AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth CareGeographicals
DengueDefective VirusesDengue VirusSevere DengueHemorrhagic Fever, CrimeanHemorrhagic Fevers, ViralHemorrhagic Fever with Renal SyndromeHemorrhagic Fever Virus, Crimean-CongoMurine Acquired Immunodeficiency SyndromeFeverHemorrhagic Fever, AmericanHemorrhagic Fever, EbolaQ FeverTyphoid FeverHelper VirusesYellow FeverScarlet FeverDisease OutbreaksVirus ReplicationAedesMarburg Virus DiseaseDengue VaccinesRNA, ViralViral InterferenceLeukemia Virus, MurineCoxiella burnetiiHantaan virusHantavirusEbolavirusArenaviruses, New WorldAntibodies, ViralGenes, ViralCell LineDNA, ViralViral ProteinsSalmonella typhiMarburgvirusFrench GuianaLassa FeverGenome, ViralInsect VectorsTravelJunin virusLassa virusRNA VirusesFever of Unknown OriginMolecular Sequence DataDemocratic Republic of the CongoThailandRift Valley FeverIndiaArenaviridae InfectionsFiloviridae InfectionsArenavirusImmunoglobulin MFiloviridaeMalariaPuumala virusVero CellsCulicidaeAntibody-Dependent EnhancementGenetic Complementation TestIncidenceAntigens, ViralVaccinia virusRheumatic FeverNicaraguaReceptors, VirusBase SequenceCommunicable Diseases, EmergingVirus CultivationCercopithecus aethiopsPhylogenyPichinde virusHemorrhagic Fever, OmskDisease VectorsArenaviridaeEnzyme-Linked Immunosorbent AssayMosquito ControlSerotypingVietnamVirus DiseasesSeasonsFlavivirusHantavirus InfectionsBrazilSeroepidemiologic StudiesAntiviral AgentsPolynesiaViremiaSpace-Time ClusteringAfrican Swine Fever VirusVirus SheddingMissions and MissionariesEndemic DiseasesSri LankaRainFlavivirus InfectionsVirus AssemblyArterivirus
EbolaCytomegalovirusEncephalitisManifestationsPathogenRenal failureSyndromeInfectionViral infectionsMalariaInfectionsSingle-strandedFlavivirusTransmitted by mosquitoesHantavirusZikaChillsEnterovirusProteinsSevereDiseasesOnsetHerpesEmergingBacteriaVirulentClinicalVectorsReplicationGeneticMeaslesAntigensImmuneReplicateInfectiousOccurDevelopRespiratoryHigh feverParticlesMutationsDiseaseMonkeys
Ebola16
  • While the person was in- Ebola virus. (cdc.gov)
  • We present a potential exposure to Ebola virus that tamination of the site also reduced potential for infection. (cdc.gov)
  • 2) there was inter- before with a mouse-adapted variant of the Zaire species est in ensuring all infection control procedures were being of Ebola virus (ZEBOV) ( 2 ). (cdc.gov)
  • Efficiency of Field Laboratories for Ebola Virus Disease Outbreak during Chronic Insecurity, Eastern Democratic Republic of the Congo, 2018-2020. (cdc.gov)
  • in the past decade the zaire strain of ebola virus (zebov) has emerged repeatedly into human populations in central africa and caused massive die-offs of gorillas and chimpanzees. (liverpool.ac.uk)
  • human recombinant antibodies to ebola virus: preparation and characteristics]. (liverpool.ac.uk)
  • human recombinant antibodies against a purified ebola virus (ev) lysate were selected from a combinatorial library of scfv-antibodies using the phage display technique. (liverpool.ac.uk)
  • protective cytotoxic t-cell responses induced by venezuelan equine encephalitis virus replicons expressing ebola virus proteins. (liverpool.ac.uk)
  • infection with ebola virus causes a severe disease accompanied by high mortality rates, and there are no licensed vaccines or therapies available for human use. (liverpool.ac.uk)
  • filovirus vaccine research efforts still need to determine the roles of humoral and cell-mediated immune responses in protection from ebola virus infection. (liverpool.ac.uk)
  • laboratory diagnosis of ebola and marburg hemorrhagic fever. (liverpool.ac.uk)
  • the status of current laboratory diagnostics for ebola and marburg virus infections is discussed in terms of the assays available and their interpretation. (liverpool.ac.uk)
  • ebola virus circulation in africa: a balance between clinical expression and epidemiological silence. (liverpool.ac.uk)
  • nearly thirty years after the first epidemics, ebola virus (ebov) remains hardly described, its transmission unclear and its reservoir elusive. (liverpool.ac.uk)
  • soon after the ebola fever outbreak and virus discovery in 1976 and in order to investigate the distribution of ebov in central africa, several countries including a range of ecological zones were investigated in the early 1980s, using extensive survey: central african republic (car), cameroon, chad, congo, gabon and equatorial guinea. (liverpool.ac.uk)
  • Some of the most virulent diseases are caused by viruses, e.g., the hemorrhagic fever caused by Ebola virus. (unboundmedicine.com)
Cytomegalovirus1
  • Cytomegalovirus PCR and tests for Epstein Barr Virus were not done due to unaffordability. (pediatriconcall.com)
Encephalitis4
  • Flaviviruses are important human pathogens and include dengue (DENV), West Nile (WNV), Yellow fever virus (YFV), Japanese encephalitis (JEV) and Zika virus (ZIKV). (bvsalud.org)
  • Contrasting the Practices of Virus Isolation and Characterization between the Early Period in History and Modern Times: The Case of Japanese Encephalitis Virus. (cdc.gov)
  • Insects like mosquitos and ticks, of course, host and transmit many kinds of viral infections, including yellow fever, dengue, and encephalitis. (patrickmalonelaw.com)
  • It is transmitted to humans by the mosquito or tick bite and is implicated in some cases of encephalitis. (unboundmedicine.com)
Manifestations3
  • Hadchouel M, Prieur AM, Griscelli C. Acute hemorrhagic, hepatic and neurologic manifestations in juvenile rheumatoid arthritis: possible relationship to drugs or infection. (pediatriconcall.com)
  • Hemorrhagic fever with renal failure syndrome (HFRS) occurs mainly in Europe and Asia and is characterized by fever and renal failure associated with hemorrhagic manifestations. (medscape.com)
  • Despite revised clinical classifications of dengue infections by the World Health Organization, the wide spectrum of the manifestations of dengue illness continues to pose challenges in diagnosis and patient management for clinicians. (frontiersin.org)
Pathogen3
  • daily laboratory studies (coagulation patients (3, 6, 7, and 18) would likely not be admitted to- studies, blood counts, chemistries, viral isolation, D-dimer) day: 2 involved dengue virus (now a BSL-2 pathogen) and and regular physician assessments were performed. (cdc.gov)
  • Given that these enhanced responses are triggered by failed attempts to control the infecting virus, VAED typically presents with symptoms related to the target organ of the infection pathogen. (cov19longhaulfoundation.org)
  • However, a case fatality rate that ranges from 0.5% to nearly 20% depending on age and other risk factors, and the understanding that SARS-CoV-2 is now a well-adapted human pathogen that will continue to cause disease in susceptible populations, makes the development of an effective vaccine a global priority. (cov19longhaulfoundation.org)
Renal failure7
  • Hemorrhagic fever with renal failure syndrome is caused by an airborne contact with secretions from rodent hosts infected with the group of viruses belonging to the genus Hantavirus of the family Bunyaviridae . (medscape.com)
  • Hemorrhagic fever with renal failure syndrome was initially recognized between 1913 and 1930 by Soviet scientists, who described sporadic outbreaks of fever with renal failure in the eastern Soviet Union. (medscape.com)
  • Antibody specific to the viral antigen can be detected close to the onset of hemorrhagic fever with renal failure syndrome symptoms. (medscape.com)
  • T-cell activation occurs very early in the course of hemorrhagic fever with renal failure syndrome and is associated with an absolute increase in the number of neutrophils, monocytes, B cells, and CD8+ (suppressor) T cells. (medscape.com)
  • Activation of both classic and alternative complement pathways also occurs in hemorrhagic fever with renal failure syndrome. (medscape.com)
  • Some investigators have suggested that hemorrhagic fever with renal failure syndrome is primarily an allergic disease. (medscape.com)
  • The viruses of the genus Hantavirus (family Bunyaviridae) cause different forms of hemorrhagic fever with renal failure syndrome. (medscape.com)
Syndrome2
  • DENV, transmitted by mosquitoes, causes diseases ranging in severity from mild dengue fever with non-specific flu-like symptoms to fatal dengue hemorrhagic fever and dengue shock syndrome. (bvsalud.org)
  • He was diagnosed as a case of Macrophage Activation syndrome and advised regular follow up. (pediatriconcall.com)
Infection9
  • The term 'cytokine storm' entered the popular lexicon with previous influenza virus pandemics but has become even more mainstream because of the severe inflammation that can accompany SARS-CoV-2 infection 1 . (nature.com)
  • Mosquito-borne dengue viruses (DENVs) have evolved to four serotypes with 69%-78% amino acid identities, resulting in incomplete immunity, where one serotype's infection does not cross-protect against secondary infections by other serotypes. (bvsalud.org)
  • The incidence of DENV infection has increased dramatically in recent decades and the CDC estimates 400 million dengue infections occur each year, resulting in â ¼25,000 deaths mostly among children and elderly people. (bvsalud.org)
  • Hepatitis E virus (HEV), an important agent of viral hepatitis worldwide, can cause severe courses of infection in pregnant women and immunosuppressed patients. (mdpi.com)
  • The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
  • Chikungunya is an arbo virus infection transmitted by the bite of the Aedes mosquito, a small, innocuous insect with an attractive striped body. (findmeacure.com)
  • There is a reservoir of infection as the virus survives in warm blooded vertebrates like monkeys, rodents and birds. (findmeacure.com)
  • When the Zika epidemic spread through the American continent and then later to Africa and Asia in 2015, researchers compared the characteristics of the Zika infection to Dengue, considering both these viruses were transmitted primarily through the same vector, the Aedes aegypti female mosquitoes. (frontiersin.org)
  • In their paper published, the research team reports finding that dendritic cells of elite controllers are better able to detect the presence of HIV paradoxically through a greater susceptibility to HIV infection which enables them to stimulate the generation of T cells specifically targeting the virus. (regenerativemedicine.net)
Viral infections1
  • Finally, a summary of the immune biomarkers that have been reported for dengue and Zika viral infections are discussed which may be useful indicators for future anti-viral targets or predictors for disease severity. (frontiersin.org)
Malaria2
Infections6
  • An important difference to note, however, was that the Zika epidemic diffused in a shorter time span compared to the persisting feature of Dengue infections, which is endemic in many Asian countries. (frontiersin.org)
  • This review discusses similarities between Dengue and Zika infections, comparing their disease transmissions and vectors involved, and both the innate and adaptive immune responses in these infections. (frontiersin.org)
  • Consideration of the genetic identity of both the Dengue and Zika flaviviruses as well as the cross-reactivity of relevant T cells along with the actions of CD4+ cytotoxic cells in these infections are also presented. (frontiersin.org)
  • Together, this information appraises the current understanding of both Zika and Dengue infections, providing insights for future vaccine design approaches against both viruses. (frontiersin.org)
  • Viruses are also responsible for the common cold, childhood exanthems (such as chickenpox, measles, rubella), latent infections (such as herpes simplex), some cancers or lymphomas (such as Epstein-Barr virus), and diseases of all organ systems. (unboundmedicine.com)
  • The virus is harmless to macaques or may cause only a herpetic rash in macaques, but in humans it often produces fatal infections of the brain and meninges. (unboundmedicine.com)
Single-stranded3
  • we reviewed published reports on 254-nm uv inactivation and tabulated the sensitivities of a wide variety of viruses, including those with double-stranded dna, single-stranded dna, double-stranded rna, or single-stranded rna genomes. (liverpool.ac.uk)
  • Dengue virus (DENV) is an enveloped, single-stranded RNA virus belonging to the Flaviviridae family. (frontiersin.org)
  • AAVs are nonenveloped single-stranded DNA viruses used in gene therapy to insert copies of missing genes into host cells. (unboundmedicine.com)
Flavivirus2
  • Dengue virus (DV) is a mosquito-borne flavivirus that causes hemorrhagic fever in humans. (unboundmedicine.com)
  • Hence, there is an urgent need to develop therapeutics that interfere with essential enzymatic steps, such as protease in the flavivirus lifecycle as these viruses possess significant threat to future pandemics. (bvsalud.org)
Transmitted by mosquitoes1
  • Dengue is a disease transmitted by mosquitoes, with the primary vector being the Aedes Aegypti mosquito. (frontiersin.org)
Hantavirus1
  • In 1993 in the southwestern United States, an outbreak of respiratory illness occurred during the spring and was caused by a virus belonging to the genus Hantavirus called Sin Nombre virus. (medscape.com)
Zika1
  • Meanwhile, the cross-reactivity of CD8+ and CD4+ T cells response to Dengue and Zika viruses provide important clues for further development of potential treatments. (frontiersin.org)
Chills1
  • A 7 year old boy born of non-consanguineous marriage presented with fever with chills for 10 days. (pediatriconcall.com)
Enterovirus1
  • The 400 known viruses are classified in several ways: by genome core (RNA or DNA), host (animals, plants, or bacteria), method of reproduction (such as retrovirus), mode of transmission (such as enterovirus), and disease produced (such as hepatitis virus). (unboundmedicine.com)
Proteins1
Severe1
  • If a pregnant woman is infected, the virus can cross the placental barrier and can spread to her fetus, causing severe brain malformations in the child including microcephaly and other birth defects. (bvsalud.org)
Diseases2
Onset1
  • He was suspected to have underlying systemic onset juvenile idiopathic arthritis {JIA} in view of associated arthritis at the onset of fever. (pediatriconcall.com)
Herpes1
  • A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. (lookformedical.com)
Emerging1
  • The Case Definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2 vaccines and other emerging pathogens. (cov19longhaulfoundation.org)
Bacteria3
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
  • The largest virus is smaller than the tiniest bacteria, so tiny they cannot even be seen with a regular light microscope. (patrickmalonelaw.com)
  • And unlike bacteria, viruses, as far as we know, are never good for you. (patrickmalonelaw.com)
Virulent1
  • There are proposals to remove the virulent genes from viruses to create vaccines. (wikipedia.org)
Clinical1
  • A case for investment in clinical metagenomics in low-income and middle-income countries. (cdc.gov)
Vectors1
  • Viruses play an important role as vectors for inserting genetic information into other organisms. (wikipedia.org)
Replication1
  • However, we observed that endocytosis-defective DC-SIGN molecules allow efficient DV replication, indicating that DC-SIGN endocytosis is dispensable for the internalization step in DV entry. (unboundmedicine.com)
Genetic6
  • Deoxyribonucleic acid that makes up the genetic material of viruses. (lookformedical.com)
  • Viruses whose genetic material is RNA. (lookformedical.com)
  • Viruses, as experts know them now, consist of little more than strings of their own genetic information (DNA or RNA) housed in a protein shell. (patrickmalonelaw.com)
  • When viruses replicate in giant numbers, as they do, they also may undergo fundamental changes, notably in their DNA genetic code. (patrickmalonelaw.com)
  • They appear in the genetic double-helix in patterns, captured in scientific terms by letter chains like A-T-C-G. Scientists have learned to map or sequence these, giving them i mportant new ways to detect and protect against viruses . (patrickmalonelaw.com)
  • When HIV infects a cell it first injects its genetic material RNA in this case into the cell along with the reverse transcriptase enzyme that transcribes the single-strand RNA molecule into a double-stranded DNA molecule. (regenerativemedicine.net)
Measles1
  • Classic examples of VAED are atypical measles and enhanced respiratory syncytial virus (RSV) occurring after administration of inactivated vaccine for these pathogens. (cov19longhaulfoundation.org)
Antigens2
  • B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma . (lookformedical.com)
  • The common influenza viruses have antigens that mutate or combine readily, requiring new vaccines with each mutation. (unboundmedicine.com)
Immune3
  • Classifying MAS using the immunological disease continuum model, with strict boundaries that define the limits of innate and adaptive immunity, at one boundary is MAS with loss of immune function, as occurs in the 'perforinopathies' and some cases of sJIA-AOSD. (nature.com)
  • Viruses with lipid envelopes have a greater ability to adhere to cell membranes and to avoid destruction by the immune system. (unboundmedicine.com)
  • We have shown that dendritic cells, which play a critical role in generating virus-specific T cells, have an improved ability to recognize HIV and build effective immune responses in elite controllers. (regenerativemedicine.net)
Replicate1
  • ABBR: AAV A genus in the parvovirus family whose members cannot replicate without the presence of another virus. (unboundmedicine.com)
Infectious1
  • Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). (lookformedical.com)
Occur1
  • 3} MAS is postulated to occur due to a defective function of perforin, a protein involved in the cytolytic processes and control of lymphocyte proliferation. (pediatriconcall.com)
Develop1
  • The case definition format of the Brighton Collaboration was followed to develop a consensus definition and defined levels of certainty, after an exhaustive review of the literature and expert consultation. (cov19longhaulfoundation.org)
Respiratory1
  • The potential for vaccination against SARS-CoV-2 to be associated with disease enhancement is of theoretical concern, given similar observations with other respiratory viruses in general, and in animal models of highly pathogenic coronaviruses in particular [14] . (cov19longhaulfoundation.org)
High fever1
  • In view of persistent high fever and delirium at the height of fever, he was treated with IV Methyl Prednisolone to which the fever responded and hemogram became normal. (pediatriconcall.com)
Particles2
  • The expelling of virus particles from the body. (lookformedical.com)
  • After HIV DNA enters the nucleus of an infected cell, it becomes integrated into the cellular DNA, turning it into an HIV factory that generates more virus particles. (regenerativemedicine.net)
Mutations2
  • Major drawbacks of this therapy are that RBV is not approved for administration to pregnant women and that the virus can acquire mutations, which render the intra-host population less sensitive or even resistant to RBV. (mdpi.com)
  • Sometimes mutations can allow viruses to make a dramatic leap from one species to another, particularly if they are close by and have close contact with the original host. (patrickmalonelaw.com)
Disease3
  • Dengue is a major public health concern, affecting almost 400 million people worldwide, with about 70% of the global burden of disease in Asia. (frontiersin.org)
  • This is a Brighton Collaboration Case Definition of the term "Vaccine Associated Enhanced Disease" to be utilized in the evaluation of adverse events following immunization. (cov19longhaulfoundation.org)
  • When viruses enter a cell, they may immediately trigger a disease process or may remain quiescent for years. (unboundmedicine.com)
Monkeys1
  • A virus commonly found in macaques (Old World monkeys) but not in other primates. (unboundmedicine.com)