Dendritic cell stromal cells. Medical search. Frequent questions

IL-23 is mainly secreted by activated dendritic cells, macrophages or monocytes. (wikipedia.org)
The larger population are CD34+ and resemble haemopoietic stem cells while the smaller population are CD34-CD11b+ MHC Class II+ macrophages. (arvojournals.org)
Antigen acquisition by stromal cells, including macrophages and CD11b+ dendritic cells, correlated with surface GAP formation. (jci.org)
These features may be responsible for the recruitment and activation of T cells, macrophages and dendritic cells, characterizing the stromal component of this lymphoma, and may point towards innate immunity and a tumor tolerogenic immune response in T-cell/histiocyte-rich large B-cell lymphoma. (haematologica.org)
Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
It is expressed on vascular endothelium in lymphoid tissues, thymic stromal cells, peripheral blood monocytes, peritoneal macrophages and mast cells, dendritic cells, and weakly on peripheral lymphocytes and thymocytes. (bdbiosciences.com)
Dendritic cells and macrophages found in large quantities at the corticomedullary junction arise from mesodermal tissues (bone marrow). (medscape.com)
Programmed death 1 (PD-1) is an immunoreceptor of the CD28/CTLA-4 family whose expression is induced in activated T- and B-cells and in macrophages ( 1 , 2 ). (diabetesjournals.org)
Such populations include regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells. (ox.ac.uk)
The major histocompatibility complex participates in interactions between T cells and thymic epithelial cells, in addition to interactions between T cells and dendritic cells, macrophages and myoid cells. (nel.edu)
This work briefly summarizes morphological and ultrastructural characteristics of thymic epithelial cells, dendritic cells, macrophages and myoid cells. (nel.edu)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

IL-23 expression by dendritic cells is further induced by thymic stromal lymphopoietin, a proallergic cytokine expressed by keratinocytes that is elevated in psoriatic lesions. (wikipedia.org)
IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. (nih.gov)
The plasma levels of thymic stromal lymphopoietin (TSLP) and tumor necrosis factor-α increased the most in DSS-treated conventional mice. (scirp.org)
To explore the effect of thymic stromal lymphopoietin (TSLP) on transformation of dendritic cell (DC) and T cell in vitro. (bvsalud.org)
Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. (fishersci.com)

We found that human intestinal epithelial cells (IECs) triggered IgA(2) class switching in B cells, including IgA(1)-expressing B cells arriving from mucosal follicles, through a CD4(+) T cell-independent pathway involving a proliferation-inducing ligand (APRIL). (nih.gov)
The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. (aai.org)
In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the vitamin A-converting enzyme RALDH1 in intestinal epithelial cells in vivo and in vitro, respectively. (aai.org)
Furthermore, our data showed that the expression levels of RALDH1 in small intestinal epithelial cells correlated with the activity of vitamin A-converting enzymes in mesenteric lymph node dendritic cells, along with increased numbers of intestinal regulatory T cells and a higher production of luminal IgA. (aai.org)
Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
The epithelial cells and these other stromal tissues of the thymus influence the selection and maturation of the T lymphocytes. (medscape.com)
The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)
The thymic microenvironment consists of a network of reticular epithelial cells and other fixed and free cells. (nel.edu)

Mouse-derived immature dendritic cells and T lymphocytes were co-cultured in vitro, which were divided into 4 groups (TSLP stimulation group, TSLP stimulation and its receptor blocking group, ovalbumin stimulation group and ovalbumin stimulation and TSLP receptor blocking group). (bvsalud.org)

IL-23 stabilises RORγt and thus enables Th17 cells to release their effector cytokines, such as IL-17, IL-21, IL-22 and GM-CSF, which mediate protection against extracellular fungi and bacteria and participate in barrier immunity. (wikipedia.org)
Effects similar to those IL-23 has on Th17 cells were described for type 3 innate lymphoid cells, which actively secrete Th17 cytokines upon IL-23 stimulation. (wikipedia.org)
CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. (biolegend.com)
The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers. (hindawi.com)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
These anaphylatoxins promote release of proinflammatory cytokines and serve as chemoattractants for effector cells. (hindawi.com)
Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
These LL37-specific autoimmune T cells produce Th17 cytokines which, on one hand, elicit the psoriatic phenotype and, on the other hand, sustain the antimicrobial peptide expression by keratinocytes, providing a feedback loop that perpetuates skin inflammation in psoriasis. (chuv.ch)
In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells. (fishersci.com)
these responses may include proinflammatory cytokines, inflammasome activation, barrier integrity, skin microbiota, and the presence of immune cells. (cdc.gov)

It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. (biolegend.com)
Its expression is upregulated on activated lymphocytes and endothelial cells. (bdbiosciences.com)
In the normal thymus, bone marrow-derived precursor cells destined to become thymocytes (or T lymphocytes) enter the thymus at the corticomedullary junction and differentiate as they pass through the thymus. (medscape.com)
CXCL13 was not expressed by atypical lymphocytes in all cases but did stain stromal cells consistent with follicular dendritic cells in 1 case. (umn.edu)
and T-LYMPHOCYTES, and is produced by various cell types, including epithelial and dendritic cells. (bvsalud.org)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)

IL-23 also induces proliferation of CD4 memory T cells (but not naïve T cells). (wikipedia.org)
Low concentrations of IL-23 support lung tumor growth whereas high concentrations inhibit proliferation of lung cancer cells. (wikipedia.org)
details] Effects of Low-Intensity Electromagnetic Fields on the Proliferation and Differentiation of Cultured Mouse Bone Marrow Stromal Stem Cells [med. (emf-portal.org)
details] A 60 Hz uniform electromagnetic field promotes human cell proliferation by decreasing intracellular reactive oxygen species levels [med. (emf-portal.org)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Case Report: Castleman Disease With an Associated Stromal Spindle Cell Proliferation, PDGFRB Mutation and p53 Expression: Clonal Origins of a Rare Disease. (stanford.edu)
Hence, we describe an index case with morphology consistent with the hyaline vascular subtype of UCD with concomitant atypical smooth muscle actin (SMA)-positive stromal spindle cell proliferation containing a recurrent PDGFRB N666S mutation and upregulation of p53 expression. (stanford.edu)
and T-cell proliferation, adoptive transfer, and islet transplantation were performed to evaluate the PD-L1 transgene-mediated immune-protective mechanisms. (diabetesjournals.org)
All of these cells play a critical role in the proliferation, differentiation and selection of precursor cells in the T-cell lineage, but the precise mechanisms not well understudood. (nel.edu)
In addition, a local RAS is expressed in many tissues and mainly acts at the cellular level, where it mediates cell proliferation, growth, and metabolism. (nutriforce.cn)
Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)

Combined staining for F-actin and leukocyte differentiation markers clearly showed that the corneal stroma contains a population of CD45+ resident bone marrow-derived cells, while the major proportion of cells were CD45-F-Actin+ keratocytes. (arvojournals.org)
In this context, a new molecule, B-cell activating factor (BAFF), has emerged as a positive regulator of B cell survival and differentiation functioning through various signaling pathways and potentiating the activity of various receptor complexes through pleiotropic means. (medsci.org)
Microbiota-dependent presence of murine enteric glial cells requires myeloid differentiation primary response protein 88 signaling. (mhh.de)
We are delineating the cellular and molecular mechanisms that mediate the differentiation of stromal cells towards lymphoid tissue organizing cells, allowing the attraction of hematopoietic cells to the developing lymph nodes. (vumc.nl)
In addition, the subsequent differentiation of these cells into the different stromal cell subsets that are present within lymph nodes are studied. (vumc.nl)
Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
Here, they undergo antigen-driven clonal expansion and differentiation into plasma and memory cells. (rupress.org)
T cell differentiation occurs via T cell receptors. (nel.edu)
The neuroendocrine system regulates early T cell differentiation by the transcription of neuroendocrine genes in the stromal network and expression of cognitive receptors by immature T cells. (nel.edu)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Few reports have suggested that underlying stromal cells in UCD are clonally neoplastic and may be of fibroblastic reticular cell (FRC) or follicular dendritic cell (FDC) origins given their close clonal relationship. (stanford.edu)

High inductive magnetic stimuli and their effects on mesenchymal stromal cells, dendritic cells, and fibroblasts [med. (emf-portal.org)
They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)

Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)

A very few CD45+ cells expressed the B220 marker suggesting a plasmacytoid dendritic cells phenotype. (arvojournals.org)
A very small percentage comprise plasmacytoid dendritic cells. (arvojournals.org)
The pathogenesis of PTLDs seems to be multifactorial-EBV is main one .Antigenic stimulation Plasmacytoid dendritic cells (PDCs) , regulatory T cells are other factors .Whilst most are high-grade B-cell non-Hodgkin's lymphoma (NHLs), a few are classical Hodgkin's lymphomas. (iriakerala.org)

2017). Dendritic Cell-derived Extracellular Vesicles mediate Mesenchymal Stem/Stromal Cell recruitment . (up.pt)
2017). Systemic delivery of bone marrow mesenchymal stem cells for in situ intervertebral disc regeneration . (up.pt)
Mesenchymal stem cells are mobilized from the bone marrow during inflammation , Frontiers in Antigen Presenting Cell Biology , 2013, Front. (vumc.nl)
To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
Mesenchymal stem/stromal cells including adipose-derived stromal cells (ADSC) are a promising cell source for this application. (biomedcentral.com)
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. (issca.us)
Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (issca.us)
Fascinated with the unlimited potential of adipose tissue-derived mesenchymal stem cells, making them the most preferred choice? (kosheeka.com)
Worldwide researchers are using adipose tissue-derived mesenchymal stem cells for cosmetic research? (kosheeka.com)

This mechanism activates skin pDC but also other cell types such as conventional DC, monocytes ( Chamilos et al . (chuv.ch)

1A29 mAb inhibits Phorbol 12-Myristate 13-Acetate (PMA)-induced aggregation of phytohemagglutinin (PHA)-stimulated splenic blasts, as well as the adhesion of mitogen-stimulated blasts to high endothelial venule (HEV) cells and purified ICAM-1. (bdbiosciences.com)
Blood 2012) , keratinocytes, and endothelial cells ( Ramos et al . (chuv.ch)
To study the migration of microglia across the BBB, we developed an in vitro co-culture system of mouse brain endothelial cells (MBECs) and Ra2 microglia using Transwell inserts. (portlandpress.com)
The addition of microglia or ATP led to the disruption of the MBEC monolayer and significantly decreased barrier function as measured by trans-endothelial electrical resistance (TEER) and electric cell-substrate impedance sensing (ECIS). (portlandpress.com)
In conclusion, we offer evidence that microglia migration across the brain endothelial cell monolayer is increased in the presence of ATP in a manner that involves MMP secretion. (portlandpress.com)

Analyses of TNFR1/RelA-deficient embryonic tissues and of radiation chimeras suggest that the dependence on RelA is manifest not in hematopoietic cells but rather in radioresistant stromal cells needed for the development of secondary lymphoid organs. (rupress.org)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

Over the past few years, MSCs researches have achieved some inspiring results and some of which moved up to clinic period from preclinical phases, resulting in the marketing approval of a few cell-based therapy products (CTPs) by different national regulatory authorities [18]. (researchsquare.com)
Regulatory immune cells in transplantation. (ox.ac.uk)
We consider the potential of these regulatory immune cells to develop and function in transplant recipients and their potential use as cellular therapies to promote long-term graft function. (ox.ac.uk)
CD4+CD25high regulatory cells in peripheral blood of cancer patients. (nel.edu)
Regulatory T cells (Treg) that prevent autoimmune diseases by suppression of self-reactive T cells may also suppress the immune response against cancer. (nel.edu)
The purpose of the study was to identify a CD4+ population of regulatory T cells expressing high levels of CD25(CD4+CD25 high) in the peripheral blood of cancer patients and provide the opportunity to determine whether cancer patients exhibit an expanded CD4+CD25high pool. (nel.edu)
Liu L, Wu G, Yao J, Ding Q, Huang S. CD4+CD25high regulatory cells in peripheral blood of cancer patients. (nel.edu)

This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors. (medscape.com)
The microenvironment of thymus is very important for the selection and maturation of T cells. (nel.edu)
In detail, thymus-settling progenitors enter the thymus and generate early T-cell progeni- tors (ETP/DN1 stage), which in turn give rise to DN2, DN3 and DN4 cells. (lu.se)

Bone marrow stromal cells (BMSC) are multipotent stem cells and are considered good candidates for cell restoration in injured brain tissue. (sld.cu)
Bone marrow stromal cells (BMSC) are adult stem cells with characteristics that make them an attractive candidate in cellular therapy for neurological diseases (1). (sld.cu)

The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)

Dr. Keenan notes that effector T cells align with positive outcomes, while suppressive myeloid cells and cytokine signals within the TME often signify a less favorable prognosis and resistance to immunotherapy. (oncologytube.com)
During the presentation, Dr. Keenan explores targeting the TME through immunotherapies, focusing on tumor metabolism and immunosuppressive myeloid cells. (oncologytube.com)

Stem Cells Translational Medicine, 6 (3), 1029 - 1039. (up.pt)
Stem Cells International. (regionh.dk)

It has been shown to be a key cytokine for T helper type 17 cell (Th17 cell) maintenance and expansion. (wikipedia.org)
cytokine levels cause a decline in cell numbers. (123dok.net)

Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)

The logical gating of antigen recognition further addresses the perennial challenge of identifying suitable tumor antigens in CAR T cell therapy, showcasing the evolving landscape of adoptive T cell therapies. (oncologytube.com)
Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured tissue and the adaptive immune response stimulated by mismatched donor and recipient histocompatibility antigens to enable the transplant to survive and function. (ox.ac.uk)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

DN1 stage) T-cell progenitors. (lu.se)

The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. (nutriforce.cn)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

2 , 3 , 9 Indeed, the atypical B cells of NLPHL and THRLBCL share many characteristics, including expression of pan-B-cell markers, germinal center B-cell origin and common chromosomal imbalances. (haematologica.org)
Primed T cells and antigen-activated B cells then migrate into the primary follicles where they associate with follicular dendritic cells (FDCs), giving rise to germinal centers (GCs). (rupress.org)
Scattered follicles showing onion skinning of the mantle zones and hyalinised atrophic germinal centres with predominance of follicular dendritic cells and "lolipop"shaped blood vessels were noted. (iriakerala.org)

In the pathogenesis of psoriasis, dermal dendritic cells are stimulated to release IL-23 by nociceptive neurons. (wikipedia.org)

Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)

It has been described that the brainderived neurotrophic factor (BDNF) regulates neurotransmitter release and dendritic and axonal growth. (sld.cu)
Here, we review evidence that hypoxia regulates cell plasticity, resistance to cell-mediated cytotoxicity, and immune suppression. (nutriforce.cn)

This new understanding of the role of B cells opened up novel therapeutic options for the treatment of autoimmune diseases. (hindawi.com)
and current B-cell-based therapeutic treatments. (hindawi.com)
Despite these challenges, ongoing strategies in T cell engineering, patient selection, and optimization seek to enhance the therapeutic window for these cell therapies. (oncologytube.com)
The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
Cells' therapeutic potential can be also increased by expression of proangiogenic factors by viral transduction. (biomedcentral.com)

The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. (haematologica.org)
Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
By quantitative reverse transcriptase polymerase chain reaction we verified that these 20 selected cases were representative of the entire population of T-cell/histiocyte-rich large B-cell and nodular lymphocyte-predominant Hodgkin's lymphomas. (haematologica.org)
Results We observed that the microenvironment in nodular lymphocyte-predominant Hodgkin's lymphoma is molecularly very similar to a lymph node characterized by follicular hyperplasia, while the microenvironment in T-cell/histiocyte-rich large B-cell lymphoma is clearly different. (haematologica.org)
Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)
1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)

2017). Targeting dendritic cells for the treatment of autoimmune disorders . (up.pt)
2017. Cancer Cell. (biolegend.com)

Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. (hindawi.com)
Traditionally, autoimmune disorders were classified as T cell mediated or autoantibody mediated. (hindawi.com)
The observation that most autoantibodies in traditionally autoantibody-mediated diseases are of the IgG isotype and carry somatic mutations strongly suggests T-cell help in the autoimmune B-cell response. (hindawi.com)
Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
however, it needs to be emphasized that most autoimmune diseases are driven by a dysfunction in the immune network consisting of B cells, T cells, and other immune cells. (hindawi.com)
These cells are believed to recognize self too strongly and to have autoimmune potential. (medscape.com)
It is likely that in the case of autoimmune diseases, a high degree of organization will worsen the disease since efficient presentation of autoantigens will enhance activation of autoreactive T cells. (vumc.nl)
We discovered that one of these antimicrobial peptide called LL37 not only triggers innate immune activation but also acts as an epidermal autoantigen targeted by autoimmune T cells in psoriasis Lande et al . (chuv.ch)
We investigated the protective potential of PD-L1 on autoimmune diabetes by transgenically overexpressing PD-L1 in pancreatic β-cells in nonobese diabetic (NOD) mice. (diabetesjournals.org)
CONCLUSIONS -Our results demonstrate the protective potential of transgenic PD-L1 in autoimmune diabetes and illustrate its role in downregulating diabetogenic T-cells in NOD mice. (diabetesjournals.org)

Immunostaining for terminal deoxynucleotidyl transferase (TdT) was positive in tumor cells, supporting the diagnosis of cutaneous involvement by T-ALL. (karger.com)
The tumor cells of both lymphomas share several characteristics, while the cellular composition of their microenvironment is clearly different. (haematologica.org)
8 , 10 - 12 Recently, genome-wide analysis of isolated tumor cells from NLPHL and THRLBCL revealed further similarities between the tumors cells of the two lymphomas. (haematologica.org)
Gene expression profiling of lymphomas clearly illustrated that apart from the characteristics of the tumor cells, the microenvironment of the tumor also defines the profile of the lymphoma, and, more importantly, plays a role in predicting the prognosis. (haematologica.org)
The 1A29 antibody can reportedly inhibit leucocyte infiltration in in vivo systems, blocks induction of experimental allergic encephalomyelitis, and reduces NK-cell adhesion to tumor cells. (bdbiosciences.com)

Lymph nodes are organized to mediate an efficient interaction of antigen presenting cells and T cells. (vumc.nl)

Cell therapy using adipose-derived stromal cells (ADSC) is an intensively developing approach to promote angiogenesis and regeneration. (biomedcentral.com)

Innate lymphoid cells and γδ T cells also produce IL-23. (wikipedia.org)
Although these changes were not observed in SKH1 mice, SKH1 mice exposed to triclosan had a higher number and frequency of type 2 innate lymphoid cells in the skin. (cdc.gov)

c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
Right panel: antigen binds to the BCR of antigen-specific B cells and is internalized. (hindawi.com)
The generation of an immune response is dependent on efficient interaction of rare antigen-specific T cells with dendritic cells that present the antigen. (vumc.nl)

The normal mouse cornea contains two populations of bone marrow derived leukocytes, both of which are distinct from stromal keratocytes. (arvojournals.org)
In the 1970s, Friedenstein and colleagues [1] first reported that locally applied culture-expanded populations of bone marrow stroma-derived fibroblastic cells remained at their injection sites under the kidney capsule, where an ectopic hematopoiesis was initiated. (issca.us)
Here, we discuss the leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation. (ox.ac.uk)
Taken together, these results demonstrate that exposure to an immunomodulatory chemical, triclosan, differentially impacts immune cell populations in the skin of haired and hairless mice. (cdc.gov)

In brain, IL-23 is able to activate γδ T cells to increase their expression of IL-17, which contributes to the inflammatory response and thus plays a key role in secondary brain injury after spontaneous intracerebral hemorrhage. (wikipedia.org)
Deposited immune complexes can activate complement and effector cells. (hindawi.com)
We have identified the factors that activate skin pDC and uncovered a fundamental function of cationic antimicrobial peptides in breaking innate tolerance to self-nucleic acids released by dying cells and activate skin pDC ( Lande et al . (chuv.ch)
Hypoxic cells activate a number of adaptive responses coordinated by various cellular pathways. (nutriforce.cn)

The barrier dysfunction, which may facilitate allergen entry, as a key epidermis also contains keratinocytes and Langerhans cells, a factor in the development of atopic asthma and sensitization. (cdc.gov)

check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

13 Despite the similarities of their malignant cells, an important difference between the two lymphomas lies in their clinical presentation and prognosis. (haematologica.org)
The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progression, its hostility, and heterogeneity. (nutriforce.cn)

Reciprocal roles of T-cell help for B cells during adaptive immune responses and B-cell help in CD4+ T-cell activation are being increasingly recognized. (hindawi.com)
Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, preventing and reversing damage to organs, and restoring balance to compromised immune systems. (nih.gov)
It is essential for the development and maintenance of normal immune system, especially cell-mediated immunity. (nel.edu)
Thus, solid tumors seem to build up a hostile hypoxic microenvironment that hampers cell-mediated immunity and dampen the efficacy of the immune response. (nutriforce.cn)
This versatile cell type orchestrates a broad spectrum of biological functions and exerts very complex and even opposing functions on cell death, immune stimulation or suppression, and angiogenesis, resulting in an overall pro- or antitumoral effect. (nutriforce.cn)
It has become clear that hypoxia shapes and induces specific macrophage phenotypes that serve tumor malignancy, as hypoxia promotes immune evasion, angiogenesis, tumor cell survival, and metastatic dissemination. (nutriforce.cn)
This major dendritic cell of the skin that can acquire antigen, migrate article highlights recent findings from a diverse literature that to draining lymph notes, and initiate immune responses (3). (cdc.gov)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)

Further analysis of 21 additional cases of UCD identified increased p53 expression by digital image analysis and SMA positive stromal cells predominantly within the paracortical and intrafollicular areas further strengthening the hypothesis of the stromal cellular derivation and origins of UCD. (stanford.edu)

Journal of Cell Biology, 215 (6), 789 - 799. (up.pt)
Kalbasi, MD, explained how these cutting-edge techniques leverage synthetic biology to modulate cell function post-administration, offering potential avenues to minimize toxicity and improve efficacy. (oncologytube.com)

These cells are in intimate contact with corneal keratocytes which stained only for F-actin and were negative for all leukocyte markers. (arvojournals.org)

Targeted gene deletion and radiation chimera analyses have provided insights into the molecular machinery underlying the development of secondary lymphoid organs, emphasizing the importance of crosstalk between hematopoietic and nonhematopoietic cells. (rupress.org)

Natural killer cells also express the IL-23 receptor. (wikipedia.org)
B cells produce IL-23 through B cell antigen receptor signaling. (wikipedia.org)
Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1 [med. (emf-portal.org)
These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
Notably, CAR T cells targeting IL 13 receptor alpha 2 and GD2 showcased early success in glioblastoma and midline glioma, respectively, indicating a shift in the narrative for solid tumor treatments. (oncologytube.com)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

abstract = "Angioimmunoblastic T-cell lymphoma is known to frequently involve bone marrow. (umn.edu)

More recently, we found that this inflammatory pathway is also at the heart of a side effect of anti-TNF treatment, called paradoxical psoriasis, which in contrast to psoriasis, is characterized by an exaggerated activation of skin pDC that does not lead to T cell autoimmunity (Conrad et al . (chuv.ch)

107 immature T-cells per day competence. (lu.se)

One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)

Leukemic cell infiltration of the skin (i.e., leukemia cutis) typically occurs after the diagnosis of leukemia and may precede the appearance of leukemic blasts in the peripheral blood [ 2 ]. (karger.com)
In contrast, the remaining population of CD45+ CD34- cells in the corneal stroma expressed CD11b, MHC Class II+ but not CD11c, and were found mostly in anterior and peripheral part of stroma. (arvojournals.org)

Mouse ADSC (mADSC) isolated from C57 male mice were expanded for CS formation (10 6 cells per CS). (biomedcentral.com)
BALB/c mice exposed to triclosan (2%) had a higher number and frequency of neutrophils and lower number and frequency of dendritic cells in the skin compared to controls. (cdc.gov)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Anatomy58

Organisms11

Diseases9

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes43

Disciplines and Occupations1

Information Science2

Health Care1

Macrophages12

Lymphopoietin5

Epithelial cells9

TSLP1

Cytokines10

Lymphocytes6

Proliferation11

Differentiation10

Follicular dend1

Fibroblasts2

Mast cells1

Plasmacytoid3

Mesenchymal Stem9

Monocytes1

Endothelial5

Tissues2

Regulatory7

Thymus3

Bone marro2

Extracellular Vesicles2

Myeloid2

Stem cells2

Cytokine2

Regenerative medicine1

Antigens3

Progenitors1

Inflammatory cells2

Germinal3

Dermal1

Splenic1

Regulates2

Therapeutic5

Lymphocyte6

20172

Autoimmune10

Tumor cells5

Mediate1

Adipose1

Innate lymphoid cells2

Antigen-specific3

Populations4

Activate4

Keratinocytes1

Peritoneal1

Malignant2

Immune8

Cellular1

Biology2

Actin1

Crosstalk1

Receptor6

Abstract1

Psoriasis1

Immature T cells1

Humans1

Peripheral2

Mice3