Dendrimers. Medical search. Frequent questions

All of our studies focused on polyamidoamine (PAMAM) dendrimers. (confex.com)
The effect of 5th generation polyamidoamine (PAMAM G5) dendrimers on multilamellar dipalmitoylphosphocholine (DPPC) vesicles was investigated. (mtak.hu)
PAMAM was added in two different concentration to the lipids (10-3 and 10-2 dendrimer/lipid molar ratios). (mtak.hu)
The partial modification of carboxylic acid terminated polyamidoamine (PAMAM) dendrimers with glucosamine has been reported to give dendrimer glucosamine conjugates novel immuno-modulatory and anti-angiogenic properties. (herts.ac.uk)
Importantly, the structural features and the dynamic behavior of the partially glycosylated generation 3.5 PAMAM dendrimer showed that its flexibility and polarity changed with the incremental addition of glucosamine. (herts.ac.uk)
Surface immobilized polyamidoamine (PAMAM) dendrimer templated Pt nanoparticles were employed as precursors to heterogeneous catalysts. (psu.edu)
Infrared spectroscopy showed that PAMAM dendrimer amide bonds begin decomposing at temperatures as low as 75°C. Although the amide stretches are completely removed after 3 h of oxidation at 300°C, 16 h were required to reach maximum catalytic activity. (psu.edu)
Singh, A & Chandler, BD 2005, ' Low-temperature activation conditions for PAMAM dendrimer templated Pt nanoparticles ', Langmuir , vol. 21, no. 23, pp. 10776-10782. (psu.edu)
Molecular docking studies suggested that glycosylated dendrimers block the TLR4-MD-2-LPS complex, and a 13.6 kDa polyamidoamine (PAMAM) dendrimer glucosamine (DG) reduced the induction of human monocyte interleukin (IL)-6 by Gram-negative bacteria. (ox.ac.uk)
Specifically, the polyamidoamine (PAMAM) dendrimer is a small molecule that targets the largest family of pore-forming virulence proteins that are found in a variety of bacterial plant pathogens belonging to Erwinia spp. (duke.edu)
Dynamic light scattering, cryogenic TEM and steady-state fluorescence spectroscopy are utilized to investigate the interaction between cationic poly(amido amine) (PAMAM) dendrimers and double stranded DNA. (lu.se)
This systematic study reveals how the size, composition and morphology of aggregates formed between DNA and PAMAM dendrimers are affected by dendrimer size and charge. (lu.se)

A label-free and highly sensitive impedimetric aptasensor based on a polyamidoamine dendrimer modified gold electrode was developed for the determination of thrombin. (unboundmedicine.com)
Amino-terminated polyamidoamine dendrimer was firstly covalently attached to the cysteine functionalized gold electrode through glutaraldehyde coupling. (unboundmedicine.com)
In this study, the anti-biofilm activity of previously fabricated polyamino-phenolic ligands and polyamidoamine dendrimers was investigated against legionella mono-species and multi-species biofilms formed by L. pneumophila in association with other bacteria that can be found in tap water ( Aeromonas hydrophila , Pseudomonas aeruginosa , Escherichia coli , Klebsiella pneumoniae ). (frontiersin.org)

Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. (mdpi.com)
Adsorption of cationic dendrimers. (unige.ch)

Janus dendrimers, discovered by Virgil Percec of the University of Pennsylvania and coworkers a few years ago, are molecules that branch out repetitively from a point and, like the Roman god Janus, have two faces. (acs.org)
Conjugating drug molecules onto dendrimers containing targeting moieties can improve all of these shortcomings. (europa.eu)
The research that started with this project has evolved into three parts: The first part is the synthesis of dendrons (dendrimer pieces) with targeting groups, the second part is the attachment of drug molecules to another dendron and the third and final part is the development of methodology for putting these two pieces together. (europa.eu)
The covalent immobilization of dendrimer on the electrode surface not only improved the immobilization capacity of probe molecules but also magnified the response signal. (unboundmedicine.com)
These data suggest that the studied compounds, especially dendrimers, could be considered as novel molecules in the design of research projects aimed at the development of efficacious anti-biofilm disinfection treatments of water systems in order to minimize legionellosis outbreaks. (frontiersin.org)
Along with being compact and globular in structure, dendrimers also exhibit interior cavity spaces and multiple surface functional groups, which play a vital role in encapsulating drug molecules both in the interior of the dendrimers (physical encapsulation) as well as in the surface functional groups (covalent conjugations). (eurekaselect.com)
Some proposed applications involve dendrimer interactions with aromatic and hydrophobic hydrocarbons, or molecules containing moieties with these properties. (confex.com)
All-atom MD simulations with explicit water were used to investigate the mechanistic details of association of model aromatic hydrocarbon guest molecules, naphthalene (NPH), and its derivatives, with 3rd - 6th generation (G3-G6) dendrimers. (confex.com)
However, we observe dendrimer branches form local pocket-like structures around NPH molecules associated with the dendrimers. (confex.com)
Of particular note, we find that NPH molecules associated closer to the dendrimer center are not necessarily more protected from the water environment. (confex.com)
We found no clear saturation point, but instead observe a transition to NPH molecules aggregating together on the dendrimers. (confex.com)
The team studied dendrimers, which are branched amphiphilic molecules possessing both polar and apolar character. (upenn.edu)
Since the central core of a dendrimer is hollow, think of it as a cavity or a pouch which can be used to trap or store "guest molecules. (trynano.org)
Experimental analysis of these glycosylated dendrimers showed that, on average, eight glucosamine molecules were covalently bound to each dendrimer. (herts.ac.uk)
It was shown that the surface loading and distribution of zero length amide bond-conjugated glucosamine molecules was determined by both electronic effects and by the different dynamic conformations adopted by the modified dendrimer during the incremental addition of glucosamine. (herts.ac.uk)
Further consideration of these data indicated that, while the dendrimers containing rigid ligands had better encapsulated redox cores for a given molecular weight, these molecules had higher electron-transfer rates for a given molecular radius. (ncsu.edu)

A combination of solution NMR, dynamic light scattering (DLS), and fluorescence quenching assays were employed to obtain insights into the dynamics and structural features of a polyplex system consisting of HIV-1 transactivation response element (TAR) and PEGylated generation 5 poly(amidoamine) dendrimer (G5-PEG). (duke.edu)

Dendrimers have a high level of control over the synthesis of dendritic architecture, well-defined size, shape, molecular weight, membrane interaction and monodispersity, making them a perfect example of one such multifunctional smart nanocarrier. (eurekaselect.com)
Dendrimers are a single dendritic polymer consisting of three layers, its core, dendron regularly branched from the core, and the exterior surface layer. (tcichemicals.com)
Dendritic systems and in particular dendrimers are one of the most promising research lines within the Chemistry field, mainly due to the wide range of their potential applications suchs as biomedicine. (dendrobionet.com)
Interestingly, LEDs based on these dendrimers exhibit better device performance than those of the two-side dendritic wedges substituted dendrimers. (edu.hk)

synthesis Ferrocene-containing dendrimers can be synthesized by convergence and diffusion methods. (wikipedia.org)
The research involves synthesis of novel segment block dendrimers, attachment of the desired drug and targeting groups on these dendrimers and finally their evaluation in vitro as cancer chemotherapy agents. (europa.eu)
The most important scientific achievement of the project is the synthesis of bone targeting dendrons and the methodologies developed to successfully join the two pieces to yield dendrimers. (europa.eu)
Both flexible and stiff repeat units that have been employed previously in the synthesis of dendrimers were considered. (ncsu.edu)

Methylene Blue Functionalized Poly(amido amine) Dendrimer. (au.dk)

Dendrimers are interesting in the field of biomedical applications due to their unique characteristics. (eurekaselect.com)
Biomedical applications of metallodendrimers and dendrimer nanocomposites will be discussed, including biomimetic catalysts, imaging contrast agents (especially for MRI imaging), or biomedical sensors and therapeutic agents. (eurekaselect.com)
As a consequence of the intense research activity carried out by different national research groups in this field, countersigned by their publications and research projects, along with their national and international scientific collaborations and the organization of international and national scientific events hold in Spain, the members of the research team that establish this initiative, propose building a national network based on the use of dendrimers in biomedical applications. (dendrobionet.com)
v) To provide greater social visibility of the use of dendrimers for biomedical applications related to the technology transfer possibilities that may arise from the scientific collaboration that the network demands. (dendrobionet.com)

Ferrocenylsilylation of Dendrons: A Fast Convergent Route to Redox-Stable Ferrocene Dendrimers", Chem. (wikipedia.org)
In this work, we show that multivalent presentations of these glycomimetics based on polyester dendrons and dendrimers lead to very potent inhibitors (in the nanomolar range) of cell infection by Ebola pseudotyped viral particles by blocking DC-SIGN receptor. (unimi.it)
Two series of redox-active, iron−sulfur core dendrimers of the general structure (nBu4N)2[Fe4S4(S-Dend)4] (Dend = dendrons of generations 1 through 4) were prepared. (ncsu.edu)

Multifunctional dendrimers have a high potential for drug delivery applications as they accommodate a high density and wide variety of functional groups on their surface. (europa.eu)

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Dendrimers can self-assemble into nano- sized vesicles known as dendrimersomes, and scientists are interested in developing dendrimersomes because these hollow vesicles can encapsulate drugs and biomolecules for applications in both basic research and medicine. (upenn.edu)
Dendrimersomes have a number of advantages over traditional lipid-based vesicles, such as increased stability, uniformity, and the ability to be tuned to have a specified size and shape by altering the composition of their dendrimer precursors. (upenn.edu)

I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
Sol-gel chemistry was used to chemically immobilize dendrimer- and poly-THFbased hybrid organic-inorganic coatings on fused silica capillary inner surface. (usf.edu)
Anne-Marie Caminade is Director of Exceptional Class Research at CNRS, in the Laboratory of Coordination Chemistry of Toulouse, where she is also Director of the "Dendrimers and heterochemistry" team. (ueuromed.org)

Dendrimers offer desirable properties, such as precise control of the size, shape, and chemical functionality of the molecule. (confex.com)
For all dendrimers, the different generations within each molecule were found to be radially distributed throughout its interior. (ncsu.edu)
This observation indicated that protons in each set of topologically different repeat units (generation) of the dendrimer approach the core of the molecule closely in space. (ncsu.edu)

en.china.cn is a good place to supply polymer resin No applications have been identified for ferrocene-containing dendrimers. (wikipedia.org)

The concentration of the chemicals tested as anti-biofilm agents was chosen based on cytotoxicity assays: the highest non-cytotoxic chemical concentration was used for biofilm inhibition assays, with dendrimer concentration 10-fold higher than polyamino-phenolic ligands. (frontiersin.org)
While Macrophen and Double Macrophen were the most active substances among polyamino-phenolic ligands, dendrimers were overall twofold more effective than all other compounds with a reduction up to 85 and 73% of legionella and multi-species biofilms, respectively. (frontiersin.org)
Phosphine ligands equipped with urea acetic groups, a binding motive complementary to that of the dendrimer host, have been prepared and assembled to the dendrimer support. (tue.nl)

The incorporation of multiple p-carborane cages within an aliphatic polyester dendrimer was accomplished through the preparation of a bifunctional carborane synthon. (mcmaster.ca)

Dendrimers are polymeric compounds with highly branched structures and functionally tunable peripheral groups. (eurekaselect.com)
Upon peripheral deprotection to liberate a polyhydroxylated dendrimer exterior, these structures exhibited aqueous solubility as long as a minimum of eight hydroxyl groups per carborane were present. (mcmaster.ca)

Ferrocene-containing dendrimers can be synthesized by both convergent and divergent methods. (wikipedia.org)
Convergent approaches can also be used to make dendrimers with peripheral ferrocene. (wikipedia.org)
As an example, figure 1 shows a 54-ferrocene dendrimer which was synthesized by a fast convergent approach. (wikipedia.org)

Two-directional arborols are synthetic bolaform amphiphilic dendrimers. (lsu.edu)

In order to better understand the driving forces of NPH association with dendrimers, we studied the association of increasingly hydrophilic model compounds. (confex.com)

Flexible-unit dendrimers were found to be globular but not completely spherical. (ncsu.edu)

The solgel coatings were created using a coating solution containing a sol-gel active organic component (dendrimer or poly-THF), a sol-gel precursor (methyltrimethoxysilane, MTMOS), a sol-gel catalyst (trifluoroacetic acid, TFA, 5% water) and a deactivating reagent (hexamethyldisilazane, HMDS). (usf.edu)
Dendrimers are highly branched organic macromolecules with successive layers orgenerations of branch units surrounding a central core [1,4]. (isc.ac)
Dendrimers are an attractive class of solution-processible materials for organic LEDs. (edu.sa)
In this approach, the initially constructed organometallic dendrimers are irradiated with 365 nm wavelength, transforming them to fully organic dendrimers which are emissive in solution and in the aggregate state. (advancedsciencenews.com)
These organic dendrimers possess tunable dual emissions at 368 nm, as well as at 469 nm. (advancedsciencenews.com)

Dendrimers are a class of branched macromolecules with generational growth that have been explored for applications in fields including water purification, drug delivery and light harvesting. (confex.com)
A detailed description of the interactions between dendrimers and aromatic hydrocarbons can assist researchers in selecting and tuning dendrimer properties for specific applications. (confex.com)
We highlight the importance of considering both dendrimer-guest and guest-guest interactions when designing dendrimers for host-guest applications. (confex.com)
Insights from our results can be used when designing dendrimers for specific applications. (confex.com)
Adsorbed dendrimers films could have interesting applications in material science. (unige.ch)
The interior and the core of dendrimers can thus be tailored for different applications. (trynano.org)
With the attachment of metals ions and/or metals, metallodendrimers or dendrimer nanocomposites, respectively, provide diverse characters for a variety of applications. (eurekaselect.com)

Asymmetric Redox-Active Dendrimers Containing a Ferrocene Subunit. (wikipedia.org)
Molecular structure-property relationships for electron-transfer rate attenuation in redox-active core dendrimers. (ncsu.edu)

On the basis that iron can effectively reach the brain by using transferrin receptors for crossing the blood-brain barrier, we propose to investigate if a transferrin-bearing generation 3-polypropylenimine dendrimer would allow the transport of plasmid DNA to the brain after intravenous administration. (nih.gov)
The study encompassed dendrimers of generation one to four (G1-G4), modified to bear 6-48 amino end-groups, where the G2-G4 proved to be capable of siRNA complexation and protection against RNase-mediated degradation. (mdpi.com)
The adsorbed layers are normally irreversibly adsorbed, but desorption may occur for dendrimers of lower generation, especially under acidic and high salt conditions. (unige.ch)
A p-carborane derivative having an acid and a protected alcohol functionality was found to efficiently couple to peripheral hydroxyl groups of low-generation dendrimers under standard esterification conditions. (mcmaster.ca)
This approach was used to prepare fourth- and fifth-generation dendrimers that contain 4, 8, and 16 carborane cages within their interior. (mcmaster.ca)

In vitro, the conjugation of transferrin to the polypropylenimine dendrimer increased the DNA uptake by bEnd.3 murine brain endothelioma cells overexpressing transferrin receptors, by about 1.4-fold and 2.3-fold compared to that observed with the non-targeted dendriplex and naked DNA. (nih.gov)

The number of bilayers formed in the dendrimersomes depends on the concentration of the dendrimer starting material used to make them. (acs.org)
We show here that the concentration of these quenchers can also be controlled by changing the time spent by the dendrimer solution under illumination prior to spin-coating. (elsevierpure.com)

The 3D nano-polymeric architecture of dendrimer makes it an appropriate choice for drug and gene delivery vectors. (eurekaselect.com)
The phenylthiourea grafted dendrimer is coordinated with cuprous ions to prepare the polymeric carrier, which efficiently bind cargo proteins via a combination of coordination, ionic and hydrophobic interactions . (bvsalud.org)

Along with their well-defined molecular structure, segmented spherical construction of dendrimers offers an interesting architecture. (europa.eu)

The functional groups attached on the surface of dendrimers permit the addition of other moieties that can actively target certain diseases, which are now widely used as tumor-targeting strategies. (eurekaselect.com)

Scholars@Duke publication: Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. (duke.edu)

Researchers report on the preparation of a dual-emissive dendrimer with tunable aggregate and solution state emission. (advancedsciencenews.com)

We used all-atom molecular dynamics (MD) simulations to investigate the interactions between dendrimers and hydrocarbons. (confex.com)
We performed extensive simulations of aromatic hydrocarbon-dendrimer interactions, totaling several microseconds of simulation time for 70,000+ atom systems. (confex.com)
Effect of repeat unit flexibility on dendrimer conformation as studied by atomistic molecular dynamics simulations. (ncsu.edu)
The effect of repeat unit structure on the shape and internal organization of various dendrimers was probed using atomistic molecular dynamics simulations. (ncsu.edu)

Thiourea Dendrimer Achieves Excellent Cytosolic Protein Delivery via Enhanced Cell Uptake and Endosome Escape. (bvsalud.org)

In all dendrimer generations, NPH associates at a distance from the dendrimer center that is accessible to the water solvent. (confex.com)
In addition, by comparing T1 values of protons at two slightly different temperatures, the terminal groups in both sets of dendrimers were concluded to be, on average, more mobile than the other generations within the dendrimers. (ncsu.edu)

This structure originates from screened Coulomb repulsions between the charge dendrimers, which can be tuned by addition of salt but also through the charge of the substrate. (unige.ch)
Because of their low polydispersity, high degree of molecular uniformity, and precisely controlled structure, dendrimers are excellent models for demonstrating a variety of biological activities. (eurekaselect.com)
The obtained results show that the dendrimers added in 10-3 molar ratio to the lipids generate minor perturbations in the multilamellar structure and thermal character of liposomes, while added in 10-2 molar ratio dendrimers cause major disturbance in the vesicular system. (mtak.hu)
The terminal amino groups of the dendrimers are in strong interaction with the phosphate headgroups and through this binding dendrimers disrupt the regular multilamellar structure of DPPC. (mtak.hu)
This is a Cerius2 modeled structure of cored dendrimer with internal cross-links, created in the VMIL. (illinois.edu)
The second aspect of the research reported shows how the structure of the dendrimer can be modified so that a host material is not required. (edu.sa)

These results suggest that transferrin-bearing polypropylenimine dendrimer is a highly promising gene delivery system to the brain. (nih.gov)
The reversible nature of the swelling process of adsorbed dendrimers could be used as an alternative scheme for drug or gene delivery. (unige.ch)

Some ferrocene-containing dendrimers feature ferrocene cores and others do not. (wikipedia.org)
Dendrimers with ferrocene cores have been synthesized by decorating suitably functionalized ferrocenes, e.g., decaallylferrocene. (wikipedia.org)
The longitudinal relaxation time constants (T1) of the protons in a series of dendrimers that alternatively had paramagnetic ([Fe4S4(SR)4]2-, R = dendron) and diamagnetic (tetraphenylmethane) cores were compared. (ncsu.edu)

The efficient reversible functionalization of the periphery of urea adamantyl poly(propylene imine) dendrimers with catalytic sites using noncovalent interactions is described. (tue.nl)

Dendrimers with peripheral ferrocene groups are usually synthesized by attaching ferrocene to the core by either olefin metathesis or by hydrosilylation. (wikipedia.org)
4]. The convergence method can also be used to make dendrimers with peripheral ferrocene. (wikipedia.org)

Dr. Anne-Marie Caminade gave a conference on the theme Phosphorus dendrimers: examples of properties in catalysis, materials and biology, addressed to the entire doctoral and professorial staff of the Euromed Faculty of Engineering. (ueuromed.org)
We are investigating the conditions, such as membrane and dendrimer properties, under which this occurs using ellipsometry, QCM-D, neutron reflectometry and different fluorescence techniques. (lu.se)

These forces are also responsible for flattening of the adsorbed dendrimers and their swelling on the surface. (unige.ch)

The authors prepared dendrimers which were functionalized on the periphery with tetraphenylethene. (advancedsciencenews.com)

This method will take some of the guess work out of dendrimer research and speed the development of dendrimersomes as useful cell membrane mimics. (upenn.edu)

We find that the mechanism of NPH association with the dendrimers is similar for G3-G6 dendrimers. (confex.com)
Our results provide a detailed mechanism of NPH association with dendrimers. (confex.com)

Percec's group identified the new Janus dendrimers during a molecular library search. (acs.org)

We demonstrate that photoluminescence (PL) quantum yield and PL lifetime of fac-tris(2-phenylpyridyl) iridium(III) [Ir(ppy) 3 ]-cored dendrimers in neat film and dispersed into a 4,4′-bis(]V-carbazoly])bipheny] host can be significantly improved by a simple adjustment of the solution preparation. (elsevierpure.com)

In contrast, stiff-unit dendrimers had a more eccentric, disk-like shape. (ncsu.edu)

The dendrimers contain a siloxane core and silylalkyl groups Carbosiloxane dendrimers containing at least one siloxane unit with general formula (I) and at least one siloxy group of formula (II) are new. (epo.org)

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes1

Disciplines and Occupations1

Technology, Industry, Agriculture7

PAMAM12

Polyamidoamine3

Cationic dendrimers2

Molecules16

Amidoamine1

Dendritic4

Synthesis4

Amido amine1

Biomedical Applications4

Dendrons3

Multifunctional1

20013

Vesicles2

Chemistry3

Molecule3

Polymer1

Ligands3

Aliphatic1

Structures2

Convergent3

Amphiphilic1

Compounds1

Globular1

Organic5

Applications7

Redox2

Generation5

Vitro1

Concentration2

Polymeric2

Spherical1

Moieties1

Publication1

Researchers1

Simulations4

Uptake1

Generations2

Structure6

Gene2

Cores3

Reversible1

Peripheral2

Properties2

Surface1

Periphery1

Dendrimersomes1

Mechanism2

Search1

Preparation1

Contrast1

Groups1