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  • plasmacytoid dendr
  • Barratt-Boyes SM, Wijewardana V, Brown KN (2010) In acute pathogenic SIV infection plasmacytoid dendritic cells are depleted from blood and lymph nodes despite mobilization. (springer.com)
  • Here, we report that sphingosine 1-phosphate (S1P)-S1PR1 signaling in plasmacytoid dendritic cells (pDCs) directly inhibits IFN-α autoamplification by induced degradation of the interferon alpha receptor 1 (IFNAR1) receptor and suppression of signal transducer and activator of transcription 1 (STAT1) signaling. (pnas.org)
  • maturation
  • After a period of maturation the foreign body cells are infused into the recipient. (medindia.net)
  • Contact with pathogens is followed by their maturation and migration to the secondary lymphoid organs, where they stimulate naïve T and B cells to proliferate and differentiate into CD8+ or CD4+ T lymphocytes, and into antibody-producing plasma cells. (frontiersin.org)
  • Maturation is also required for CMV reactivation to occur in LC differentiated from latently infected CD34+ progenitor cells. (frontiersin.org)
  • In other words, the DC has sensed that some pattern receptor triggering (and generally trouble to the body) invador is present and it undergoes a developmental pathway (maturation) that turns it into a cell that can elicit an immune response (co-stimulatory molecules are increased so that the DC can trigger other cells to activate, antigen presentation on the surface is increased, inflammatory cytokines are released). (protocol-online.org)
  • myeloid cells
  • Berger G, Durand S, Fargier G, Nguyen XN, Cordeil S, Bouaziz S, Muriaux D, Darlix JL, Cimarelli A (2011) APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells. (springer.com)
  • pDCs
  • Here, we show that mutant mice can generate CDPs and cDCs in the absence of BCL11A, whereas pDCs (and also B cells) are abolished. (pnas.org)
  • We observed a lower ratio between anti-apoptotic Bcl-2/Bcl-xL and pro-apoptotic Bax/Bak in shorter-lived myeloid DCs (mDCs) than in longer-lived plasmacytoid DCs (pDCs) or T cells. (uniprot.org)
  • freshly isolated
  • O'Doherty U., Steinman R.M., Peng M., Cameron P.U., Gezelter S., Kopeloff I., Swiggard W.J., Pope M. and Bhardwaj N. (1993) Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. (springer.com)
  • Start directly from freshly isolated mononuclear cells without the need for an additional purification step with our Monocyte Attachment Medium. (promocell.com)
  • Disease
  • In addition to their antigen-presenting functions, dendritic cells have the ability to modulate the lung environment to promote atopic disease. (hindawi.com)
  • This paper focuses on these data demonstrating how different populations of dendritic cells are capable of bridging the adaptive and innate immune systems, ultimately leading to the translation of viral illness into atopic disease. (hindawi.com)
  • Patients with a history of any other neoplastic disease less than 5 years ago (excepting treated carcinomas in situ of the cervix and basal/squamous cell carcinomas of the skin). (knowcancer.com)
  • Barratt-Boyes SM, Wijewardana V (2011) A divergent myeloid dendritic cell response at virus set-point predicts disease outcome in SIV-infected rhesus macaques. (springer.com)
  • lymphoid organs
  • Hematopoietic stem cells from bone marrow are the origin of IDCs, which are localized in T-zones of lymphoid organs. (atlasgeneticsoncology.org)
  • The sphingosine 1-phosphate receptor (S1PR1) is known to act by multiple mechanisms: limiting lymphocyte egress from secondary lymphoid organs, suppressing proinflammatory endothelial cell function, and acting directly on neurons and astrocytes. (pnas.org)
  • immunology
  • Dr. Jagadeesh Bayry from INSERM discusses his recent research in the field of immunology, and how T regulatory cells activate, rather than suppress, basophils. (news-medical.net)
  • In: Ricciardi-Castagnoli P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. (springer.com)
  • tissues
  • A type of antigen-presenting cell found in many tissues throughout the body. (nih.gov)
  • markers
  • The power of this approach is that it offers an unbiased assessment of relationships between cells rather than reliance upon a small selection of markers. (biomedsearch.com)
  • inflammatory
  • Inaba K, Turley S, Iyoda T, Yamaide F, Shimoyama S, Reis e Sousa C, Germain RN, Mellman I, Steinman RM (2000) The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. (springer.com)