Dendritic precursors bone marrow transplantation. Medical search. Frequent questions

Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. (mdpi.com)
Results: BPDCN is derived from precursor plasmacytoid dendritic cells. (elsevierpure.com)

AML treatment is often started with intensive chemotherapy, followed by consolidation with or without allogeneic hematopoietic stem cell transplantation. (1440dev.com)
Allogeneic hematopoietic stem cell transplantation, particularly when performed during the first remission, may produce durable remissions in selected adults. (elsevierpure.com)

All together, we demonstrate that host nc-moDCs surprisingly mediate immunosuppression in the context of murine intestinal GVHD - as opposed to classical "inflammatory" monocyte-derived dendritic cells (mo-DCs) - via coinhibitory signaling. (uni-wuerzburg.de)
Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells. (uchc.edu)

A series of sublethal doses of radiation is directed at the patient's lymphoid tissue (spleen, thymus, and lymph nodes in the neck, chest, and abdomen), with bone marrow and other vital organs shielded from the exposure [ 387 ]. (nanomedicine.com)
In due course, the stem cells in the bone marrow reconstitute the peripheral lymphoid system but the newly formed T cells seem to accept the graft as self [ 403 ]. (nanomedicine.com)
It was recently shown that bone marrow functions not only as a primary lymphoid organ responsible for hematopoiesis, but also as a secondary lymphoid organ, where inflammatory response can be initiated. (termedia.pl)
Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking. (termedia.pl)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

Silencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-1 27-35. (uchc.edu)

Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Transplantation is the transfer of living cells, tissues, or organs from one person, the donor, to another, the recipient (e.g., a blood transfusion), or from one part of the body to another (e.g., skin grafts) with the goal of restoring a missing function [ 361 ]. (nanomedicine.com)
These agents also damage all tissues (e.g., gut epithelium, bone marrow) where rapid cell division is occurring, creating other undesirable side effects, thus often may not be suitable for use in medical nanorobotics. (nanomedicine.com)
Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages. (hindawi.com)
Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)

In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
Acute myeloid leukemia has a number of subtypes and precursor neoplasms that are distinguished from each other by morphology, immunophenotype, cytochemistry, and genetic abnormalities (see also The 2016 World Health Organization [WHO] Classification of myeloid neoplasms ) all of which have important implications for prognosis and treatment. (msdmanuals.com)
The two presentations relate to Medigene's clinical research including detailed results from the dendritic cell (DC) vaccine Phase I/II clinical trial completed earlier this year (presented by the study's Principal Investigator, Dr Yngvar Floisand), as well as preclinical data on the evaluation of PRAME expression and HLA genotype distribution in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). (1440dev.com)
Listeria monocytogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system. (termedia.pl)

Allogeneic hematopoietic cell transplantation (HCT) is the only currently available curative therapy. (bvsalud.org)
Parabiosis experiments revealed that tissue-resident non-classical CX3CR1+ monocytes differentiated in situ into intestinal CD11b+ nc-moDCs after allogeneic hematopoietic cell transplantation (allo-HCT). (uni-wuerzburg.de)

In addition, accumulating reports have indicated that bone marrow participates in the development of rheumatoid arthritis as a site of activated lymphocytes homing and proinflammatory cytokines overproduction. (termedia.pl)
Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. (termedia.pl)
Paramithiotis E, Cooper MD. Memory B lymphocytes migrate to bone marrow in humans. (termedia.pl)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. (thermofisher.com)

Examination of peripheral blood smear and bone marrow is diagnostic. (msdmanuals.com)
Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes. (elsevierpure.com)
Most patients with BPDCN have skin lesions and simultaneous involvement of the peripheral blood, bone marrow, and lymph nodes.Methods: A search of PubMed and Medline was conducted for English-written articles relating to BPDCN, CD4+CD56+ hematodermic neoplasm, and blastic natural killer cell lymphoma. (elsevierpure.com)

In situ vaccine (ISV), combining Flt3L, local radiotherapy, and a TLR3 agonist (poly-ICLC), could recruit, antigen-load and activate intratumoral cross-presenting dendritic cells (DCs) in indolent non-Hodgkin's lymphomas (iNHLs) treatment (clinical trial: NCT01976585). (wikipedia.org)
In addition to Medigene's development focus on T cell-receptor modified T cells (TCR-Ts), the Company has developed a new generation of antigen-tailored dendritic cell (DC) vaccines. (1440dev.com)
Dendritic cells (DC) can take up antigens, process them and present peptides on their surface in a form that can induce antigen-specific T cells to mature and proliferate. (1440dev.com)
Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. (biomedcentral.com)
Finally, mononuclear cells isolated from lung (L-MCs), which are used as precursors for L-DCs, expressed more antigen-presenting cell-associated markers such as MHC class II and CD172α compared to their counterparts from blood. (biomedcentral.com)
Dendritic cells (DCs) are the most important antigen-presenting cells (APCs) in the body. (biomedcentral.com)
Bone marrow as a priming site for T-cell responses to blood-borne antigen. (termedia.pl)
Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. (termedia.pl)
Antigen induced arthritis (AIA) can be transferred by bone marrow transplantation: evidence that interleukin 6 is essential for induction of AIA. (termedia.pl)
He is also Leader of the Dendritic Cells (DC) Antigen Presentation research group. (euroacadti.eu)
His main scientific contributions in the last 10 years relate to antigen presentation in dendritic cells and immunotherapy. (euroacadti.eu)

A shift in the nature of complications from early to late graft dysfunction has been similarly observed after transplantation of other solid organs 2 . (ersjournals.com)
In this paper we apply the tissue-centric perspective to discuss the role of resident and infiltrating macrophages and dendritic cells in different organs. (hindawi.com)
On one end, the clinical spectrum includes an acute, fulminant, disseminated disease called Letterer-Siwe disease, and, on the other end, solitary or few, indolent and chronic lesions of bone or other organs called eosinophilic granulomas . (medscape.com)

Recent evidence also suggests involvement of innate immunity, including dendritic cells (DC), in the initiation and maintenance as well as progression of MS [ 11 ]. (hindawi.com)
T-cell priming in bone marrow: the potential for long-lasting protective anti-tumor immunity. (termedia.pl)
Matthew Albert is Director of Research INSERM and Head of the Laboratory of Dendritic Cell Immunobiology at the Institut Pasteur, Paris, leading a team in the area of dendritic cell immunobiology and tumor immunity. (euroacadti.eu)

The role of circulating bone marrow derived endothelial progenitor cells (EPCs) for vascular repair in scleroderma (SSc) remains unclear. (hku.hk)

Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells. (termedia.pl)
In the after-math of the bombings of Hiroshima and Nagasaki in 1945, researchers discovered that bone marrow (BM) transplanted into irradiated mice produced hematopoiesis [ 1 ]. (biomedcentral.com)
In the 1970s, Friedenstein and colleagues [1] first reported that locally applied culture-expanded populations of bone marrow stroma-derived fibroblastic cells remained at their injection sites under the kidney capsule, where an ectopic hematopoiesis was initiated. (issca.us)
this includes regulation of bone marrow processes like hematopoiesis. (brainimmune.com)
In this chapter we attempt to uncover the different roles of tachykinins in human disease and homeostatic conditions, in particular hematopoiesis within the bone marrow cavity. (brainimmune.com)

AML is caused by uncontrolled growth of dysfunctional hematopoietic precursor cells in the bone marrow. (1440dev.com)
Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery. (termedia.pl)

Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (issca.us)
This concept started from the observation that bone marrow transplantation can provide stromal cells able to synthesize intact collagen type I, replacing deficient patient cell function and ameliorating disease symptoms [5]. (issca.us)

Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with an aggressive clinical course. (elsevierpure.com)

This is the first description of huPLN transplantation into SCID mice, and of the functional effects of SDF-1 regarding the migration of human cells into huPLN in vivo . (biomedcentral.com)

Differentiation of this intestinal DC subset depended on CSF-1 but not on Flt3L, thus defining the precursors as monocytes and not pre-DCs. (uni-wuerzburg.de)
Importantly, CX3CR1 but not CCR2 was required for this DC subset differentiation, hence defining the precursors as non-classical monocytes. (uni-wuerzburg.de)

In addition grafts retain some of the histological features of the pretransplantation tissue, such as follicular dendritic cell-associated B-cell aggregates, lymphatic and HEV markers. (biomedcentral.com)

These results suggest that dexamethasone is a potent inhibitor of intracellular events that are involved on NO synthesis, in skin dendritic cells. (pdffox.com)
Pivotal studies by the group of Horwitz in children with osteogenesis imperfecta, an inherited enzyme deficiency of collagen synthesis by mesenchymal cells in bone, opened the field for intravenous use of MSCs. (issca.us)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)

Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. (termedia.pl)

FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development. (wikipedia.org)
In this study, we systematically analyzed CD19 CAR-T cells of 10 children with R/R B-ALL enrolled in the CARPALL trial via high-throughput single-cell gene expression and T cell receptor sequencing of infusion products and serial blood and bone marrow samples up to 5 years after infusion. (nature.com)
We studied 15 consecutive patients with high-risk or relapsed CD19 + B-ALL treated with CD19 CAR-T cell therapy on the CARPALL study ( NCT02443831 ) and in whom adequate CAR-T cells could be isolated for subsequent analyses from cryopreserved samples of blood or bone marrow. (nature.com)
Plasma cell biology: Foundations for targeted therapeutic development in transplantation. (cincinnatichildrens.org)
Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
The scientific team of Medigene has developed new, fast and efficient methods for generating autologous (patient-specific) mature dendritic cells, which have the relevant characteristics to generate very strong T cell and NK cell immune responses. (1440dev.com)
The diagnosis of BPDCN is based on the characteristic cytology and immunophenotype of malignant cells coexpressing CD4, CD56, CD123, blood dendritic cell antigens 2 and 4, and CD2AP markers. (elsevierpure.com)
In this work, we investigated the effect of dexamethasone on NO production induced by the epidermal cytokine granulocyte / macrophage colony-stimulating factor (GM-CSF) in a mouse fetal skin dendritic cell line.Methods: NO production was assessed by the method of Griess. (pdffox.com)
Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
Edry E, Azulay-Debby H, Melamed D. TOLL-like receptor ligands stimulate aberrant class switch recombination in early B cell precursors. (termedia.pl)
SDF-1 (CXCL12), a CXC chemokine, has a primary role in signalling the recruitment of haematopoietic stem-cell precursors to the bone marrow during embryonic development. (biomedcentral.com)
As the Bone Marrow (BM) develops and becomes functional, it becomes the main site of blood and immune cell formation. (brainimmune.com)
Recently, the lab of Dr. P. Agostinis documented that immunogenic cell death mediated by ER stress can be harnessed to develop novel and clinically relevant, next-generation dendritic cell-based immunotherapies for brain tumors. (euroacadti.eu)
Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)

thymus from marrow-derived progenitors circulating in the blood. (lu.se)

Portal biliopathy treated by liver transplantation. (unifi.it)
Outcomes after liver transplantation in MPV17 deficiency: Arebuttal. (stanfordchildrens.org)
Has the Risk of Liver Re-Transplantation Improved Over the Two Decades? (stanfordchildrens.org)

On the other hand, it favors exaggerated tissue injury in sepsis, hypersensitivity or autoimmunity, by promoting inflammation or cytotoxicity of innocent bystander cells.1 In the skin, NO is produced by iNOS in several cells, namely in keratinocytes, fibroblasts, Langerhans cells and other dendritic cells. (pdffox.com)
Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation. (termedia.pl)

However, relapsed ALL remains a leading cause of childhood death despite intensive cytotoxic chemotherapy often including allogeneic bone marrow transplantation. (nature.com)

In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)

Since recent evidence supports a crucial role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC. (hindawi.com)
Moreover, the results of experimental and clinical investigations that confirm the contribution of bone marrow to the pathogenesis of rheumatoid arthritis are reviewed. (termedia.pl)

Bcl-2 Is Necessary to Counteract Bim and Promote Survival of TCRαβ+CD8αα+ Intraepithelial Lymphocyte Precursors in the Thymus. (cincinnatichildrens.org)

A lack of FLT3L results in low levels of dendritic cells. (wikipedia.org)
In strains of plasmodium, FLT3L was shown to be released from mast cells and cause the expansion of dendritic cells, leading to the activation of CD8+ T cells. (wikipedia.org)
The same paper suggested that FLT3L release was caused by stimulation of mast cells with uric acid, produced from a precursor secreted by the plasmodium parasite. (wikipedia.org)

Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. (ersjournals.com)
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have contributed to increase the 1‐yr patient survival after lung transplantation (LTx) to 70-80% 1 . (ersjournals.com)

Allogeneic intra-bone marrow transplantation prevents rheumatoid arthritis in SKG/Jcl mice. (termedia.pl)

Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)

Within the bone marrow, the tachykinins have been shown to have critical effects on the microenvironment, including metastasis and dormancy of cancer cells during clinical remission. (brainimmune.com)
The intermediate clinical form called Hand-Schüller-Christian disease is characterized by multifocal, chronic involvement and classically presents as the triad of diabetes insipidus, proptosis, and lytic bone lesions. (medscape.com)

Dendritic cells can also induce natural killer cells (NK cells) to attack tumor cells. (1440dev.com)
The dendritic cells can be loaded with various tumor antigens to treat different forms of cancer. (1440dev.com)

Employing multi-color confocal microscopy we observed a dramatic loss of steady state host-type CD103+ DC subset immediately after transplantation, followed by an enrichment of immune-regulatory CD11b+ nc-moDCs. (uni-wuerzburg.de)

In the present paper, the role of bone marrow in normal (physiological) immune response is briefly described. (termedia.pl)

Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. (termedia.pl)

Anatomy28

Organisms14

Diseases62

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment74

Psychiatry and Psychology2

Phenomena and Processes40

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

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Named Groups3

Health Care14

Plasmacytoid Dendr2

Allogeneic hematopoietic stem c2

Monocyte-derived dendritic cells2

Lymphoid5

Human dendritic cells1

Tissues5

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Hematopoietic cell transplantation2

Lymphocytes5

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Liver3

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Langerhans1

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Flt3l3

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Recruitment1