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  • selection and proliferation
  • Because AID is the key enzyme triggering class switch recombination (CSR) and somatic hypermutation (SHM) ( 3 ), these results strongly support that a local selection and proliferation of reactive B cells take place within disease-targeted organs and these data therefore fit with the findings that pathogenic Abs are produced within chronically inflamed tissues ( 4 , 5 ). (jimmunol.org)
  • depletion
  • However, cDC depletion did not impair Tfh cell differentiation or germinal center formation, and long-lived IgG1 responses of unaltered affinity developed in mice lacking cDCs at the time point for immunization. (jimmunol.org)
  • monoclonal antibodies
  • Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. (semanticscholar.org)
  • Flow cytometric assessment of the reactivity of a panel of monoclonal antibodies (mAb) against two populations of human dendritic cells (DC). (ximbio.com)
  • induce
  • To define the accessory role of cDCs during the concurrent development of Tfh and effector Th1 cells, we performed high-dose Ag immunization in conjunction with the Th1-biased adjuvant polyinosinic:polycytidylic acid (pI:C). In the absence of cDCs, pI:C failed to induce Th1 cell commitment and IgG2c production. (jimmunol.org)
  • centers
  • It was shown later that implementation of immune response in germinal centers involves (besides T-helpers, follicular T-helpers) T-regulatory cells that could produce a positive effect in FL owing to specific features of the regulation or B-cell response. (scirp.org)
  • In line with what we have previously published on chronic allograft rejection ( 2 ), the authors report that activation-induced cytidine deaminase (AID) is expressed by B cells of ectopic germinal centers (tertiary lymphoid organs or TLOs) associated with autoimmune sialoadenitis. (jimmunol.org)
  • somatic hypermutation
  • GCs are located within secondary Fo and this is where mature B cells can proliferate, undergo somatic hypermutation (SHM), class-switch recombination and differentiate into high-affinity plasmocytes and memory cells. (ens-lyon.fr)