Dendritic cells induce antitumor immune responses antigen of tumor. Medical search. Frequent questions

In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
In hematological malignancies, tumor-derived EVs might reprogram the bone marrow environment, suppress antileukemic immunity, mediate drug resistance and interfere with immunotherapies. (nature.com)
EVs collected from the serum of leukemic samples might correlate with disease stage, drug-/immunological resistance, or might correlate with antileukemic immunity/immune response. (nature.com)
Here, we illustrated that myeloid cells in K14HPV16/H2b mice possess potent immunosuppressive activity toward antigen-presenting cells and CD8 + T cells, dampening antitumor immunity. (nih.gov)
These results established immunosuppressive myeloid cells in lymphoid organs as an HPV + cancer-induced means of circumventing tumor immunity that will require targeted abrogation to enable the induction of efficacious antitumor immune responses. (nih.gov)
Cancer progression is mainly driven by the expansion of tumor cells, but tumor microenvironment and anti-tumor immunity may also play a role. (amegroups.org)
These effects are named abscopal effects and appear to be immune mediated, particularly by adaptive immunity. (amegroups.org)
As a consequence, they cannot directly activate the specific CD4+ T cell-mediated tumor immunity, which is essential for the development of adaptive immune responses. (amegroups.org)
Thus, monocyte depletion by gemcitabine administration reduced the generation of these DC and increased vaccine-induced immunity, which rejected about 20% of LLC-OVA and B16-OVA tumors, which are non-responders to anti-PD-1. (unav.edu)
We studied the in vivo requirement of cross-talk between cDCs and pDCs for eliciting antitumor immunity against in situ released tumor antigens in the absence or presence of the Toll-like receptor (TLR) 9 agonist CpG. (pasteur.fr)
The present study shows that cDCs are indispensable for cross-presentation of ablation-released tumor antigens and for the induction of long-term antitumor immunity. (pasteur.fr)
Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. (biomedcentral.com)
OVs armed with GM-CSF (such as T-VEC and Pexa-Vec) or other immunostimulatory genes, induce potent anti-tumor immunity in both animal models and human patients. (biomedcentral.com)
Coadministration with a HDAC inhibitor inhibits innate immunity transiently to promote infection and spread of OVs, and significantly enhances anti-tumor immunity and improves the therapeutic index. (biomedcentral.com)
Combination with cyclophosphamide further induces ICD, depletes Treg, and thus potentiates antitumor immunity. (biomedcentral.com)
The antitumor immunity helps eliminate the uninfected cancer cells in primary and metastatic nodules, and enforce micrometastases in dormant state. (biomedcentral.com)
a Mechanisms by which oncolytic viruses (OVs) stimulate antitumor immunity. (biomedcentral.com)
Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity. (rochester.edu)
This is a normal part of the second wave of cell mediated immunity. (shu.edu)
2015). "Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity" Nature 521(7550): 99-104. (bioxcell.com)
Whereas cancers grow within host tissues and evade host immunity through immune-editing and immunosuppression, tumours are rarely transmissible between individuals. (bioxcell.com)
How such tumour-eradicating immunity is initiated remains unknown, although elucidating this process could provide the basis for inducing similar responses against naturally arising tumours. (bioxcell.com)
These results reveal that tumour-binding allogeneic IgG can induce powerful antitumour immunity that can be exploited for cancer immunotherapy. (bioxcell.com)
However, alum hardly induces T helper 1 (Th1) immune responses that are required for anti-tumor immunity. (elsevierpure.com)
In vivo study demonstrated that Cu- and Zn-AMSs markedly induced anti-tumor-immunity and enhanced CD 4 + and CD 8 + T cell populations in splenocytes of mice. (elsevierpure.com)
set out to explore the role of different myeloid cell populations in the regulation of T cell immunity and PD-1/PD-L1 blockade. (acir.org)
Taken together, our data demonstrated that HSP70 expression on apoptotic tumor cells stimulated DC maturation and DC with phagocytosis of apoptotic tumor cells expressing HSP70 in early phase of apoptosis more efficiently induced tumor-specific CTL responses and immunity than DC with phagocytosis of apoptotic tumor cells in late phase of apoptosis. (usask.ca)
Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. (elifesciences.org)
As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)
In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)
Finally, the innate immunity or adaptive immunity is stimulated leading to regulation and inhibition of tumor growth. (thno.org)
On the basis of recent advances in the understanding of antitumor immunity, we designed a three-step approach to in situ immunization to lymphoma: (i) inducing immunogenic tumor cell death with the chemotherapeutic drug doxorubicin. (aacrjournals.org)
In these cases, the release of neutrophil granules and engagement of antitumor immunity may play an important role in eliminating residual disease. (bioxcell.com)
Alexandra Gabriela Barros Ferreira defends her Ph.D. thesis "Restoring antitumor immunity with dendritic cell reprogramming strategies" on Friday, 17 November, 2023. (lu.se)
My Ph.D. studies have focused on restoring anti-tumor immunity with dendritic cell reprogramming strategies. (lu.se)
Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. (medsci.org)

However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Thus, ICIs and sufficient antigen combinations into the tumor microenvironment (TME) is important to produce strong tumor-specific adaptive immune responses. (bvsalud.org)
Vaccination alone or in combination with anti-PD-1/anti-CTLA4 did not elicit tumor regression nor increase CD8 + T cells in the tumor microenvironment (TME), suggesting the presence of immune-suppressive barriers. (nih.gov)
3. Effects of ICD Hallmarks on Immune Cells in Tumor Microenvironment The definition of apoptosis like a non-immunogenic, but silent or tolerogenic, physiological process has been progressively questioned after ICD finding. (antiviralbiologic.com)
The targeted intraoperative radiotherapy (TARGIT) method, using INTRABEAM ® , could reduce tumor recurrence, modifying the wound microenvironment, and eradicating residual tumor cells when applied immediately after surgery procedure. (amegroups.org)
Although chemotherapy (CT) and traditional fractionated radiation have been described as immunosuppressive ( 2 ), recent data suggests that RT can modulate anti-tumor immune responses ( 3 ), modifying tumor and its microenvironment ( 4 ). (amegroups.org)
Besides the direct effects of radiation in reducing viable cancer cells, RT may induce modifications on the local microenvironment that can affect tumor development ( 5 ). (amegroups.org)
These changes in the tumor microenvironment may lead to tumor cell death and eventually to a long-term memory immune response against tumor antigens. (drugdiscoverynews.com)
There is an extensive body of evidence that demonstrates that modulating the tumor microenvironment is critical to a successful outcome in cancer immunotherapy," added Dr. Sudhir Agrawal, president of Research at Idera. (drugdiscoverynews.com)
Integrative analyses of similar to 500 mice and similar to 1,000 patients revealed a common MAPK-MYC genetic pathway that accelerated time to progression from precursor states across genetically heterogeneous MM. MYC-dependent time to progression conditioned immune evasion mechanisms that remodeled the BM microenvironment differently. (unav.edu)
In vivo , GC induced a potent response of type I IFN and upregulated genes associated with STING signaling within the tumor microenvironment (TME). (biorxiv.org)
Local administration or OV mediated-expression of ligands for Toll-like receptors can rescue the function of tumor-infiltrating CD8 + T cells inhibited by the immunosuppressive tumor microenvironment and thus enhances the antitumor effect. (biomedcentral.com)
Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)
Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy. (rochester.edu)
Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment. (rochester.edu)
In the tumor microenvironment, tumor-associated macrophages (TAMs) display an array of phenotypes beyond the M1/M2 paradigm, ranging from antitumoral to immunosuppressive, proangiogenic, immunomodulatory and tissue-remodeling phenotypes ( 7 - 9 ). (frontiersin.org)
Another myeloid population in the tumor microenvironment (TME) are DCs, that originate from different precursors and display various phenotypes, ranging from immunosuppressive monocyte-derived DCs (Mo-DCs) to immunocompetent cDC1 and cDC2 subsets ( 22 ). (frontiersin.org)
Costimulatory and co-inhibitory ligand-receptor interactions between a T cell and a dendritic cell, a tumor cell, and a macrophage, respectively, in the tumor microenvironment. (shu.edu)
A series of studies have revealed that exosomes-mediated intercellular transfer of proteins, nucleic acids, and metabolites plays a crucial role in the initiation and progression of HCC, hypoxia and angiogenesis, chemotherapy sensitivity, and cell death mode and regulates the immune microenvironment. (hindawi.com)
We laid particular focus on those researches that reveal how exosomes regulate the tumor immune microenvironment (TIME) and how exosomal cargos affect the progression of HCC. (hindawi.com)
Besides, we emphasize some prospective directions to achieve a more accurate and complete analysis of the HCC immune microenvironment. (hindawi.com)
This is associated with the formation of the HCC immunosuppressive microenvironment which seriously hinders the antitumor effect of immune checkpoint inhibitors, attenuating the efficacy of immunotherapy [ 2 ]. (hindawi.com)
HCC-derived exosomes participate in changing tumor progression by regulating the tumor microenvironment and tumor immune status [ 14 , 15 ]. (hindawi.com)
Although there is ample evidence that the chemotherapeutic drugs trigger an immune response, the efficient tumor rejection or regression is not guaranteed probably due to the massive immunosuppression within the tumor microenvironment. (thno.org)
This work represents a novel approach for cancer immunotherapy by integrating nanotechnology and platinum-based therapeutics which not only efficiently exerts the chemotherapeutic cytotoxic effect on tumor cell but also restores immune response of immunological cells within the tumor microenvironment. (thno.org)
First, the stimulatory or death signals are released from apoptotic tumor cells into the tumor microenvironment. (thno.org)
During the early phase of tumor development, immune cells could spontaneously infiltrate into the tumor microenvironment to evoke an immune response and fight against the growth of the tumor. (thno.org)
In situ immunization aims at generating antitumor immune responses through manipulating the tumor microenvironment. (aacrjournals.org)
To this end, we assessed the tumor immune microenvironment using transcriptomics analysis on tumor tissues. (snmjournals.org)
Following stimulation, NKT cells lead to activation of both innate and adaptive immune cells in the tumor microenvironment. (msdmanuals.com)

Author information Abstract Immunotherapy is a growing therapeutic strategy in oncology based on the stimulation of innate and adaptive immune systems to induce the death of tumour cells. (ebi.ac.uk)
Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. (nih.gov)
In recent years, immunotherapy to activate anti-cancer host immune cells to kill tumors has become a new area of research for the treatment of prostate cancer. (asmepress.com)
As an important component of immunotherapy, cancer vaccines have a unique position in the precise treatment of malignant tumors. (asmepress.com)
In the past decades, immunotherapy has been used to treat prostate cancer through anti-tumor effects driven by immune response. (asmepress.com)
As an important part of immunotherapy, cancer vaccines have unique and significant advantages against prostate cancer, including monocyte vaccines and dendritic cells,accines, viral vaccines, peptide vaccines and DNA/mRNA vaccines [9]. (asmepress.com)
Sipuleucel-T (Provenge®, Dendreon, USA) is an active immune cell-based immunotherapy that induces an immune response against prostate acid phosphatase (PAP). (asmepress.com)
instead of targeting tumor cells, the goal of immunotherapy is to augment and expand the immune system's intrinsic antitumor response. (frontiersin.org)
In ICB-refractory MM models, increasing CD8(+) T cell cytotoxicity or depleting T-reg cells reversed immunotherapy resistance and yielded prolonged MM control. (unav.edu)
Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials. (unav.edu)
Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)
Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)
Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. (nwbio.com)
However, to date, the role for reovirus-induced immunotherapy against MM, and the impact of the bone marrow (BM) niche, have not been reported. (bmj.com)
Next, we explored the potential for reovirus-induced immunotherapy using human co-culture models to mimic the myeloma-supportive BM niche. (bmj.com)
Conclusion These data highlight the importance of reovirus-induced immunotherapy for targeting MM cells within the BM niche and suggest that combination with agents which boost antitumor immune responses should be a priority. (bmj.com)
Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma. (rochester.edu)
Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)
As shown by multiplex tissue immunofluorescence and intravital microscopy, combined immunotherapy treatments enhance T cell infiltration and the intratumoral performance of T lymphocytes. (unav.edu)
Unlike chemotherapy or radiation which directly attack tumors, immunotherapy helps train the immune cells to recognize markers on cancer cells and boosts their killing capability. (theusaknowledge.net)
PD-1 axis blockade has been proven time and again to be a successful immunotherapy for a wide variety of cancer types, and it is assumed to work by reversing or preventing T cell exhaustion. (acir.org)
Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)
Finally, we will provide an overview of how utilizing an understanding of T cell metabolism may inform strategies to alter the TME or enhance T cell metabolism to strengthen the immunotherapy arsenal. (elifesciences.org)
With a better understanding of molecular details in tumor immunology and tumor biology, tailored cancer immunotherapy is considered as a promising strategy for cancer treatment. (thno.org)
Cancer immunotherapy approaches designed to surmount tumor suppression take into consideration the pivotal molecular processes involved in the activation of immune system. (thno.org)
2016). "Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses" Nat Med. (bioxcell.com)
Immunotherapy can fail in patients with cancer when certain cancer cells can hide from the immune system. (lu.se)
However, cDC1 can be compromised in cancer patients and some cancer cells lack these antigen-presenting proteins on their surface, impacting immunotherapy response. (lu.se)
When used in combination with radiotherapy and immunotherapy, they even help control 'cold tumors' that are otherwise almost completely impervious to immune attack. (ludwigcancerresearch.org)
The researchers found that, with ZnCDA treatment, a mouse model of pancreatic cancer became vulnerable to anti-PD-L1 immunotherapy, extending the survival of tumor-bearing mice. (ludwigcancerresearch.org)
The researchers also showed that ZnCDA could traverse the blood-brain barrier and accumulate in gliomas, where it drew T cells into tumors and, when combined with anti-PD-L1 immunotherapy, prolonged the survival of treated mice. (ludwigcancerresearch.org)
DENIM (DENdritic cell Immunotherapy for Mesothelioma) is an open-label, randomised, phase II/III study in 230 adults with pleural mesothelioma, to assess the efficacy and anti-tumour activity of MesoPher as maintenance treatment after chemotherapy. (amphera.nl)

The innate immune system includes macrophages, dendritic cells (DC), and natural killer (NK) cells, which respond quickly to an immunological threat. (nature.com)
Tumor Associated Antigens (TAAs) may suffer from an immunological tolerance due to expression on normal cells. (bvsalud.org)
Latest scientific trials showed the efficacy of in situ DC vaccination in achieving immunological and scientific responses. (antiviralbiologic.com)
recently introduced SLCO2A1 the concept of transmission 1 to refer to the activation of cell death pathways as an initiating immunological event, according to the ICD definition [6] Flumazenil (Number 1). (antiviralbiologic.com)
In this way, ITI's vaccines (DNA or RNA) have the potential to utilize the body's natural biochemistry to develop a broad immune response including antibody production, cytokine release, and critical immunological memory. (biospace.com)
Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
When it comes to tumors, Immunological diagnosis of foreign antigens consists of humoral mechanisms like antibodies and cellular mechanisms. (techsling.com)
A lot goes on in immunological diagnosis for tumors so let's dive right in. (techsling.com)
That just about covers immunological diagnosis in tumors although it is a rather large field. (techsling.com)
Additionally, induced co -expression of luciferase, EGFP, and the melanosomal antigen gp100 facilitates studies on the underlying immunological mechanisms. (unav.edu)
In an earlier phase I/II study of MesoPher the product was very well tolerated and clinically active, with an immunological (T-cell) response induced in all patients. (amphera.nl)

For optimal delivery, the adjuvants can be encapsulated in nanoparticles, liposomes, or immunostimulatory complexes specifically targeting DCs [61,62,63], whereas to guarantee a sufficient availability of immunogenic TAAs, in situ vaccination can be combined with ICD-inducing therapeutic modalities, such as doxorubicine or radiotherapy. (antiviralbiologic.com)
The tumor-associated derived antigens (TAAs) released to the tumor periphery can be captured by DCs. (amegroups.org)
The antigens may be cell surface proteins or maybe intracellular proteins like TAAs. (techsling.com)
These cells take up tumor-associated proteins, process them and then present the TAAs to T cells to stimulate the CTL response against the tumor. (techsling.com)
The patient's immature DCs are then loaded with PheraLys to create activated, mature DCs, capable of presenting key tumour-associated antigens (TAAs) to the immune system. (amphera.nl)
T cells carry out immunologic surveillance, then proliferate and destroy newly transformed tumor cells after recognizing TAAs. (msdmanuals.com)
These antigens may be cell surface proteins or may be intracellular proteins (eg, TAAs) that are expressed on the surface in combination with class I major histocompatibility complex (MHC) molecules. (msdmanuals.com)

Mice were treated with cisplatin, and human cancer cells were exposed to inflammatory cytokines, to confirm increased PD-L1 and major histocompatibility complex (MHC) I expression by tumor cells or dendritic cells. (bvsalud.org)
These cells can produce immunosuppressive cytokines and the recruitment of inhibitory and regulatory cell types, decrease expression of antigens, lose expression of MHC class I molecules, have an aberrant antigen processing, cause anergy or deletion of T cells, and generate the dysfunction of dendritic cells (DCs) ( 5 - 8 ). (amegroups.org)
Cytokines, cancer vaccines, adoptive cell transfers, and especially checkpoint inhibitors constitute valuable elements in the immunotherapeutic armamentarium. (frontiersin.org)
The CD56 bright population produces immunoregulatory cytokines, including interferon-γ (IFN-γ), tumor necrosis factor-beta (TNF-B), tumor necrosis factor-α (TNF-α), granulocyte macrophage-colony stimulating factor (GMCSF), IL-10, and IL-13 ( 4 ). (frontiersin.org)
However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
Killed Propionibacterium acnes (P. acnes) exerts immunomodulatory effects by increasing the phagocytic and tumoricidal activities of macrophages, promoting DC maturation, inducing pro-inflammatory cytokines production and increasing the humoral response to different antigens. (unifesp.br)
These cells are referred to as antigen-presenting cells and are supported by cytokines. (techsling.com)
Cytokines affect the growth of all blood cells as well as other cells that help the boy's immune and inflammation responses. (techsling.com)
The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
Pathogen clearance is mediated by mechanisms such as phagocytosis, respiratory burst with the production of ROS and RNS and release of bacteriostatic peptides, but also through the cell-extrinsic initiation of inflammation via the release of proinflammatory cytokines and chemokines ( 24 ). (frontiersin.org)
High doses of cytokines like IL-2 can be administered to boost anti-cancer immune activity. (theusaknowledge.net)
Cytokines like IL-2 stimulate activity and growth of T-cells, NK cells and macrophages - key players in anti-tumor immune response. (theusaknowledge.net)
DCneu displayed an upregulation of immunologically important molecules and inflammatory cytokines expression such as IL-6 that partially mediated conversion of the regulatory T (Tr) cell suppression. (usask.ca)
For example, antibodies specific to tumor antigens, adoptively transferred immune cells, therapeutic vaccines, and recombinant cytokines effectively boost the host immune system to recognize tumor cells as pathogens and eliminate them [ 1 - 3 ]. (thno.org)
However, the limitations were found in clinical application that (1) iNKT cells failed to produce cytokines and proliferate when additional doses of α-GalCer were given by systemic route and (2) poor hydrophilicity of α-GalCer. (tmu.edu.tw)
Cytokines, antigen-specific antibodies and subtype antibodies of serum and nasal wash fluid will be analyzed in order to investigate the enhancement of the Th1/Th2 immune-modulatory pathway. (tmu.edu.tw)
NKT cells are innate-like T cells that quickly respond to antigenic stimulation and rapidly produce large amounts of cytokines and chemokines. (msdmanuals.com)

The efficacy of such htcPep was assessed in C57BL/6 mice injected with syngeneic melanoma B16F10 or lung TC1 tumor cell lines, in combination with metronomic chemotherapy and immune checkpoint inhibitors. (bvsalud.org)
Mathematical model approach to describe tumour response in mice after vaccine administration and its applicability to immune-stimulatory cytokine-based strategies. (ebi.ac.uk)
This type of mathematical approaches may be helpful to maximize the information obtained from experiments in mice, reducing the number of animals and the cost of developing new antitumor immunotherapies. (ebi.ac.uk)
Leveraging a transgenic mouse model of HPV-derived cancers, K14HPV16/H2b, we demonstrated that a potent nanoparticle-based E7 vaccine, but not a conventional "liquid" vaccine, induced E7 tumor antigen-specific CD8 + T cells in cervical tumor-bearing mice. (nih.gov)
ROCKVILLE, Md.--( BUSINESS WIRE )-- Immunomic Therapeutics , Inc. will present data on its investigational nucleic acid platform, UNITE (UNiversal Intracellular Targeted Expression), that elicits potent immune responses and inhibits tumor growth when used with its investigational vaccine, ITI-4000, in mice. (biospace.com)
We report that the ITI-4000 induced IFNγ- and TNFα-producing effector memory CD4 T and CD8 T cells, with complete rejection of EBNA1-expressing tumors observed in 50% of mice. (biospace.com)
Mice rejecting tumors were protected from rechallenge with CT26-EBNA1, demonstrating that antigen-specific memory was induced in these animals. (biospace.com)
To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-kappa B, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. (unav.edu)
Depletion of pDCs or applying this model in type I IFN receptor-deficient mice abrogated CpG-mediated responses. (pasteur.fr)
We have identified a survivin peptide mimic containing human MHC class I epitopes and a potential class II ligand that induces a potent antitumor response in C57BL/6 mice with GL261 cerebral gliomas. (elsevierpure.com)
This peptide is able to elicit both CD8+ CTL and T helper cell responses in C57BL/6 mice. (elsevierpure.com)
We show that treatment of the mice with a combination of anti-CTLA-4 + anti-PD1 mAbs results in partial clearance of the tumor with an improvement in survival. (unav.edu)
Here we find that allogeneic tumour rejection is initiated in mice by naturally occurring tumour-binding IgG antibodies, which enable dendritic cells (DCs) to internalize tumour antigens and subsequently activate tumour-reactive T cells. (bioxcell.com)
T cells from these patients responded vigorously to autologous tumour antigens after culture with allogeneic-IgG-loaded DCs, recapitulating our findings in mice. (bioxcell.com)
Consistent with in vitro observations, in mice with PD-L1-deficient MC38 colorectal tumors where only host cells were the source of PD-L1, antibody blockade of both PD-1/PD-L1 and PD-L1/B7-1 interactions reduced tumor growth, while blocking only PD-L1/B7-1 interactions slightly accelerated tumor growth due to an increased availability of PD-L1. (acir.org)
In animals bearing PD-L1-deficient MC38 tumors, mice with total PD-L1 knockout (KO) controlled tumor growth better than wild-type (WT) mice, as observed previously. (acir.org)
PD-L1 ΔDC mice controlled tumors as effectively as PD-L1 KO mice, while PD-L1 ΔMF mice were not effective, reducing tumor growth only slightly compared to WT controls. (acir.org)
Similar results were observed in mice bearing PD-L1-sufficient tumors. (acir.org)
Treating tumor-bearing PD-L1 ΔDC mice with anti-PD-L1 antibodies that blocked either only the PD-L1/B7-1 interactions or both the PD-L1/B7-1 interactions and PD-L1/PD-1 interactions did not further enhance tumor control. (acir.org)
Analysis of T cell responses at day 10 post inoculation revealed increased frequency and number of CD8 + T cells within PD-L1-deficient MC38 tumors of PD-L1 KO and PD-L1 ΔDC mice compared to WT controls. (acir.org)
Wildtype FVB/N mice immunized with DCneu induced stronger HER-2/neu-specific humoral and cellular immune responses compared to plasmid DNA immunized mice. (usask.ca)
Furthermore, mice immunized with DCneu remained completely protected from tumor challenge compared to partial or no protection observed in DNA immunized mice in two tumor animal models. (usask.ca)
In FVBneuN transgenic mice, which develop spontaneous breast tumors at 4-8 months of age, DCneu significantly delayed tumor onset when immunization conducted in mice at a younger age. (usask.ca)
We found that DC with phagocytosis of MCA/HSP in the early phase of apoptosis expressed more peptide-major histocompatibility class (pMHC) I complexes, stimulated stronger cytotoxic T lymphocytes (CTL) responses and induced greater immune protection against MCA tumor cell challenge, compared to mice immunized with DC that phagocytosed MCA/HSP cells in the late phase of apoptosis. (usask.ca)
Wpep-DGL/Pt showed potent antitumor efficacy in MDA-MB-231 cells tumor-bearing nude mice with a deficient immune system, demonstrating targeted delivery of chemotherapeutics and the resultant cytotoxicity. (thno.org)
Furthermore, in immunocompetent mice bearing 4T1 cells tumors, Wpep-DGL/Pt activated immune cells and induced cell death proving their dual function of chemotherapeutic and immunomodulatory efficacy. (thno.org)
In mice, this three-step therapy induced CD4- and CD8-dependent systemic immune responses that enhanced T-cell infiltration into distant tumors, leading to their eradication and significantly improving survival. (aacrjournals.org)
During the second year, mice will be immunized with α-GalCer-incorporated liposome vaccine via intravenous or intranasal routes and T cell activities will be analyzed. (tmu.edu.tw)
For the last year, mice will be immunized and the activities of cytotoxic T cells and NK cells will be illustrated. (tmu.edu.tw)
Here, RT was combined with curcumin to investigate how curcumin affects RT-induced abscopal effects in mice with bilateral CT26 colorectal tumors. (mdpi.com)
The nanoparticles developed by the Lin lab release a drug that targets macrophages and can activate potent antitumor immune responses that extend the survival of mice bearing a variety of tumors," said Chicago Center Co-director Weichselbaum. (ludwigcancerresearch.org)

In particular, the H-2Db-specific scaffold significantly potentiated the peptides' immunogenicity and control of tumor growth was comparable to wt peptide in a therapeutic setting. (bvsalud.org)
However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune response-enhancing treatments involving therapeutic vaccination against these viral neoantigens. (nih.gov)
Harnessing the immune system for therapeutic benefit. (mayo.edu)
Dr. Kankeu Fonkoua's major research focus is understanding ways to integrate and exploit the synergy among therapeutic modalities to reprogram or boost the host's anti-tumor immune response. (mayo.edu)
Dr. Kankeu Fonkoua's research efforts aim to harness the power of the immune system to develop safer and more-effective therapeutic strategies for patients with gastrointestinal and hepatobiliary cancers. (mayo.edu)
Therapeutic intervention aims to reverse tumor-induced NK cell suppression and sustain NK cells' tumorlytic capacities. (frontiersin.org)
Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
ITI's UNITE platform could potentially have broad therapeutic applications in oncology, including viral antigens, cancer antigens, neoantigens, and antigen-derived antibodies as biologics. (biospace.com)
Moreover, DC transfer studies revealed that merocytic cDCs and CD8α(+) cDCs were most susceptible to pDC help and subsequently promoted tumor-free survival in a therapeutic setting. (pasteur.fr)
Synthesized from chitosan and galactose, GC is a new chemical entity that significantly enhances the immune-stimulating properties of its parental material, chitosan, making it a promising therapeutic agent. (biorxiv.org)
Our findings demonstrate GC's unique ability to activate STING and stimulate a broad type I IFN response which holds therapeutic promise in generating antitumor and antiviral immunities. (biorxiv.org)
Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
Upon mRNA intratumoral injections in the transplantable mouse cancer models CT26, MC38, and B16OVA, potent therapeutic effects were observed following repeated injections into the tumors. (unav.edu)
Immune checkpoint-inhibitor combinations are the best therapeutic option for advanced hepatocellular car-cinoma (HCC) patients, but improvements in efficacy are needed to improve response rates. (unav.edu)
The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)
Furthermore, the therapeutic efficacy of α-GalCer-incorporated liposome against tumor will be investigated. (tmu.edu.tw)
OCTOBER 27, 2022, NEW YORK - A Ludwig Cancer Research study has developed a novel nanotechnology that triggers potent therapeutic anti-tumor immune responses and demonstrated its efficacy in mouse models of multiple cancers. (ludwigcancerresearch.org)
The researchers also tested the therapeutic potential of ZnCDA against two types of tumors, pancreatic cancer and glioblastoma. (ludwigcancerresearch.org)
These molecules are excellent therapeutic targets in order to restore the immune surveillance in cancer patients, which has been demonstrated in recent years by the impressive clinical efficacy of immune checkpoint inhibitors, such as PD-1 inhibitors. (apogenix.com)

By isolating immature and immunosuppressive cells from a patient's blood, transforming them into potent immune-stimulatory cells in the laboratory, and then injecting them back directly into the patient's bloodstream or tumor, these novel therapies have the potential to induce long-term tumor-specific durable responses. (mayo.edu)
The antitumor activity is the result of intratumoral administration of IMO-2125 in combination with an inhibitor of the immunosuppressive enzyme, indoleamine-pyrrole 2,3-dioxygenase (IDO1). (drugdiscoverynews.com)
However, as tumors progress, cancerous cells develop immunosuppressive mechanisms that circumvent NK cell-mediated killing, allowing for tumor escape and proliferation. (frontiersin.org)
Rapid MYC-driven progressors exhibited a high number of activated/exhausted CD8(+) T cells with reduced immunosuppressive regulatory T (T-reg) cells, while late MYC acquisition in slow progressors was associated with lower CD8(+) T cell infiltration and more abundant T-reg cells. (unav.edu)
To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)
Our results indicate that gemcitabine is a suitable combination therapy with vaccines aimed at enhancing PD-1 therapies by targeting vaccine-induced immunosuppressive DC. (unav.edu)
In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)
Immunosuppressive enzyme blocked to enhance T cell activity. (theusaknowledge.net)
For now, preclinical studies showed that tumor growth in melanoma seems to play a critical role in reprogramming the host immune system by regulating hematopoiesis, which might be associated with the expansion of immunosuppressive cells such as tumor-associated macrophages, regulatory T cells, and myeloid-derived suppressor cells (MDSCs) ( 7 ). (snmjournals.org)
Patients with high BM glucose metabolism displayed an immunosuppressive phenotype with increased MDSCs and decreased CD8+ T cells ( 8 ). (snmjournals.org)

Blockade of CTLA-4 by antibodies has potentiated antitumor T-cell responses in both preclinical models and clinical trials. (aacrjournals.org)
By injecting the antibodies in a subcutaneous slow-release delivery formulation in the tumor area, we show that an eight-fold lower dose of antibody is as effective in inducing tumor eradication as systemic delivery. (aacrjournals.org)
These immune-inhibitory effects inhibited synergistic effects of combining our oncoprotein vaccine with immune checkpoint-blocking antibodies. (nih.gov)
Some cells require the presence of humoral antibodies directed against the tumor cells to initiate the interactions that eventually lead to the death of tumor cells. (techsling.com)
PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)
B, blockade of this pathway by anti-PD-1 antibodies prevents this downregulation, and allows T cells to maintain their antitumor functionality and ability to mediate tumor cell death. (shu.edu)
CD137 (4-1BB) is a member of the TNFR family that mediates potent T cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies (mAbs). (unav.edu)
To assess the clinical relevance of these findings, we studied antibodies and cells from patients with lung cancer. (bioxcell.com)
By binding to these antigens, monoclonal antibodies can flag cancer cells for destruction by the immune system. (theusaknowledge.net)
Monoclonal antibodies bind to target proteins on cancer cells, flagging them for destruction. (theusaknowledge.net)

In a scientific research, where CCL21 transduced DCs had been found in non-small cell lung carcinomas, a substantial increase in Compact disc8+ T cell infiltration was discovered in 56% of sufferers and it had been connected with PD-L1 up-regulation [65]. (antiviralbiologic.com)
Activation of dendritic cells is a prerequisite for other critical activities, such as T cell infiltration/expansion and Th1 response. (drugdiscoverynews.com)
NK cell infiltration into tumor tissue is associated with better disease prognosis in colorectal cancer, clear cell renal cell carcinoma, and lung carcinomas ( 9 - 11 ). (frontiersin.org)
In preclinical studies, ITI-4000, a DNA vaccine targeting EBNA1, demonstrated robust activation of anti-tumor CD4 and CD8 T cells in vivo and promoted tumor infiltration with activated TNFα-producing CD8 T cells. (biospace.com)
This improved efficacy was associated with higher tumor T-cell infiltration and overexpression of PD-1/PD-L1. (unav.edu)
There is increasing evidence that tumors expressing CD95L are able to kill activated T cells, thereby preventing their infiltration into the tumor as well as their survival inside the tumor. (apogenix.com)
STARD14 was negatively associated with the infiltration of CD8+T cells, while positively with CCL28 and immune checkpoints, including CTLA4 as well as PD-L2. (medsci.org)
STARD12 and STARD14 were expected to be potential biomarkers for LUAD, which were associated with epigenetic regulation, immune infiltration and ferroptosis. (medsci.org)

Immune checkpoint inhibitors (ICIs), including programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated protein 4 have shown promising cancer clinical outcomes. (bvsalud.org)
IDO is one of several immune checkpoints involved in tumor immune escape, and IDO-1 inhibitors are currently in clinical development, according to the company. (drugdiscoverynews.com)
In preclinical models, previously we have seen compelling systemic antitumor effects with intratumoral IMO-2125 monotherapy, in combination with inhibitors of CTLA-4, PD-1 and now IDO. (drugdiscoverynews.com)
According to Doody, preclinical studies using IMO-2125 either as a single-agent or in combination with several checkpoint inhibitors-such as anti-CTLA-4, anti-PD-1 and IDO-1 inhibitor-have shown robust tumor regression. (drugdiscoverynews.com)
Combination with checkpoint inhibitors will potentiate IMO-2125's antitumor activity. (drugdiscoverynews.com)
The recent FDA approvals of the programmed cell death protein 1 (PD-1)-targeted checkpoint inhibitors pembrolizumab and nivolumab mark the latest successes in the rapidly expanding field of cancer immunotherapies. (frontiersin.org)
Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. (unav.edu)
Checkpoint inhibitors work by blocking proteins that inhibit T-cell response, thereby removing restraints on the immune system and allowing T-cells to proliferate and kill cancer cells. (theusaknowledge.net)
A recent addition to the list of immune checkpoint inhibitors is the CD95 ligand (CD95L). (apogenix.com)
To this end, the authors studied a population of 92 patients with a diagnosis of metastatic melanoma treated with immune checkpoint inhibitors (ICIs) ( 1 ). (snmjournals.org)

They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
Differentiated airway epithelial cells can revert into stable and functional stem cells in vivo. (wikipedia.org)
They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
In order to overcome the low quantity of pre-existing tumor-infiltrating DCs, another possible approach is represented by the intratumoral inoculation of ex lover vivo generated unloaded DCs, also called in situ DC vaccination. (antiviralbiologic.com)
Indeed, if antigen identification and their immunogenicity definition are expensive and time-consuming, the planning of tumor cell lysates is certainly at the mercy of restrictions also, among which, mainly, the paucity of autologous tumor cells amenable to ex girlfriend or boyfriend vivo manipulation. (antiviralbiologic.com)
In fact, in vivo employment of ICD inducers results not only in TAA launch by dying cells, but also in the secretion of DC activating DAMPs and more efficient engulfment of tumor cells by DCs [57,58,69,70,71]. (antiviralbiologic.com)
The antitumor effect provided by natural killing has been observed in tumors of hematopoietic and non-hematopoietic origins and reported in diverse in vivo models and clinical series ( 8 ). (frontiersin.org)
Previous data indicated that CpG boosted tumor-specific T-cell responses after in vivo tumor destruction and increased survival after tumor rechallenges. (pasteur.fr)
Additionally, the 5TGM1-Kalw/RijHSD immunocompetent in vivo model was used to examine reovirus efficacy and characterize reovirus-induced immune responses in the BM and spleen following intravenous administration. (bmj.com)
Results Using the 5TGM1-Kalw/RijHSD immunocompetent in vivo model we have demonstrated that reovirus reduces both MM tumor burden and myeloma-induced bone disease. (bmj.com)
Co-administration of a clinically relevant dexamethasone dosage with ablative radiotherapy reduces peripheral lymphocytes but does not alter in vivo intratumoral lymphocyte phenotype or inhibit efficacy of radiotherapy in a murine colorectal tumor model. (rochester.edu)
The RA3.3A1/6.1 antibody is commonly used for in vivo B cell depletion. (bioxcell.com)
Yet nearly everything we do in clinical trials in depression old minimizes treatment response, enhances placebo response, and, in the case of AZD0530 in vivo combination treatment approaches, inflates the value of active psychosocial comparators. (anti-cancers.com)
We utilized an in vivo murine tumor model expressing the rat neu Ag to compare the immunization efficacy between DC transduced with replication-deficient adenovirus containing neu (AdVneu), to form DCneu, and plasmid DNA (pcDNA) vaccine. (usask.ca)
A series of in vitro and in vivo analyses, including physical and chemical characterizations, targeting property, biosafety, and antitumor efficacy of Wpep-DGL/Pt were systematically carried out. (thno.org)

An approach that targets multiple essential processes of tumorigenesis can overcome tumor-associated plasticity, clonal evolution and adaptive resistance, all of which limit the durable efficacy of current treatments. (mayo.edu)
B16-OVA tumors benefited from a synergistic effect, reaching 75% of tumor rejection, but higher levels of exhausted T-cells in LLC-OVA tumors co-expressing PD-1, LAG3 and TIM3 precluded similar levels of efficacy. (unav.edu)
For example, the relative inefficiency of delivering OVs to tumor nodules, selective viral replication inside tumor nodules and spread to distant micrometastases limits its overall efficacy. (biomedcentral.com)
While tumor imaging and radiotherapy strategies are crucial for tumor identification and treatment, the presence of metastasis and radiation resistance has reduced the efficacy of treatment in cancer patients. (biomedcentral.com)
New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy. (rochester.edu)
CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models. (rochester.edu)
Efficacy was dependent on the number of CD8+ T cells able to recognize tumor antigens that infiltrated the malignant tissue. (unav.edu)
Combining tumor-specific adoptive T cell therapy to the aCTLA-4/aPD1/rIL2 or aCTLA-4/aPD1/aCD137 reg-imens enhances efficacy in a synergistic manner. (unav.edu)
In this study, we investigated the impacts of apoptotic transgenic MCA/HSP tumor cells expressing HSP70 on DC maturation, T cell stimulation and overall vaccine efficacy. (usask.ca)

Cancer vaccines use tumor cell-associated antigens to induce a specific anti-tumor immune response that is durable and robust. (asmepress.com)
These include personalized anti-cancer vaccines (dendritic cell based) and chimeric antigen receptor (CAR)-T cell therapies for gastrointestinal and hepatobiliary cancers. (mayo.edu)
Immunomic Therapeutics, Inc. (ITI) is a privately-held, clinical stage biotechnology company pioneering the development of vaccines through its proprietary technology platform, UNiversal Intracellular Targeted Expression (UNITE), which is designed to utilize the body's natural biochemistry to develop vaccines that generate broad immune responses. (biospace.com)
Hybrid vaccines, which are vaccine models of total antigens expressed by a tumor cell combined with the ability of a dendritic cell (DC) to stimulate immune responses, have been investigated in clinical and experimental studies. (unifesp.br)
However, the response triggered by these vaccines is often weak, requiring the use of adjuvants to increase vaccine immunogenicity. (unifesp.br)
These results revealed the adjuvant effect of a killed P. acnes suspension, as it improved specific humoral and cellular immune responses elicited by DC-tumor cell hybrid vaccines. (unifesp.br)
Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. (nwbio.com)
With this favorable immune backdrop, genetic engineering of OVs and rational combinations further potentiate OVs as cancer vaccines. (biomedcentral.com)
Cancer vaccines are designed to boost the body's immune system to protect itself from carcinogenesis and progression of cancer. (biomedcentral.com)
First, OVs are tumor-selective, thus in situ cancer vaccines, providing higher cancer specificity and better safety margin. (biomedcentral.com)
Cancer vaccines introduce tumor antigens to the immune system. (theusaknowledge.net)
Taken together, our results may have an important impact in designing DC-based antitumor vaccines. (usask.ca)
Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)

First described in 1975, NK cells were initially identified as a distinct sub-population of lymphocytes by their capacity to spontaneously lyse tumor cells ( 1 ). (frontiersin.org)
Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
Upon the stage of tumorigenesis, down-regulation of the major histocompatibility complex class-I (MHC-I) molecules and also the overexpression of the stress-induced ligands on the surface of malignant cells to avoid recognition by cytotoxic T-lymphocytes (CTLs), make them more sensitive to NK cell-mediated death. (biomedcentral.com)
MM cells co-cultured with BM stromal cells displayed resistance to reovirus-induced oncolysis and bystander cytokine-killing but remained susceptible to killing by reovirus-activated NK cells and MM-specific cytotoxic T lymphocytes. (bmj.com)
CEACAM1 is expressed on epithelial and endothelial cells, lymphocytes, and myeloid cells . (shu.edu)
This review will discuss the metabolic changes that drive T cells into different stages of their development and how the TME imposes barriers to the metabolism and activity of tumor infiltrating lymphocytes. (elifesciences.org)
Some EBOV infections generate a cytokine storm, which hinders peripheral natural killer cells (NK) and T and B lymphocytes. (cdc.gov)

We use different preclinical mouse models of cancer to investigate the local administration of CTLA-4 blocking antibody and its effect on cancer progression and the antitumor T-cell response. (aacrjournals.org)
The mathematical model developed presented the following main components: (1) tumour progression in the animals without treatment was described with a linear model, (2) vaccine effects were modelled assuming that vaccine triggers a non-instantaneous immune response inducing cell death. (ebi.ac.uk)
Furthermore, the addition of P. acnes to a hybrid vaccine increased the cytotoxic activity of splenocytes toward B16F10 in vitro and avoided late tumor progression in a pulmonary colonization model. (unifesp.br)
In clinical series, high CD8(+) T/T-reg cell ratios underlie early progression in untreated smoldering MM, and correlated with early relapse in newly diagnosed patients with MM under Len/Dex therapy. (unav.edu)
Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
Neutrophils also contribute to tumor progression, yet establishing the difference between PMN-MDSCs and tumor-associated neutrophils (TAN) remains challenging ( 11 , 15 , 16 ). (frontiersin.org)
In this paper, we reviewed the recent researches on the multiple roles of tumor-associated exosomes in the progression of HCC. (hindawi.com)
A number of studies have proved that exosomes are important mediators for the initiation, progression, angiogenesis, and metastasis of tumors [ 10 ]. (hindawi.com)

The main target and effector cells of the CTLA-4 blockade treatment in the studied tumor models are tumor-specific endogenous CD8 + T cells that are capable of eradicating also distant tumors, whereas CD4 + T cells do not play a prominent role in the antibody-mediated tumor eradication. (aacrjournals.org)
There is compelling clinical and experimental evidence to suggest that natural killer (NK) cells play a critical role in the recognition and eradication of tumors. (frontiersin.org)
Either systemic administration of DCs loaded with allogeneic-IgG-coated tumour cells or intratumoral injection of allogeneic IgG in combination with DC stimuli induced potent T-cell-mediated antitumour immune responses, resulting in tumour eradication in mouse models of melanoma, pancreas, lung and breast cancer. (bioxcell.com)

Here, we evaluated the effect of P. acnes on a specific antitumor immune response elicited by a hybrid vaccine in a C57Bl/6 mouse model of melanoma. (unifesp.br)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model. (rochester.edu)
ZnCDA also extended survival in a model of B-cell lymphoma, suppressed tumors in melanoma and prostate cancer models and induced anti-tumor effects in a model of a type of lung cancer that resists STING activators. (ludwigcancerresearch.org)
Because there is a cross talk between the tumor immune environment and BM, our team evaluated the association between bone marrow glucose metabolism and transcriptomics in patients with a diagnosis of metastatic cutaneous melanoma treated with ICIs ( 4 ). (snmjournals.org)

Previous studies have suggested the potential to combine EZH2i with immune checkpoint blockade targeting coinhibitory receptors like PD-(L)1 and CTLA-4, but whether it can also enhance the activity of agents targeting costimulatory receptors is not known. (bvsalud.org)
TL-532 also demonstrated its remarkable ability to overcome Immune Checkpoint Inhibitor (ICI) tumor-resistance, thus increasing the clinical landscape for ICI combination treatment. (pipelinereview.com)
However, we are also very excited to further understand what other areas we can apply the technology to, such as in tumors that may not be immunogenic and perhaps unresponsive to checkpoint inhibition. (drugdiscoverynews.com)
Single-cell transcriptomics and functional assays defined a high ratio of CD8(+) T cells versus T-reg cells as a predictor of response to immune checkpoint blockade (ICB). (unav.edu)
We have discussed checkpoint blockade by PD-1, previously - PD-1 is a molecule expressed in the surface of T-cells , which when binding to PD-L1, causes the T-cell to down-regulate, that is, to no longer mount an anti-tumor immune response. (shu.edu)
Collectively, these negative regulatory receptors are now commonly referred to as immune-checkpoint molecules. (shu.edu)
Checkpoint inhibitor drugs block these proteins and take the brakes off the immune system, enabling it to recognize and eliminate tumor cells. (theusaknowledge.net)
Checkpoint proteins that suppress T cell response. (theusaknowledge.net)
Checkpoint protein that downregulates T cell function. (theusaknowledge.net)
Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)
Because of the vesicant activity of doxorubicin, microparticles made of biodegradable polymer poly(lactide-co-glycolide) or PLGA can safely deliver doxorubicin intratumorally and are effective vaccine adjuvants, (ii) enhancing T-cell activation using anti-OX40 and (iii) sustaining T-cell responses by checkpoint blockade using anti-CTLA-4. (aacrjournals.org)

Risk-adapted therapies for AML, ALL, and CLL patients consist of chemotherapy with/without stem cell transplantation (SCT), but the rate of early failures and relapses is still unsatisfying. (nature.com)
These data support the requirement of EZH2 function in 4-1BB-mediated CD8+ T cell expansion and effector programming and emphasize the consideration that must be given when combining such antitumoral therapies. (bvsalud.org)
The proposed model structure was successfully applied to describe antitumor effect of IL-12, suggesting its applicability to different immune-stimulatory therapies. (ebi.ac.uk)
In addition, a simulation exercise to evaluate in silico the impact on tumour size of possible combination therapies has been shown. (ebi.ac.uk)
These therapies boost the immune system's ability to detect and destroy cancer cells by exposing it to tumor-specific antigens or genetically modified immune cells programmed to recognize cancer. (theusaknowledge.net)
However, many patients fail to respond to these therapies, and metabolic barriers imposed on T cells by the TME may contribute. (elifesciences.org)
Amphera B.V., an advanced-clinical-stage biotechnology company developing dendritic cell therapies to treat cancer, announces that it has recruited the first patients to its pivotal phase II/III study of MesoPher to treat pleural mesothelioma, a rare cancer of the lining of the lungs. (amphera.nl)
Amphera is an advanced-clinical-stage biotechnology company developing dendritic cell therapies to treat cancer. (amphera.nl)

Our data highlighted a link between HPV-induced cancers, systemic amplification of myeloid cells, and the detrimental effects of myeloid cells on CD8 + T-cell activation and recruitment into the TME. (nih.gov)
Idera Pharmaceuticals Inc. has announced new data demonstrating enhanced systemic antitumor activity in preclinical cancer models. (drugdiscoverynews.com)
As Doody explained, "Tumor regression was not only observed in the injected tumor but also in the uninjected tumor, essentially creating a systemic response. (drugdiscoverynews.com)
These studies suggest that IMO-2125 can induce memory T cell responses, leading to a robust systemic antitumor activity. (drugdiscoverynews.com)
The abscopal effect, referring to the unexpected shrinkage observed in non-irradiated tumors after radiation therapy, is thought to be mediated by systemic immune activation. (mdpi.com)
Most studies showed that these imaging biomarkers were associated with clinical outcomes as well as systemic inflammatory responses (high C-reactive protein, low albumin, high neutrophils or leukocytes or platelets). (snmjournals.org)
challenges have focused primarily on local responses in IgE is strongly associated with the prevalence of asthma, it the skin and have pretty much ignored any systemic raises the interesting question of whether allergen sensitization effects. (cdc.gov)
It is well established that the systemic immune ated with a lesser asthma severity. (cdc.gov)
Brinkman et al5 examined whether the presence and foods.1,2 However, much less is known about the poten- severity of AD was predictive of the occurrence and mag- tial influence that skin challenges have on the systemic nitude of early and late asthmatic responses to inhaled immune response, in particular whether sensitization allergens. (cdc.gov)

In this paper, we have developed a population semi-mechanistic model able to characterize the mechanisms implied in tumour growth dynamic after the administration of CyaA-E7, a vaccine able to target antigen to dendritic cells, thus triggering a potent immune response. (ebi.ac.uk)
Tumor cells develop multiple and complex mechanisms to fully escape immune surveillance. (amegroups.org)
Oncolytic viruses (OVs) specifically induce cancer cells death by infection of and spreading on tumor cells through different mechanisms such as direct lysis effect or adjacent cells fusion. (biomedcentral.com)

Preclinical data is currently being developed to explore whether LAMP nucleic acid constructs may amplify and activate the immune response in highly immunogenic tumor types and be used to create immune responses to tumor types that otherwise do not provoke an immune response. (biospace.com)
Taken together, this research supports an important role for early activity by Ly6G(+) cells in the generation of long-term PDT responses in mesothelioma, and it points to luminol chemiluminescence as a potentially useful approach for preclinical monitoring of neutrophil activation by PDT. (bioxcell.com)

This provided the effective, clinical treatment for the multi-drug resistance tumour. (uwi.edu)
Dr. Kankeu Fonkoua collaborates with scientists and clinicians from various disciplines to conduct clinical trials and translational studies evaluating novel rational combinations to enhance anti-tumor immune response and improve clinical outcomes. (mayo.edu)
Dr. Kankeu Fonkoua aims to establish immunologic correlates of clinical outcomes, which would increase the ability to identify and validate prognostic immune signatures and biomarkers. (mayo.edu)
ITI believes that these early clinical studies may provide a proof of concept for UNITE therapy in cancer, and if successful, set the stage for future studies, including combinations in these tumor types and others. (biospace.com)
CD137 agonists attain immunotherapeutic antitumor effects in cancer mouse models, and multiple agents of this kind are undergoing clinical trials. (unav.edu)
1 ). Although The Journal of Nuclear Medicine has published several papers highlighting the clinical value of sequential 18 F-FDG PET/CT for response assessment ( 2 , 3 ), this new article showed that baseline 18 F-FDG PET/CT could also be used to guide treatment decisions. (snmjournals.org)
The Company has three ongoing clinical programmes with MesoPher - its personalised immuno-oncology cell therapy, comprised of autologous dendritic cells loaded with PheraLys, its proprietary allogeneic lysate of cancer cell lines. (amphera.nl)
The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)
We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). (cdc.gov)
Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD. (cdc.gov)

Prostate cancer is one of the most common malignant tumors of the urinary system. (asmepress.com)
Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Compared with conventional cancer treatments, the main advantage of oncolytic virotherapy is its tumor-selective replication followed by the destruction of malignant cells without damaging healthy cells. (biomedcentral.com)
We compared the ability of autologous dendritic cells loaded with SVN53-67 peptide and SVN53-67/M57 in CTL assays against allomatched and autologous, survivin-expressing, human malignant glioma and PCNSL cells. (elsevierpure.com)
By targeting these critical regulators of immune response to cancer, immunotherapies augment the natural defenses of the body to attack malignant cells across multiple pathways. (theusaknowledge.net)
In a healthy organism, malignant cells are generally eliminated by a process called immune surveillance, meaning they are rapidly destroyed by the immune system. (apogenix.com)
However, over time, malignant cells gain the ability to evade immune surveillance by expressing molecules that block the anti-tumor response of the immune system through the activation or inhibition of certain signaling pathways. (apogenix.com)
Lung cancer is the first leading diagnosed malignant tumor globally [ 1 ]. (medsci.org)

RCC is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)
Renal cell carcinoma is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
CTLs recognize antigens on target cells and lyse these cells. (techsling.com)
Such lymphokines include (IL-2) also known as T cell growth factor and IL-12 produced by dendritic cells and specifically induces CTLs enhancing antitumor immune responses. (techsling.com)
In contrast to CTLs, NK cells lack receptors for antigen detection but can still recognize normal cells infected with viruses and cancer cells. (msdmanuals.com)

Patients with cervical cancer have poor dendritic cell functions, have weak cytotoxic lymphocyte responses, and demonstrate an accumulation of myeloid cells in the periphery. (nih.gov)
However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. (frontiersin.org)
Despite the arsenal of defense strategies against foreign invaders, myeloid cells succumb to the instructions of an established tumor. (frontiersin.org)
Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)
Altogether, the myeloid compartment in the TME is heterogenous and varies across tumor types, individuals and tumor stage ( 23 ). (frontiersin.org)
Nevertheless, the majority of scientific discoveries points toward a more tumor-supporting role for myeloid cells in the TME. (frontiersin.org)
Analysis of the tumor-infiltrating myeloid populations at days 3, 7, and 14 post tumor inoculation revealed that the majority of myeloid cells were macrophages, which far outnumbered cross-presenting dendritic cells (DCs). (acir.org)
Most myeloid cells within tumors and tumor-draining lymph nodes expressed PD-L1 without co-expressing B7-1 (but still expressing B7-2, which does not interact in cis with PD-L1), thus leaving plenty of PD-L1 free to interact with PD-1 on T cells. (acir.org)
Most intratumoral PD-L1 + myeloid cells were macrophages (~75%), while cross-presenting DCs accounted for less than 2% of this population by day 14 post tumor inoculation. (acir.org)
Interestingly, however, mature DCs in NSCLC tumors had the highest level of PD-L1 (and B7-1) expression on a per cell basis among intratumoral myeloid populations. (acir.org)
Ly6G is expressed differentially during development by cells in the myeloid lineage including monocytes, macrophages, granulocytes, and neutrophils. (bioxcell.com)

In the beginning, UPR has protective effect, but in prolonged ER stress UPR triggers apoptotic cell death. (helsinki.fi)
The accumulated experimental evidence strongly supports the idea that in situ DC vaccination benefits from tumor pretreatment with pro-apoptotic providers [64,67,68] and, in particular, with ICD inducers. (antiviralbiologic.com)
In another study, we examined the use of a DC-based cancer vaccine involving the phagocytosis of apoptotic tumor cells expressing heat shock protein 70 (HSP70). (usask.ca)

Bystander effects are mediated via cell-to-cell gap junctions or through secreted, diffusible signaling molecules into the local milieu. (amegroups.org)
After RT treatment, there is an increase pool of peptides for antigen presentation displayed by MHC-I molecules ( 6 ). (amegroups.org)
The activation of DCs is characterized by the upregulation of cell surface molecules involved in antigen presentation and costimulation (e.g. (amegroups.org)
Evidence suggests that class I MHC molecules on the surface of normal cells inhibit NK cells and prevent lysis. (techsling.com)
In this manner, the reduced detection of self MHC-I molecules by NK cell-inhibitory receptors coupled with an increase in activating signals by recognition of stress-induced surface ligands promote the cytolytic activity of NK cells. (biomedcentral.com)
These laboratory-produced molecules are engineered to target specific antigens found on cancer cells. (theusaknowledge.net)
Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be loaded into MHC-class-I-related CD1d molecules by dendritic cells and has been shown to stimulate invariant natural killer T (iNKT) cells. (tmu.edu.tw)
Though STING is a prized target for drug development, the drug-like molecules that can activate the molecular sensor-known as cyclic dinucleotides (CDNs)-have been plagued by issues of poor bioavailability, low stability and high toxicity in the absence of any means to target them specifically to tumors. (ludwigcancerresearch.org)

Chemotherapy shifted the TME to express high PD-L1 and MHC I, resulting in targeted ICI cargo delivery and enhanced generation and activation of tumor antigen-specific T cells. (bvsalud.org)
Yu and co-workers showed that just the mix of chemotherapy with in situ DC vaccination induced effective antigen-specific Compact disc8+ and Compact disc4+ T-cell mediated replies within an advanced-stage breasts Flumazenil cancer tumor model, whereas neither chemotherapy nor DC inoculation elicited antitumor immune system responses when used as single remedies [64]. (antiviralbiologic.com)
Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer. (rochester.edu)

Fifteen genetically diverse models developed bone marrow (BM) tumors fulfilling MM pathogenesis. (unav.edu)
Multiple myeloma (MM) is a tumor of terminally differentiated plasma cells which expand in the bone marrow (BM). (bmj.com)
Moreover, Cu- and Zn-AMSs enhanced maturation and cytokine release of bone marrow dendritic cells in vitro. (elsevierpure.com)
In a recent review published in JNM , tumor and bone marrow glucose metabolism were analyzed in 12 studies including 2,588 cancer patients who underwent both 18 F-FDG PET/CT scans and biochemical assessments with blood samples ( 6 ). (snmjournals.org)
Strikingly, high bone marrow metabolism was associated with an upregulation of genes related to dendritic cells, regulatory T cell activity, and memory T cells phenotypes ( 4 ). (snmjournals.org)

Ionizing radiation (IR) is used as a main treatment for many types of localized solid tumors where radiation therapy (RT) is considered the primary non-surgical modality in the curative treatment of cancer ( 1 , 2 ). (amegroups.org)
The presence of TAMs in most solid tumors is correlated with poor prognosis and overall survival of patients ( 10 ). (frontiersin.org)
A collaboration between Bristol-Myers Squibb and Kyowa Hakko Kirin to test a combination of Kyowa's Poteligeo (mogamulizumab), an anti-CCR4 antibody, and BMS' Opdivo (nivolumab) in a Phase I/II trial in advanced or metastatic solid tumors was announced. (shu.edu)

Its activation promotes inflammation and drives immune cells like macrophages and dendritic cells to process and present cancer antigens to T cells, helping to stimulate and direct the immune assault on tumors. (ludwigcancerresearch.org)

Therefore, this article reviews the latest progress on prostate cancer vaccine, especially Sipuleucel-T vaccine based on mononuclear cells. (asmepress.com)
General view of vaccine for prostate cancer (DC, dendritic cell). (asmepress.com)
Prostate acid phosphatase (PAP) is expressed in approximately 95% of prostate cancers and is mainly limited to prostate tissue, which is a target for prostate cancer tumor vaccine development. (asmepress.com)
The active components of Sipuleucel-T are autologous APCs and PAP-GM-CSF, in addition to T cells, B cells, natural killer cells, and other cells that specifically bind to PAP expressed in prostate cancer tissue to kill tumor cells. (asmepress.com)
The result is the immunogenic cell death of tumor cells, accompanied by an auto-vaccination preventing the recurrence of cancer. (pipelinereview.com)
Ionizing radiation therapy (RT), either alone or in combination with additional immune stimulators, can render cancer cells visible to the immune system. (amegroups.org)
The interaction of all these factors could lead to cancer cells escaping the immune system ( 6 ). (amegroups.org)
In the time since then, the world of utilizing the immune system in the battle against cancer has emerged in a different light. (drugdiscoverynews.com)
In the early phases of cancer immune surveillance, NK cells directly identify and lyse cancer cells. (frontiersin.org)
Additionally, a 11-year prospective cohort study of Japanese inhabitants linked low peripheral-blood NK cell cytotoxicity with increased cancer risk ( 12 ). (frontiersin.org)
Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)
In an immunoassay test for tumors, they boost anti-cancer activity by sending signals that help kill abnormal cells and elongate the lifetime of normal cells. (techsling.com)
They kill infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells via tumor vasculature targeting and bystander effect. (biomedcentral.com)
The first is the direct oncolysis of cancer cells by the virus, which is, in most cases a mixture of apoptosis, necrosis, pyroptosis and autophagic cell death, often with one as predominant for a particular OV. (biomedcentral.com)
Survivin is a tumor-associated antigen with significant potential as a cancer vaccine target. (elsevierpure.com)
Radiotherapy exacerbates tumor-promoting innervation and nerve signaling in rectal cancer. (rochester.edu)
Although tumor-promoting functions have been attributed to other granulocytes, like eosinophils ( 17 ), basophils ( 18 ) and mast cells ( 19 ), further research is required to fully elucidate their role in cancer, as antitumoral roles have also been described ( 20 , 21 ). (frontiersin.org)
Nivolumab is an antibody that binds to PD-1 and blocks it from interacting with PD-L1 (expressed on cancer cells and antigen presenting cells), which then prevents Cytotoxic T-cells from becoming down-regulated against the antigens expressed on the neighboring TCR (T-cell receptor) - see article . (shu.edu)
Blocking a blocker allows the anti-tumor response (first wave) to proceed unabated, which in the context of cancer is the desired outcome. (shu.edu)
Antitumor effects of agonist anti-CD137 mAbs are critically dependent on the integrity of cIAPs in cancer mouse models, and cIAPs are also required for signaling from CARs encompassing CD137's cytoplasmic tail. (unav.edu)
We confirmed that Cu- and Zn-AMSs promoted intracellular uptake of model cancer antigen (ovalbumin, OVA) by THP-1-differentiated macrophage-like cells in vitro. (elsevierpure.com)
It involves harnessing the power of the body's own immune system to seek out and destroy cancer cells. (theusaknowledge.net)
This enables a more targeted, long-lasting, and effective anti-cancer response with better tolerance. (theusaknowledge.net)
They can also block proteins that cancer cells use to grow and spread. (theusaknowledge.net)
There are certain proteins like PD-1, PD-L1 , and CTLA-4 that act as immune checkpoints, preventing T-cells from attacking cancer. (theusaknowledge.net)
This involves extracting a patient's T-cells, genetically modifying them to enhance their cancer-fighting ability, growing more of them in the lab, and transfusing them back into the patient to attack the tumor. (theusaknowledge.net)
This activates helper T cells and cytotoxic T cells that can now recognize and attack cancer cells containing these antigens. (theusaknowledge.net)
These enhanced CAR T-cells can now detect and destroy cancer cells efficiently. (theusaknowledge.net)
They also block proteins that cancer cells need for growth and survival. (theusaknowledge.net)
Protein that promotes cancer cell growth, blocked by cetuximab. (theusaknowledge.net)
A similar PD-L1 expression distribution was observed in RNASeq data from human non-small cell lung cancer (NSCLC) tumors. (acir.org)
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. (anti-cancers.com)
Human Epidermal Growth Factor Receptor 2 (HER-2/neu) is a breast tumor antigen (Ag) commonly overexpressed in 30% of breast cancer cases. (usask.ca)
The TME, however, can be metabolically hostile due to insufficient vascular exchange and cancer cell metabolism that leads to hypoxia, depletion of nutrients, and accumulation of waste products. (elifesciences.org)
Hanahan and Weinberg's seminal paper 'The Hallmarks of Cancer' was revised in 2011 to include deregulating cellular energetics and evasion of immune destruction ( Hanahan and Weinberg, 2011 ). (elifesciences.org)
Her research involves direct reprogramming approaches, which function like a Trojan horse, enabling cancer cells to be targeted by the immune system. (lu.se)
By using direct reprogramming strategies, I could induce the expression of tumor antigens on the surface of cancer cells, making them visible to the immune system again. (lu.se)
We focused particularly on harnessing reprogramming, or direct cellular reprogramming, to induce antigen presentation in cancer cells. (lu.se)
when it comes to cancer they are critical as they present tumor antigens to the killer cells of the immune system and orchestrate the anti-tumor immune response. (lu.se)
Direct reprogramming strategies with cDC1-specific factors can induce antigen-presentation in cancer cells, making cancer cells visible to the immune system and easier to fight. (lu.se)
A single dose of the nanoparticles, called ZnCDA (owing to the zinc ions at their core), suppressed tumor growth in two mouse models of colon cancer: a subcutaneously injected solid tumor and a model of liver metastases. (ludwigcancerresearch.org)
Macrophages in tumors exist in a biological gradient between two states, or phenotypes: one, known as M1, in which they stimulate anti-tumor immune responses and attack cancer cells themselves-literally eating them up-or another (M2), in which they support cancer cell proliferation and survival. (ludwigcancerresearch.org)
We found that ZnCDA is taken up particularly well by a subpopulation of macrophages in which it switches on gene expression programs that both push them toward the M1 state and promote their presentation of cancer antigens to T cells," said Yang. (ludwigcancerresearch.org)
Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
In patients with gynecologic cancer, high BM glucose metabolism was mainly due to the production of granulocyte colony-stimulating factor (G-CSF) by tumor cells ( 8 ). (snmjournals.org)
Natural killer (NK) cells are another population of effector cells with anti-cancer activity. (msdmanuals.com)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)

More importantly, GC drives alternative activation of STING leading to inflammatory cell death that enhances dendritic cell (DC) activation, which triggers a variety of nucleic acid sensing pattern recognition receptors (PRRs) and IL-1β production. (biorxiv.org)
Doxorubicin enhances the expression of "eat-me" signals by dying tumor cells, facilitating their phagocytosis by dendritic cells (DC). (aacrjournals.org)

They are dedicated antigen-presenting cells present in barrier tissues like the skin and lymph nodes. (techsling.com)
Then these signals are engulfed as antigens and presented by antigen-presenting cells within the tumor-derived lymph nodes. (thno.org)
On returning the activated DCs to the patient, they migrate to the lymph nodes, where they induce an immune response, including NK-cells, B- and T-cells, to attack the tumour. (amphera.nl)

Targeting EBNA1 allows for an immunotherapeutic approach by exploiting the potential of the immune system to recognize tumor cells through their expression of this viral antigen. (biospace.com)

Now although most humoral responses cannot prevent further tumor growth, effector cells like T cells have effective tumoricidal abilities. (techsling.com)
Most humoral responses cannot prevent tumor growth. (msdmanuals.com)

Nascent transformed cells elicit NK cell activation and are eliminated. (frontiersin.org)
In this case, the stimulation of endoplasmic reticulum (ER) stress and subsequent immunogenic cell death (ICD) process in OVs-infected cells elicit a range of anti-tumor immune responses. (biomedcentral.com)

However, a class of important immune-modulators is conspicuously absent: agents that utilize the power of innate immune cells to eradicate tumors. (frontiersin.org)
An important class of innate immune cells that play a critical role in mediating the antitumor immune response is the natural killer (NK) cell. (frontiersin.org)

In fact, specific anticancer medicines (such as anthracyclines or platinum compounds) and physical restorative modalities can promote the modulation of a subset of DAMPs in malignancy cells that are capable of inducing both apoptosis and an antigen-specific immune response [72]. (antiviralbiologic.com)
TNFSF-mediated signaling induces a wide range of biological effects, including programmed cell death (i.e., apoptosis), proliferation, differentiation, and tumor growth. (apogenix.com)

They are produced by immune cells to stimulate growth or induce activities of other immune cells. (techsling.com)
These are proteins like interferons and interleukins that occur naturally in the body and can stimulate an immune response. (theusaknowledge.net)
The anti-tumor immune response involves numerous signaling pathways that directly stimulate the activation and proliferation of immune cells. (apogenix.com)

One example is the transformation of iris cells to lens cells in the process of maturation and transformation of retinal pigment epithelium cells into the neural retina during regeneration in adult newt eyes. (wikipedia.org)
The fact that transdetermination (change of the path of differentiation) often occurs for a group of cells rather than single cells shows that it is induced rather than part of maturation. (wikipedia.org)
The maturation and cytokine production of dendritic cells will also be investigated after cultured with α-GalCer-incorporated liposomes in vitro. (tmu.edu.tw)

Intratumoral injection of IMO-2125 leads to interferon-alpha production and activation of dendritic cells. (drugdiscoverynews.com)
Intratumoral IL-12-producing dendritic cells and iNOS-producing macrophages were also induced by the vaccine. (biospace.com)

The differences in function, location, and migratory pattern of conventional dendritic cells (cDC) and plasmacytoid DCs (pDC) not only point to specialized roles in immune responses but also signify additive and interdependent relationships required to clear pathogens. (pasteur.fr)
In 2018, our research group identified the three transcription factors that allow us to convert fibroblasts, for example from the skin, into type 1 conventional dendritic cells (cDC1). (lu.se)

Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors. (rochester.edu)
Both diseases are generally incurable and aggressive, characterized by cold tumors that resist radiotherapy and all existing immunotherapies. (ludwigcancerresearch.org)

The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
Effective immune surveillance of patients with hematologic malignancies such as leukemia is mediated by cellular and noncellular arms of the innate and adaptive immune system. (nature.com)
The defining functional feature of NK cells remains their intrinsic ability to conduct "natural killing" of cellular targets without prior sensitization. (frontiersin.org)
Concerning the cellular immune response, the absolute number of memory CD4 and CD8 T cells was increased. (unifesp.br)
Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Цитокіни The immune system consists of cellular components and molecular components that work together to destroy antigens (Ags). (msdmanuals.com)

Sipuleucel-T consists of autologous peripheral blood mononuclear cells including antigen presenting cells (APCs). (asmepress.com)
Herein we demonstrate that GC drives type I IFN production and IFN responses in antigen presenting cells (APCs) and has superior potency compared to its corresponding chitosan. (biorxiv.org)
This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
K562 cells expressing PD-L1, B7-1, or both were used as artificial APCs. (acir.org)
Together, these experiments showed that PD-L1 expression on antigen-presenting cells (APCs) played a role in antitumor T cell responses via PD-1 interactions. (acir.org)

After cytokine-induced killer cells (CIK) were co-cultured with dendritic cells (DC) loaded with multi-drug resistance tumor antigen, the higher antitumour immune response was evaluated to multi-drug resistance tumor expressed as the same tumour antigen. (uwi.edu)
Cytokine-induced killer cells (CIK) are capable of lysing tumor cell and recognizing these cells in a non-MHC restricted fashion. (uwi.edu)
Furthermore, other cells at the interface of the innate and the adaptive immune system (e.g cytokine-induced killer cells (CIK) or invariant natural killer T-cells (iNKT)) are important mediators in antitumor-, autoimmune-, and antimicrobial responses and tumor surveillance. (nature.com)

These DCs become active via toll-like receptors (TLRs) recognition, in which endogenous danger signals emitted by dying tumor cells are identified. (amegroups.org)
NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors. (frontiersin.org)
On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)
Tim-3 can therefore be classed along with other negative regulatory receptors such as CTLA-4 and PD-1, which are also expressed on T cells and serve to contract T cell responses. (shu.edu)
The notable difference between Tim-3 and these other negative regulatory receptors is that Tim-3 expression is restricted to Th1 and Tc1 cells, whereas the others are expressed on all T cells. (shu.edu)
It is part of the Carinoembryonic Antigen (CEA) family of adhesion molecule receptors. (shu.edu)
Adoptive cell transfer involves engineering patient's own T-cells to create receptors on their surface that recognize specific tumor antigens. (theusaknowledge.net)
To initially investigate a model system, the researchers generated Jurkat cells with chimeric receptors comprising an extracellular PD-1 domain, an intracellular human CD3ζ signaling chain, and a luciferase reporter gene. (acir.org)
Further, inhibitory receptors present in the TME can inhibit T cell metabolism and alter T cell signaling both directly and through release of extracellular vesicles such as exosomes. (elifesciences.org)
Many key regulators of immune cell function belong to the so-called tumor necrosis factor superfamily (TNFSF) and their cognate receptors, the so-called TNF receptor superfamily. (apogenix.com)
TNFSF receptors are of great importance in the anti-tumor immune process . (apogenix.com)
This diverse expression pattern highlights the critical role that TNFSF receptors play in many parts of the body and in the various phases of the anti-tumor immune response. (apogenix.com)
The interaction of trimeric TNFSF ligands with their specific cell surface receptors leads to clustering of these receptors, followed by intracellular signal transduction. (apogenix.com)
Apogenix' TNF receptor agonists mimic natural trimeric ligands, thus inducing optimal trimeric assembly of the TNF receptors. (apogenix.com)
We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. (cdc.gov)

When used in combination with antigenic material, GC stimulates innate and adaptive antitumor and antiviral immunities. (biorxiv.org)

Here, we explore the combination between EZH2i and an agonist antibody targeting the T cell costimulatory receptor 4-1BB (α4-1BB). (bvsalud.org)
They don't have the receptor for antigen detection but can still recognize normal cells infected with viruses or tumor cells. (techsling.com)
Alternative names are indicated, as is the range of cells expressing each receptor. (shu.edu)
The trivalent structure of the TNFSF proteins and the resulting receptor clustering are prerequisites for the transmission of a signal delivered into the cell. (apogenix.com)
STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)

Moreover, a MHC-optimized scaffold was designed for improved antigen presentation to TCR by H-2Db allele. (bvsalud.org)

Effector cell activity is inducted by other cells that present tumor-specific antigens or tumor-associated antigens on their surface. (techsling.com)

Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. (biomedcentral.com)

Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)
We evaluated several amino acid substitutions in putative human MHC I anchor positions in SVN53-67 to identify potential peptide mimics that could provide an enhanced antitumor immune response against human glioma and primary central nervous system lymphoma (PCNSL) cells in culture. (elsevierpure.com)
We evaluated survivin peptides with predicted binding to human HLA-A*0201 antigen using peptide-loaded dendritic cells from PBMC of patients with these malignancies. (elsevierpure.com)
Thus, SVN53-67/M57 may act as a peptide mimic to induce an enhanced antitumor CTL response in tumor patients. (elsevierpure.com)

CTLA-4 (Yervoy - ipilimumab) and PD-1 (Opdivo - nivolumab) blockade accomplish similar objectives, though they act on different immune cells at different times in the immune response. (shu.edu)

ICIs included anti-PD1 as single-agent (88%) or in combination (12%) with anticytotoxic T-lymphocyte antigen-4 or antilymphocyte activation gene-3. (snmjournals.org)
Macrophages can kill specific tumor cells when activated by a combination of factors, including lymphokines (soluble factors produced by T cells) and interferon. (msdmanuals.com)

They carry out immunologic surveillance and then annihilate newly transformed tumor cells after identifying tumor-associated antigens. (techsling.com)

In addition to the direct effects of radiation, the ensuing immune response promotes the expression of inflammatory and immunostimulatory mediators, which act on neighboring, non-irradiated, cells. (amegroups.org)
The immune modulation mediated by this pathway ensures protection of tissue from collateral damage during an inflammatory response. (shu.edu)
Inflammatory cells, most especially neutrophils, can be a necessary component of the antitumor activity occurring after administration of photodynamic therapy. (bioxcell.com)

Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
Much like transplanted allogeneic organs, allogeneic tumours are reliably rejected by host T cells, even when the tumour and host share the same major histocompatibility complex alleles, the most potent determinants of transplant rejection. (bioxcell.com)

Different classes of these cells can mediate tumor promotion or suppression. (techsling.com)
Exosomes act as a signal-transmitting medium between cells to mediate intercellular communication and change the functional status of recipient cells [ 11 ]. (hindawi.com)

Thus, the decreased levels of class I molecule expression characteristic of many tumor cells may allow activation of NK cells as well as subsequent tumor lysis. (techsling.com)

Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. (msdmanuals.com)

Anatomy33

Organisms12

Diseases26

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Health Care3

Immunity36

Microenvironment30

Immunotherapy32

Immunological11

TAAs7

Cytokines17

Mice31

Therapeutic19

Immunosuppressive10

Antibodies10

Infiltration8

Inhibitors10

Vivo15

Efficacy9

Vaccines13

Lymphocytes7

Progression9

Eradication3

Melanoma5

Checkpoint11

Therapies8

Systemic9

Mechanisms3

Preclinical2

Clinical10

Malignant8

Immunogenic tumor2

CTLs4

Myeloid12

Apoptotic3

Molecules8

Chemotherapy3

Bone marrow5

Solid tumors3

Macrophages and dendritic cells1

Cancer47

Enhances2

Lymph nodes3

System to recognize tumor cells1

Humoral responses cannot prevent2

Elicit2

Innate immune cells2

Apoptosis2

Stimulate3

Maturation3

Intratumoral2

Conventional dendritic cells2

Radiotherapy2

Cellular6

APCs5

Cytokine-induced killer cells3

Receptors15

Adaptive antitumor1

Receptor5

Improved antigen presentation1

Specific antigens1

Oncolytic Viruses1

Peptide4

Blockade1

Combination2

Newly transformed tumor cells1

Inflammatory3

Allogeneic2

Mediate2

Subsequent tumor lysis1

Recognize1