Dendritic cd11b antigen is present on macrophages antigens cd11c. Medical search. Frequent questions

These cells include dermal resident dendritic cells (DC), epidermal Langerhans cells, neutrophils and monocytes, which are released from the blood when the dermal capillary is disrupted and a reputed blood lake is formed [ 3 - 6 ]. (biomedcentral.com)
CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. (wikipedia.org)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
According to the classical model, it proposes a common myeloid progenitor (CMP) as the precursor of both monocytes/macrophages and DCs. (origene.com)
CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. (thermofisher.com)
CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. (thermofisher.com)
The lung compartment is later experienced CCR2 dependent influx of monocytes, which are later differentiated into monocyte derived alveolar macrophages (MoAM) that can drive lung inflammation and lung fibrosis. (biomedcentral.com)
However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. (frontiersin.org)
Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
Ly6G is expressed differentially during development by cells in the myeloid lineage including monocytes, macrophages, granulocytes, and neutrophils. (bioxcell.com)
Blood monocyte-derived DCs (B-DCs), as one group of myeloid DCs, can be generated by incubation of monocytes that are isolated from PBMCs with exogenous granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) for 6-7 days [ 3 ]. (biomedcentral.com)

Soon after, neutrophils and macrophages may still be recruited in response to local inflammatory stimuli that persist for 2-3 days [ 6 ]. (biomedcentral.com)
The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
Leishmania major is an intracellular protozoan that infects and multiplies within macrophages, although it can also infect Langerhans cells (LCs), DCs, and neutrophils ( 1 , 2 ). (silverchair.com)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Dendritic cells (DCs) are hematopoietic-derived highly specialized antigen-presenting cells (APCs) that display potent ability to induce both specific immune responses and deletion of potentially autoreactive T cells. (ashpublications.org)

These subtypes include conventional dendritic cells (cDC1 and cDC2), plasmacytoid dendritic cells (pDCs), monocyte-derived dendritic cells (moDCs), and Langerhans cells (LCs). (origene.com)
Pulmonary macrophages, such as tissue-resident alveolar and interstitial macrophages and recruited monocyte-derived macrophages, are the major macrophages present in the lungs during homeostasis and diseased conditions. (biomedcentral.com)
These recruited monocyte-derived macrophages also protect lung function by their heightened production of antipathogen factors and active phagocytosis of cellular debris (Aegerter et al. (biomedcentral.com)
Human splenocytes gave production of predominantly myeloid dendritic-like cells, with minor subsets resembling conventional dendritic cells (cDC) cells, and myeloid or monocyte-derived DC. (bvsalud.org)

Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. (mdpi.com)
Plasmacytoid dendritic cells (pDCs), are round plasma-shaped cells specialized for the production of large amounts of type I and type III interferon in response to viral infection. (origene.com)

Conventional dendritic cells (cDCs), also known as myeloid dendritic cells or classical dendritic cells, are a type of antigen-presenting cell (APC), cDCs originate from hematopoietic stem cells, specifically from the common myeloid progenitor in the bone marrow. (origene.com)
In humans and mice, conventional dendritic cells are divided into two main subtypes: cDC1 and cDC2, each with distinct functions and markers [2]. (origene.com)

Coincubation with Leishmania changes the migratory pattern of dendritic cells in vivo . (biomedcentral.com)
Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. (medsci.org)
Basis of treatment based dendritic cells to combat coronavirus infections is summarized. (medsci.org)
Here, we show that successful treatment of cervical carcinoma in mouse models with synthetic long peptide (SLP) vaccines induced influx of cytokine-producing CD8 T cells that strongly altered the numbers and phenotype of intratumoral macrophages. (aacrjournals.org)
These changes of the intratumoral myeloid composition coincided with macrophage recruitment by chemokines, including CCL2 and CCL5, and were completely dependent on a vaccine-induced influx of tumor-specific CD8 T cells. (aacrjournals.org)
Incubation of tumor cells with T cell-derived IFNγ and TNFα recapitulated the chemokine profile observed in vivo , confirming the capacity of antitumor CD8 T cells to mediate macrophage infiltration of tumors. (aacrjournals.org)
The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells. (wikipedia.org)
The CD11c+ cells in turn present the antigen to CD4+ T cells, which can lead to an enhanced antibody response. (wikipedia.org)
Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. (wikipedia.org)
CD23 can also be demonstrated in germinal centre follicular dendritic cells using immunohistochemistry but is minimally expressed by benign germinal center B cells. (wikipedia.org)
Dendritic cells (DCs) treated with IL-15 and p38 MAPK inhibitor stimulate IL-17 release from T cells in culture. (bmj.com)
DC vaccines treated with IL-15 and p38 MAPK inhibitor are more effective than standard DC vaccines at generating antigen-specific Th17 T cells in vivo. (bmj.com)
Dendritic cells (DCs) are bone-marrow-derived immune cells found in blood, lymphoid organs, and various tissue of the body. (origene.com)
First discovered by Ralph Steinman and Zanvil A. Cohn in the 1970s, named for their tree-like branches or "dendrites", these cells patrol our bodies, ingest pathogens, process them, and present fragments (antigens) to T-cells, thus initiating a targeted immune response [2]. (origene.com)
Unlike other immune cells, dendritic cells are not just a single entity, but a complex assortment of subtypes with varying functions. (origene.com)
Several models are proposed to describe the development and differentiation of dendritic cells (DCs). (origene.com)
The maturation pathway involves several stages, with differentiating cells passing through a monocyte-like stage before fully maturing into dendritic cells. (origene.com)
cDC1: These cells are very effective at presenting antigens to CD8+ T cells, a type of cytotoxic T cell that can kill infected or cancerous cells. (origene.com)
cDC2: These cells are specialized in presenting antigens to CD4+ T cells, a type of helper T cell that helps coordinate the immune response. (origene.com)
CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. (thermofisher.com)
N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer. (thermofisher.com)
2021 ). Not only are macrophages among the first immune cells to encounter viral particles in the lung, but they also maintain lung function by engulfing small debris and regulating surfactant turnover (Aegerter et al. (biomedcentral.com)
Murine spleen has been shown to harbour stromal cells that support hematopoiesis with production of myeloid antigen-presenting cells. (bvsalud.org)
Combined data now show that splenic stroma of both human and murine origin provides a mesenchymal stromal cell microenvironment which is WNT pathway-dependent, and which supports in vitro myelopoiesis with production of specific subsets of myeloid and dendritic-like cells. (bvsalud.org)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
Absence of ILC2s leads to utero-placental abnormalities, including poor vascular remodelling, increased Il1b and decreased Il4, Il5 , and Il13 gene expression, and reduced alternative activation of dendritic cells (DCs) and macrophages. (elifesciences.org)
Innate lymphoid cells (ILCs) lack antigen receptors but are equipped with receptors for cytokines, hormones, and paracrine signals enabling them to sense their environment and respond quickly by producing factors that influence parenchymal cells and other resident immune cells. (elifesciences.org)
Despite often comprising only a small proportion of tissue resident immune cells, ILCs are present in most tissues and have been shown to orchestrate inflammatory responses to viruses, intracellular bacteria and parasites. (elifesciences.org)
Follicular dendritic cells also express CD19. (thermofisher.com)
Pre-requisite of tumor response to ICBs is the co-expression by cancer cells of immunogenic tumor antigens and targetable immune checkpoint molecules. (biomedcentral.com)
The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)
In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal thymus displayed a myeloid-related phenotype prompted us to re-examine the developmental origin of thymic DCs, a cell type hitherto considered to represent a homogeneous lymphoid-derived population. (ashpublications.org)
and the innate immune cells contain natural killer (NK) cells and dendritic cells (DCs) (Fig. 1 ). (biomedcentral.com)
Mechanistic investigation defined that Axl inhibition reprograms the immunological microenvironment leading to the increased proliferation, activation and effector function of tumor-infiltrating CD4 + and CD8 + T cells possibly through preferential accumulation and activation of CD103 + cross-presenting dendritic cells. (oncotarget.com)
MHC II-positive macrophages are a primary target of infection and a crucial effector cell controlling parasite growth, yet their function as antigen-presenting cells remains controversial. (silverchair.com)
We explored the antigen-presenting cell requirement during primary L. major infection using a mouse model in which MHC II, I-A β b , expression is restricted to CD11b + and CD8α + dendritic cells (DCs). (silverchair.com)
Importantly, B cells, macrophages, and LCs are all MHC II-negative in these mice. (silverchair.com)
Clearance of L. major in resistant C57Bl/6 mice requires IL-12-driven Th1 CD4 + T cells and macrophage activation for the killing of intracellular amastigotes ( 2 ). (silverchair.com)
MHC II-positive B cells, macrophages, and DCs accumulate in draining LNs of resistant mice ( 3 ) and class II-deficient (A β b−/− ) mice cannot control the infection ( 4 ). (silverchair.com)
MHC II + DCs prime CD4 + Th1 cells to nominal antigens ( 5 ) and could fulfill this role during L. major infection ( 1 ). (silverchair.com)
According to this theory, the immune system consists of cells which have specific receptors on their surface to recognize antigens. (wikidoc.org)
Upon immunization with an antigen, more of these receptors are formed, and they are then shed from the cells to circulate in the blood. (wikidoc.org)
Kupffer cells and other macrophage cell types help clear complement-coated pathogens. (wikidoc.org)
Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. (biomedcentral.com)
Finally, mononuclear cells isolated from lung (L-MCs), which are used as precursors for L-DCs, expressed more antigen-presenting cell-associated markers such as MHC class II and CD172α compared to their counterparts from blood. (biomedcentral.com)
Dendritic cells (DCs) are the most important antigen-presenting cells (APCs) in the body. (biomedcentral.com)
Besides, cells were treated with the STAT3 inhibitor to further detect the macrophage polarization level. (impactaging.com)
Intestinal macrophages were later co-cultured with intestinal epithelial cells to observe the degree of epithelial cell injury. (impactaging.com)
It is currently discovered that, Th1 cells are a kind of pro-inflammatory T cells, which exert mutual regulation with natural killer (NK) cells and macrophages [ 5 ]. (impactaging.com)
Th1 cells are the inflammatory cells with high expression of IFN-γ and TNF-α [ 7 ], therefore, this work analyzed the proportion of Th cells in tissues of IBD patients, so as to further reveal its regulatory relation with macrophages. (impactaging.com)
These differentially expressed immune-related genes were deemed to have a role in the process of Plasmodium infection in the host via dendritic/T regulatory cells and the TGF-β/Smad 2/3 signaling pathway. (biomedcentral.com)
Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)

Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. (thermofisher.com)
6 , 7 Murine DCs with the reciprocal CD8α + CD11b − phenotype, although present at various levels in all lymphoid organs, represent the prototype of the DC population resident in the postnatal thymus. (ashpublications.org)

Lung macrophages play a critical role in shaping homeostasis and immune regulation and encounter pathogens (Hou et al. (biomedcentral.com)
It is likely that L-DCs play an important role in antigen uptake and processing of respiratory pathogens and are major contributors to respiratory tract immunity and may be ideal tools for future in vitro or ex vivo studies. (biomedcentral.com)

Strikingly, complete regressions of large established tumors depended on the tumor-infiltrating macrophages that were induced by this immunotherapy, because a small-molecule drug inhibitor targeting CSF-1R diminished the number of intratumoral macrophages and abrogated the complete remissions. (aacrjournals.org)
However, chimeric antigen receptor T (CAR-T) cell immunotherapy and immune checkpoint blockade (ICB), which have produced unprecedented clinical benefits in a variety of different cancers, produce promising results in only some highly selected patients with PDAC. (biomedcentral.com)

This review article discusses the crucial role of distinct lung macrophage subsets in the immune response to respiratory viral infections such as influenza (IAV), respiratory syncytial virus (RSV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (biomedcentral.com)
We demonstrate that antigen presentation by these DC subsets is sufficient to control a subcutaneous L. major infection. (silverchair.com)

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. (thermofisher.com)

Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage-colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre-T-cell receptor α (pTα) gene transcriptional activation. (ashpublications.org)

To determine if Th17-inducing vaccines are therapeutically effective in OC, we created a murine model of Th17-inducing dendritic cell (DC) (Th17-DC) vaccination generated by stimulating IL-15 while blocking p38 MAPK in bone marrow-derived DCs, followed by antigen pulsing. (bmj.com)

The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. (thermofisher.com)
These receptors, which we now call "antibodies", were called by Ehrlich "amboceptors" to emphasize their bifunctional binding capacity: they recognize and bind to a specific antigen, but they also recognize and bind to the heat-labile antimicrobial component of fresh serum. (wikidoc.org)

In the tumor microenvironment, tumor-associated macrophages (TAMs) display an array of phenotypes beyond the M1/M2 paradigm, ranging from antitumoral to immunosuppressive, proangiogenic, immunomodulatory and tissue-remodeling phenotypes ( 7 - 9 ). (frontiersin.org)

The following product was used in this experiment: CD11c Monoclonal Antibody (N418), PE-Cyanine7, eBioscience™ from Thermo Fisher Scientific, catalog # 25-0114-82, RRID AB_469590. (thermofisher.com)
Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. (thermofisher.com)

However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)

Such changes in dendritic cell migration may be associated with immunological events that maintain inflammation at the sites of infection. (biomedcentral.com)
Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. (medsci.org)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
The combination of Programmed Cell Death 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) blockade has dramatically improved the overall survival rate for malignant melanoma. (biomedcentral.com)
Control of the intracellular protozoan, Leishmania major , requires major histocompatibility complex class II (MHC II)-dependent antigen presentation and CD4 + T cell T helper cell 1 (Th1) differentiation. (silverchair.com)
Therefore, CD11b + and CD8α + DCs are not only key initiators of the primary response but also provide all the necessary cognate interactions for CD4 + T cell Th1 effectors to control this protozoan infection. (silverchair.com)
CD8α + and CD11b + DCs can be infected in vitro ( 6 ), and T cell priming to an immunodominant L. major peptide is mediated by CD11b + DCs ( 7 ). (silverchair.com)
Therefore, the M1 macrophages play an important pro-inflammatory role in IBD, which represent the major cell type inducing IBD progression [ 4 ]. (impactaging.com)
In research on IBD, the change in Th cell proportions and the interaction with macrophages have not been completely illustrated yet. (impactaging.com)

After a respiratory virus infection, the pool of resident macrophages is highly affected. (biomedcentral.com)
The results of the present study confirmed that Plasmodium infection-induced lncRNA expression is a novel mechanism used by Plasmodium parasites to modify host immune signaling. (biomedcentral.com)

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated. (thermofisher.com)

They act as a surveillance system to detect foreign antigens and shape immunogenic or tolerogenic responses [ 1 ]. (biomedcentral.com)

CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. (thermofisher.com)

Later, the changes in life state and body weight of mice were observed, the proportion of M1 macrophages in mucosal tissues and mucosal barrier damage were detected. (impactaging.com)

The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)

We also present the data of our own research concerning evaluation of the prognostic role of cytokines and lymphocyte subpopulations in peripheral blood of the TNBC patients. (cttjournal.com)
M1 macrophages can be activated by cytokines such as interferon-γ (IFN-γ) and tumor necrosis factor (TNF)-α [ 3 ]. (impactaging.com)
Under the IBD status, M1 macrophages can secrete inflammatory cytokines IL-1α, IL-1β and TNF-β, which aggravate inflammatory response. (impactaging.com)

As discovered from tissue detection of IBD patients, the number of intestinal macrophages apparently increases, At the same time, the intestinal macrophages have different subpopulations and phenotypes [ 1 ]. (impactaging.com)

While tissue-resident macrophages act as sentinels of the alveolar space and play an important role in maintaining homeostasis and immune regulation, recruited macrophages accumulate in the respiratory tract after acute viral infections. (biomedcentral.com)
Macrophages produce inducible nitric oxide synthase, accumulate at infected sites, and control parasite numbers in the absence of MHC II expression. (silverchair.com)

On the basis of the expression of CD11b, CD11c, F4/80, Ly6C, Ly6G, and MHC II, we identified four myeloid subpopulations that increased in numbers from 2.0-fold to 8.7-fold in regressing tumors. (aacrjournals.org)

Notably, these recruited macrophages may have distinct metabolic, proliferative, and inflammatory gene expression than resident AMs (Mould et al. (biomedcentral.com)
In the IBD mouse model, Th1 induced the M1 polarization of macrophages, aggravated the intestinal inflammatory response, and resulted in the increased mucosal barrier permeability. (impactaging.com)

More recent studies suggested that DCs derived from tissues without "danger" signal stimulation should be regarded as immature DCs, based on their major role in antigen uptake and endocytosis of antigens [ 11 , 14 ]. (biomedcentral.com)

1-5 In mice, DCs bearing the myeloid marker CD11b (Mac-1), but lacking CD8α, derive efficiently from myeloid precursors and represent the major DC subset in the periphery. (ashpublications.org)
After treatment with macrophage scavenging agent (Clodronate Liposomes, CLL), the influence of Th1 on IBD mice was observed. (impactaging.com)

The goal of the present study was to isolate and characterize equine lung-derived DCs (L-DCs) for use in studies of respiratory viruses and compare their features with equine blood-derived DCs (B-DCs), which are currently used for these types of studies. (biomedcentral.com)

Tumor-promoting functions of macrophages include angiogenesis, metastasis formation, and suppression of Th1-type immune responses. (aacrjournals.org)

Despite sharing similar anatomical niches, these macrophages are distinct in terms of their origins, surface marker expression, and transcriptional profiles, which impart macrophages with distinguished characteristics in physiological and pathophysiological conditions. (biomedcentral.com)

At present, it is known that lncRNAs participate in transcriptional and post-transcriptional gene regulation. (biomedcentral.com)

Antigens which enter the blood stream can be captured by antigen specific IgE antibodies. (wikipedia.org)
The classical complement pathway typically requires antibodies for activation (specific immune response), while the alternative and mannose-binding lectin pathways can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). (wikidoc.org)
The classical pathway is triggered by activation of the C1-complex (which consists of one molecule C1q and two molecules C1r and C1s), either by C1q's binding to antibodies from classes M and G, complexed with antigens , or by its binding C1q to the surface of the pathogen. (wikidoc.org)

The human leukocyte antigen ( HLA ) is a gene complex that encodes the major histocompatibility complex ( MHC ) proteins . (amboss.com)

For immune defense, the respiratory tract contains DCs that function as a robust antigen presentation system. (biomedcentral.com)

Then, the intestinal macrophages were co-cultured with Th1 in vitro to observe the influence of Th1 on the polarization of intestinal macrophages. (impactaging.com)

They play an essential role in the induction of adaptive immune response against infectious agents and in generating tolerance against self-antigens [3]. (origene.com)

Ruan S , Xu L , Sheng Y , Wang J , Zhou X , Zhang C , Guo L , Li W , Han C , . Th1 promotes M1 polarization of intestinal macrophages to regulate colitis-related mucosal barrier damage. (impactaging.com)

Ehrlich believed that each antigen-specific amboceptor had its own specific complement, while Bordet believed that there is only one type of complement. (wikidoc.org)

There was no consistent decrease in the migration of CD11b + F4/80 + (macrophage) or SSC hi GR-1 + (neutrophil) populations. (biomedcentral.com)

At present, the immunoregulatory mechanism of M1 polarization of macrophages in IBD has not been completely revealed. (impactaging.com)

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