• Dendritic cells (DCs) are bone-marrow-derived immune cells found in blood, lymphoid organs, and various tissue of the body. (origene.com)
  • Conventional dendritic cells (cDCs), also known as myeloid dendritic cells or classical dendritic cells, are a type of antigen-presenting cell (APC), cDCs originate from hematopoietic stem cells, specifically from the common myeloid progenitor in the bone marrow. (origene.com)
  • Each kit includes exosomes isolated from either HEK293 cells or JAWS II mouse bone marrow dendritic cells and Exo-Fect-a novel transfection reagent that enables the transfer of RNAs, DNAs (including plasmids), and small molecules directly into isolated exosomes. (reportergene.com)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • dashed line histograms) or BD Horizon BB515 Rat Anti-Mouse Dendritic Cells antibody (Cat. (bdbiosciences.com)
  • The 1G11 antibody inhibits T lymphocyte adhesion to TNF-stimulated endothelial cells. (beckman.com)
  • The 1A8 antibody binds specifically to Ly-6G, whereas another commonly used antibody, clone RB6-8C5, binds to both Ly-6G and Ly-6C. (stemcell.com)
  • This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse Neutrophil Enrichment Kit (Catalog #19762). (stemcell.com)
  • We demonstrated that the polyclonal fraction of the tumor-reactive T-cell repertoire consisting of relatively minor clones increased in tumor-bearing mice treated with anti-PD-L1 or anti-CD4 monoclonal antibody, which was correlated with antitumor effect. (biorxiv.org)
  • Description: The Anti Human DOR Monoclonal Antibody (Clone No. 1E7) is available in Europe and for worldwide shipping via Gentaur. (oegterm.at)
  • Description: The Anti Human CD36 Monoclonal Antibody (Clone No. NF189) is available in Europe and for worldwide shipping via Gentaur. (oegterm.at)
  • Description: The Anti Rat Macrophage/Dendritic Cells Monoclonal Antibody (Clone No. RM-4) is available in Europe and for worldwide shipping via Gentaur. (oegterm.at)
  • 185-520 Monoclonal Antibody (Clone No. 2E9) is available in Europe and for worldwide shipping via Gentaur. (oegterm.at)
  • The aim of the project was to investigate how CD11c is distributed in the blood, how 2 CD11c antibody clones affect dendritic cell maturation and if they are internalized by the dendritic cells. (aau.dk)
  • Neither of the CD11c antibody clones induced maturation of dendritic cells. (aau.dk)
  • Applications Tested: This MR6F3 antibody has been tested by intracellular staining and flow cytometric analysis of mouse resident peritoneal exudate cells using the Intracellular Fixation & Permeabilization Buffer Set (cat. (fishersci.com)
  • A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (fishersci.com)
  • Murine monoclonal antibodies are produced by injecting a mouse with an antigen, harvesting its spleen to obtain B cells that are producing antibody specific to that antigen, fusing those cells with immortal mouse myeloma cells, growing these hybridoma cells (eg, in cell culture), and harvesting the antibody. (msdmanuals.com)
  • In both cases, the process usually begins as above with production of mouse hybridoma cells that make antibody to the desired antigen. (msdmanuals.com)
  • The resultant DNA is placed in a mammalian cell culture, which then expresses the resultant gene, producing the desired antibody. (msdmanuals.com)
  • Role of CD8+ T cells and lymphoid dendritic cells in protection from ocular herpes simplex virus 1 challenge in immunized mice. (invivogen.com)
  • PSGL-1 is expressed on cells of myeloid, lymphoid and dendritic lineage. (biovendor.com)
  • The fluorescence histogram showing Dendritic Cells antigen expression (or Ig Isotype control staining) were derived from either CD11b+ CD11c- (Left Panel) or CD11b [intermediate] CD11c+ (Right Panel) gated events, as indicated, with the forward and side light-scatter characteristics of intact leucocytes. (bdbiosciences.com)
  • Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
  • Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. (frontiersin.org)
  • During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. (frontiersin.org)
  • The CD106 antigen, also known as Vascular Cell Adhesion Molecule-1 (VCAM-1), is an adhesion molecule which binds to integrin α4/β1 (VLA‑4) and integrin α4/β7 on lymphocytes. (beckman.com)
  • Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. (biomedcentral.com)
  • These professional antigen-presenting cells are able to discriminate unmodified self from non-self thanks to pattern recognition receptors such as the Toll like Receptors (TLR) and Scavenger Receptors (SR). SR were originally identified by their ability to bind and internalize modified lipoproteins and microorganisms but also particles and TLR agonists. (biomedcentral.com)
  • DC are professional antigen-presenting cells that are essential for initiating adaptive immune responses. (biomedcentral.com)
  • These results validate the capacity of XS52 DC to digest PPD into immunogenic peptides inducing antigen specific T cell immune responses. (uni-frankfurt.de)
  • Dendritic cells have been studied intensely for a few decades for their excellent antigen-presenting capabilities, and lately the focus has been on the idea of utilizing them for therapeutic cancer vaccines. (aau.dk)
  • Single-cell sequencing revealed an antigen processing and presentation signature, including induced expression of CD72 and CCR7 as surface markers. (bvsalud.org)
  • CD72 blockade impeded this effect suggesting a new downstream suppressor mechanism that regulates antigen-specific T cell tolerization. (bvsalud.org)
  • Thus, our results indicate that autoreactive antigen-specific naïve B cells tolerize infiltrating T cells against self-antigens to impede the development of tissue-specific autoimmune inflammation. (bvsalud.org)
  • Here, in mice carrying pathogenic C5024T in mt-tRNAAla and in patients with mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS) syndrome carrying A3243G in mt-tRNALeu, we found memory T and B cells to have lower pathogenic mtDNA mutation burdens than their antigen-inexperienced naive counterparts, including after vaccination. (bvsalud.org)
  • Rapid dilution of the C5024T mutation in T and B cell cultures could be induced by antigen receptor-triggered proliferation and was accelerated by metabolic stress conditions. (bvsalud.org)
  • In PRA testing, recipient serum is incubated with white blood cells pooled from a group of blood donors with human leukocyte antigen (HLA) types representative of the community. (medscape.com)
  • Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)
  • Chimeric monoclonal antibodies activate antigen-presenting cells (APCs) and T cells more effectively than murine monoclonal antibodies but can still induce production of human anti-chimeric antibodies. (msdmanuals.com)
  • In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
  • One of the research areas at the MDC is immunology and inflammation, which covers tumor immunology, DNA repair in B lymphocytes, the role of tumor stroma-immune cell interaction in cancers, the role of innate immune cells in gliomas and neurodegenerative diseases, and the development of immunotherapy strategies. (mdc-berlin.de)
  • The identification of lymphocytes as the main cell type responsible for both cellular and humoral immunity started in the early 1950s with the emergence of cell culture techniques. (frontiersin.org)
  • For the activation of CD4 + T-helper lymphocytes, dendritic cells were further incubated with the PAN-DR-binding peptide PADRE. (aacrjournals.org)
  • In humans, at least two subsets of DC are known in the blood, myeloid DC (also known as interstitial or dermal DC), and plasmacytoid DC (pDC) and Langerhans cells (LC) in the tissues [ 3 ]. (biomedcentral.com)
  • During a tour through the facility, Professor Hart explained the work being done to fight blood cancers (acute myeloid leukaemia) by isolating the dendritic cells in the blood stream, to which Mr Hockey said, "There's a lot who want my blood," in a light moment. (dcresearch.org.au)
  • and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. (curehunter.com)
  • DEFENSINS found mainly in epithelial cells. (lookformedical.com)
  • The labeled Human EV Shuttles were then added to mouse embryonic stem cells and imaged for cargo delivery after 18 hours. (reportergene.com)
  • The Human EV Shuttles were well-tolerated and the EVs were taken up efficiently by the mouse embryonic stem cells. (reportergene.com)
  • Genetic modification of dendritic cells through the directed differentiation of embryonic stem cells. (ox.ac.uk)
  • Other responses include: respiratory burst, production of arachidonic acid metabolites, dendritic cell maturation, and phagocytosis of the ligand. (wikipedia.org)
  • The maturation pathway involves several stages, with differentiating cells passing through a monocyte-like stage before fully maturing into dendritic cells. (origene.com)
  • We found that efficient gene transfer into pDC can be achieved with VSVG-pseudotyped lentiviral vectors (LV) under the control of phoshoglycerate kinase (PGK) and elongation factor-1 (EF1α) promoters (28% to 90% of E-GFP + cells, respectively) in the absence of phenotypic and functional maturation. (biomedcentral.com)
  • CD11c distribution was analyzed by flow cytometry, dendritic cell maturation by flow cytometry and microscopy and CD11c internalization by confocal microscopy and flow cytometry. (aau.dk)
  • In humans, pDCs can be identified by the expression of several specific cell surface proteins, including CD123 (the IL-3 receptor alpha chain), BDCA-2, and BDCA-4. (origene.com)
  • Several models are proposed to describe the development and differentiation of dendritic cells (DCs). (origene.com)
  • Here, we describe how another defining property of ES cells, their demonstrable pluripotency, may be harnessed for their directed differentiation along the DC pathway, enabling the generation of limitless numbers of DC faithfully expressing candidate genes of interest. (ox.ac.uk)
  • It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. (joplink.net)
  • It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. (joplink.net)
  • Sry-related HMG-BOX gene 10, (SOX-10), a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage, has been recently shown to be a sensitive marker of melanoma. (thermofisher.com)
  • Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
  • Generation and characterization of infectious molecular clones of transmitted/founder HIV-1 subtype C viruses. (harvard.edu)
  • Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. (lookformedical.com)
  • Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. (bvsalud.org)
  • E-selectin is expressed on endothelial cells. (biovendor.com)
  • In contrast, based on ligand binding analysis and receptor level (as assessed using anti-CXCR7, clone 11G8), surface expression of CXCR7 was reported to be restricted to tumor cells, activated endothelial cells, fetal liver cells, and few other cell types (J. Exp. (rndsystems.com)
  • As a member of this receptor family, dectin-1 recognizes β-glucans and carbohydrates found in fungal cell walls, some bacteria and plants, but may also recognize other unidentified molecules (endogenous ligand on T-cells and ligand on mycobacteria). (wikipedia.org)
  • Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
  • The MHC genes are codominantly expressed, which means that each individual expresses these genes from both the alleles on the cell surface. (medscape.com)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • Expression has also been studied on other immune cells including eosinophils and B cells. (wikipedia.org)
  • The metastic potential of the majority of cells which bind to Pselectin is however in close correlation with the functional expression of PSGL-1 on these cells. (biovendor.com)
  • Reports of mRNA levels and/or protein expression (as assessed using anti-CXCR7, clone 9C4) (J. Biol. (rndsystems.com)
  • To test whether beta-defensin expression was inducible, gingival keratinocyte cell cultures were treated with interleukin-1beta (IL-1beta) or bacterial lipopolysaccharide (LPS) for 24 h. (lookformedical.com)
  • To systematically study such transitions, we introduce a method that simultaneously measures protein expression and thermal stability changes in cells and provide the web-based visualization tool ProteoTracker. (bvsalud.org)
  • When fluorochrome conjugated antibodies are bound to CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)
  • The basis of these inconsistent observations is not known but may be attributed to cell context and the use of different antibodies that may recognize different epitopes. (rndsystems.com)
  • Cell kill indicates that the recipient has antibodies against the donor cells. (medscape.com)
  • Two clones were selected to evaluate the test performance of three assays to measure antibodies to Pgp3: multiplex bead assay (MBA), enzyme-linked immunosorbent assay (ELISA), and lateral flow assay (LFA). (cdc.gov)
  • Furthermore, their propensity for self-renewal, one of the cardinal features of a stem cell, permits cloning at the single cell level and the rational design of ES cell lines, uniformly expressing a desired, mutant phenotype. (ox.ac.uk)
  • The dendritic phenotype observed after erbin depletion is rescued by overexpression of δ-catenin and requires a domain in δ-catenin that has been shown to regulate dendritic branching. (jneurosci.org)
  • Immunization of type VII collagen in athymic nude SJL mice did not induce an autoimmune response, whereas the repletion of T cells from type VII collagen-immunized wild-type mice to the thymic mice showed autoantibody production and resulted in a blistering disease phenotype, supporting the role of T cells in the induction of epidermolysis bullosa acquisita. (medscape.com)
  • Dectin-1 is a transmembrane protein containing an immunoreceptor tyrosine-based activation (ITAM)-like motif in its intracellular tail (which is involved in cellular activation) and one C-type lectin-like domain (carbohydrate-recognition domain, CRD) in the extracellular region (which recognizes β-glucans and endogenous ligands on T cells). (wikipedia.org)
  • In mice, they express the cell surface protein XCR1, while in humans, they can be identified by the presence of CD141 (or BDCA-3). (origene.com)
  • The cleavage of the protein from the cell surface is one mechanism involved in the deactivation process. (biovendor.com)
  • Dendritic cells (DC) are known to present exogenous protein Ag effectively to T cells. (uni-frankfurt.de)
  • The quality dependable for WAS, the WAS protein quality (WASP), was cloned and sequenced in 1994. (alliedacademies.org)
  • The WASP quality has 12 exons and encodes a 502 amino-acid protein (WASP), which is overwhelmingly communicated in nonerythroid hematopoietic cells [ 3 ]. (alliedacademies.org)
  • The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and δ-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. (jneurosci.org)
  • In sentinel node, SOX-10 is positive in metastatic melanomas and nodal capsular nevus but not in dendritic cells, which usually express S100 protein. (thermofisher.com)
  • A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. (fishersci.com)
  • Induction of an active model of autoimmunity against type VII collagen in a hairless mouse strain (SKH1) revealed that regulatory T cells, which have been identified for their ability to inhibit the development of autoimmune diseases, do not inhibit the development of autoantibodies against the self-protein mouse-type VII collagen. (medscape.com)
  • Previous studies have shown great potential of using the CD11c molecule as a target on the dendritic cells. (aau.dk)
  • The DKFZ is a multidisciplinary center covering cancer biology from basic molecular and cell biology to clinical research and care. (mdc-berlin.de)
  • The capability for Professor Derek Hart and his team at Dendritic Cell Biology and Therapeutics Group (DCBTG) to deliver a world-wide boost for a cure for cancer is another step closer following the visit. (dcresearch.org.au)
  • To delineate if a specific subset of NKT cells was responsible for this effect, we generated different subsets of human CD4- and CD4+ Vα24i NKT clones and demonstrate that a CD4-CD8αα+ subset with highly efficient cytolytic ability was unique among the clones in being able to suppress the proliferation and expansion of activated T cells in vitro. (ox.ac.uk)
  • This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
  • Lselectin is constitutively expressed on neutrophils, P-selectin is found on platelets and is stored in Weibel-Palade bodies from where it is transported to the cell surface upon endothelial activation. (biovendor.com)
  • In the periphery, Gr-1 is found predominantly on neutrophils and is a useful marker for these cells. (stemcell.com)
  • DEFENSINS found in azurophilic granules of neutrophils and in the secretory granules of intestinal PANETH CELLS. (lookformedical.com)
  • We show that short hairpin RNA-mediated knockdown of erbin and knockdown or genetic ablation of δ-catenin severely impaired dendritic morphogenesis in hippocampal neurons. (jneurosci.org)
  • Use the EV Shuttle Kit for a range of applications including cargo delivery for therapeutic development, virus-free creation of stable cell lines, and gene delivery in hard-to-transfect cells. (reportergene.com)
  • Put exosomes to work-directly transfect JAWS II exosomes with RNA, plasmids, metabolites, or other small molecules for delivery to recipient cells. (reportergene.com)
  • However, our knowledge of the cellular and molecular mechanisms that promote the formation and maintenance of dendritic arbors remains incomplete. (jneurosci.org)
  • The siRNA-loaded EV Shuttles were then added to naive mouse monocyte macrophage cells (RAWS 264.7) in culture. (reportergene.com)
  • Immunologic variations from the norm of WAS incorporate T-cell lymphopenia, flawed proliferative reaction to CD3 cross-linking, disabled counter acting agent reaction to polysaccharide antigens, flawed monocyte chemotaxis, anomalies of fortified dendritic cells, and an expanded lymphocyte apoptosis with age. (alliedacademies.org)
  • How is the tissue specificity of immune cells generated and how is it affected by environmental influences, plasticity and the tissue microenvironment? (mdc-berlin.de)
  • This tissue may contain both positive and negative staining cells or tissue components and serve as both the positive and negative control tissue. (thermofisher.com)
  • Mechanistically, PTPN22 mediates cDC2 homeostasis in a cell intrinsic manner by restricting cDC2 proliferation. (frontiersin.org)
  • Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin. (harvard.edu)
  • We analyzed here, the transduction efficiency of a pDC cell line, GEN2.2, and of pDC derived from CD34+ progenitors, using lentiviral vectors (LV) pseudotyped with different envelope glycoproteins such as the vesicular stomatitis virus envelope (VSVG), the gibbon ape leukaemia virus envelope (GaLV) or the feline endogenous virus envelope (RD114). (biomedcentral.com)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • Researchers are uncovering ever more details about the complex system of organs, tissues, and different cell types that make up the human immune system. (mdc-berlin.de)
  • Transplantation is the act of transferring cells, tissues, or organs from one site to another, typically between different individuals. (medscape.com)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Overall, the present study describes a novel and potent pathway of pDC activation that is linked to the macrophage-mediated clearance of infected cells. (nature.com)
  • Also operating as a co-stimulatory molecule via recognition of an endogenous ligand on T-cells, which leads to cellular activation and proliferation, CLEC7A can bind both CD4+ and CD8+ T cells. (wikipedia.org)
  • The mucin-like glycoprotein PSGL-1 (P-selectin Glycoprotein Ligand-1) has been cloned and sequenced. (biovendor.com)
  • In humans and mice, conventional dendritic cells are divided into two main subtypes: cDC1 and cDC2, each with distinct functions and markers [2]. (origene.com)
  • Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)
  • In comparison, cDC2s are potent activators of CD4 + T cells ( 8 ). (frontiersin.org)
  • It has been demonstrated that only a small fraction of CD206 is present at the cell surface, therefore, intracellular staining is recommended. (fishersci.com)
  • DCs are unique subsets of white blood cells that are responsible for initiating and directing immune responses. (dcresearch.org.au)
  • Moreover, the polyclonal fraction was enriched in progenitor exhausted T cells, which are essential for a durable antitumor response, and was more dependent on CCR7 + migratory dendritic cells, which are responsible for priming tumor-reactive T cells in the tumor-draining lymph nodes. (biorxiv.org)
  • This process relies on the formation of a blastema, a pool of progenitor cells that is formed in response to amputation. (lu.se)
  • We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
  • Under polarizing inflammatory conditions, cDC2 induce Th2 responses in the lung ( 9 , 10 ), drive Th17 responses through IL-23 secretion ( 11 - 17 ), and initiate SIRPα dependent induction of T follicular helper cells (T FH ) and germinal center (GC) formation ( 18 ). (frontiersin.org)
  • These results suggest that the expansion of diverse tumor-reactive clones ("clonal spreading") is an important mechanism by which anti-PD-L1 and anti-CD4 treatments induce robust and durable antitumor T-cell responses. (biorxiv.org)
  • Renegade T cell clones and autoimmune disease. (harvard.edu)
  • They are known to have a role in preventing autoimmune diseases and are involved in optimally mounted immune responses to pathogens and tumor cells. (ox.ac.uk)
  • We were interested in understanding how these cells provide protection in autoimmune diseases. (ox.ac.uk)
  • Recent years have witnessed a progressive acceptance of the dual role played by dendritic cells (DC) in the initiation of immune responses and their specific attenuation through the induction of immunological tolerance. (ox.ac.uk)
  • Standard Lipofectamine transfection protocols were also compared to Human EV Shuttles on RAWS 264.7 cells using 100 pmol of Texas Red-labeled control siRNA. (reportergene.com)
  • First discovered by Ralph Steinman and Zanvil A. Cohn in the 1970s, named for their tree-like branches or "dendrites", these cells patrol our bodies, ingest pathogens, process them, and present fragments (antigens) to T-cells, thus initiating a targeted immune response [2]. (origene.com)
  • cDC1: These cells are very effective at presenting antigens to CD8+ T cells, a type of cytotoxic T cell that can kill infected or cancerous cells. (origene.com)
  • cDC2: These cells are specialized in presenting antigens to CD4+ T cells, a type of helper T cell that helps coordinate the immune response. (origene.com)
  • Functionally, cDC1 cross-present exogenous antigens to activate CD8 + T cells and can promote IL-12 dependent Th1 responses ( 1 , 5 - 7 ). (frontiersin.org)
  • It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and CompBead to ensure that BD Comp beads are appropriate for your specific cellular application. (bdbiosciences.com)
  • Filipe Pereira has found his niche at the interface of cellular reprogramming and blood cell identity. (lu.se)
  • Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (harvard.edu)
  • This discrepancy is explained by thymic selection where the fate of T-cell precursors is dependent on the recognition of self-peptides (self-p) presented by MHC molecules on thymic stromal cells ( 28 ). (frontiersin.org)
  • By using skin cells as the starting cell-type, he managed to identify the three molecules needed to "program" dendritic cells in just nine days. (lu.se)
  • In the next step, he used the same molecules to reprogram cancer cells into dendritic cells. (lu.se)
  • In other words, using the molecules as a trojan horse to "force" cancer cells to develop into immune cells. (lu.se)
  • Загальні відомості про імунну систему The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
  • Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy. (harvard.edu)
  • These observations may also suggest that in the case of drug/chemical allergy, the T-cell repertoire results from particular properties of certain TCR to recognize hapten-modified peptides without need for previous thymic selection. (frontiersin.org)
  • Localized heterochrony integrates overgrowth potential of oncogenic clones. (harvard.edu)
  • One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
  • Here, we demonstrate that upon phagocytosis of SARS-CoV-2-infected cells, MDMs are activated and secrete IL-6 and TNF. (nature.com)
  • Embryonic stem (ES) cells are, by contrast, relatively amenable to genetic modification. (ox.ac.uk)
  • B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. (bvsalud.org)
  • As a consequence, cDC2 dependent CD4 + T cell proliferation and T follicular helper cell responses are increased. (frontiersin.org)
  • We suggest that one mechanism by which CD1d-restricted NKT cells can exert a regulatory role is by containing the proliferation of activated T cells, possibly through timely lysis of APCs or activated T cells bearing CD1d. (ox.ac.uk)
  • A phase I trial was conducted to evaluate the feasibility, safety, and efficacy of a dendritic cell-based vaccination in patients with metastatic renal cell carcinoma (RCC). (aacrjournals.org)