• Dengue and dengue hemorrhagic fever (DHF) result from infection by any of four serotypes of dengue viruses. (cdc.gov)
  • G. Screaton and J. Mongkolsapaya explain potential roles of T-cell responses in dengue hemorrhagic fever. (cdc.gov)
  • Here we investigate the immunoglobulin responses of patients with dengue fever (DF) and dengue hemorrhagic fever (DHF) to NS1. (ox.ac.uk)
  • In a small proportion of cases, the disease develops into a more severe dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. (wikipedia.org)
  • WHO currently estimates 50 million people (2% WPDI) are infected by dengue hemorrhagic fever worldwide each year (World Dengue Infected / WDI) (1). (dhf-revolutionafankelijkheid.net)
  • In a small proportion of cases, the virus causes increased vascular permeability that leads to a bleeding diathesis or disseminated intravascular coagulation (DIC) known as dengue hemorrhagic fever (DHF). (medscape.com)
  • The WHO estimates that 50-100 million cases of dengue infection occur annually, with approximately 500,000 of those cases resulting in dengue hemorrhagic fever (DHF), with an estimated 22,000 deaths per year, mostly in children. (medscape.com)
  • Severe dengue was previously known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) [ 8 ]. (hindawi.com)
  • Hemostatic defects in dengue hemorrhagic fever. (microbiologyresearch.org)
  • Recently, Sri Lanka has experienced a string of widespread dengue epidemics annually which has now become a hyperendemic with frequent reports of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) [ 3 ]. (biomedcentral.com)
  • Up to 96 million individuals express symptoms which range from flu like uncomplicated dengue fever to life threatening cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), the latter being characterized by severe vascular leak and dysfunction of endothelial cells, which form blood vessels. (berkeley.edu)
  • 11. Kurane I. Dengue hemorrhagic fever with special emphasis on immunopathogenesis. (rjptonline.org)
  • A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever. (ijpediatrics.com)
  • Kamath SR, Ranjith S. Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in south India. (ijpediatrics.com)
  • Nimmannitya S, Thisyakorn U, Hemsrichart V. Dengue hemorrhagic fever with unusual manifestations. (ijpediatrics.com)
  • Dengvaxia is safe and effective in reducing dengue-related hospitalizations and severe dengue among persons who have had dengue infection in the past. (cdc.gov)
  • Previous natural infection is important because Dengvaxia is associated with an increased risk for severe dengue in those who experience their first natural infection (i.e., primary infection) after vaccination. (cdc.gov)
  • ACIP recommends vaccination with Dengvaxia for children aged 9-16 having evidence of a previous dengue infection and living in areas where dengue is endemic. (cdc.gov)
  • Evidence of previous dengue infection, such as detection of anti-DENV immunoglobulin G with a highly specific serodiagnostic test, will be required for eligible children before vaccination. (cdc.gov)
  • Whereas any dengue infection can lead to severe dengue, a second infection with a dengue virus is the most likely to cause severe dengue compared with the first and post-secondary infections ( 9 , 10 ). (cdc.gov)
  • The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
  • AbstractThe role of NS1-specific antibodies in the pathogenesis of dengue virus infection is poorly understood. (ox.ac.uk)
  • In addition, healthy individuals, with past non-severe dengue infection have a similar antibody repertoire as those with mild acute infection (DF). (ox.ac.uk)
  • The Incidence of dengue infection is growing rapidly in the world in recent decades. (dhf-revolutionafankelijkheid.net)
  • Such figures are also recognized by Murray, as he said that death number caused by dengue infection ± 20,000 people, with 75% coming from South East Asia (8) . (dhf-revolutionafankelijkheid.net)
  • Thus it can be said the mortality rate is approximately 0.05% of dengue infection worldwide (WDI). (dhf-revolutionafankelijkheid.net)
  • Or patients who have been clear with dengue infection and recommended to be treated by the doctors, refused to be treated because of economic difficulties and so on. (dhf-revolutionafankelijkheid.net)
  • Hospital reporting system for patients with dengue infection is not perfect yet as well. (dhf-revolutionafankelijkheid.net)
  • Then, the approximationof dengue infection rate in Indonesia (IDI) is 2% x Indonesia Potential Dengue Infection (IPDI) = 2% x 240,000,000 = 4,800 000. (dhf-revolutionafankelijkheid.net)
  • [ 3 ] Secondary infection by a different dengue virus serotype has been confirmed as an important risk factor for the development of DHF. (medscape.com)
  • Thrombocytopenia and hemoconcentration are consistent findings in dengue infection. (medscape.com)
  • There is no specific pharmacologic treatment for dengue infection. (medscape.com)
  • Patients with suspected dengue infection who are maintaining adequate hydration orally and have no warning signs/symptoms may be treated on an outpatient basis with appropriate anticipatory guidance and outpatient follow-up within 24 hours for reassessment. (medscape.com)
  • Dengue vaccine was approved by the FDA in 2019 for prevention of dengue disease caused by dengue virus serotypes 1, 2, 3, and 4 in individuals aged 9-16 years with laboratory-confirmed previous dengue infection who live in endemic areas. (medscape.com)
  • When the Zika epidemic spread through the American continent and then later to Africa and Asia in 2015, researchers compared the characteristics of the Zika infection to Dengue, considering both these viruses were transmitted primarily through the same vector, the Aedes aegypti female mosquitoes. (frontiersin.org)
  • Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. (hindawi.com)
  • Knowledge about the pathogenesis of dengue infection is limited, but both viral and immune host factors appear to be associated with severe illness [ 26 ]. (hindawi.com)
  • Prospective studies are needed to fully assess the risk of dengue infection after exposure to Zika and chikungunya viruses and to determine whether the supposed cross-protection is long-lasting. (paho.org)
  • This study describes the susceptibility to dengue virus infection of a monocytic cell line at different states of differentiation. (microbiologyresearch.org)
  • Increased blood vessel permeability, which occurs in dengue haemorrhagic fever and dengue shock syndrome patients, has been correlated with secondary heterotypic infections and has been postulated to arise from antibody-enhanced infection of monocytes. (microbiologyresearch.org)
  • Infection enhancement of dengue type 2 virus in the human U-937 monocyte line by antibodies to Flavivirus cross-reactive determinants. (microbiologyresearch.org)
  • Her work combines classical experimental virology and animal models with systems biology approaches to study the global response to infection and how that contributes to pathogenesis or protection from emerging pathogens. (elsevier.com)
  • Symptomatic dengue virus infection ranges in disease severity from an influenza-like illness to life-threatening shock. (vumc.org)
  • A better understanding of the humoral immune response to natural dengue virus infection in humans is sorely needed. (vumc.org)
  • Employing this technology, we have generated over 250 hybridomas secreting human mAbs to dengue virus from subjects who had recovered from primary or secondary infection. (vumc.org)
  • In conclusion, curcumin and 6‐gingerol exhibit antiviral properties against DENV infection and could provide a new therapeutic approach for dengue disease treatment strategies. (ugm.ac.id)
  • Despite the high prevalence of both these infections, co-infection of leptospirosis and dengue has not been reported previously in Sri Lanka. (biomedcentral.com)
  • We present the first case of co-infection with leptospirosis and dengue in a Sri Lankan male. (biomedcentral.com)
  • In areas where both leptospirosis and dengue are endemic, both infections should be include in the differential diagnosis when evaluating patients with acute febrile illness and should consider the possibility of co-infection. (biomedcentral.com)
  • Leptospirosis, a zoonotic infection and dengue, an arthropod born viral infection, are endemic in countries with humid subtropical or tropical climates and have epidemic potential [ 1 ]. (biomedcentral.com)
  • Laboratory investigations on admission showed thrombocytopenia with normal white cell count and increased levels of blood urea, serum creatinine, liver transaminases, prothombin time, creatinine phosphokinase and trophonin I. Both IgG and IgM dengue antibody tests were positive indicating recent dengue infection. (biomedcentral.com)
  • Vaccine development for the prevention of dengue infection is challenging because there are 4 different serotypes of dengue and an individual can be infected consecutively with different serotypes. (pasteur-kh.org)
  • Clinical outcome after infection range from asymptomatic infection to life threatening dengue shock syndrome. (pasteur-kh.org)
  • We have thereby identified that altered levels of the pro-resolving mediator AnxA1 are of pathological relevance in DENV infection, suggesting FPR2/ALX agonists as a therapeutic target for dengue disease. (gla.ac.uk)
  • 1,2 The mosquito-borne infection can cause severe illness and death and is considered a national priority emerging infectious disease among dengue-endemic countries in the World Health Organization (WHO) Western Pacific Region. (who.int)
  • Males would be the high risk group if the observed male excess in dengue cases was due to differential exposure or to sex differentials in the biological response to infection. (who.int)
  • For patients with suspected chikungunya disease, it is important to rule out dengue virus infection because proper clinical management of dengue can improve the outcome. (cdc.gov)
  • Correlation of C-reactive protein levels, gene polymorphism and platelets count in Dengue infection. (cdc.gov)
  • GBWT in dengue virus infection mimicking acute cholecystitis is a differential diagnosis one should take into consideration in travellers returning from endemic areas and should be managed conservatively because of an high risk of bleeding and increased mortality under surgical therapy. (biomedcentral.com)
  • Dengue fever is a viral infection with increasing incidence worldwide, almost 30-fold in the last 50 years. (biomedcentral.com)
  • Dengue Haemorrhagic Fever is a mosquito-borne viral infection endemic in the tropical and sub-tropical regions. (dengue.lk)
  • 1. Heydari M, Metanat M, Rouzbeh-Far MA, Tabatabaei SM, Rakhshani M, Sepehri-Rad N, Keshtkar-Jahromi M. Dengue fever as an emerging infection in southeast Iran. (rjptonline.org)
  • 15. Thomas EA, John M, Bhatia A. Muco-Cutaneous manifstations of dengue viral infection in Punjab. (rjptonline.org)
  • This study concludes prevalence of hepatic dysfunction was seen 30.6%, most of them seen in severe dengue 59.2% of the cases suggesting any febrile child with hepatic dysfunction, dengue infection should be suspected. (ijpediatrics.com)
  • Wiwanitkit V. Liver dysfunction in dengue infection, an analysis of the previously published Thai cases. (ijpediatrics.com)
  • Soundravally R, Narayanan P, Bhat B. Fulminant hepatic failure in an infant with severe Dengue infection. (ijpediatrics.com)
  • Itha S, Kashyap R, Krishnani N. Profile of liver involvement in dengue virus infection. (ijpediatrics.com)
  • Kumar R, Tripathi P, Tripathi S. Prevalence of dengue infection in north Indian children with acute hepatic failure. (ijpediatrics.com)
  • Poovorawan Y, Hutagalung Y, Chongsrisawat V. Dengue virus infection: a major cause of acute hepatic failure in Thai children. (ijpediatrics.com)
  • ADE is an in vitro observation in which sub-neutralizing concentrations of antibody can facilitate cell infection, and has been proposed as a central hypothesis for severe dengue pathogenesis. (glopid-r.org)
  • A literature search for studies reporting risk factors of severe dengue among individuals with dengue virus infection was conducted in PubMed, Scopus and Web of Science database from inception to December 31, 2020. (biomedcentral.com)
  • Our meta-analysis identified children, secondary infection, diabetes and renal disease(s) as important predictors of severe dengue. (biomedcentral.com)
  • Dengue is an arboviral infection caused by a dengue virus (DENV) belonging to the Flaviviridae family. (biomedcentral.com)
  • Only adults aged 9-45 years living in an area of ≥ 70% dengue prevalence, and whose serostatus is positive for past dengue infection are recommended for immunization [ 6 ]. (biomedcentral.com)
  • Dengue is the most common and widespread arthropod-borne viral infection in the world. (who.int)
  • There are four distinct virus serotypes, each capable of producing a wide spectrum of signs and symptoms that characterize dengue fever, ranging from subclinical infection, to a debilitating but self-limiting illness with symptoms resembling influenza, to severe disease known as dengue haemorrhagic fever. (who.int)
  • A reduction in platelet number or function can occur through a variety of mechanisms, including autoimmune destruction, spleen sequestration, bone marrow infiltration by tumor cells, infection (e.g. dengue fever), and adverse drug reaction. (bvsalud.org)
  • Face-to-face health education significantly decreased the risk of dengue infection. (who.int)
  • Dengue virus infection has emerged as marker in clinical practice ( 11 ). (who.int)
  • Dengue is caused by four closely related viruses (DENV-1-4), and a person can be infected with each serotype for a total of four infections during their lifetime. (cdc.gov)
  • The four dengue virus serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) all circulate globally, and most countries where dengue is endemic have reported circulation of all four serotypes. (cdc.gov)
  • Dengue is endemic throughout the tropics and subtropics, with an estimated 3.8 billion persons (95% confidence interval [CI]: 3.5 billion-4.1 billion), or approximately 53% of the global population, living in areas suitable for DENV transmission ( 3 ). (cdc.gov)
  • In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
  • Mosquito -borne flaviviruses , including dengue virus (DENV) and Zika virus ( ZIKV ), are a growing public health concern. (bvsalud.org)
  • Dengue virus (DENV) is an enveloped, single-stranded RNA virus belonging to the Flaviviridae family. (frontiersin.org)
  • It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
  • Dengue is an arthropod-borne disease caused by the Dengue virus (DENV) [ 1 ]. (hindawi.com)
  • Nevertheless, the involved DENV type and the host genetic makeup may explain some differences in clinical manifestations observed, since genetic polymorphisms appear to provide protection or predispose to more severe forms of dengue [ 27 ]. (hindawi.com)
  • In order to discuss this hypothesis it must be taken into account that Zika, dengue (DENV) and chikungunya viruses are closely related flaviviruses, with identical urban transmission and some immune interactions (1). (paho.org)
  • Dengue virus (DENV) is the most geographically widespread arbovirus causing dengue disease epidemics in tropical and subtropical regions. (ugm.ac.id)
  • Dengue is caused by dengue virus (DENV), a virus which can be transmitted by Aedes mosquitos. (pasteur-kh.org)
  • Immunocompetent, interferon (alpha and beta) receptor one knockout (KO), AnxA1 KO, and formyl peptide receptor 2 (FPR2) KO mice were infected with dengue virus (DENV) and treated with the AnxA1 mimetic peptide Ac2-26 for analysis. (gla.ac.uk)
  • We observed that circulating levels of AnxA1 were reduced in dengue patients and DENV-infected mice. (gla.ac.uk)
  • Dengue virus was isolated in 1943 in Japan (DENV 1) and 1945 in Hawaii (DENV 2) for the first time as a member of the family of Flaviviridae . (biomedcentral.com)
  • Dengue Virus (DENV) is transmitted by mosquito bite. (rjptonline.org)
  • The vaccine is a live-attenuated, chimeric tetravalent dengue vaccine built on a yellow fever 17D backbone. (cdc.gov)
  • Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. (wikipedia.org)
  • Paracetamol (acetaminophen) is recommended instead of nonsteroidal anti-inflammatory drugs (NSAIDs) for fever reduction and pain relief in dengue due to an increased risk of bleeding from NSAID use. (wikipedia.org)
  • Typically, people infected with dengue virus are asymptomatic (80%) or have only mild symptoms such as an uncomplicated fever. (wikipedia.org)
  • Therefore, travelers returning from endemic areas are unlikely to have dengue fever if symptoms start more than 14 days after arriving home. (wikipedia.org)
  • The characteristic symptoms of dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, and a rash. (wikipedia.org)
  • An alternative name for dengue, "breakbone fever", comes from the associated muscle and joint pains. (wikipedia.org)
  • Firstly known in 1950, the outbreak of dengue fever was found in the Philippines and Thailand. (dhf-revolutionafankelijkheid.net)
  • 2.5 billion people or 2/5 of the world's population including more than 100 countries around the world are at risk of getting infected by dengue fever (Dengue Potential World Infected / WPDI) (1,2). (dhf-revolutionafankelijkheid.net)
  • It means that tens of millions of people suffering from dengue fever are not treated. (dhf-revolutionafankelijkheid.net)
  • In such reasons, Jacqueline LDeen et al, doubted the rate of dengue fever reported from the hospital (9) . (dhf-revolutionafankelijkheid.net)
  • Of the 4.8 million, it was only 45 964 people were reported as dengue fever patients. (dhf-revolutionafankelijkheid.net)
  • Thus,as described above, over 99% of people suffering from dengue fever in Indonesia are at stake. (dhf-revolutionafankelijkheid.net)
  • Dengue fever is a benign, acute febrile syndrome occurring in tropical regions. (medscape.com)
  • Dengue fever is not contagious through person-to-person contact. (medscape.com)
  • Colombia is an endemic country for dengue fever where the four serotypes of virus dengue (DENV1-4) circulate simultaneously, and all types are responsible for dengue cases in the country. (mdpi.com)
  • Symptomatic infections vary from a mild, flu-like illness known as dengue fever (DF) to a life-threatening form called severe dengue (SD) [ 8 ]. (hindawi.com)
  • Clinical symptoms in dengue fever manifest acutely after an incubation period of 4 to 7 days and can be divided into three phases: febrile, critical, and recovery. (biomedcentral.com)
  • Here, we present a 23-year-old woman with ultrasound findings of marked acute cholecystitis associated with dengue fever after her return to Germany from Thailand and discuss the challenges of managing this condition in a low-incidence country. (biomedcentral.com)
  • Dengue fever is a febrile illness that affects infants, young children and adults. (dengue.lk)
  • Abdominal pain may occur and if severe suggests DHF pattern.The signs of dengue fever/ Dengue haemorrhagic fever are- High fever, rash, hypotension and narrow pulse pressure, poor capillary refill. (dengue.lk)
  • This paper discusses the importance of Dengue Fever (DF) as an emerging disease in the world. (rjptonline.org)
  • Until the mid-20th century, Dengue fever was restricted to special parts of the tropics and subtropics. (rjptonline.org)
  • Dengue fever is a serious global threat to the lives of over 2.5 billion people in over 100 countries. (rjptonline.org)
  • 6. Linares EM, Pannuti CS, Kubota LT, Thalhammer S. Immunospot assay based on fluorescent nanoparticles for dengue fever detection. (rjptonline.org)
  • Hepatic dysfunction is common in dengue fever and the degree of liver dysfunction in children varies from mild injury with to severe injury. (ijpediatrics.com)
  • Prospective and descriptive study was conducted on all the laboratory confirmed cases of dengue fever in children admitted at SIMS and RC over a period of 1 year from Dec 2015 to Nov 2016 both clinically and biochemically. (ijpediatrics.com)
  • Dengue and dengue haemorrhagic fever. (ijpediatrics.com)
  • Dengue haemorrhagic fever: diagnosis, treatment, prevention and control. (ijpediatrics.com)
  • Before 1970, only nine countries had experienced dengue haemorrhagic fever. (who.int)
  • 1.2 million cases of dengue fever and dengue haemorrhagic fever were reported from 56 countries, was unprecedented. (who.int)
  • it is estimated that each year 50 million infections occur, with 500 000 cases of dengue haemorrhagic fever and at least 12 000 deaths, mainly among children, although fatalities could be twice as high. (who.int)
  • The resurgence of epidemic dengue fever and the emergence of dengue haemorrhagic fever as major public health problems are rooted in the demographic trends and socioeconomic policies of the twentieth century. (who.int)
  • The A aegypti mosquito is a known transmitter of both dengue fever and yellow fever. (medscape.com)
  • Results of laboratory tests revealed severe thrombocytopenia and a careful history disclosed dengue fever as the cause. (bvsalud.org)
  • thrombocytopenia, platelet disorder, dengue fever. (bvsalud.org)
  • Though most of these manifestations are noted on ocular mucosa like conjunctiva, sclera, there have been reports of dengue fever presenting as small vesicles on soft palate, erythema and crusting of lips and tongue 5 . (bvsalud.org)
  • Here we report a case of thrombocytopenia associated with dengue fever, which showed only oral manifestations, thus highlighting the significance of recognizing the oral signs. (bvsalud.org)
  • Patient had suffered from dengue fever six months before, for which she had undergone blood transfusion, as per her previous medical reports. (bvsalud.org)
  • Based on the clinical examination, hematological disorder due to dengue fever was chiefly considered, while differential diagnoses included oral squamous cell carcinoma of tongue and buccal mucosa and other infections like influenza, measles, rubella and bacterial sepsis. (bvsalud.org)
  • ABSTRACT Dengue fever resurged sharply in Jeddah in 2004 and rose to 1308 cases in 2006. (who.int)
  • The reason for the problem of dengue fever in a certain control/case ratio was 1.9. (who.int)
  • 50-100 million cases of dengue fever brate hosts of dengue virus in nature cessed by multiplex polymerase chain and 500 000 of dengue haemorrhagic are humans and several species of Asian reaction (PCR) in which the presence fever (DHF) reported annually ( 4 ). (who.int)
  • Dengue can be caused by any one of the four distinct but related viruses, and a person can be infected with each serotype for a total of four dengue infections during their lifetime ( 4 ). (cdc.gov)
  • Meanwhile, the cross-reactivity of CD8+ and CD4+ T cells response to Dengue and Zika viruses provide important clues for further development of potential treatments. (frontiersin.org)
  • Together, this information appraises the current understanding of both Zika and Dengue infections, providing insights for future vaccine design approaches against both viruses. (frontiersin.org)
  • Our group works on the immunology, pathogenesis, and epidemiology of helminth infections (particularly filariasis, strongyloidiasis, and hookworms), TB, and coexistent infectious diseases (helminths/ viruses and TB). (nih.gov)
  • In addition, the recent introduction of Zika and chikungunya viruses in the Americas and the large-scale exposure of a uniformly unexposed population could affect subsequent transmission of dengue virus. (paho.org)
  • Replication of dengue and Junin viruses in cultured rabbit and human endothelial cells. (microbiologyresearch.org)
  • Her research focuses on the role of the host in virus susceptibility and pathogenesis, with a particular interest in emerging viruses that are or have the potential to be major threats to global health, such as avian influenza virus, dengue virus, Ebola virus, mpox (monkeypox) virus, MERS-CoV, and SARS-CoV-2. (elsevier.com)
  • 2013. Performance of commercial dengue NS1 ELISA and molecular analysis of NS1 gene of dengue viruses obtained during surveillance in Indonesia. (ugm.ac.id)
  • Here we review biogenesis of lipid droplets as well as the role of lipid droplets in the pathogenesis of selected viruses, bacteria, protists and yeasts. (microbiologyresearch.org)
  • Chikungunya and dengue viruses cocirculate in Paraguay and surrounding countries, are transmitted by the same species of mosquitoes, and have similar clinical presentations during acute illness. (cdc.gov)
  • Zika virus also has similar clinical features and transmission patterns as chikungunya and dengue viruses. (cdc.gov)
  • Dengue is transmitted by the bite of an Aedes mosquito infected with any one of the four dengue viruses. (dengue.lk)
  • Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. (rjptonline.org)
  • Some 2500 million to 3000 million people live in areas where dengue viruses can be transmitted. (who.int)
  • During the past five decades, the population of the world has more than doubled, with the most rapid acceleration taking place in developing countries in the tropics and subtropics where the mosquito-borne dengue viruses are spread. (who.int)
  • Areas where dengue is endemic in the United States and its territories and freely associated states include Puerto Rico, American Samoa, the U.S. Virgin Islands, the Federated States of Micronesia, the Republic of Marshall Islands, and the Republic of Palau. (cdc.gov)
  • The second reason dengue should concern health care providers in this country is the potential for encountering cases of dengue among travelers arriving from dengue-endemic areas. (cdc.gov)
  • all the rest were travelers arriving from dengue-endemic areas. (cdc.gov)
  • Diagnosis of Dengue is regarded in significant by the patients with high body temperature remaining less than 7 days as they went to private doctors in endemic areas and the doctor did not perform tourniquet tests. (dhf-revolutionafankelijkheid.net)
  • 35,000) living in dengue-endemic areas. (medscape.com)
  • Dr. Harris' field work focuses on laboratory-based and epidemiological studies of dengue in endemic Latin American countries, particularly in Nicaragua, where ongoing projects include clinical and biological studies of severe dengue, a pediatric cohort study of dengue and influenza transmission in Managua, and a project on evidence-based, community-derived interventions for prevention of dengue via control of its mosquito vector. (pewtrusts.org)
  • An important difference to note, however, was that the Zika epidemic diffused in a shorter time span compared to the persisting feature of Dengue infections, which is endemic in many Asian countries. (frontiersin.org)
  • Leptospirosis and dengue are endemic in countries with subtropical or tropical climates and have epidemic potential. (biomedcentral.com)
  • Leptospirosis, being a condition having definitive antibiotic therapy, should always be ruled out even if the patient is positive for dengue serology in regions endemic to both these diseases as early initiation of antibiotic therapy can reduce mortality significantly. (biomedcentral.com)
  • To investigate potential surveillance bias and to assess the validity of the observed dengue distribution, an investigation was conducted in the Lao People's Democratic Republic, a dengue-endemic country in the Region that experienced a dengue epidemic in 2010. (who.int)
  • We aim to elucidate the consequences of these evolutionary strategies for viral pathogenesis and the epidemiology of viral diseases. (ucsf.edu)
  • The Harris laboratory in the division of infectious diseases in the School of Public Health at the UC Berkeley has developed a multidisciplinary approach to study the molecular virology, pathogenesis, and epidemiology of dengue. (pewtrusts.org)
  • After further work in the U.K. and Sri Lanka, he joined the University of Hong Kong in 1995 and developed a multi-disciplinary research program with strong international collaboration that made a major impact in understanding the ecology, epidemiology, pathogenesis and control of animal and human influenza and coronaviruses. (hku.hk)
  • Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. (bvsalud.org)
  • This review discusses similarities between Dengue and Zika infections, comparing their disease transmissions and vectors involved, and both the innate and adaptive immune responses in these infections. (frontiersin.org)
  • Consideration of the genetic identity of both the Dengue and Zika flaviviruses as well as the cross-reactivity of relevant T cells along with the actions of CD4+ cytotoxic cells in these infections are also presented. (frontiersin.org)
  • Finally, a summary of the immune biomarkers that have been reported for dengue and Zika viral infections are discussed which may be useful indicators for future anti-viral targets or predictors for disease severity. (frontiersin.org)
  • Dengue, zika, and chikungunya outbreaks in Central and South America countries have presented significant challenges related to their prevention and control. (paho.org)
  • However, in Salvador, Brazil, after the zika outbreak there was a significant decrease in the frequency of dengue cases (4). (paho.org)
  • A similar situation was observed in Colombia, where the decrease in dengue cases following the zika and chikungunya outbreaks went from 334.1 cases per 100 000 people in 2015 to 90.7 cases per 100 000 in 2017 and 173,1 cases per 100 000 in 2018 (5). (paho.org)
  • Although temporary associations do not prove causation, the strength and consistency of the observations suggest that infections with Zika virus and chikungunya virus could induce cross-protective immunity against dengue. (paho.org)
  • 216, 171-181) published a report identifying several biomarkers for the control of Zika virus pathogenesis. (glopid-r.org)
  • Two types of dengue vaccine have been approved and are commercially available. (wikipedia.org)
  • Patients were randomized 2:1 to receive either the vaccine or saline placebo and monitored for symptomatic virologically confirmed dengue (VCD) starting at day 0. (medscape.com)
  • The vaccine was approximately 76% effective in preventing symptomatic VCD disease among patients aged 9-16 years who were seropositive for dengue at baseline. (medscape.com)
  • To date, there is no effective vaccine or specific antiviral therapy for dengue. (hindawi.com)
  • Although observations support this hypothesis, the potential direct implications of this hypothesis for epidemiological surveillance, immunological research on pathogenesis and vaccine development require additional studies. (paho.org)
  • There is a concern that potent neutralizing antibodies must be generated to all four dengue virus serotypes, as a vaccine that induce weakly cross-reactive non-neutralizing antibodies may increase the likelihood of developing severe disease. (vumc.org)
  • Ideally, the reactivity of epitopes bound by enhancing antibodies should be reduced or eliminated in candidate antigens during the rational development of a dengue vaccine, so as to discourage such dominant recognition of these antigenic features by the humoral immune response. (vumc.org)
  • Associations of human leukocyte antigen with neutralizing antibody titers in a tetravalent dengue vaccine phase 2 efficacy trial in Thailand. (cdc.gov)
  • There is no specific treatment and the dengue vaccine [CYD-TDV (Dengvaxia ® )] is licensed only in 20 countries [ 6 ]. (biomedcentral.com)
  • Due to the challenges associated with the need to collect information on the burden and seroprevalence profiles of the local population, and the recent reports of vaccine-related severe dengue and deaths, the use of the dengue vaccines is not widespread [ 9 ]. (biomedcentral.com)
  • Dengue Branch and the Division of Vector Borne Infectious Diseases, Centers for Disease Control, CID, Fort Collins, CO. Duane J. Gubler, Sc.D and Edward B. Hayes, MD. (cdc.gov)
  • Mice models are essential tools to study the pathogenesis of infectious diseases and for the preclinical evaluation of vaccines and therapies against various human pathogens. (medgadget.com)
  • Sophie is a Consultant Physician in Infectious Diseases and General Medicine and is the Dengue Research Group Head at the Oxford University Clinical Research Unit (OUCRU), based in Ho Chi Minh City, Vietnam. (imperial.ac.uk)
  • 10) Adding to the concern of indigenous dengue transmission is the recent establishment in the United States of another known dengue vector, Aedes albopictus, which was probably imported in shipments of tires from Asia. (cdc.gov)
  • Dengue is spread by several species of female mosquitoes of the Aedes genus, principally Aedes aegypti. (wikipedia.org)
  • Dengue is a disease transmitted by mosquitoes, with the primary vector being the Aedes Aegypti mosquito. (frontiersin.org)
  • and dengue and chikungunya vectors Aedes albopictus (0.9%) and Ae. (unicamp.br)
  • The risk for severe dengue varies on the basis of many factors, including the number of previous dengue infections a person has had. (cdc.gov)
  • Molecular Pathogenesis of Virus Infections describes our current understanding of the pathogenesis of selected virus and prion infections. (cdc.gov)
  • Despite revised clinical classifications of dengue infections by the World Health Organization, the wide spectrum of the manifestations of dengue illness continues to pose challenges in diagnosis and patient management for clinicians. (frontiersin.org)
  • Immune responses, pathogenesis and biomarker discovery in pulmonary and extrapulmonary TB, and the effect of co-infections and comorbidities (diabetes mellitus. (nih.gov)
  • She currently leads a translational programme of dengue research in OUCRU-Vietnam, including pathogenesis studies, innovative technology for monitoring critically ill patients, physiology studies of severe dengue infections as well as clinical trials of novel therapeutics. (imperial.ac.uk)
  • With the increasing number of dengue virus infections imported into Germany, knowledge about the different phases of the disease and possible complications is essential for the treatment of patients. (biomedcentral.com)
  • Hepatic dysfunction in childhood dengue infections. (ijpediatrics.com)
  • Pathogenesis of liver involvement during dengue viral infections. (ijpediatrics.com)
  • Other flaviviral infections include dengue, Japanese encephalitis, and tick-borne encephalitis. (medscape.com)
  • Les cas étaient des infections de dengue confirmées par des examens de laboratoire (n = 244), alors que les témoins avaient obtenu des résultats négatifs (n = 406). (who.int)
  • C. Dye and S. Siddell discuss the pathogenesis of feline coronavirus, an animal disease model that has provided insights into the study of the newly recognized disease, severe acute respiratory syndrome. (cdc.gov)
  • Study of Single Nucleotide Polymorphisms in Endosomal Toll-Like Receptors-3, 7, and 9 Genes in Patients With Dengue: A Case-Control Study. (cdc.gov)
  • One of the earliest, if not the first, dengue epidemics described in the medical literature occurred in Philadelphia in 1780. (cdc.gov)
  • 5-7) Dengue epidemics were reported in various parts of the south- eastern United States through the 19th and 20th centuries, (6) most recently in Louisiana in 1945. (cdc.gov)
  • Dengue-like epidemics occurred in Egypt and on Java in 1779, but these may actually have been caused by chikungunya virus. (cdc.gov)
  • 7) Dengue or dengue-like epidemics were reported through- out the 19th and early 20th centuries in the Americas, southern Europe, North Africa, the Middle East, Asia and Australia and on various islands in the Indian Ocean, South and Central Pacific and the Caribbean. (cdc.gov)
  • 7) Deaths occurred during dengue epidemics in Australia in 1897 and in Greece in 1928, when over 1000 deaths were reported. (cdc.gov)
  • 17) Hemorrhagic manifestations, including gastrointestinal hemorrhage, were described during dengue epidemics in Texas and Louisiana in 1922. (cdc.gov)
  • Dengue usually occurs as epidemics in Sri Lanka following monsoon seasons. (dengue.lk)
  • The early history of dengue is clouded by the similarity of its clinical picture to that of other febrile illnesses. (cdc.gov)
  • Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines. (mdpi.com)
  • She has clinical academic experience in a variety of tropical diseases, including Chagas disease, malaria and dengue, having worked in northern Australia, Kenya, Tanzania and Honduras. (imperial.ac.uk)
  • The incidence of both these diseases peaks during monsoons and both diseases present with similar clinical manifestations making differentiation of leptospirosis from dengue difficult. (biomedcentral.com)
  • the authors compared the hallmarks of clinical ADE (like viremia, clinical symptoms and cytokine levels) in both dengue naïve and exposed patients and showed no evidence of ADE. (glopid-r.org)
  • Therefore, rapid identification of severe cases and appropriate clinical management remains the mainstay to avoid dengue-related case fatalities. (biomedcentral.com)
  • A rational approach of case management through proper understanding of the determinants of severe dengue is key to improving clinical outcomes [ 11 ]. (biomedcentral.com)
  • 14,18,19) Nevertheless through the first half of the 20th century, dengue was generally described as a self-limited, nonfatal febrile illness, with occasional hemorrhagic manifestations such as petechiae, epistaxis, gingival bleeding and menorrhagia, that only rarely resulted in more severe or fatal outcomes. (cdc.gov)
  • ABSTRACT Dengue is one of the most important arthropod-borne viral diseases. (who.int)
  • Treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously for mild or moderate disease. (wikipedia.org)
  • The ultrasound findings were consistent with an acute acalculous cholecystitis, but were interpreted as dengue associated gallbladder wall thickening (GBWT). (biomedcentral.com)
  • This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. (hindawi.com)
  • This review presents a comprehen- sive but concise overview of pathogenesis, management and prevention of IAH in SCD. (bvsalud.org)
  • Dengue- Guidelines for Diagnosis, Treatment, Prevention and Control. (rjptonline.org)
  • Although research on dengue vaccines for public health use is in process, currently the only method for the prevention and control of the disease is vector control. (who.int)
  • Host immune responses contribute to dengue's pathogenesis and severity, yet the possibility that failure in endogenous inflammation resolution pathways could characterise the disease has not been contemplated. (gla.ac.uk)
  • Association of self-reported allergic rhinitis with dengue severity: A case-control study. (cdc.gov)
  • 2. Mardani M, Abbasi F, Aghahasani M, Ghavam B. First Iranian imported case of dengue. (rjptonline.org)
  • The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. (hindawi.com)
  • The incidence of dengue has surged dramatically with an eightfold increase over the last two decades, from 505 430 cases in 2000 to over 2.4 million in 2010, and 4.2 million in 2019 [ 3 ]. (biomedcentral.com)
  • Incidence of dengue has increased many fold in the past 50 years and has expanded to areas that were previously free from the disease. (who.int)
  • There is currently no specific treatment for dengue, and vector control and vaccination are the only effective methods to prevent future outbreaks. (who.int)
  • Dengue has been called the most important mosquito-transmitted viral disease in terms of morbidity and mortality. (medscape.com)
  • Dengue is the most important reemerging mosquito-borne viral disease worldwide. (hindawi.com)
  • Due to the large circulation of the dengue virus, a hypothesis was raised that immunity to the dengue virus could facilitate the establishment of ZCS, based in a phenomenon called Antibody Dependent Enhancement (ADE). (glopid-r.org)
  • Though we can connect dengue NS1 to these symptoms, the mechanism of pathogenesis remains unknown. (berkeley.edu)
  • Travel-Associated Dengue Cases This report reveals that travel-associated dengue cases in the United States peaked in 2019, with a 168% increase over the annual average from the prior 8 years. (medscape.com)
  • It is approved only in individuals previously infected by any dengue virus serotype or in whom this information is unknown. (medscape.com)
  • Or the patients are not treated because the doctor does not think that it is a dengue symptom due to the patient's platelets that remain above 100,000 / mm3. (dhf-revolutionafankelijkheid.net)
  • The long-term goal is to use such molecular information in the rational design of dengue vaccines that enhance the induction of protective neutralizing antibodies and reduce the risk of development of severe disease. (vumc.org)
  • Mice models are an essential resource for studying the mechanisms underlying infectious disease pathogenesis and as platforms for testing potential vaccines and therapies. (medgadget.com)
  • 1) Outbreaks of the more severe form of dengue, DHF, occurred in Cuba in 1981 (2) and in Venezuela in 1989. (cdc.gov)
  • 9) Outbreaks of indigenous dengue transmission occurred in Texas in 1980 and again in 1986. (cdc.gov)
  • The increase in dengue incidence has been associated with explosive outbreaks and geographical expansion to new areas [ 3 ]. (biomedcentral.com)
  • As the pathogenesis of viral illnesses is affected by host immune responses, various immune modulators have been proposed as biomarkers to predict the risk of the disease progression to a severe form, at a much earlier stage of the illness. (frontiersin.org)
  • Mice with xenografted human immune systems have been used to study the pathogenesis of various infectious agents, including Plasmodium falciparum (malaria), Mycobacterium tuberculosis, dengue virus, and influenza virus. (medgadget.com)
  • Now, we know that complement system, protecting the host through innate immune system, could trigger harmful endothelial pathogenesis. (biomedcentral.com)
  • The role of immune response in pathogenesis has not yet been established. (medscape.com)
  • 13-15) From 1980 through 1989, 1457 suspected and 276 confirmed cases of dengue in the continental United States and Hawaii were reported to the Centers for Disease Control. (cdc.gov)
  • review our current understanding of the pathogenesis of Ebola and Marburg filoviruses, paying particular attention to the factors that contribute to lethal disease. (cdc.gov)
  • Dengue is a major public health concern, affecting almost 400 million people worldwide, with about 70% of the global burden of disease in Asia. (frontiersin.org)
  • Dr Barvalia explains Boger's approach in his interview, where he highlighted the concept of pathogenesis [5] which is consideration of phenomena of disease with its evolution and characteristic aspect, which is definitely more that isolated pathology. (hpathy.com)
  • Results from this project may contribute to the discovery and development of novel therapeutics with utility in treating severe dengue disease. (berkeley.edu)
  • We hypothesised that inadequate AnxA1 engagement underlies the cytokine storm and vascular pathologies associated with dengue disease. (gla.ac.uk)
  • 3. Sharifi Mood B, Mardani M, Dengue: A Re-Emerging Disease. (rjptonline.org)
  • 16. Rasheed S, Butlin R, Boots M A review of dengue as an emerging disease in Pakistan. (rjptonline.org)
  • Alpha-synuclein: Implications for Parkinson's Disease This review summarizes the physiological and pathological roles of alpha-synuclein and its implication in Parkinson's disease pathogenesis. (medscape.com)
  • This case-control study determined factors potentiating the spread of the disease to provide an epidemiological baseline to help dengue control. (who.int)