• These results provide new evidence that dendritic cells represent a differentiation pathway distinct from lymphocytes and monocytes. (silverchair.com)
  • M-CSF R engagement is continuously required for macrophage survival and regulates lineage decisions and maturation of monocytes, macrophages, osteoclasts and DC (3, 4). (rndsystems.com)
  • Infiltrating monocytes take up the modified low-density lipoproteins and become foam cells, which make plaques unstable, resulting in acute myocardial infarction [ 5 ]. (hindawi.com)
  • Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. (bdbiosciences.com)
  • Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
  • These cells include dermal resident dendritic cells (DC), epidermal Langerhans cells, neutrophils and monocytes, which are released from the blood when the dermal capillary is disrupted and a reputed blood lake is formed [ 3 - 6 ]. (biomedcentral.com)
  • These cells are closely related to neutrophils and monocytes. (aacrjournals.org)
  • Mononuclear myeloid cells include terminally differentiated macrophages and dendritic cells (DC), as well as monocytes, which under inflammatory conditions differentiate in tissues to macrophages and DCs. (aacrjournals.org)
  • Myeloid cells generated under these conditions, although similar to neutrophils and monocytes in morphology and phenotype, have different genomic and biochemical profiles and functional activity. (aacrjournals.org)
  • The field started changing in the late 1990s when the Gr1 + CD11b + cellular phenotype was suggested as defining the immune-suppressive myeloid cells in spleens of mice and when these cells were shown to be phenotypically similar but functionally distinct from monocytes and neutrophils ( 2, 3 ). (aacrjournals.org)
  • Sia + IgG induced increased expression of CD80 and dendritic cell immunoreceptor (DCIR) on monocytes, whereas the expression of HLA-DR was decreased. (scirp.org)
  • D. Bruder, E. , O. Richards, J. , M. Michel, K. and Oaks, M. (2016) Differential Effects of Alternative Glycoforms of IgG on Human Monocytes and Macrophages: Sialylated IgG Induces Novel Expression Signatures of Cell Surface Markers, Cytokines, and Chemokines. (scirp.org)
  • Myeloid cells are a type of immune cell that includes macrophages, neutrophils, and monocytes, as well as some types of dendritic cells and megakaryocytes. (upenn.edu)
  • Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. (thermofisher.com)
  • The Use of Primary Human Cells (Fibroblasts, Monocytes, and Others) to Assess Human Cytomegalovirus Function. (bio-protocol.org)
  • MPS is part of the innate immune system and comprises of monocytes, macrophages, and dendritic cells (DC). (upenn.edu)
  • Tol-DCs are not lineage specific and their immune-suppressive functions is due to their state of activation and/or differentiation. (wikipedia.org)
  • Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. (nih.gov)
  • The lineage of dendritic cells is not fully characterized, although prior studies have shown that growth and differentiation are controlled by cytokines, particularly granulocyte/macrophage colony-stimulating factor (GM-CSF). (silverchair.com)
  • [ 1 ] Within the 2016 World Health Organization (WHO) category of "acute myeloid leukemia and related neoplasms," the related neoplasms derive from immature cells with evidence of myeloid differentiation, or from precursors of plasmacytoid dendritic cells. (medscape.com)
  • The intracellular domain of activated M-CSF R binds more than 150 proteins that affect cell proliferation, survival, differentiation and cytoskeletal reorganization. (rndsystems.com)
  • Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. (bdbiosciences.com)
  • Several models are proposed to describe the development and differentiation of dendritic cells (DCs). (origene.com)
  • CD19 is involved in B cell development, activation, and differentiation. (biolegend.com)
  • DC are professional antigen-presenting cells with the unique capacity to polarize the differentiation of T cells, thereby regulating the balance between inflammation and tolerance [ 12 ]. (hindawi.com)
  • This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)
  • We have previously shown that the sialic acid-containing (Sia + ) fraction of intravenous immune globulin (IVIG) influences cell surface marker expression and cytokine/ chemokine secretion during the differentiation and maturation of human dendritic cells (DC). (scirp.org)
  • Notch signaling is a pathway that plays a role in the development and differentiation of many cell types, including myeloid cells. (upenn.edu)
  • This can involve the activation of Notch receptors on one cell type by ligands on another cell type, or the production of signaling molecules by one cell type that affect the differentiation or function of another cell type. (upenn.edu)
  • Hence, it is important to unravel how differentiation and/or activation of DC are linked with Th-cell-intrinsic mechanism that directs differentiation toward a specific effector Th subset. (life-science-alliance.org)
  • Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103 + CD11b + cDC2s and alters characteristics of CD103 − CD11b + cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt + Th17 cells and type 3 Rorγt + regulatory T cells. (life-science-alliance.org)
  • The natural process of blood cell formation, hematopoietic stem cell differentiation, and generation of myeloid and lymphoid cell lineages. (oncomine.com)
  • CSF-1 signaling through CSF-1R regulates the proliferation and differentiation of cells in the monocytic lineage. (thermofisher.com)
  • My overall goal is to characterize the mechanism of immune cell lineage differentiation and the function of immune subsets, with the aim to improve immunotherapy. (wustl.edu)
  • My research has been mainly focused on understanding the transcriptional regulation of dendritic cells development, and the function of type 2 classical dendritic cells in directing T cell differentiation. (wustl.edu)
  • We show here that these novel intrathymic DCs are truly myeloid, as they arise from CD34 + early thymic progenitors through CD34 lo intermediates which have lost the capacity to generate T cells, but display myelomonocytic differentiation potential. (ashpublications.org)
  • Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression Cell. (upenn.edu)
  • Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
  • T cell differentiation. (cdc.gov)
  • Blastic plasmacytoid dendritic cell neoplasm. (oncolink.org)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy derived from plasmacyoid dendritic cells. (medscape.com)
  • The precursors of plasmacytoid dendritic cells are the cells of origin for blastic plasmacytoid dendritic cell neoplasm (BPDCN), a clinically aggressive disease with a proclivity for the skin and leukemic involvement and for which no consensus currently exists regarding optimal treatment modalities. (medscape.com)
  • Frequent sites of occurrence of blastic plasmacytoid dendritic cell neoplasm (BPDCN) include the skin, as well as the peripheral blood (PB) and bone marrow (BM). (medscape.com)
  • A diffuse infiltrate of medium-sized cells with dispersed chromatin ("blastic") is characteristic of blastic plasmacytoid dendritic cell neoplasm (BPDCN). (medscape.com)
  • Pathology of blastic plasmacytoid dendritic cell neoplasm (BPDCN).Skin involvement by blastic plasmacytoid dendritic cell neoplasm. (medscape.com)
  • The neoplastic cells in blastic plasmacytoid dendritic cell neoplasm (BPDCN) are typically positive for CD45, HLA-DR, CD43, CD4, CD56, and cutaneous lymphocyte-associated antigen (CLA). (medscape.com)
  • cultured epidermal dendritic cells (i.e., epidermal Langerhans cells) had 500/cell and spleen dendritic cells approximately 70/cell. (silverchair.com)
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
  • In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
  • The ultrastructural hallmark of the Langerhans cell, the Birbeck granule, was described a century later. (medscape.com)
  • The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
  • Although the epidermal Langerhans cell has been presumed to be the cell of origin in LCH, recent studies have called this belief into question. (medscape.com)
  • Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
  • Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
  • As a result, the pathologic cells of LCH have been hypothesized to represent Langerhans cells in a state of arrested maturation. (medscape.com)
  • [ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
  • The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)
  • These subtypes include conventional dendritic cells (cDC1 and cDC2), plasmacytoid dendritic cells (pDCs), monocyte-derived dendritic cells (moDCs), and Langerhans cells (LCs). (origene.com)
  • CD207 (Langerin) is an antigen described as selectively expressed by Langerhans cells (LC), a subset of immature dendritic cells (DC) formed in epidermis and mucosa. (beckman.com)
  • Its expression, restricted to the Langerhans cell lineage, is demonstrated at both the surface membrane and in the cytoplasm. (beckman.com)
  • Several lines of evidence indicate that Langerin is a marker specific for the acquisition of the Langerhans cell phenotype. (beckman.com)
  • No consensus exists for the optimal therapy for Langerhans cell histiocytosis (LCH), particularly in the case of multisystem organ disease. (medscape.com)
  • Single-agent chemotherapy with cladribine (2-chlorodeoxyadenosine/2-CdA) may be a promising treatment for single-system pulmonary Langerhans cell histiocytosis. (medscape.com)
  • Efficient human cytomegalovirus reactivation is maturation dependent in the Langerhans dendritic cell lineage and can be studied using a CD14 + experimental latency model. (bio-protocol.org)
  • Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
  • Гістіоцитоз легеневих клітин Лангерганса Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
  • Langerhans cell histiocytosis (LCH) is a dendritic cell (antigen-presenting cell) disorder. (msdmanuals.com)
  • Symptoms and signs of Langerhans cell histiocytosis vary considerably depending on which organs are infiltrated. (msdmanuals.com)
  • These cells, including macrophages and neutrophils, were found to provide a rapid response to virtually all pathogens and to initiate inflammation at sites of local infection. (aacrjournals.org)
  • In fact, in patients suffering from severe COVID-19, massive infiltration of proinflammatory immune cells, including activated macrophages, was detected in infected lung tissue. (nature.com)
  • While APC cells come from the so-called myeloid lineage, which includes, for example, macrophages or dendritic cells, "our" RORγt+ APCs actually belong to cells from the lymphoid lineage, which includes, for example, T-cells. (cuni.cz)
  • DCs and macrophages are thought to play important role in cancer by modulating host-immune responses against the tumor cells, promoting metastasis, angiogenesis, etc. (upenn.edu)
  • Such a staggeringly high number is the impact factor of the Nature Review Immunology journal, whose latest issue has just published a paper with Jan Dobeš from the Department of Cell Biology at the Faculty of Science, Charles University as the co-author. (cuni.cz)
  • This particular gene is also expressed in "our" RORγt+ APC cells, although it probably does completely different things there ," explains Jan Dobeš, who now heads the Laboratory of Microbial Immunology at the Faculty of Science of Charles University. (cuni.cz)
  • Although most studies have been based on the mouse model, which is overwhelmingly dominant in immunology, there are now several studies showing that humans have these cells too. (cuni.cz)
  • Generally, properties of all types of dendritic cells can be highly affected by local micro-environment such as presence of pro or anti-inflammatory cytokines, therefore tolerogenic properties of tol-DCs are often context dependant and can be even eventually overridden into pro-inflammatory phenotype. (wikipedia.org)
  • Fully activated immunostimulatory DCs express high levels of costimulatory molecules, produce pro-inflammatory cytokines, and stimulate T cell proliferation, whereas tolerogenic DCs express low levels of costimulatory molecules, produce immunomodulatory cytokines and impair T cell proliferation. (nih.gov)
  • Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, is driven by immune cells and cytokines. (hindawi.com)
  • Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
  • To perform this function, DC are capable of capturing antigens, processing them, and presenting them on the cell surface complexed to major histocompatibility (MHC) molecules, for example, human leukocyte antigen- (HLA-) DR. Along with that, context-dependent expression of costimulatory molecules, such as CD80 and CD86, and secretion of cytokines occurs. (hindawi.com)
  • IDO promotes the degradation of tryptophan to N-formylkynurenin leading to reduced T cell proliferation, whereas HO- 1 catalyzes degradation of hemoglobin resulting in production of monoxide and lower DC immunogenicity. (wikipedia.org)
  • Meanwhile IL-27 exerts proinflammatory effects by promoting Th1, CD8, natural killer (NK), T follicular helper (Tfh), and B cell proliferation/functions and by inhibiting Treg and Th2 cell generation in parasites infection [ 4 ]. (hindawi.com)
  • Mechanistically, PTPN22 mediates cDC2 homeostasis in a cell intrinsic manner by restricting cDC2 proliferation. (frontiersin.org)
  • As a consequence, cDC2 dependent CD4 + T cell proliferation and T follicular helper cell responses are increased. (frontiersin.org)
  • Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections 8 and blocking of B cell proliferation. (biolegend.com)
  • Myeloproliferative neoplasms present with the clonal proliferation of 1 or more myeloid cell lineages.10 The role of genetic and genomic aberrations in pathogenesis has been well documented for these disorders. (oncomine.com)
  • The ability of the M. tuberculosis infected DC to induce T cell proliferation using 5 and 6-carboxyfluorescein diacetate succinimidyl ester (CFSE) dilution technique was also investigated. (biomedcentral.com)
  • It was revealed that the M. tuberculosis infected DC induced T cell proliferation. (biomedcentral.com)
  • These data clearly demonstrate that M. tuberculosis induces activation and maturation of human monocyte-derived immature DC as well as induces T cell proliferation in vitro . (biomedcentral.com)
  • Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)
  • Blastic natural killer (NK) cell lymphoma ( also termed CD4+CD56+ hematodermic neoplasm ) is a recently described entity, with the first case reported in 1994. (medscape.com)
  • Blastic natural killer (NK) cell lymphoma, also termed CD4+CD56+ hematodermic neoplasm (CD4/CD56 HN) is a rare clinical entity encompassing distinct genetic, morphologic, etiologic, and diagnostic criteria. (medscape.com)
  • 5 Hematopoietic disruptions in the myeloid lineage can lead to 3 major disease categories: acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndrome (MDS). (oncomine.com)
  • Because of these mutations, LCH is now considered an oncogene-driven cancer of myeloid lineage. (msdmanuals.com)
  • Therefore, in this study, we investigated the expression of three immune checkpoints on peripheral blood DC subsets, in basal conditions and upon exposure to pro-inflammatory and anti-inflammatory stimuli, by using a flow cytometric panel that allows a direct comparison of the activatory/inhibitory phenotype of DC-lineage and inflammatory DC subsets. (nih.gov)
  • Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)
  • I am interested in the mechanisms underlying this Foxp3+ regulatory T cell expansion in vivo and have focused on whether antigen presenting cells such as dendritic cells are re-programmed to a tolerogenic, regulatory T cell inducing, phenotype following infection. (cam.ac.uk)
  • These cells have a plasmacytoid dendritic cell phenotype, a distinct response to TLR ligation and present antigen to T cells far less efficiently on comparison to conventional CD11c(hi) dendritic cells. (cam.ac.uk)
  • In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal thymus displayed a myeloid-related phenotype prompted us to re-examine the developmental origin of thymic DCs, a cell type hitherto considered to represent a homogeneous lymphoid-derived population. (ashpublications.org)
  • Since recent evidence supports a crucial role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC. (hindawi.com)
  • In particular, the role of Dendritic cells (DCs) in the initiation of specific T cell immunity to M. tuberculosis has not been clearly elucidated. (biomedcentral.com)
  • It has been reported that IL-27 performs an anti-inflammatory function by acting on conventional CD4 + T cells to induce IL-10-producing cells that are implicated in controlling inflammatory responses [ 3 ]. (hindawi.com)
  • Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. (frontiersin.org)
  • Under polarizing inflammatory conditions, cDC2 induce Th2 responses in the lung ( 9 , 10 ), drive Th17 responses through IL-23 secretion ( 11 - 17 ), and initiate SIRPα dependent induction of T follicular helper cells (T FH ) and germinal center (GC) formation ( 18 ). (frontiersin.org)
  • Based on previous efforts focusing on the role of the adaptive immune system in the pathogenesis of MS, it is currently well established that autoreactive T helper type 1 (Th1) and Th17 cells mediate the inflammatory processes in the CNS [ 10 ]. (hindawi.com)
  • Our data indicate that the Sia + fraction of IVIG possesses the ability to influence inflammatory processes in multiple immune cell types and induces novel signatures in cell surface marker expression and cytokine/chemokine production. (scirp.org)
  • Most notably, some gut helminths can also downregulate T cell responses to inflammatory stimuli including asthmatic and allergic reactions through stimulation and expansion of Foxp3+ regulatory T cells. (cam.ac.uk)
  • Inhibition of inflammatory interleukin-6 activity via extracellular signal-regulated kinase-mitogen-activated protein kinase signaling antagonizes human cytomegalovirus reactivation from dendritic cells. (bio-protocol.org)
  • Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. (rndsystems.com)
  • Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)
  • In humans and mice, conventional dendritic cells are divided into two main subtypes: cDC1 and cDC2, each with distinct functions and markers [2]. (origene.com)
  • Acquired immune responses are initiated by activation of CD4 + helper T (Th) cells via recognition of antigens presented by conventional dendritic cells (cDCs). (life-science-alliance.org)
  • Conventional dendritic cells (cDCs) are specialized antigen-presenting cells of the immune system. (life-science-alliance.org)
  • There are many subsets of DCs with different phenotypes derived from either conventional or lymphoid lineages. (biomedcentral.com)
  • Conventional lineage DCs generally differentiate into myeloid DCs which originally come from tissues, such as epithelial or interstitial DCs. (biomedcentral.com)
  • High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity. (wustl.edu)
  • Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. (nih.gov)
  • Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. (bdbiosciences.com)
  • These models are based on experimental evidence and observations and aim to explain different DC subsets' sequential stages and lineage relationships. (origene.com)
  • These cells are functionally, phenotypically, and developmentally heterogeneous with many distinct subsets. (upenn.edu)
  • Anti-type 1 IL-1 receptor (R) mAbs also visualized these receptors by flow cytometry on freshly isolated epidermal dendritic cells. (silverchair.com)
  • Human peripheral blood mononuclear cells treated with LPS and fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). (rndsystems.com)
  • To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer ( FC004 ) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I ( FC005 ). (rndsystems.com)
  • To analyze the interactions between M. tuberculosis and immune cells, human peripheral blood monocyte-derived immature DCs were infected with M. tuberculosis H37Rv wild type strain and flow cytometry was used to analyse cell surface expression markers. (biomedcentral.com)
  • Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells. (bdbiosciences.com)
  • I have found that chronic helminth infection is associated with the expansion of CD11c(lo) dendritic cells in the draining lymph nodes of the gut. (cam.ac.uk)
  • CD11c(lo) cells polarise naive T cells to distinct T cells lineages, encouraging the expansion of antigen-specific Foxp3 T cells and polarisation away from Th17 cells. (cam.ac.uk)
  • [ 4 , 5 ] Previously used terms for this disorder have included CD4+CD56+ hematodermic tumor and blastic natural killer (NK) cell lymphoma. (medscape.com)
  • In the current World Health Organization (WHO) classification of lymphoid malignant neoplasms, the diagnostic entity termed blastic NK-cell tumors has been proposed for tumors satisfying the diagnostic criteria for CD4/CD56 HN. (medscape.com)
  • Cite this: Blastic NK-Cell Lymphomas (Agranular CD4+CD56+ Hematodermic Neoplasms) - Medscape - May 01, 2005. (medscape.com)
  • Tolerogenic dendritic cells (a. k. a. tol-DCs, tDCs, or DCregs) are heterogenous pool of dendritic cells with immuno-suppressive properties, priming immune system into tolerogenic state against various antigens. (wikipedia.org)
  • Functionally, cDC1 cross-present exogenous antigens to activate CD8 + T cells and can promote IL-12 dependent Th1 responses ( 1 , 5 - 7 ). (frontiersin.org)
  • Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
  • First discovered by Ralph Steinman and Zanvil A. Cohn in the 1970s, named for their tree-like branches or "dendrites", these cells patrol our bodies, ingest pathogens, process them, and present fragments (antigens) to T-cells, thus initiating a targeted immune response [2]. (origene.com)
  • cDC1: These cells are very effective at presenting antigens to CD8+ T cells, a type of cytotoxic T cell that can kill infected or cancerous cells. (origene.com)
  • cDC2: These cells are specialized in presenting antigens to CD4+ T cells, a type of helper T cell that helps coordinate the immune response. (origene.com)
  • Interestingly, the number of CD80 + pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1), an important cell type for maintaining peripheral tolerance to self-antigens. (hindawi.com)
  • Dendritic cells (DCs) can take up an array of different antigens, including microorganisms which they can process and present more effectively than any other antigen presenting cell. (biomedcentral.com)
  • M-CSF receptor is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta (1). (rndsystems.com)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • Overall, the present study describes a novel and potent pathway of pDC activation that is linked to the macrophage-mediated clearance of infected cells. (nature.com)
  • The present study examined the effects of Sia + IgG on human peripheral blood mononuclear cell (PBMC)-derived monocyte and macrophage surface marker expression and cytokine/chemokine secretion. (scirp.org)
  • Sia + IgG also increased the expression of cell surface markers associated with macrophage polarization (e.g. (scirp.org)
  • Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage-colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre-T-cell receptor α (pTα) gene transcriptional activation. (ashpublications.org)
  • Myeloid malignancies arise from mutations in hematopoietic stem or progenitor cells. (oncomine.com)
  • Dendritic cells (DCs) are hematopoietic-derived highly specialized antigen-presenting cells (APCs) that display potent ability to induce both specific immune responses and deletion of potentially autoreactive T cells. (ashpublications.org)
  • The DCGM4 antibody stains exclusively immature DCs of the LC lineage. (beckman.com)
  • The gene is preferentially expressed by immature dendritic cells and memory T cells. (cancerindex.org)
  • An aggressive disease (rapid onset and progression) that occurs primarily in adulthood and is marked by an abnormal increase and accumulation of myeloblasts (immature myeloid cells) in the bone marrow and blood, which leads to impaired hematopoiesis and bone marrow failure. (oncomine.com)
  • 10,14 The eventual accumulation of immature white blood cells (myeloblasts or blasts) in the blood and bone marrow impairs other blood cell development and leads to a shortage of red blood cells (anemia) and platelets. (oncomine.com)
  • 107 immature T-cells per day competence. (lu.se)
  • In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
  • Understanding the paradoxical importance of dendritic cells in immunity and tolerance will inform the development of successful cancer immunotherapies. (aacrjournals.org)
  • We now understand that adaptive immunity is the purview of a second set of leukocytes, T and B lymphocytes, which are responsible not only for antibody production but also for the generation of T cells that can directly identify and kill host cells infected by pathogens (e.g., viruses). (aacrjournals.org)
  • Recent evidence also suggests involvement of innate immunity, including dendritic cells (DC), in the initiation and maintenance as well as progression of MS [ 11 ]. (hindawi.com)
  • Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)
  • Collectively, our data demonstrate that PTPN22 controls cDC2 homeostasis, which in turn ensures appropriate cDC2-dependent T cell responses under antigenic challenge. (frontiersin.org)
  • DCs are also the only cell type which can activate naïve T cells and induce antigen-specific immune responses. (wikipedia.org)
  • We also show that a Runx-binding enhancer in the Rorc gene is essential for T cells to integrate cDC-derived signals to induce Rorγt expression. (life-science-alliance.org)
  • During her Master's, in the Pereira Lab, Abby identified the transcription factor combination necessary to induce plasmacytoid dendritic cell identify from fibroblasts. (lu.se)
  • Finally, mononuclear cells isolated from lung (L-MCs), which are used as precursors for L-DCs, expressed more antigen-presenting cell-associated markers such as MHC class II and CD172α compared to their counterparts from blood. (biomedcentral.com)
  • Lymphoid lineage DCs primarily differentiate into plasmacytoid DCs and occupy approximately 0.5% of peripheral blood mononuclear cells (PBMCs) in humans [ 2 ], but the cell population percentage is unclear in horses. (biomedcentral.com)
  • Dendritic cells form a system of antigen presenting cells that are specialized to stimulate T lymphocytes, including quiescent T cells. (silverchair.com)
  • IL-27 binds to IL-27ra and gp-130 complex, which is expressed on multiple cell types, including T lymphocytes [ 2 ]. (hindawi.com)
  • Several groups in the US have in turn discovered that these cells can modulate the function of T-lymphocytes so that they do not attack the gut microbiota. (cuni.cz)
  • The first is that although they have the properties and capabilities of known antigen-presenting cells (APCs), they belong to a distinct cell lineage. (cuni.cz)
  • Although some GRN methods developed for bulk sample data may be applicable to single-cell data, the distinct characteristic of single-cell expression, i.e., the dropout phenomenon, has driven the appearance of GRN algorithms designed specifically for single-cell data. (biomedcentral.com)
  • 1-3 These nonoverlapping functions have been proposed to result from the actions of 2 major DC populations which have been characterized as myeloid and lymphoid DCs, respectively, on the basis of their anatomical localization and cell-surface phenotypes and, ultimately, of their distinct developmental origin. (ashpublications.org)
  • Lselectin is constitutively expressed on neutrophils, P-selectin is found on platelets and is stored in Weibel-Palade bodies from where it is transported to the cell surface upon endothelial activation. (biovendor.com)
  • Granulocytic myeloid cells include populations of terminally differentiated polymorphonuclear neutrophils, eosinophils, basophils, and mast cells. (aacrjournals.org)
  • Collectively characterized by an abnormal increase in multiple blood lineages (granulocytes neutrophils, eosinophils, and myelocytes) that exhibit variable degrees of cellular maturity, especially in bone marrow and blood, CMDs also have the potential to undergo clonal evolution. (oncomine.com)
  • Henderson et al reported that human monocyte derived DC phagocytose M. tuberculosis efficiently, suggesting a role for this important cell in the early response to TB infection. (biomedcentral.com)
  • The maturation pathway involves several stages, with differentiating cells passing through a monocyte-like stage before fully maturing into dendritic cells. (origene.com)
  • Notch-dependent cooperativity between myeloid lineages refers to the process by which different myeloid cell types interact and cooperate with each other through the Notch signaling pathway. (upenn.edu)
  • Understanding how myeloid cells interact and cooperate through the Notch pathway can help researchers understand how the immune system functions and how to treat or prevent immune-related diseases. (upenn.edu)
  • Activated via three pathways, the classical pathway (CP), the lectin pathway (LP), and the alternative pathway (AP), the complement system leads to the formation of a membrane attack complex (MAC) that disrupts the membrane of target cells, leading to cell lysis and death. (bvsalud.org)
  • a partial map of receptors on human mast cells cultured in vitro. (bdbiosciences.com)
  • Experiments in our lab have shown that Foxp3+ regulatory T cell expansion in vitro can be linked to a TGF -beta-like activity present in the excretory/secretory products of the rodent gut helminth Heligmosomoides Polygyrus. (cam.ac.uk)
  • Rapamycin does not inhibit human cytomegalovirus reactivation from dendritic cells in vitro . (bio-protocol.org)
  • Together with recent findings on the effects of IL-1 and GM-CSF on epidermal dendritic cells in situ (see Results and Discussion), the data lead to a proposal whereby IL-1 signals IL-1R to upregulate GM-CSF receptors and thereby, the observed responsiveness of dendritic cells to GM-CSF for growth, viability, and function. (silverchair.com)
  • Coincubation with Leishmania changes the migratory pattern of dendritic cells in vivo . (biomedcentral.com)
  • My research is now focusing on manipulating plasmacytoid dendritic cell populations in vivo and determining the cause for the changes in the CDllc(lo) and Foxp3+ T cell populations following infection. (cam.ac.uk)
  • Circulating dendritic cells isolated from healthy seropositive donors are sites of human cytomegalovirus reactivation in vivo . (bio-protocol.org)
  • We also demonstrate that phenotypically and functionally equivalent myeloid precursors devoid of T-cell potential do exist in vivo in the postnatal thymus. (ashpublications.org)
  • 8 As these latter DCs derive from an intrathymic lymphoid-restricted progenitor able to generate also T, B, and NK cells, but not myeloid cells, upon transfer in vivo, 5 , 9 , 10 they have hitherto been considered of lymphoid origin. (ashpublications.org)
  • Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
  • The cellular or innate immune system was first described by the pathologist Elie Metchnikoff who recognized the existence of cells in the blood and tissues whose role was to identify, capture, and destroy invading pathogens. (aacrjournals.org)
  • It has long been appreciated that the innate and adaptive arms of the immune system must be coordinated, but it was not until the discovery of dendritic cells (DC) by Ralph Steinman at The Rockefeller University in the early 1980s that we truly understood conceptually how the immune system functions as a coherent unit. (aacrjournals.org)
  • Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development. (wustl.edu)
  • Expressed in group2 innate lymphoid cells (ILC2s) during lung disease (PubMed:27043409). (affbiotech.com)
  • T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. (nih.gov)
  • It is a member of the immunoglobulin superfamily expressed on B-cells (from pro-B to blastoid B cells, absent on plasma cells) and follicular dendritic cells. (biolegend.com)
  • In lymph nodes, the tumor cells infiltrate the interfollicular areas and medullary areas, often diffusely, whereas bone marrow evaluation may show variable degrees of infiltration ranging from sparse to significant. (medscape.com)
  • However, in cancer, myeloid cells are largely converted to serve a new master-tumor cells. (aacrjournals.org)
  • The major clinical, histopathologic, and phenotypic aspects of the disease and diagnostic criteria and data suggesting a plasmacytoid dendritic cell origin for the tumor cells are provided. (medscape.com)
  • Cell Reports 15(11): 2462-2474, June 2016. (upenn.edu)
  • Mast cell-lineage versus basophil lineage involvement in myeloproliferative and myelodysplastic syndromes: diagnostic role of cell-immunophenotyping. (bdbiosciences.com)
  • Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses. (aacrjournals.org)
  • 2020. Cell Reports. (biolegend.com)
  • 2020. Cell Host Microbe. (biolegend.com)
  • Cell Reports/Elsevier, 31(13): 107825, June 2020 Notes: DOI: 10.1016/j.celrep.2020.107825. (upenn.edu)
  • Cell/Elsevier, 180(6): 1098-1114, March 2020. (upenn.edu)
  • Plasmacytoid dendritic cells (pDCs), are round plasma-shaped cells specialized for the production of large amounts of type I and type III interferon in response to viral infection. (origene.com)
  • In humans, pDCs can be identified by the expression of several specific cell surface proteins, including CD123 (the IL-3 receptor alpha chain), BDCA-2, and BDCA-4. (origene.com)
  • Importantly, activated MDMs in turn mediate strong activation of plasmacytoid dendritic cells (pDCs), leading to the secretion of high levels of IFN-α and TNF. (nature.com)
  • She hopes her efforts will help not only to better understand immune cell fate decisions but can also be repurposed towards patient-specific immunotherapies. (lu.se)
  • Tolerogenic DCs are essential in maintenance of central and peripheral tolerance through induction of T cell clonal deletion, T cell anergy and generation and activation of regulatory T (Treg) cells. (wikipedia.org)
  • After that, they present these peptides in complexes together with their MHC molecules on their cell surface. (wikipedia.org)
  • Moreover, tolerogenic DCs may also express various inhibitory surface molecules (e.g. programmed cell death ligand (PDL)-1, PDL-2) or can modulate metabolic parameters and change T cell response. (wikipedia.org)
  • Classical activation of these cells takes place as a response to strong signals that usually come in the form of pathogen-associated molecular patterns (PAMP) or danger-associated molecular patterns (DAMP) molecules. (aacrjournals.org)
  • Dendritic cells (DCs) are bone-marrow-derived immune cells found in blood, lymphoid organs, and various tissue of the body. (origene.com)
  • Sufficient numbers of dendritic cells were purified from spleen and skin to do quantitative binding studies with radiolabeled M-CSF, GM-CSF, and interleukin 1 (IL-1). (silverchair.com)
  • In the groups (both the initiation and the progression) receiving recombinant IL-27 administration, the formation of atherosclerotic plaques was suspended, and the percentage of regulatory T cells (LAP + or Foxp3 + ) in the spleen and peripheral blood was increased. (hindawi.com)
  • The CD123 antibody, clone 9F5, is derived from the hybridization of NS-1 mouse myeloma cells with spleen cells isolated from BALB/c mice immunized with IL-3Rα-transfected COS cells. (bdbiosciences.com)