Dendritic cells progenitor blood cells differentiation of cells. Medical search. Frequent questions

Leukemic myoblast differentiation into PDCs occurs as a result of sharing a common hematopoietic precursor to dendritic cells, monocytes, and myeloid cells. (news-medical.net)
These CD1a- leukocytes include (1) LC as evidenced by the presence of Birbeck granules (BG), (2) CD14+ monocytes, and (3) Birbeck granule-negative cells with a dendritic morphology. (ashpublications.org)
Addition of interleukin (IL)-4 to the cytokine cocktail interfered with the development of monocytes and led to a reduction in the overall yield but, on the other hand, resulted in an increased percentage of CD1a+ cells (mean: 24%) among all cells generated. (ashpublications.org)
These cells are closely related to neutrophils and monocytes. (aacrjournals.org)
Mononuclear myeloid cells include terminally differentiated macrophages and dendritic cells (DC), as well as monocytes, which under inflammatory conditions differentiate in tissues to macrophages and DCs. (aacrjournals.org)
Myeloid cells generated under these conditions, although similar to neutrophils and monocytes in morphology and phenotype, have different genomic and biochemical profiles and functional activity. (aacrjournals.org)
The field started changing in the late 1990s when the Gr1 + CD11b + cellular phenotype was suggested as defining the immune-suppressive myeloid cells in spleens of mice and when these cells were shown to be phenotypically similar but functionally distinct from monocytes and neutrophils ( 2, 3 ). (aacrjournals.org)
According to the classical model, it proposes a common myeloid progenitor (CMP) as the precursor of both monocytes/macrophages and DCs. (origene.com)
Graded numbers of CD34+CD38-Lin- HSC from bone marrow and cord blood had been co-cultured with OP9-GFP stromal cells and had been phenotypically assayed just after 2-3 weeks for the presence in the following populations: undifferentiated CD34+ HSC, CD14+HLA-DR+ monocytes and CD15+ granulocytes. (idhinhibitor.com)
As shown in Table 2, the frequency of bone marrow HSC and cord blood HSC differentiating into CD34+ HSC and CD14+ HLA-DR+ monocytes didn't differ substantially. (idhinhibitor.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. (thermofisher.com)

Background: Fms-like tyrosine kinase-3 ligand (Flt3L) is a hemopoietic cytokine and dendritic cell (DC) growth factor that promotes the proliferation and differentiation of progenitor cells into DCs. (utmb.edu)
Her work deals with themes such as Neuroscience and Cytokine, which intersect with Dendritic cell. (research.com)
Her research integrates issues of In vitro, Cytokine and Follicular dendritic cells in her study of Cell biology. (research.com)
A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)
In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)
Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
The importance of proinflammatory T-cells and their cytokine production in patients with autoimmune arthritis has been widely described. (biomedcentral.com)
The aim of this study was to investigate the influence of MSCs on the phenotype, cytokine profile, and functionality of naive and non-naive CD4 + T-cells from healthy donors (HD) and patients with autoimmune arthritis under Th17-cytokine polarizing conditions in an explorative way using a transwell system prohibiting any cell-cell-contact. (biomedcentral.com)
Magnetically isolated naive and non-naive CD4 + T-cells were stimulated under Th17-polarizing proinflammatory cytokine conditions in presence and absence of bone marrow derived mesenchymal stromal cells (MSCs). (biomedcentral.com)
The results of the study indicate significant immunomodulatory properties of MSCs, as under Th17-polarizing conditions MSCs are still able to control T-cell differentiation and proinflammatory cytokine production in both HD and patients with autoimmune arthritis. (biomedcentral.com)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Human Langerhans cells (LC) are CD1a+ dendritic cells (DC) that function as potent antigen-presenting cells for primary and secondary immune responses. (ashpublications.org)
Dendritic cells (DCs) are hematopoietic-derived highly specialized antigen-presenting cells (APCs) that display potent ability to induce both specific immune responses and deletion of potentially autoreactive T cells. (ashpublications.org)
Previous studies have focused intensively on the interactions between HCC cells and a wide variety of immune cells such as Kupffer cells, NK cells, T cells, and several antigen-presenting cells. (biomedcentral.com)
Antigen-presenting cells (APCs) produce and release a broad spectrum of EVs involved in the pathogenesis of atherosclerosis. (bmrat.org)
They are secreted by a wide array of cells, including cardiac myocytes, mature and progenitor endothelial cells, mesenchymal stem cells, immune cells like antigen-presenting cells (APCs), and malignant cells 5 , 6 . (bmrat.org)

In vitro stimulation of these cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha led to their vigorous proliferation and differentiation resulting in the emergence of CD45+/CD68+/CD3-/CD19- /CD56- leukocytes some of which (mean: 12%) express CD1a and exhibit anti-CD4 and anti-major histocompatibility complex (MHC) class II reactivity. (ashpublications.org)
Both C/EBPs command and control molecular programs of proliferation and differentiation into innate immune cells , including various types of myeloid cells. (mdc-berlin.de)

Tolerogenic DCs are essential in maintenance of central and peripheral tolerance through induction of T cell clonal deletion, T cell anergy and generation and activation of regulatory T (Treg) cells. (wikipedia.org)
The HIV/AIDS pandemic in the 1980s then gave a dramatic impulse to the technology of counting specific cells, since it became clear that the quantification of peripheral blood CD4+ T cells was crucial to follow the course of the infection, and eventually for monitoring response to therapy ( 2 ). (frontiersin.org)
95%) from the peripheral blood of healthy adults. (ashpublications.org)
Collected and neutralized eluates were concentrated using tangential flow filtration increasing the concentration of immunoglobulins 10fold as compared to peripheral blood and leading to probably eight times more neutralizing antibodies than in one plasma unit. (bvsalud.org)
The product label for Cancer Peripheral Blood Mononuclear Cells, Frozen has been updated from "Full Collection" to "5-19 million cells" to more accurately reflect the cell number provided (in millions). (stemcell.com)
Start immuno-oncology experiments confidently with a reliable supply of ethically sourced, cryopreserved peripheral blood products from donors diagnosed with multiple myeloma (MM). Options include cancer-sourced frozen peripheral blood mononuclear cells (MNCs or PBMCs) and custom-isolated frozen products such as plasma and serum. (stemcell.com)
Cancer-sourced primary human MNCs are isolated from peripheral blood, leukapheresis, or whole blood samples using density gradient separation or red blood cell lysis and cryopreserved in animal component-free CryoStor® CS10 medium. (stemcell.com)
Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. (andymatthewsphotography.com)
The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
An accurate diagnosis is necessary given that different clinical management is required: the first step in a definitive diagnosis is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and a specific Flow Cytometric Analysis (FCA). (fortuneonline.org)
OMIP-055: Characterization of Human Innate Lymphoid Cells from Neonatal and Peripheral Blood. (spp-innatelymphoidcells.de)
IL-9 and Th9 cells are overexpressed in synovial tissue while proportion of Th9 cells are increased in peripheral blood from RA patients [ 28 ]. (biomedcentral.com)
All experiments performed on human Peripheral blood mononuclear cells in the presence of human SeroBlock ( BUF070A ). (bio-rad-antibodies.com)
Determined by its ability to chemoattract using human peripheral blood eosinophils using a concentration of 50.0-100.0 ng/ml. (peprotech.com)
The secondary antibody repertoire generation is antigen and T-cell dependent and occurs in peripheral lymphoid organs, mainly through the interaction between CD40L (CD154), expressed on activated CD4 + T cells, and CD40, expressed on B cells (see image below). (medscape.com)

DCs are also the only cell type which can activate naïve T cells and induce antigen-specific immune responses. (wikipedia.org)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
Membrane vesicles, actively released by cells, represent a mechanism of intercellular communication that is conserved evolutionarily and involves the transfer of molecules able to induce epigenetic changes in recipient cells. (unicyte.ch)
In vivo R12-31 agonist activity was demonstrated by its ability to induce the formation of intestinal villous microfold cells in mice. (cnrs.fr)
Different groups have established several protocols to induce the differentiation of MSCs into HLCs in vitro . (springer.com)
In the presence of TGF-β, IL-9 may induce differentiation of naive CD4 + T-cells towards Th17 cells, while IL-9 also affects thymus-derived natural Tregs (nTregs) and enhances their suppressive function in vitro [ 26 ]. (biomedcentral.com)
Both in animal models and humans, it has been shown that cell therapy can induce therapeutic angiogenesis, making mesenchymal stromal cell-based therapy one of the most promising therapeutic alternatives. (unav.edu)
CD40L is expressed on activated T lymphocytes and is necessary for T cells to induce B cells to undergo immunoglobulin (Ig) class-switching from immunoglobulin M (IgM) to immunoglobulin G (IgG), immunoglobulin A (IgA), and immunoglobulin E (IgE). (medscape.com)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Dendritic cells (DCs) are bone-marrow-derived immune cells found in blood, lymphoid organs, and various tissue of the body. (origene.com)
Unlike other immune cells, dendritic cells are not just a single entity, but a complex assortment of subtypes with varying functions. (origene.com)
Myeloid derived suppressor cells (MDSC) are immune cells that dampen immune responses. (iospress.com)

Therefore, targeting these cells may represent an attractive therapeutic opportunity. (aacrjournals.org)
Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. (medsci.org)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Dendritic-cell-based therapeutic cancer vaccines. (research.com)
Due to their immunomodulatory properties, mesenchymal stem cells (MSCs) have come into focus as a potential therapeutic concept. (biomedcentral.com)

Unlike enzyme-based solutions, the Macrophage Detachment Solution DXF does not alter cell surface proteins and neutralization is not necessary.Note: The Macrophage Detachment Solution DXF is not suitable for the dissociation of other adherent cell types. (sigmaaldrich.com)
Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage-colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre-T-cell receptor α (pTα) gene transcriptional activation. (ashpublications.org)
The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
The review focuses on the role of APC-derived EVs in regulating the transformation of macrophage phenotype, shaping foam cells, driving autophagy and/or inhibiting apoptosis of Th4 + cells, T regulatory cells, endothelial and smooth muscle cells (SMCs), as well as in facilitating oxidative stress in vasculature. (bmrat.org)
These include macrophage and smooth muscle cell (SMC) phenotypic switching and various inflammatory signaling, such as IL-33/suppression of tumorigenesis 2 (ST2), Ras-Raf-MEK-ERK pathways, and JAK-STAT signaling pathways 14 , 15 , 16 , 17 . (bmrat.org)
Because CD40L is required in the functional maturation of T lymphocytes, dendritic cells, and macrophages, patients with XHIGM also have a variable defect in T-lymphocyte, dendritic cells, and macrophage effector function. (medscape.com)

The TNF-family member Receptor Activator of NF-kappaB (RANK) is known for its role in bone homeostasis and is increasingly recognized as a central player in immune regulation and epithelial cell activation. (cnrs.fr)
A human liver cell atlas reveals heterogeneity and epithelial progenitors. (spp-innatelymphoidcells.de)
Selective expression of constitutively activated STAT6 in intestinal epithelial cells promotes differentiation of secretory cells and protection against helminths. (spp-innatelymphoidcells.de)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism. (umassmed.edu)

Both categories of cells resulting from atypical PDC differentiation are thought to represent two ends of a spectrum of maturation. (news-medical.net)
The maturation pathway involves several stages, with differentiating cells passing through a monocyte-like stage before fully maturing into dendritic cells. (origene.com)
The neutrophil maturation and differentiation pathway termed myelopoiesis takes approximately 12 days. (medscape.com)
There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
As a result, the pathologic cells of LCH have been hypothesized to represent Langerhans cells in a state of arrested maturation. (medscape.com)

The IL-3R plays an important role in hematopoietic progenitor cell growth and differentiation. (bdbiosciences.com)
Product bundle consisting of Skeletal Muscle Cell Growth and Differentiation Media and subculture reagents. (promocell.com)
The Skeletal Muscle Cell Differentiation Starter Package includes growth and differentiation media, as well as subculturing reagents optimized for expansion and subsequent induction of skeletal muscle cell myotube formation. (promocell.com)

Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. (thermofisher.com)

A research team from the University Hospitals of Cleveland Medical Center in western Pennsylvania has discovered the existence of myeloid neoplasms (MNs) that can undergo plasmacytoid dendritic cell (PDC) differentiation. (news-medical.net)
This work builds on existing knowledge that PDCs can be divided into two categories: mature PDC proliferations which result in myeloid neoplasms (MPDMN) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). (news-medical.net)
We demonstrate that tDCs originate from bone marrow progenitors shared with plasmacytoid DCs (pDCs). (stanford.edu)
These subtypes include conventional dendritic cells (cDC1 and cDC2), plasmacytoid dendritic cells (pDCs), monocyte-derived dendritic cells (moDCs), and Langerhans cells (LCs). (origene.com)
It suggests that DCs arise from a common DC progenitor (CDP), which gives rise to pre-DCs that subsequently differentiate into conventional DCs (cDCs) and plasmacytoid DCs (pDCs). (origene.com)
Plasmacytoid dendritic cells (pDCs), are round plasma-shaped cells specialized for the production of large amounts of type I and type III interferon in response to viral infection. (origene.com)

In vitro generated CD1a+, but not CD1a- HPC-derived cells are potent stimulators of the primary mixed leukocyte reaction and, as such, promising candidates for vaccination purposes. (ashpublications.org)
In vitro, conditioned medium from exo-adipocytes promoted HepG2 cell migration and increased tube formation of human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)
Described here are some of the general requirements of in vitro test methods for skin sensitization, and progress that has been made in developing suitable approaches with particular emphasis on the utility of dendritic cell culture systems. (cdc.gov)
B cells of patients with XHIGM are intrinsically normal, in that they can be induced to proliferate and undergo CSR upon in vitro activation by CD40 agonists and appropriate cytokines. (medscape.com)
Our findings were subsequently tested by in vitro experiments, where putative early and later-stage DN1 progenitors from the thymus were purified and their pro- gression into DN2 was measured. (lu.se)

They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)

Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
All experiments performed on human blood gated on live single mononuclear cells, in the presence of 10% human serum. (bio-rad-antibodies.com)

Karolina Palucka mostly deals with Immunology, Immune system, Dendritic cell, Cancer and Cancer research. (research.com)
Karolina Palucka focuses mostly in the field of Immunology, narrowing it down to topics relating to Cytotoxic T cell and, in certain cases, LNCaP. (research.com)
In 2015, the International Union of Immunology Societies (IUIS) Phenotypic Classification for Primary Immundeficiencies named it CD40 ligand deficiency and classified XHIGM under combined immunodeficiency without T cell lymphopenia. (medscape.com)

High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs), including a population of transitional DCs (tDCs) in mice and humans. (stanford.edu)
One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)

GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration. (mayo.edu)
Progenitors and fibroblasts in synovium: Two sides of the same coin? (ewrr2023.com)

Generally, properties of all types of dendritic cells can be highly affected by local micro-environment such as presence of pro or anti-inflammatory cytokines, therefore tolerogenic properties of tol-DCs are often context dependant and can be even eventually overridden into pro-inflammatory phenotype. (wikipedia.org)
In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal thymus displayed a myeloid-related phenotype prompted us to re-examine the developmental origin of thymic DCs, a cell type hitherto considered to represent a homogeneous lymphoid-derived population. (ashpublications.org)
Growing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. (unicyte.ch)
Growth factors may act either in an autocrine or a paracrine fashion and their temporal and spatial concentration modulates the cell phenotype and function. (unicyte.ch)
The cell phenotype is therefore determined by signals that target the cells received within a defined microenvironment. (unicyte.ch)
Our results demonstrated that HCC cell HepG2-derived exosomes could be actively internalized by adipocytes and caused significant transcriptomic alterations and in particular induced an inflammatory phenotype in adipocytes. (biomedcentral.com)
In isolated naive CD4 + T-cells from HD and patients, MSCs suppressed the differentiation of naive towards an effector phenotype while memory and naive cells showed higher percentages in culture with MSCs. (biomedcentral.com)

We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5. (hindawi.com)

This antibody is useful for western blotting and for immunofluorescent labelling of cells for fluorescence microscopy or flow cytometry. (bdbiosciences.com)
1. Incubate (~1 million) cells with ~2 µg of antibody for 45-60 minutes at 4° C. Wash three times in PBS/0.1% sodium azide/1.0% heat -inactivated fetal bovine serum (PBS-FBS). (bdbiosciences.com)
NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
Her Immunotherapy research focuses on Adoptive cell transfer and how it connects with Cell, Cancer, Monoclonal antibody, Antibody and Blockade. (research.com)
The concepts of her Immune system study are interwoven with issues in Antibody and Cell biology. (research.com)
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
My lab is interested in what controls the initiation of antibody gene rearrangement during B cell development. (umassmed.edu)
In order to pin-point when progenitors have acquired the ability to rearrange antibody genes, we are using a novel retroviral substrate assay for V(D)J recombination, utilizing very bright mutants of Green fluorescent protein (GFP). (umassmed.edu)
During the primary antibody response, B cells in the bone marrow produce IgM and immunoglobulin D (IgD) antibodies of low avidity. (medscape.com)
Once IgM B cells are engaged with antigens, B cells start the secondary antibody repertoire generation by undergoing 2 genetic alterations to improve specificity and avidity of the antibody to specific microorganisms. (medscape.com)

Both antibodies recognized human Langerhans cells, previously shown to express RANK, while dermal dendritic cells were poorly labeled. (cnrs.fr)

Granulocytic myeloid cells include populations of terminally differentiated polymorphonuclear neutrophils, eosinophils, basophils, and mast cells. (aacrjournals.org)

Our findings suggest that tDCs are a distinct pDC-related subset with a DC2 differentiation potential and unique proinflammatory function during viral infections. (stanford.edu)
Using single-cell RNA-seq, we identify a myeloid-biased subset within the LT-HSC population (mLT-HSCs) that is much more common amongst aged LT-HSCs and is uniquely primed to respond to acute inflammatory challenge. (biorxiv.org)

Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
The ultrastructural hallmark of the Langerhans cell, the Birbeck granule, was described a century later. (medscape.com)
The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
Although the epidermal Langerhans cell has been presumed to be the cell of origin in LCH, recent studies have called this belief into question. (medscape.com)
Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)

Hematopoietic stem cells in the bone marrow sustain their own maintenance and give rise to "transit amplifying", lineage committed cells that terminally differentiate into distinct, mostly short-lived cell types. (mdc-berlin.de)
Ligation of Flk-2 with Flt3 ligand regulates the growth of hematopoietic stem cells and promotes the survival of primitive hematopoietic progenitor cells with myeloid as well as B lymphoid potential. (biolegend.com)
Regulate the growth of hematopoietic stem cells and promote the survival of primitive hematopoietic progenitor cells. (biolegend.com)
Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute red blood cell mass caused by stimulation of red blood cell production. (nature.com)
Conventional dendritic cells (cDCs), also known as myeloid dendritic cells or classical dendritic cells, are a type of antigen-presenting cell (APC), cDCs originate from hematopoietic stem cells, specifically from the common myeloid progenitor in the bone marrow. (origene.com)
HPCs are immature cells that develop from hematopoietic stem cells, cells that can both self-renew and differentiate into hematopoietic progenitor cells. (andymatthewsphotography.com)
What is a hematopoietic stem cell? (andymatthewsphotography.com)
Hematopoietic stem cells (HSCs) have the capacity to self-renew and the potential to differentiate into all of the mature blood cell types. (andymatthewsphotography.com)
The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. (andymatthewsphotography.com)
Graded numbers of CD34+CD38-Lin- HSC from bone marrow and cord blood were co-cultured with OP9-DL1 stromal cells, and assayed phenotypically IRAK4 medchemexpress immediately after 4-5 weeks for the presence ofFaster and more substantial T-cell differentiation by cord blood hematopoietic stem cellsGiven this reduction in T-lineage prospective in adult bone marrow HSC. (idhinhibitor.com)
Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. (biorxiv.org)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)

We study the development of blood cells and the emergence of leukemia by focusing on the molecular genetics of self-renewal and its connection to differentiation into functional cells of the innate immune system, like macrophages, granulocytes, and dendritic cells. (mdc-berlin.de)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)

Tol-DCs are not lineage specific and their immune-suppressive functions is due to their state of activation and/or differentiation. (wikipedia.org)
Beck's team further determined that the differentiation of PDC's may occur in the presence of monocytic or myeloid DC differentiation, or as a differentiation lineage possessing a predominant myoblast population. (news-medical.net)
Hematopoietic transcription factors (= gene regulatory proteins) concertedly control cell proliferation, lineage commitment, and cell differentiation. (mdc-berlin.de)
It is expressed on early B lymphoid lineage cells in bone marrow, on primitive myeloid progenitors within the BM CD34+ cell population. (biolegend.com)
Hodgkin's disease, ALCL and dendritic cell lines Commonly the assignment of any given hematopoietic cell line to a cell lineage and stage of arrested differentiation, based on its immunological and other phenotypes, does not present any problems. (andymatthewsphotography.com)
Lineage Negative (Lin-) Markers Note A select list of Lin- markers are provided as examples of markers that have been used in the literature to exclude particular lineages of cells in order to help identify the cell type of interest. (andymatthewsphotography.com)
Importantly, the frequency was two times greater in cord blood than in bone marrow HSC when the possible to differentiate into CD5+CD7+ early T cells was evaluated, and this enhanced to a 3-fold distinction when CD5+CD7+CD1+CD4+ committed T-lineage precursors had been scored at a later stage of differentiation. (idhinhibitor.com)

He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)

We also demonstrate that phenotypically and functionally equivalent myeloid precursors devoid of T-cell potential do exist in vivo in the postnatal thymus. (ashpublications.org)
Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses. (stanford.edu)

Single-cell RNA-seq unmasked the existence of two subsets within the LT-HSC population that was apparent upon stimulation but not steady-state. (biorxiv.org)

PDCs are a class of specialized dendritic cells that play a role in immunomodulatory functions and antigen presentation. (news-medical.net)
They examined multiple markers of cell identity (CD22, CD123, CD303, and CD304) to determine the subgroups of PDCs. (news-medical.net)
In both analysis types, all PDCs showed partial to moderate expression of the cell marker CD34 indicating premature PDCs. (news-medical.net)
In humans, pDCs can be identified by the expression of several specific cell surface proteins, including CD123 (the IL-3 receptor alpha chain), BDCA-2, and BDCA-4. (origene.com)

In particular, stem cells are highly sensitive to extracellular signals that play a critical role in mainten- ance of stem cell characteristics, differentiation, and interplay with somatic cells. (unicyte.ch)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
Interleukin-22 protects intestinal stem cells against genotoxic stress. (spp-innatelymphoidcells.de)
Mesenchymal stem cells (MSCs) are multipotent adult stem (or stromal) cells with the capacity of self-renewal and differentiation potential towards several mesodermal linages such as osteogenic, chondrogenic and adipogenic differentiation (more citations) [ 1 ]. (biomedcentral.com)
In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
This is consistent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ stem cells. (jneurosci.org)

Autophagy is an intracellular degradation system that ensures a dynamic recycling of a variety of building blocks required for self-renewal, homeostasis, and cell survival under stress. (hindawi.com)
MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)

Innate lymphoid cell is closely connected to Antigen-presenting cell in her research, which is encompassed under the umbrella topic of Dendritic cell. (research.com)
T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation. (spp-innatelymphoidcells.de)
Targeting Cellular Fatty Acid Synthesis Limits T Helper and Innate Lymphoid Cell Function During Intestisnal Inflammation and Infection. (spp-innatelymphoidcells.de)

Even so, the possible to create into CD15+ granulocytes was greater in cord blood HSC than in bone marrow HSC. (idhinhibitor.com)

PDC progenitors are in common with monocytic and myeloid cell progenitors. (news-medical.net)

In synergy with constantly adapting new single-cell analysis approaches and subsequent accumulating big data collections from these platforms, whole atlases of cell types and cellular and sub-cellular interaction networks are created. (frontiersin.org)
In this review we will discuss how combinations and fusions of different -omic workflows on a single cell level can be used to examine cellular phenotypes, immune effector functions, and even dynamic changes, such as metabolomic state of different cells in a sample or even in a defined tissue location. (frontiersin.org)
We will also shortly discuss how leveraging single cell multi-omic approaches can be used to accelerate cellular biomarker discovery during clinical trials to predict response to therapy, follow responsive cell types, and define novel druggable target pathways. (frontiersin.org)
Single cell proteome approaches already have changed how we explore cellular mechanism in disease and during therapy. (frontiersin.org)
Basal macroautophagy (thereafter referred to as autophagy), a catabolic recycling system in cells, is key to maintaining cellular homeostasis and survival. (hindawi.com)
Using a cell apoptosis assay based on stimulation of a RANK:Fas fusion protein, and a cellular NF-kappaB signaling assay, we showed that R12-31 was agonist for both species. (cnrs.fr)
Here, we explore the role of HCC-derived exosomes in the cellular and molecular conversion of adipocytes into tumor-promoting cells. (biomedcentral.com)

These tolerogenic effects are mostly mediated through regulation of T cells such as inducing T cell anergy, T cell apoptosis and induction of Tregs. (wikipedia.org)

After that, they present these peptides in complexes together with their MHC molecules on their cell surface. (wikipedia.org)
Moreover, tolerogenic DCs may also express various inhibitory surface molecules (e.g. programmed cell death ligand (PDL)-1, PDL-2) or can modulate metabolic parameters and change T cell response. (wikipedia.org)
Isolation of multiple types of molecules (DNA, RNA, or protein) from a single cell simultaneously, stands at the beginning of each approach and having standardized and validated protocols for single cell solutions is surely the foundation of all the herein described approaches. (frontiersin.org)
Classical activation of these cells takes place as a response to strong signals that usually come in the form of pathogen-associated molecular patterns (PAMP) or danger-associated molecular patterns (DAMP) molecules. (aacrjournals.org)
Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
Загальні відомості про імунну систему The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)

We show here that these novel intrathymic DCs are truly myeloid, as they arise from CD34 + early thymic progenitors through CD34 lo intermediates which have lost the capacity to generate T cells, but display myelomonocytic differentiation potential. (ashpublications.org)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)

Besides that, tolerogenic DCs also may produce retinoic acid (RA), which induces Treg differentiation. (wikipedia.org)
Correction: Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138+ Cells. (umassmed.edu)

The main functional characteristic of these cells is their potent ability to suppress various types of immune responses. (aacrjournals.org)
In the present review we focus on the extracellular vesicle-induced epigenetic changes in recipient cells that may lead to phenotypic and functional modifications. (unicyte.ch)
Information exchange between cells coordinates devel- opment and functional interplay in complex organisms. (unicyte.ch)

The group concluded by stating that acute leukemia with PDC differentiation and typical cases of acute myeloid leukemia, NOS, or acute myelomonocytic leukemia are indistinguishable. (news-medical.net)
We used primary acute myeloid leukemia (AML) samples and human AML cell lines to investigate the regulatory mechanisms of autophagy and its role in AML differentiation. (hindawi.com)

We apply targeted mouse genetics in combination with experimental hematopoiesis, genetic engineering of hematopoietic cells, human iPSC hematopoietic differentiation, proteomics and biochemistry. (mdc-berlin.de)
Together with the associated research group of Dr. Alexander Mildner we perform ATACseq, ChIPseq and single cell analysis to disclose fundamental epigenetic mechanisms in hematopoiesis, homeostasis, autoimmune diseases, and in leukemogenesis. (mdc-berlin.de)
Hematopoiesis in the embryo As the embryo continues to develop, the hematopoiesis process moves to the liver, the spleen, and bone marrow, and begins producing other types of blood cells. (andymatthewsphotography.com)
In adults, hematopoiesis of red blood cells and platelets occurs primarily in the bone marrow. (andymatthewsphotography.com)

The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
The aim of this study is to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. (unav.edu)
Mesenchymal stromal cells (MSCs) have shown benefit in other inflammatory diseases. (unav.edu)

Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells. (spp-innatelymphoidcells.de)

Taken together, these data challenge the current view that the thymus is colonized by a lymphoid-restricted progenitor and provide evidence that a more immature precursor population with lymphoid and myelomonocytic potential is actually seeding the human postnatal thymus. (ashpublications.org)
This proposal is further supported by the finding that development of thymic DCs and T cells is linked via a common precursor at an early stage of thymocyte development. (ashpublications.org)

Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and oxygen supply to the tumor cells through the decrease of the vascular network and the avoidance of new blood vessels formation. (mdpi.com)
However, in cancer, myeloid cells are largely converted to serve a new master-tumor cells. (aacrjournals.org)
Thus, it is clear that the crosstalk between tumor cells and their surrounding microenvironment is crucial for HCC development. (biomedcentral.com)

For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)

Her Immunotherapy research is multidisciplinary, incorporating elements of Blockade, Adoptive cell transfer and Sarcoma. (research.com)
Her study explores the link between Tumor microenvironment and topics such as Immunotherapy that cross with problems in Cell biology. (research.com)
Her Immunity study combines topics in areas such as Cancer cell, Blockade, Antigen, Cell biology and Immunotherapy. (research.com)

Through them, the cells modify their microenvironment and the behavior of neighboring cells. (frontiersin.org)
Exosomes, released by malignant cells, represent a novel way of cell-cell interaction and have been shown to play an important role in cancer cell communication with their microenvironment. (biomedcentral.com)
Our results provide new insights into the concept that tumor cell-derived exosomes can educate surrounding adipocytes to create a favorable microenvironment for tumor progression. (biomedcentral.com)
Tumor behavior is determined by not only the malignant potential of tumor cell itself but also the signals from its microenvironment. (biomedcentral.com)
An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)

Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)

During the 1980s and early 1990s, work from the laboratories of Diana Lopez, Jim Talmadge, M. Rita Young, and Hans Schreiber demonstrated that various types of myeloid cells could inhibit immune function in cancer. (aacrjournals.org)

Furthermore, activation of autophagy allows to extend cell survival when exposed to different types of stressors such as starvation or cytotoxic drugs. (hindawi.com)
cDC1: These cells are very effective at presenting antigens to CD8+ T cells, a type of cytotoxic T cell that can kill infected or cancerous cells. (origene.com)
Innate immunity resides in the skin, mucous membranes, polymorphonuclear (PMN) cells, complement system, and a select group of cells that possess cytotoxic capabilities. (medscape.com)
Karolina Palucka interconnects Epitope and Cytotoxic T cell in the investigation of issues within Virology. (research.com)

Combined signaling through interleukin-7 receptors and Flt3 selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. (biolegend.com)
They are known to secrete interleukin-12, as well as type I and type III interferons, and are believed to promote Th1 helper T cell and natural killer responses. (origene.com)

Also, the multidisciplinary coordination exercise needed to develop this clinical trial protocol will undoubtfully be useful to conduct academic clinical trials in the field of cell therapy in the near future. (unav.edu)
Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)

With the wide introduction of flow cytometry in the early 70-ies markers and subsequent cell types have evolved but it was only in the last decade that the introduction of single cell transcriptome sequencing, high dimensional cytometry and imaging cytometry started revolutionizing the way we interrogate biological samples. (frontiersin.org)
In addition, my lab studies the process of developmental committment to the B cell lineages, using 7-color flow cytometry on a state-of-the-art 3 laser FACS. (umassmed.edu)

2021. Stem Cell Reports. (biolegend.com)
2021. Cell Metab. (biolegend.com)
2021. Cell Reports. (biolegend.com)

Six of the seven cases exhibited intermediate subpopulations, which evidence differentiation from a population of leukemic myeloblasts. (news-medical.net)
After an incubation period of 6 days, the proportions of the T-cell subpopulations TEMRA (CD45RA + CD27 − ), memory (CD45RA − CD27 + ), effector (CD45RA − CD27 − ) and naive cells (CD45RA + CD27 + ) were determined. (biomedcentral.com)

Anatomy72

Organisms10

Diseases3

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Monocytes12

Cytokine10

Antigen-prese6

Proliferation and differentiation2

Peripheral15

Induce9

Macrophages and dendritic cells1

Immune cells3

Therapeutic5

Macrophage6

Epithelial5

Maturation6

Growth and differentiation3

Lymphocytes3

Plasmacytoid6

Vitro5

Endothelial cells1

Mononuclear3

Immunology3

Heterogeneity2

Fibroblasts2

Phenotype7

Neutrophil1

Antibody10

Dermal1

Mast cells1

Subset2

Langerhans8

Hematopoietic stem14

Innate immune2

Lineage7

Eosinophils1

Precursors2

Subsets1

PDCs4

Stem cells7

Self-renewal2

Lymphoid cell3

Granulocytes1

Myeloid cell1

Cellular7

Apoptosis1

Molecules6

CD342

Induces2

Functional3

Acute myeloid2

Hematopoiesis4

Stromal cells3

Characterization1

Precursor2

Tumor cells3

Pathway1

Immunotherapy3

Microenvironment5

Kinetics1

Various types of myeloid1

Cytotoxic4

Interleukin2

Therapy2

Flow cytometry2

20213

Subpopulations2