 and DENV-4. (thomsonspecialists.com)
  • However, subsequent dengue infections by other serotypes may carry high risk of developing severe dengue, dengue haemorrhagic fever or dengue shock syndrome , which can be life-threatening. (thomsonspecialists.com)
  • It is a potential target for the development of dengue vaccines and therapeutics," the researchers said.The four "serotypes" of dengue are distinguished by different antigens or proteins on the viral envelope that elicit immune responses. (ndtv.com)
  • The four dengue serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) circulate throughout the Americas, and in some countries simultaneously. (paho.org)
  • It is transmitted by the bite of a mosquito infected with one of the four serotypes of dengue virus. (paho.org)
  • The candidate vaccine is made from a mixture of four live, weakened viruses targeted to each of the four serotypes. (medicilon.com)
  • The TV005 vaccine is the only single dose tetravalent dengue vaccine, which is an important feature of this vaccine,' another scientist, Beth Kirkpatrick, who led the UVM team, said, adding it also appears to prompt immune responses to all four of the dengue serotypes, which is important for any tetravalent dengue vaccine. (bangladeshpost.net)
  • Over the past 15 years epidemics caused by all four dengue virus serotypes have occurred with increasing frequency in the Caribbean Basin. (cdc.gov)
  • The increased disease incidence, combined with the increased frequency of epidemic dengue caused by multiple virus serotypes, has increased the risk of epidemic DHF. (cdc.gov)
  • Researchers have struggled to create effective vaccines against dengue virus, in part because four distinct serotypes, or strains, cause the disease and a vaccine must immunize against all four individually. (outbreaknewstoday.com)
  • Attempts at using live dengue viruses to develop a dengue fever vaccine have often led to an imbalance in immunity to the four dengue serotypes-for instance, one recent candidate had lower efficacy against serotype 2. (outbreaknewstoday.com)
  • Previous infection with one serotype of dengue, or protection against just one serotype, can lead to more severe disease if a person contracts other serotypes, so it's vital that vaccines are available that specifically target all four strains. (outbreaknewstoday.com)
  • After immunization with the DENV2-E nanoparticles, mice had a specific antibody response to serotype 2 of the dengue virus, but not the other three serotypes. (outbreaknewstoday.com)
  • Future studies will be required to test whether the antibody levels prevent dengue infection as well as whether similar nanoparticles can be develop for all dengue serotypes. (outbreaknewstoday.com)
  • There are four types of dengue virus (serotypes). (msdmanuals.com)
  • CYD-TDV, sold under the brand name Dengvaxia and made by Sanofi Pasteur, is a live attenuated tetravalent vaccine that is administered as three separate injections, with the initial dose followed by two additional shots given six and twelve months later. (wikipedia.org)
  • In clinical testing of the Sanofi Pasteur vaccine, failure of multiple booster doses to show protection was unexpected because the children were already substantially immune from prior exposure to DENV or Japanese encephalitis vaccine. (cdc.gov)
  • The vaccine, manufactured by Sanofi-Pasteur, has been licensed in six countries so far, and multiple countries are currently considering how to use this vaccine. (eurekalert.org)
  • In 2012, Sanofi Pasteur was racing to develop a vaccine against dengue, a mosquito-borne disease, and was evaluating this product in a Phase IIb trial conducted with school children in Thailand. (hbs.edu)
  • Guillaume Leroy, vice president of the Dengue Company at Sanofi Pasteur, reflected on the Phase IIb trial's surprising outcome and the way forward. (hbs.edu)
  • The 20 countries where Sanofi Pasteur hopes for authorization to market the vaccine have a total population of two billion people. (ndtv.com)
  • In light of the rapidly rising incidence of dengue virus infection, now estimated to affect about 100 million individuals per year,1 the approval of the first dengue vaccine developed by Sanofi Pasteur (CYD-TDV) was a welcome step forward.2 However, the first vaccine does not present a simple solution. (ntu.edu.sg)
  • The World Health Organization had previously concluded the Sanofi Pasteur vaccine was safe, but later said children should only be immunized if they were tested first to ensure they had already had dengue. (mychamplainvalley.com)
  • The World Health Organization had beforehand concluded the Sanofi Pasteur vaccine was secure, however later mentioned youngsters ought to solely be immunized in the event that they have been examined first to make sure they'd already had dengue. (thecontact.ca)
  • We are working with health authorities to ensure that prescribers, vaccinators and patients are fully informed of the new findings, with the goal of enhancing the impact of Dengvaxia in dengue-endemic countries," said Dr. Su-Peing Ng, Global Medical Head, Sanofi Pasteur. (ponderwall.com)
  • The first vaccine against dengue, Dengvaxia, was created by leading multinational pharmaceutical company and an expert in the development of vaccinations, Sanofi Pasteur. (r0ckstarm0mma.com)
  • As of 2023, there are two commercially available vaccines, sold under the brand names Dengvaxia and Qdenga. (wikipedia.org)
  • failed verification] Dengvaxia is only recommended in those who have previously had dengue fever or populations in which most people have been previously infected. (wikipedia.org)
  • Dengvaxia is a weakened but live vaccine and works by triggering an immune response against four types of dengue virus. (wikipedia.org)
  • A vaccine to prevent dengue (CYD-TDV, Dengvaxia®) is licensed and available in 20 countries for people ages 9-45 years old. (cdc.gov)
  • In May 2019, Dengvaxia® was approved by the U.S. Food and Drug Administration (FDA) in the United States for use in children 9-16 years old living in an area with endemic dengue with laboratory confirmed prior dengue virus infection. (cdc.gov)
  • The US Advisory Committee on Immunization Practices (ACIP) Dengue Vaccine Work Group reviewed Dengvaxia ® safety and efficacy data in a systematic literature review in 2018. (cdc.gov)
  • Should 3-doses of Dengvaxia ® be administered routinely to persons 9-16 years of age with laboratory-confirmed previous dengue infection and living in endemic areas to prevent virologically confirmed dengue, hospitalizations and severe dengue? (cdc.gov)
  • MARA CEPEDA: Suspends the sale of the controversial Dengvaxia dengue vaccine for a year. (npr.org)
  • In 2019, the U.S. Food and Drug Administration approved Dengvaxia for use in children 9-16 years old with laboratory evidence of a previous dengue infection and living in areas where dengue is common. (cdc.gov)
  • The Dengvaxia vaccine is being manufactured by French pharmaceutical giant Sanofi. (ndtv.com)
  • Mexico's National Vaccination Council will meet to decide whether Dengvaxia will be among the vaccines the government distributes without cost, the head of the health regulatory agency, Mikel Arriola, told AFP. (ndtv.com)
  • Clinical tests -- carried out on 40,000 people from 15 countries -- have found Dengvaxia can immunize two-thirds of people aged nine years and older, rising to 93 percent for the more severe form of the disease, dengue hemorrhagic fever. (ndtv.com)
  • The report also analyses various issues of Dengvaxia, tiered pricing of dengue vaccine, sales channel strategy adoption, pipeline assessment, promotional activities adopted by Sanofi, and epidemiology of dengue. (pharmiweb.com)
  • Currently, there is one licensed dengue vaccine, called Dengvaxia. (singaporemotherhood.com)
  • A three-dose vaccine called Dengvaxia received limited licensure in 2016 in Mexico, the Philippines, and Brazil. (jhu.edu)
  • The Dengvaxia shot was found to increase the risk of severe disease in people who had not previously been infected with dengue and was linked to the deaths of more than 100 children. (mychamplainvalley.com)
  • Fortunately, there are supportive therapies in Singapore and also dengue vaccine, Dengvaxia®, available for the prevention of subsequent dengue infections . (thomsonspecialists.com)
  • Dengvaxia® dengue vaccine has been approved by Health Sciences Authority (HSA). (thomsonspecialists.com)
  • Who is suitable for Dengvaxia® dengue vaccine? (thomsonspecialists.com)
  • Dengvaxia® has an efficacy of 60% in reducing dengue illness, and 84% in reducing severe dengue illness. (thomsonspecialists.com)
  • If you have any questions on the Dengvaxia® dengue vaccine, you may make an appointment to consult our doctors at Thomson Wellth Clinic. (thomsonspecialists.com)
  • The Dengvaxia shot was discovered to extend the danger of extreme illness in individuals who had not beforehand been contaminated with dengue and was linked to the deaths of greater than 100 youngsters. (thecontact.ca)
  • The decision comes after the announcement of the French pharmaceutical manufacturer Sanofi ( link ) that its vaccine, Dengvaxia, is efficient only if the subject had previously had been infected. (ponderwall.com)
  • In response to this, Watsons announced today the availability of dengue vaccination (Dengvaxia) that was recently launched in the country by the Department of Health (DOH) together with the Department of Education (DepEd), and later on was made available in medical clinics last year. (r0ckstarm0mma.com)
  • A new dengue vaccine is approved for use in children aged 9-16 years with laboratory-confirmed previous dengue virus infection and living in areas where dengue is endemic (occurs frequently or continuously). (cdc.gov)
  • In 2017, the manufacturer recommended that the vaccine only be used in people who have previously had a dengue infection, as outcomes may be worsened in those who have not been previously infected. (wikipedia.org)
  • Studies on human primary immune responses to dengue infection have identified critical attachment sites on the virion for neutralizing antibodies ( 4 ). (cdc.gov)
  • Myeloid cells are major targets of dengue infection in humans. (cdc.gov)
  • To our knowledge, only once has an in vitro test correctly predicted which children would be susceptible or have silent infections accompanying a second heterotypic dengue infection ( 9 ). (cdc.gov)
  • The World Health Organization recommends that the vaccine only be given to persons with confirmed prior dengue virus infection. (cdc.gov)
  • It can only be given to kids ages 9 to 16 who have had prior dengue infection. (npr.org)
  • Dengue typically causes a mild first infection but a far worse one if someone is infected with the virus a second time. (eurekalert.org)
  • There are four types of dengue virus, and it is thought that the body's response to the first infection leads to more severe disease upon a second infection. (eurekalert.org)
  • The new research suggests that the vaccine acts very much like a natural infection but without making recipients sick. (eurekalert.org)
  • In those who have previously been infected with dengue, the vaccine acts like a silent second infection, stimulating the immune system without the more severe symptoms that may accompany a natural second infection. (eurekalert.org)
  • In those who have not yet been infected with dengue, the vaccine causes the immune system to recognize that a first dengue infection has occurred and then when exposed to dengue in a natural setting, the body reacts as if it is getting a second infection that may be more severe. (eurekalert.org)
  • The manufacturers of the three-dose vaccine have acknowledged their vaccine does not work well in people who haven't previously had a naturally occurring dengue infection before vaccination, the researchers say. (eurekalert.org)
  • Studies have found that infection with one virus type increases the risk for severe dengue fever from a different dengue virus. (nih.gov)
  • Children without a previous laboratory-confirmed dengue infection should not receive the vaccine. (mayoclinic.org)
  • Children 9-16 years old with laboratory-confirmed previous dengue infection and living in areas where dengue occurs frequently. (cdc.gov)
  • Your child must test positive for a previous dengue infection before being vaccinated. (cdc.gov)
  • Therefore, to reduce the risk of vaccinating children who have never had dengue, a blood test can check for a previous dengue infection. (cdc.gov)
  • Dose 1 can be given after confirming that your child had a prior dengue infection. (cdc.gov)
  • KENILWORTH, N.J.-( BUSINESS WIRE )-Merck (NYSE:MRK), known as MSD outside the United States and Canada, and Instituto Butantan, Sao Paulo, Brazil, a non-profit producer of immunobiologic products for Brazil today announced a collaboration agreement to develop vaccines to protect against dengue virus disease, the mosquito-borne infection. (merck.com)
  • Infection with one dengue virus does not protect against infection with the other three viruses. (aap.org)
  • After the confirmation of dengue infection, my platelet count decreased to 82,000," Khatri recalls. (gavi.org)
  • The increase in temperature is the main reason for the spread of dengue infection in the mountains. (gavi.org)
  • Today, dengue threatens about half the world's population with a risk of infection in over 125 countries, and the disease is endemic in most of the European overseas countries, territories and departments located in tropical areas. (ft.lk)
  • None of the 21 people who had received the vaccine had any evidence of infection in their blood, nor did they develop a rash or have low white blood cell counts. (jhu.edu)
  • While people who were vaccinated there developed antibodies, those antibodies did not protect against dengue 2 infection and could have played a role in causing more serious disease. (jhu.edu)
  • We identify antigens of interest that are important for dengue virus infection and pathogenesis, display them on VLPs using a variety of molecular biology techniques, and then test them for their immunogenicity and ability to elicit antibodies that can block dengue virus infection or key functions of the antigens. (frietzelab.com)
  • Dengue is a public health concern because most of the population in tropical America is susceptible to infection. (medscape.com)
  • Go to Dengue and Severe Dengue Infection for complete information on these topics. (medscape.com)
  • First time dengue infection is believed to provide lifelong immunity against that serotype. (thomsonspecialists.com)
  • How do I check for a previous dengue infection? (thomsonspecialists.com)
  • Dengue fever is a viral infection spread to people through bites from infected mosquitos . (medlineplus.gov)
  • If an infection is suspected, you will get a blood test to check for the dengue virus. (medlineplus.gov)
  • Following infection with one serotype, subsequent infection with a different serotype increases a person's risk of severe dengue and death. (paho.org)
  • These findings highlight the complex nature of dengue infection. (ponderwall.com)
  • The dengue virus is the most common mosquito-borne viral infection in the world, infecting nearly 400 million people annually. (medicilon.com)
  • All 21 volunteers who received the vaccine, TV003, were protected from infection, whereas all 20 placebo recipients developed infection. (medicilon.com)
  • The high prevalence of natural dengue infections in endemic areas means that many people have experienced infection at some point in the past and therefore may have immunity to the infecting serotype. (medicilon.com)
  • A model of dengue infection in humans is one way to overcome the absence of animal models and the challenge of high background immunity in endemic areas. (medicilon.com)
  • This modified dengue virus is very attractive for use as a challenge virus because we can use it to reliably induce dengue infection in a very high percentage of inoculated volunteers without causing serious illness," said Dr. Whitehead. (medicilon.com)
  • By inducing only rash (without fever) in the majority of recipients, the challenge virus mimics natural dengue virus infection, which often features such a rash, he noted. (medicilon.com)
  • Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). (medscape.com)
  • Immunosuppressants also increase risk of infection with concomitant live vaccines. (medscape.com)
  • The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
  • At present, the control of dengue disease is mainly hampered by the absence of antivirals or a vaccine, which results in an estimated half worldwide population at risk of infection. (fiocruz.br)
  • Most survive with few or no symptoms, but more than two million annually develop what can be a dangerous dengue hemorrhagic fever, which kills more than 25,000 people each year. (eurekalert.org)
  • Dengue hemorrhagic fever occurs when blood leaks from blood vessels into other parts of the body, which can lead to failure of the circulatory system, shock and possibly death, without prompt treatment. (eurekalert.org)
  • A severe form of dengue fever, (dengue hemorrhagic fever) can cause severe bleeding, a sudden drop in blood pressure and death. (merck.com)
  • Dengue hemorrhagic fever (DHF), a potentially lethal complication, was first recognized in the 1950s. (piedmontangelnetwork.com)
  • A New Antibody to Fight Flu Pandemics and Pneumonia )Sequential infections increase the risk for dengue hemorrhagic fever and dengue shock syndrome, characterised by fever, vomiting, internal bleeding and potentially fatal circulatory collapse. (ndtv.com)
  • It can lead to symptoms such as mild to chronic ailments, such as dengue hemorrhagic fever. (healthwire.co)
  • The ongoing resurgence of Aedes aegypti in the Americas-- abetted by poor mosquito control, urbanization, and increased air travel--has led to dengue hyperendemicity, more frequent dengue epidemics, and the emergence of dengue hemorrhagic fever (DHF). (cdc.gov)
  • Repeated epidemics of dengue and dengue hemorrhagic fever (DHF) involving up to several million people occur annually in tropical areas of Asia, Africa, the Pacific, and the Americas and may extend into temperate areas inhabited by the Aedes aegypti mosquito vector (3). (cdc.gov)
  • This strongly suggests that if there is no effective intervention, the disease pattern associated with dengue in the Americas has the potential to evolve as it did in Southeast Asia, resulting in major epidemics of severe and fatal hemorrhagic disease. (cdc.gov)
  • Every year, more than 350 million people in over 120 countries contact dengue fever, which can cause symptoms ranging from achy muscles and a skin rash to life-threatening hemorrhagic fever. (outbreaknewstoday.com)
  • Treatment of dengue focuses on relieving symptoms and, for dengue hemorrhagic fever, fluids and blood products given intravenously. (msdmanuals.com)
  • Dr. Halstead and his colleague Dr. Phillip Russell proposed that the vaccine only be used after antibody testing, to check for prior dengue exposure and avoid vaccination of sero-negative individuals. (wikipedia.org)
  • These results were obtained even though 91% of the children had circulating dengue or Japanese encephalitis antibodies before vaccination, neutralizing antibodies developed to all 4 DENVs, and neutralizing antibody titers increased 2-3 fold after 3 doses of vaccine in 80%-90% of vaccinated children. (cdc.gov)
  • In children who have not already had dengue before, the dengue vaccine increases the risk of severe illness and hospitalization if the child gets dengue after vaccination. (cdc.gov)
  • The vaccine could increase the risk of severe dengue and hospitalization in children who have not had dengue before if they are infected with dengue after vaccination. (aap.org)
  • If the person getting the vaccine is pregnant or breastfeeding, they should discuss benefits and potential risks of dengue vaccination with their health care provider. (aap.org)
  • In some cases, your health care provider may decide to postpone dengue vaccination until a future visit. (aap.org)
  • As a clinician, it is encouraging to have a new dengue vaccination tool available for a broad population of my patients. (ft.lk)
  • The TIDES trial met its primary endpoint of overall vaccine efficacy (VE) by preventing 80.2% of symptomatic dengue cases 12 months after vaccination. (ft.lk)
  • Vaccination will offer health care providers in Indonesia a welcomed advancement in dengue prevention, along with vector control, allowing us to reduce the burden of dengue and protect the broader population. (newswire.co.kr)
  • The approval of QDENGA is based on results through three years after vaccination from the ongoing Phase 3 Tetravalent Immunization against Dengue Efficacy Study (TIDES) trial that enrolled over 20,000 healthy children and adolescents ages four to 16 years living in dengue-endemic areas in Asia and Latin America. (newswire.co.kr)
  • QDENGA demonstrated continued overall protection against dengue illness and hospitalization three years after vaccination, regardless of an individual's previous dengue exposure. (newswire.co.kr)
  • The vaccine is recommended for children aged six to 16 years, and the vaccination schedule consists of two doses administered three months apart. (thaimedicalnews.com)
  • That vaccine produced antibodies against the dengue in a clinical trial and protected against dengue during the first year after vaccination. (jhu.edu)
  • But two years after vaccination, children who were under the age of nine when they received the vaccine were hospitalized for dengue at a significantly higher rate than those who received the placebo. (jhu.edu)
  • Individuals may choose to receive the Sinopharm vaccine as part of their primary series vaccination or as a booster dose. (thomsonspecialists.com)
  • In addition, this platform can be used to develop safe vaccine candidates for other flaviviruses such as Zika virus, where pregnant women are the target group for vaccination. (outbreaknewstoday.com)
  • As part of our commitment to improve the lives and health of Filipinos by making health care more accessible to them, we decided to offer dengue vaccination in our select stores nationwide. (r0ckstarm0mma.com)
  • Dengue is a recurring epidemic in the country, that's why we recognize the importance of protecting Filipinos against this deadly disease through the vaccination", says Watsons Trading Health Director, Mr. Danilo Chiong. (r0ckstarm0mma.com)
  • The dengue vaccination, to be taken in three doses at 0 - 6 - 12 months interval, can protect the individual from all four strains of the dengue virus. (r0ckstarm0mma.com)
  • The dengue vaccination is the latest addition to the vaccines offered by Watsons. (r0ckstarm0mma.com)
  • FETP residents complemented the conference pro- dengue virus continue to increase in the recommended changes of vaccination gramme. (who.int)
  • Dengue vaccine is a vaccine used to prevent dengue fever in humans. (wikipedia.org)
  • It's a vaccine to prevent dengue. (npr.org)
  • The TV003 vaccine, as it is known, was already in pretty good shape in preventing dengue 1, 3 and 4 viruses, but the portion of the vaccine that was designed to prevent dengue 2 did not induce as strong an immune response in people as the other three components. (jhu.edu)
  • The vaccine has been approved in 19 countries and the European Union, but it is not approved in the US for use in individuals not previously infected by any dengue virus serotype or for whom this information is unknown. (wikipedia.org)
  • QDENGA is also approved in Indonesia for the prevention of dengue disease by any serotype in individuals six years to 45 years of age. (ft.lk)
  • OSAKA, JAPAN & CAMBRIDGE, MASS.--( Business Wire / Korea Newswire ) August 23, 2022 -- Takeda (TSE:4502/NYSE:TAK) today announced the company's dengue vaccine, QDENGA® (Dengue Tetravalent Vaccine [Live, Attenuated]) (TAK-003), was approved by the Indonesia National Agency for Drug and Food Control, Badan Pengawas Obat dan Makanan (BPOM), for the prevention of dengue disease caused by any serotype in individuals six years to 45 years of age. (newswire.co.kr)
  • In Indonesia, QDENGA is indicated for the prevention of dengue disease caused by any dengue virus serotype in individuals six years to 45 years of age and should be administered subcutaneously as a 0.5 mL dose at a two-dose (0 and 3 months) schedule pursuant to approved dosing regimen. (newswire.co.kr)
  • The initial trial, which was focused on Dengue 2 serotype, has yielded promising results and has the potential to provide protection with one dose - unlike other technologies under development that require a multiple dose regimen. (piedmontangelnetwork.com)
  • What makes dengue so challenging and so dangerous is that antibodies generated against one "serotype" do not protect against the others. (ndtv.com)
  • Dr. Whitehead and colleagues also developed the challenge virus used in the trial, which is a genetically modified version of a dengue-2 serotype virus isolated in the Kingdom of Tonga in 1974. (medicilon.com)
  • Protection against virologically confirmed dengue, severe dengue, and hospitalization for dengue. (cdc.gov)
  • The vaccine does raise the risk of hospitalization and plasma leakage syndrome for some kids. (npr.org)
  • The only approved vaccine for dengue may actually increase the incidence of dengue infections requiring hospitalization rather than preventing the disease if health officials aren't careful about where they vaccinate, new public health research published Sept. 2 in Science suggests. (eurekalert.org)
  • They found that while the vaccine can reduce illness and hospitalization by 20 to 30 percent in places where there is high transmission of dengue, it may actually significantly increase illness and hospitalization if used in locations where there is lower transmission of the virus. (eurekalert.org)
  • If this vaccine is used correctly, many people could be spared illness and hospitalization from dengue. (eurekalert.org)
  • Severe dengue requires hospitalization. (cdc.gov)
  • Hospitalization with dengue is most common in older children and adolescents. (aap.org)
  • The TIDES trial demonstrated the efficacy of QDENGA in preventing dengue fever and hospitalization due to the virus. (thaimedicalnews.com)
  • Severe dengue, dengue haemorrhagic fever and dengue shock syndrome are dengue infections that become severe and potentially have fatal complications, which often require hospitalization. (thomsonspecialists.com)
  • The inability of a mixture of 4 dengue chimeric viruses to elicit an initial primary neutralizing antibody response in nonhuman primates and susceptible humans was recognized during preclinical testing and explained by the phenomenon of interference ( 2 ). (cdc.gov)
  • Although protective immunity was raised in susceptible rhesus monkeys inoculated with all 4 DENVs at a single site, inoculation of 4 chimeric dengue viruses at 1 or 2 sites did not result in neutralizing antibody responses to all 4 DENV ( 3 ). (cdc.gov)
  • Dengue viruses (DENV) transmitted by Aedes aegypti mosquitoes present a growing public health challenge (Shepard et al. (cdc.gov)
  • Four related viruses can cause dengue fever: DENV-1, DENV-2, DENV-3, and DENV-4. (nih.gov)
  • The ideal vaccine, therefore, would be tetravalent - meaning it protects against all 4 dengue viruses. (nih.gov)
  • These vaccines contain weakened viruses that don't cause illness but can still induce an immune response. (nih.gov)
  • In the new study, the scientists tested tetravalent combinations of the most effective vaccine candidates against each of the 4 viruses. (nih.gov)
  • None had prior exposure to dengue or other related viruses. (nih.gov)
  • Dengue is caused by one of four viruses spread through the bite of an infected mosquito. (aap.org)
  • A person can get infected by any of the four dengue viruses. (aap.org)
  • Vaccines are simply weakened or dead viruses, or components of the virus. (singaporemotherhood.com)
  • Dengue, which is transmitted by the dreaded Aedes mosquito, is caused by four different viruses. (singaporemotherhood.com)
  • To develop a dengue vaccine that's effective against four different viruses and deliver it in the same shot, while expecting to achieve a high level of immunity against all four, is truly a tall order. (singaporemotherhood.com)
  • For this reason, a good dengue vaccine needs to protect against all four dengue viruses, the researchers say. (jhu.edu)
  • Linear epitope mapping in the E and NS1 proteins of dengue and Zika viruses: Prospection of peptides for vaccines and diagnostics. (bvsalud.org)
  • According to the World Health Organization, dengue fever, chikungunya and zika viruses can also present with fever and rash…and test positive for measles - due to " non-specific reactions or formation of immune complexes that can produce a false positive IgM result in measles or rubella IgM assays [6]. (theothersideofvaccines.com)
  • One type of PCR test can check for dengue along with two other viruses that mosquitos carry. (medlineplus.gov)
  • These viruses, chikungunya and zika , are common in the same places as the dengue virus, and they cause similar symptoms. (medlineplus.gov)
  • Dengue Fever is spread by mosquito bites to humans and it is caused by one of four types of dengue viruses. (abctravelclinic.ca)
  • The result can lead to the first effective therapies and vaccines against dengue, a complex of four distinct but related mosquito-borne viruses that infect about 390 million people a year globally. (ndtv.com)
  • Four different types of viruses cause Dengue, a mosquito -borne disease. (healthwire.co)
  • Dengue fever, prevalent throughout the tropics and subtropics, is caused by any of four related dengue viruses that are spread by Aedes mosquitoes, the same mosquitoes that spread Zika virus. (medicilon.com)
  • In addition, an increasing volume of air travel has provided an ideal vehicle for transporting dengue viruses between tropical population centers. (cdc.gov)
  • Aspirin and other nonsteroidal anti-inflammatory drugs, non-steroidal should be avoided until dengue can be discarded to reduce the risk of hemorrhage.When traveling to countries where the Zika virus or other viruses transmitted by mosquitoes have been reported, the recommendation is to use insect repellent, long sleeves and pants, and stay in places with air conditioning or window and door fitted with insect screens. (bvsalud.org)
  • FILE - In this Jan. 27, 2016, file photo, an Aedes aegypti mosquito known to carry the Zika virus and the Dengue fever, is photographed through a microscope at the Fiocruz institute in Recife, Pernambuco state, Brazil. (mychamplainvalley.com)
  • The arrival of the Zika virus ( ZIKV ) in dengue virus (DENV)-endemic areas has posed challenges for both differential diagnosis and vaccine development . (bvsalud.org)
  • The aim of this study was to identify the linear epitope profile recognized by serum samples from dengue and Zika patients in the E and NS1 proteins of DENV and ZIKV . (bvsalud.org)
  • The serum samples from dengue and Zika patients detected epitopes evenly distributed across the viral proteins in a peptide microarray platform. (bvsalud.org)
  • The serum samples from dengue and Zika patients showed a high level of cross-reactivity with peptides in the DENV and ZIKV proteins . (bvsalud.org)
  • In addition, two DENV peptides detected at similarly high rates by both dengue and Zika patients were also found within the epitope hotspots. (bvsalud.org)
  • There is no vaccine and no specific antiviral treatment available for the condition of the Zika virus. (bvsalud.org)
  • Dengue fever occurs in tropical and subtropical areas of the world, where it is spread by mosquitoes. (nih.gov)
  • Dengue is a disease spread by mosquitoes through bites. (cdc.gov)
  • Dengue, which is spread by Aedes mosquitoes, has traditionally been considered a bug of lower-lying and tropical climates. (gavi.org)
  • Dr Chuman Lal Das, Director of the EDCD, says, "Diseases that occur in low-altitude areas like dengue have now started to be found in hilly and mountainous districts as the habitat of mosquitoes has shifted to higher altitudes. (gavi.org)
  • When mosquitoes make a home in the mountains, dengue isn't the only threat they bring with them. (gavi.org)
  • Dengue fever , a viral disease transmitted by mosquitoes, has been recognized by the World Health Organization (WHO) as one of the top 10 threats to global health. (thaimedicalnews.com)
  • Dengue is transmitted to humans through the bite of infected A aegypti mosquitoes. (medscape.com)
  • Dengue fever is a disease caused by the dengue virus, which is transmitted by female mosquitoes mainly of the species Aedes aegypti . (thomsonspecialists.com)
  • The vaccine being tested in this study is tetravalent dengue vaccine (TDV). (clinicaltrials.gov)
  • ICDDR,B, and the Larner College of Medicine at the University of Vermont (UVM), are the first to study a promising tetravalent dengue vaccine in dengue-endemic Bangladesh, the ICDDR'B sources said. (bangladeshpost.net)
  • Their work, evaluating the single-dose tetravalent dengue vaccine candidate TV005, demonstrated safety and immune responsiveness in children and adults, they said, adding the accompanying study was recently published in the journal The Lancet Infectious Diseases. (bangladeshpost.net)
  • Senior scientist of ICDDR'B Rashidul Haque said 'The development of an effective and tetravalent dengue vaccine is a high priority for the large population of Bangladesh, which is now having increasingly severe dengue outbreaks. (bangladeshpost.net)
  • The worldwide incidence of dengue has risen eight-fold in the past 20 years, and it continues to rise, fuelled by climate change and urbanisation. (ft.lk)
  • Dengue is a leading cause of fever in travelers returning to Europe from endemic countries, and the incidence of dengue among European travelers is generally underestimated. (ft.lk)
  • It will cost P4000 per dose or P12000 for all 3 doses, which is a reasonable price given the high incidence of dengue and high cost of treatment in the Philippines. (r0ckstarm0mma.com)
  • Age, co-morbidities, host genetics, and virus strain are risk factors for severe dengue with heterotypic secondary infections being the most prominent factor associated with severe dengue (Wilder-Smith et al. (cdc.gov)
  • The World Health Organization has estimated that up to 400 million dengue infections occur annually, resulting in 500,000 hospitalizations. (merck.com)
  • It is mostly used for people who have symptoms related to dengue fever and have recently traveled to an area where dengue infections are common. (medlineplus.gov)
  • But Rawal has been alarmed to see that this year, Mugu has recorded 12 cases of dengue - an unprecedented surge for this dilutely populated, famously isolated district. (gavi.org)
  • In 2007 alone, there were more than 890,000 reported cases of Dengue Fever in the Americas. (piedmontangelnetwork.com)
  • [ 2 ] Cases of dengue fever reported in Texas and Israel occurred from travelers who were infected with dengue while visiting other countries. (medscape.com)
  • With proper and immediate medical care, almost all cases of dengue fever can survive. (abctravelclinic.ca)
  • About 50 to 100 million cases of dengue and about 20,000 deaths occur worldwide. (msdmanuals.com)
  • Two observations from the efficacy trial in Thailand provide insights into protective immunity that could greatly improve second-generation vaccines. (cdc.gov)
  • We believe that the unanticipated results of the dengue vaccine efficacy trial in Thailand call for new methods of assessing dengue immunity. (cdc.gov)
  • But while the candidate vaccine met the high safety expectations and a good balanced immune answer, it had a proof of efficacy of only 30%, far below the 70% mark the company had targeted. (hbs.edu)
  • The goal of the trial is to determine the efficacy of the vaccine for preventing dengue, and importantly to provide additional information about its safety. (merck.com)
  • Approval from the EC was supported by results across 19 Phase 1, 2 and 3 trials with more than 28,000 children and adults, including four and a half years of follow-up data from the global, pivotal Phase 3 Tetravalent Immunization against Dengue Efficacy Study (TIDES) trial. (ft.lk)
  • SAGE reviewed data from 19 clinical trials involving over 28,000 participants, including the pivotal Phase 3 Tetravalent Immunization against Dengue Efficacy Study (TIDES). (thaimedicalnews.com)
  • The vaccine has also shown long-term protection, with substantial efficacy even after 54 months. (thaimedicalnews.com)
  • In February, based on the new findings, researchers in Brazil began administering the new single-dose vaccine in a large Phase 3 clinical trial designed to look at vaccine efficacy against naturally occurring dengue. (jhu.edu)
  • The most recent dengue vaccine trial data from Asia claims 40-70% efficacy in children aged 2-14 years. (unl.pt)
  • In fact, these results informed the recent decision by officials at Brazil's Butantan Institute to advance the TV003 vaccine into a large Phase III efficacy trial. (medicilon.com)
  • A high degree of partial immunity in a population can make it difficult to assess the efficacy of any candidate dengue vaccine. (medicilon.com)
  • Title : VFC resolution update : Dengue vaccines Personal Author(s) : Santoli, Jeanne M. Corporate Authors(s) : National Center for Immunization and Respiratory Diseases (U.S.). Immunization Services Division. (cdc.gov)
  • The endorsement of QDENGA by the WHO's Strategic Advisory Group of Experts on Immunization (SAGE) is a significant step forward in dengue prevention. (thaimedicalnews.com)
  • Two modelling systems are used: Lives Saved Tool (LiST) is used increasingly by donor organizations, and the WHO/IVB model used by the World Health Organization's Department of Immunization, Vaccines and Biologicals. (theothersideofvaccines.com)
  • The Philippines decided to suspend its dengue immunization program because the used vaccine poses health risks in people who were not previously infected. (ponderwall.com)
  • In the Philippines, the DOH together with DepEd launched the much-awaited administration of the dengue vaccine through school-based immunization approach. (r0ckstarm0mma.com)
  • Dengue is a mosquito-borne viral disease that poses a significant global public health threat, with prevalence in over 125 countries. (newswire.co.kr)
  • In addition to providing protection against the potentially fatal Dengue fever, our technology could be used to address a whole variety of insect-borne viral diseases, including West Nile, Yellow Fever and Japanese Encephalitis. (piedmontangelnetwork.com)
  • Dengue fever is a potentially fatal mosquito-transmitted viral disease. (piedmontangelnetwork.com)
  • Is the Subject Area "Viral vaccines" applicable to this article? (plos.org)
  • Dengue fever is a mosquito-borne viral disease caused by 1 of 4 antigenically distinct dengue flaviviruses: dengue virus 1 (DEN-1), dengue virus 2 (DEN-2), dengue virus 3 (DEN-3), and dengue virus 4 (DEN-4). (medscape.com)
  • Dengue is currently the most important vector-borne viral disease afflicting humanity, in terms of both morbidity and mortality (1, 2). (cdc.gov)
  • An economic evaluation from the societal perspective is salient, comparing the regular control program for dengue prevention versus an intervention of environmental management strategy by covering the most Aedes aegypti productive breeding sites with insecticide covers and additional activities. (medscape.com)
  • In the Americas, Aedes aegypti is the mosquito vector that is the main source of dengue transmission. (paho.org)
  • Dengue vaccine can help protect against dengue in people who have had dengue in the past. (aap.org)
  • For this reason, the researchers, led by Anna P. Durbin, MD, an associate professor in International Health at the Bloomberg School, were concerned that measuring antibodies alone may not truly indicate the ability of the vaccine to protect against dengue. (jhu.edu)
  • The findings from this trial are very encouraging to those of us who have spent many years working on vaccine candidates to protect against dengue, a disease that is a significant burden in much of the world and is now endemic in Puerto Rico," said Stephen Whitehead, Ph.D., of NIH's National Institute of Allergy and Infectious Diseases (NIAID). (medicilon.com)
  • Partly based on these findings, the World Health Organization is recommending that this vaccine be used only in areas where there is a known high burden of disease. (eurekalert.org)
  • Each year, dengue fever affects 50 million to 100 million people and hospitalizes nearly 500,000, according to the World Health Organization. (nih.gov)
  • Globally, dengue is the fastest-growing mosquito-borne disease, with as many as 400 million people infected every year, according to the World Health Organization. (ndtv.com)
  • Arbovax's initial focus, Dengue Fever, is ranked second only to Malaria by the World Health Organization, for its devastating global impact. (piedmontangelnetwork.com)
  • The World Health Organization (WHO) estimates that vaccines save two to three million lives each year (excluding COVID-19). (singaporemotherhood.com)
  • Health Minister Zahid Maleque on Saturday said recently developed dengue vaccine is still under trial stage, and it will be vaccinated after getting approval from the World Health Organization (WHO). (bangladeshpost.net)
  • The vaccine took more than twenty years to develop and has been thoroughly tested, based on World Health Organization (WHO) guidelines. (r0ckstarm0mma.com)
  • Although uncommon, a pregnant woman can pass the dengue virus to her fetus during pregnancy or around the time of birth (see World Health Organization [WHO]: Dengue and severe dengue ). (msdmanuals.com)
  • Seropositivity rate was defined as the percentage of participants being seropositive, derived from titers of dengue- neutralizing antibodies. (clinicaltrials.gov)
  • Often, vaccine trials are looking to see whether a person has developed antibodies to the virus. (jhu.edu)
  • Your body needs time to make specific antibodies to fight dengue. (medlineplus.gov)
  • We observed that pcTPANS1 exerts a robust protection against dengue, inducing considerable levels of anti-NS1 antibodies and T cell responses. (fiocruz.br)
  • To diagnose dengue, doctors do blood tests to check for the virus or antibodies to the virus. (msdmanuals.com)
  • The value of Dengavaxia is limited by the fact that it may increase the risk of severe dengue in those who have not previously been infected. (wikipedia.org)
  • Just one dose of a low-cost vaccine proved safe and stimulated a strong immune response against the dengue virus in most participants in an early-stage clinical trial. (nih.gov)
  • What is promising about TV003 is that it elicited solid antibody responses after just one dose," explains NIAID's Dr. Stephen Whitehead, who led development of the vaccine candidates. (nih.gov)
  • TV003's inexpensive production cost - less than $1 per dose - is critical to its potential use in developing countries where dengue is prevalent. (nih.gov)
  • It is very important that you receive the second and third dose of the vaccine series at the right times and that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. (mayoclinic.org)
  • We believe our unique and novel approach represents a real breakthrough in vaccine development that will provide strong and lasting protection with a single dose. (piedmontangelnetwork.com)
  • In a small clinical trial led by the Johns Hopkins Bloomberg School of Public Health, researchers say that a promising single-dose dengue vaccine, developed by scientists at the National Institutes of Health, was 100 percent effective in preventing human volunteers from contracting the virus, the most prevalent mosquito-borne virus in the world. (jhu.edu)
  • Only a single dose of the vaccine was necessary and while researchers believe the effects will be long lasting, they only tested it after six months. (jhu.edu)
  • second scheduled dengue vacation will be on May 14, 2017 (1st dose), November 12, 2017 (2nd dose), May 13, 2018 (3rd dose). (r0ckstarm0mma.com)
  • residents from Yemen reported multi- 18 months) and hepatitis B in Egypt ple dengue outbreaks since 2002 in al (introduction of a dose at birth). (who.int)
  • With the potential for dengue to cause local outbreaks as demonstrated in several European countries over recent years, and the threat for European travelers visiting dengue-endemic countries, gaps exist that may put some people at risk," said Berlin Centre for Travel and Tropical Medicine Medical Director and CRM Centrum für Reisemedizin Dusseldorf Scientific Director Dr. Tomas Jelinek. (ft.lk)
  • Outbreaks of dengue in nearby Caribbean, Central American, and South American countries increase the likelihood of future autochthonous transmission among people in Florida and Southeastern states. (medscape.com)
  • Singapore saw one of its worst dengue outbreaks in 2020 , recording 35,315 cases and 28 deaths. (thomsonspecialists.com)
  • Outbreaks of dengue fever are rare in the U.S. mainland. (medlineplus.gov)
  • The study ("The Live Attenuated Dengue Vaccine TV003 Elicits Complete Protection against Dengue in a Human Challenge Model"), published in Science Translational Medicine, underscores the importance of human challenge studies, in which volunteers are exposed to disease-causing pathogens under carefully controlled conditions. (medicilon.com)
  • In previous studies, we reported that a DNA vaccine containing the signal peptide sequence from the human tissue plasminogen activator (t-PA) fused to the DENV2 NS1 gene (pcTPANS1) induced protection against dengue in mice. (fiocruz.br)
  • In mountainous countries including Nepal, not only dengue but also malaria, Japanese encephalitis and other vector-borne diseases have been observed in high altitudes," says Dr Meghnath Dhimal, chief of the NHRC's research section. (gavi.org)
  • After malaria, dengue is the most diagnosed cause of fever in European travelers returning from developing countries. (mychamplainvalley.com)
  • After malaria, dengue is essentially the most recognized reason for fever in European vacationers getting back from growing international locations. (thecontact.ca)
  • In 2019, 17,992 dengue cases were reported in 68 districts. (gavi.org)
  • But the vaccine could bring the company more than $1 billion annually starting in 2018 or 2019, analysts said. (ndtv.com)
  • Dengue incidence has increased in the Americas over the past four decades, from 1.5 million cumulative cases in the 1980s to 16,2 million in the decade 2010-2019. (paho.org)
  • We are proud to participate in the evaluation of the TV005 vaccine in the Bangladeshi population and hope that our work will accelerate the development of dengue vaccines for our country,' he added. (bangladeshpost.net)
  • The safety and effectiveness of the vaccine was determined in three randomized, placebo-controlled studies involving approximately 35,000 individuals in dengue-endemic areas, including Puerto Rico, Latin America and the Asia Pacific region. (wikipedia.org)
  • Dengue can affect anyone living in or traveling to endemic areas - regardless of age, health and socio-economic circumstances," said Gary Dubin, president of Takeda's Vaccine Business Unit. (newswire.co.kr)
  • Dengue is endemic in the US territories of American Samoa, Guam, Puerto Rico, and the US Virgin Islands. (wikipedia.org)
  • Dengue is a serious and ongoing public health problem in Puerto Rico and in other US territories and US affiliated states. (cdc.gov)
  • Dengue is common in Puerto Rico. (cdc.gov)
  • The risk of getting dengue while living in Puerto Rico is high. (cdc.gov)
  • For instance, a 1977 dengue epidemic in Puerto Rico appears to have cost between US $6 and $16 million in medical services and lost work alone (9). (cdc.gov)
  • Recent estimates have put the cost of epidemic dengue in Puerto Rico since 1977 at US $100-150 million (5). (cdc.gov)
  • In the present work, we aimed to elucidate the contribution of cellular and humoral responses elicited by this vaccine candidate for protective immunity. (fiocruz.br)
  • There is no specific medicine that can cure or treat dengue fever, but most people will recover after about a week. (medlineplus.gov)
  • The vaccine was determined to be approximately 76 percent effective in preventing symptomatic, laboratory-confirmed dengue disease in individuals 9 through 16 years of age who previously had laboratory-confirmed dengue disease. (wikipedia.org)
  • Although dengue virus (DENV) control strategies have targeted vector control and disease surveillance, the development of an effective vaccine is the holy grail of prevention. (cdc.gov)
  • Using that data, they developed mathematical models to understand how a vaccine rollout would affect people in countries where transmission of the disease is high, moderate or low. (eurekalert.org)
  • Dengue tetravalent vaccine, live may increase your child's risk for severe dengue disease when vaccinated and later infected with the dengue virus. (mayoclinic.org)
  • Through our new collaboration, we together have made a commitment to help protect people around the world who are at risk of developing dengue virus disease. (merck.com)
  • Dengue fever is a mosquito-borne disease that occurs in tropical and subtropical areas of the world. (merck.com)
  • Most people infected with dengue have no symptoms or experience mild disease. (aap.org)
  • A smaller number of people with dengue will have severe disease. (aap.org)
  • If a person who has never had dengue in the past gets dengue vaccine, they are at increased risk of severe disease if they become infected with dengue in the future. (aap.org)
  • Classically a disease of lower-lying areas, dengue cases have this year surged in the hill zones of the Himalayan state. (gavi.org)
  • Takeda has announced that the European Commission (EC) granted marketing authorisation for the company's dengue vaccine QDENGA (Dengue Tetravalent Vaccine [Live, Attenuated]) (TAK-003) for the prevention of dengue disease in individuals from four years of age in the European Union (EU). (ft.lk)
  • TAK-003 has been generally well tolerated, with no evidence of disease enhancement in vaccine recipients, and no important safety risks have been identified, to date. (ft.lk)
  • 2] In recent years, Indonesia has experienced almost half of the dengue disease burden within Southeast Asia and continues to suffer from one of the highest burdens of dengue in the world. (newswire.co.kr)
  • As a doctor, I have seen firsthand the burden dengue disease places on the patients and communities I serve in Indonesia. (newswire.co.kr)
  • There is an ongoing fear of an outbreak and contracting the disease, experiencing the physical setbacks dengue can cause as well as the potential financial impacts," said Dr. Anggraini Alam, Sp.A(K), pediatric infectious disease consultant. (newswire.co.kr)
  • SAGE has recommended the introduction of QDENGA in areas with a high dengue disease burden and intense transmission. (thaimedicalnews.com)
  • With its robust scientific foundation, the vaccine has the potential to save lives and reduce the global burden of this disease. (thaimedicalnews.com)
  • While eradicating dengue is a challenging goal, this endorsement brings us one step closer to a future where dengue is a preventable and manageable disease. (thaimedicalnews.com)
  • In a statement on Friday, Oct. 14, 2022, the European Medicines Agency is recommending that a dengue vaccine made by the Japanese pharmaceutical Takeda be authorized, in a move that could provide a new tool for millions worldwide against the potentially fatal disease. (mychamplainvalley.com)
  • LONDON (AP) - The European Medicines Agency on Friday recommended the authorization of a dengue vaccine made by the Japanese pharmaceutical Takeda that could provide a new tool for millions worldwide against the potentially fatal disease. (mychamplainvalley.com)
  • This and other observations suggest an immunopathological component in dengue pathogenesis, which is referred to as immune enhancement of disease. (medicofem.com)
  • The silent transmission of dengue was demonstrated in 1992 in an area of Taiwan that was believed to be free of the disease. (medscape.com)
  • Some people who get sick with dengue will develop severe dengue disease. (medlineplus.gov)
  • This human antibody not only kills dengue virus but also prevents enhanced dengue disease," said James Crowe Jr, co-corresponding author from Vanderbilt University situated in Tennessee. (ndtv.com)
  • The disease can evolve into severe dengue, characterized by shock, shortness of breath, severe bleeding and / or complications in the organs. (paho.org)
  • PAHO/WHO provides advice and technical support for dengue prevention and control based on a regional strategy adopted by PAHO / WHO member States in 2016, called the " Strategy for arboviral disease prevention and control " (CD55.R6). (paho.org)
  • The dengue vaccine, developed by ICDDR,B, and the Larner College of Medicine at the University of Vermont (UVM), requires more trials and WHO's approval for clinical application against dengue disease, he told journalists at his residence at Gorpara village in Manikganj upazila of the district. (bangladeshpost.net)
  • No country in the world develops dengue vaccine - - - when trials of the dengue vaccine are completed, we will seek approval from the WHO,' he said, adding that the dengue vaccine will be used against the mosquito-borne disease after getting permission of the WHO. (bangladeshpost.net)
  • Bangladesh was badly affected by dengue disease this year, he said, adding the government is working sincerely to deal with the dengue outbreak as a record number of both dengue positive cases and deaths have so far been reported. (bangladeshpost.net)
  • In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
  • Serum samples from children given ≥1 doses of the dengue chimeric vaccine can now be tested for primary neutralizing antibody responses to each of the 4 DENVs. (cdc.gov)
  • Children need 3 doses of the dengue vaccine. (aap.org)
  • 3,4] In the first half of 2022 alone, Indonesia reported over 63,000 dengue cases and nearly 600 deaths spread across 455 cities in 34 provinces. (newswire.co.kr)
  • As of 28 May 2022, about 11,670 dengue cases had been reported in Singapore, with 10% of cases requiring hospitalisation. (thomsonspecialists.com)
  • October 12, 2010, Raleigh, NC - Arbovax, an early-stage company developing vaccines to protect against insect-borne diseases, has just passed a significant milestone in the development of a new Dengue fever vaccine with the successful completion of non-human primate trials. (piedmontangelnetwork.com)
  • When the tetravalent dengue chimeric vaccine was given to partially dengue-immune children and adults in the Philippines, a broad neutralizing antibody response was observed after administration of only 2 vaccine doses ( 7 ). (cdc.gov)
  • Detailed studies on innate immune responses in human myeloid cells with a variety of dengue immune complexes should proceed forthwith. (cdc.gov)
  • All 4 vaccine combinations successfully produced immune responses without any serious side effects. (nih.gov)
  • The aim of the project was to develop and validate Dengue virus DENV VLP based vaccines for the elicitation of broadly reactive immune responses. (dtic.mil)
  • The immune response against DENV is not yet fully understood and a better knowledge of it is now recognized as one of the main challenge for vaccine development. (fiocruz.br)
  • The EMA said its endorsement of the Takeda vaccine means that "a global unmet public health need is being addressed," explaining that countries beyond the EU should have confidence that the shot is safe and effective. (mychamplainvalley.com)
  • The EMA mentioned its endorsement of the Takeda vaccine signifies that "a world unmet public well being want is being addressed," explaining that international locations past the EU ought to believe that the shot is secure and efficient. (thecontact.ca)
  • Studies showed Takeda's vaccine was about 84% effective in preventing people from being hospitalized with dengue and about 61% effective in stopping symptoms four years after getting immunized. (mychamplainvalley.com)
  • Instituto Butantan's dengue vaccine candidate, TV003, is currently being evaluated in a large Phase 3 study in Brazil. (merck.com)
  • Instituto Butantan will retain responsibility for the manufacturing and commercialization of their investigational vaccine, TV003, in Brazil. (merck.com)
  • In the investigation, researchers from the Bloomberg School and the University of Vermont administered the TV003 dengue vaccine to 24 healthy adults, while 24 others received a placebo. (jhu.edu)
  • DOUCLEFF: Garin told the crowd that this shot, the world's first dengue vaccine, would save thousands of kids. (npr.org)
  • Almost half of the world's population lives in areas with a risk of dengue. (aap.org)
  • The world's first dengue vaccine won regulatory approval in Mexico on Wednesday, raising hopes that it could prevent more than 100 deaths there a year and eventually perhaps millions around the world. (ndtv.com)
  • Studies confirmed Takeda's vaccine was about 84% efficient in stopping folks from being hospitalized with dengue and about 61% efficient in stopping signs 4 years after getting immunized. (thecontact.ca)
  • Scientists in the Laboratory of Infectious Diseases at the NIAID of the NIH engineered a candidate live attenuated tetravalent vaccine against the dengue virus. (merck.com)
  • Dengue, frequently called breakbone fever, is endemic to large areas of the tropics and subtropics, including the Caribbean Islands. (medscape.com)
  • Dengue is common in the tropics and subtropics worldwide. (msdmanuals.com)
  • Dengue virus (DENV) is spread through most tropical and subtropical areas of the world and represents a serious public health problem. (fiocruz.br)
  • The authors hope that their analysis can help inform policymakers in evaluating this and other candidate dengue vaccines. (eurekalert.org)
  • This agreement recognizes the tremendous progress that scientists and clinicians at the Instituto Butantan have made in developing their investigational dengue virus vaccine," said Dr. Roger M. Perlmutter, president, Merck Research Laboratories. (merck.com)
  • ifosfamide decreases effects of influenza virus vaccine quadrivalent by pharmacodynamic antagonism. (medscape.com)
  • adalimumab decreases effects of influenza virus vaccine quadrivalent by pharmacodynamic antagonism. (medscape.com)
  • To create a new dengue virus vaccine, Stefan Metz, Shaomin Tian in the laboratories of Aravinda de Silva, Chris Luft and Joe DeSimone at the University of Carolina, Chapel Hill, USA designed nanoparticles of various shapes and sizes using Particle Replication in Non-wetting Template (PRINT) technology. (outbreaknewstoday.com)
  • The TIDES exploratory analyses showed that throughout the 4.5-year study follow-up, TAK-003 prevented 84% of hospitalised dengue cases and 61% of symptomatic dengue cases in the overall population, including both seropositive and seronegative individuals. (ft.lk)