• Dendrimers, a class of hyperbranched polymer explored in nanomedicine applications, were first described by Tomalia [ 1 ] and Newkome [ 2 ]-separately-as core-shell structures, built in a layer-by-layer way, forming generations. (springer.com)
  • Due to several initiatives, the use of these neutral dendrimers as a scaffold to introduce other functional groups has been proposed. (springer.com)
  • Currently, an important function of dendrimers as carriers of short single-stranded DNA has been applied. (springer.com)
  • Genisphere has announced the adaption of its breakthrough 3DNA dendrimer signal amplification technology for use in lateral flow (LF) point-of-care (POC) assays, delivering enhanced sensitivity and facilitating a variety of new POC tests. (azonano.com)
  • PAMAM dendrimers have been demonstrated to elicit a well defined cytotoxicological response from Alamar Blue, Neutral Red and MTT assays, where the response increases systematically with dendrimer generation and number of surface amino groups. (nsti.org)
  • The concentration of the chemicals tested as anti-biofilm agents was chosen based on cytotoxicity assays: the highest non-cytotoxic chemical concentration was used for biofilm inhibition assays, with dendrimer concentration 10-fold higher than polyamino-phenolic ligands. (frontiersin.org)
  • Polyamidoamine (PAMAM) dendrimers are the most common class of dendrimers suitable for many materials science and biotechnology applications. (sigmaaldrich.com)
  • PAMAM dendrimers consist of alkyl-diamine core and tertiary amine branches. (sigmaaldrich.com)
  • Most PAMAM dendrimers are supplied as solutions in methanol for improved long-term storage stability. (sigmaaldrich.com)
  • These PAMAM dendrimers, with surfaces fully derivatized with externally presented amidoethanol groups, have higher solubility in less polar organic solvents. (sigmaaldrich.com)
  • The results are consistent with a pathway of endosomal uptake of PAMAM, followed by endosomal rupture and subsequent localisation of PAMAM dendrimers in the mitochondria, leading to PAMAM generation, dose and time dependant biphasic ROS production and caspase- 8 and 3 activation, inflammatory responses (TNF-α, IL-6 and IL-8 expression), apoptosis and DNA damage. (nsti.org)
  • The functional group on the surface of PAMAM dendrimers is ideal for click chemistry, which gives rise to many potential applications. (wikipedia.org)
  • PAMAM dendrimers have been synthesized using two separate acrylamide monomer compounds, (2-acryloylamino-ethyl)-carbamic acid tert-butyl ester (1) and N-cyanomethyl-acrylamide (18). (openthesis.org)
  • A research team led by Seungpyo Hong, who serves as Assistant Professor of Biopharmaceutical Sciences at the University of Illinois at Chicago has developed a highly sensitive biomimetic surface utilizing the anti-epithelial cell adhesion molecule called aEpCAM and the dendrimers of seventh-generation polyamidoamine called PAMAM to remove circulating cancer cells from the blood. (azonano.com)
  • In this study, the anti-biofilm activity of previously fabricated polyamino-phenolic ligands and polyamidoamine dendrimers was investigated against legionella mono-species and multi-species biofilms formed by L. pneumophila in association with other bacteria that can be found in tap water ( Aeromonas hydrophila , Pseudomonas aeruginosa , Escherichia coli , Klebsiella pneumoniae ). (frontiersin.org)
  • His contribution to this special dendrimer issue describes the integrated dependency of dendrimer-based "dendritic effects" on critical nanoscale design parameters (CNDPs) . (rsc.org)
  • Dendrimers, the nanoscale hyper-branched structures, are evolving in the healthcare sector to enhance the properties of existing therapeutic compounds as well as for introduction of novel therapeutic/diagnostic products. (marketresearch.com)
  • Córdoba EV, Arnaiz E, Relloso M, Sánchez-Torres C, García F, Pérez-Álvarez L, Gómez R, Francisco J, Pion M, Muñoz-Fernández MÁ (2013) Development of sulphated and naphthylsulphonated carbosilane dendrimers as topical microbicides to prevent HIV-1 sexual transmission. (springer.com)
  • Vacas-Córdoba E, Maly M, De la Mata FJ, Gómez R, Pion M, Muñoz-Fernández MÁ (2016) Antiviral mechanism of polyanionic carbosilane dendrimers against HIV-1. (springer.com)
  • Carbosilane dendrimers increase the gene transfection ability of tissues to be treated. (eurekaselect.com)
  • This technical note describes how 3DNA ® Dendrimer technology was applied to a model LF POC assay, resulting in a 64 fold improvement of sensitivity. (selectscience.net)
  • Each successive generation results in a dendrimer roughly twice the molecular weight of the previous generation. (pharmainfo.net)
  • In the structure of dendrimer (Fig.6)the molecular density is theoretically highest in the periphery of the dendrimers. (pharmainfo.net)
  • It is the arithmetic invariants of a molecular graph and is fruitful and vital to correlate with physiochemical properties and bioactivities of molecular compound/network/dendrimer. (hindawi.com)
  • This property is of high importance, as it has been shown that DNA-based dendrimers have been envisioned to play a promising role in developing nanoscale-barcodes, DNA-based vaccine technologies, as well as a structural probes involving multiplexed molecular sensing processes. (innovations-report.com)
  • By means of molecular dynamics simulations the free energy of adsorption of model dendrimer characterized by monomers of different chemical affinity is predicted as a function of the number and position of the monomers. (rsc.org)
  • Her research interest centers on the role of nanomedicine (dendrimers) in immunology, molecular biology and HIV infection. (rsc.org)
  • While Macrophen and Double Macrophen were the most active substances among polyamino-phenolic ligands, dendrimers were overall twofold more effective than all other compounds with a reduction up to 85 and 73% of legionella and multi-species biofilms, respectively. (frontiersin.org)
  • Peng J, Wu Z, Qi X, Chen Y, Li X (2013) Dendrimers as potential therapeutic tools in HIV inhibition. (springer.com)
  • Lower generation dendrimers are large enough to be spherical but do not form a tightly packed surface, have enormous surface areas in relation to volume(Fig 5). (pharmainfo.net)
  • Lipid based dendrimer causes endosomal escape and improves the permeability of dendrimers. (eurekaselect.com)
  • Conclusion: Thus, surface modified dendrimers render a complete pack which offers increased siRNA loading, increased transfection and permeability, efficient targeting, endosomal escape and protecting siRNA from degradation by RNase and other such enzymes. (eurekaselect.com)
  • Finally, hydrophobic drugs which have been explored for dendrimer assisted solubilization, and the current marketing status of dendrimers will be discussed. (frontiersin.org)
  • Phosphate dendrimers having hydrophobic backbone and hydrophilic surface increase the permeability towards targeted tissue. (eurekaselect.com)
  • There have been some efforts to synthesize dendrimers that behave similar to redox proteins. (wikipedia.org)
  • However, because the actual reactions consist of many steps needed to protect the active site, it is difficult to synthesize dendrimers using either method. (wikipedia.org)
  • Physicists from the University of Vienna, the Technical University of Vienna, the Jülich Research Center in Germany and Cornell University in the U.S.A., investigated methodologies to synthesize DNA-based dendrimers in the lab and to predict their behavior using detailed computer simulations. (innovations-report.com)
  • This review will discuss the aspects and role of dendrimers in the solubility enhancement of poorly soluble drugs. (frontiersin.org)
  • In her contribution to this special issue, she presents advances in the design of innovative microbicides against HIV infection based on the use of dendrimers. (rsc.org)
  • The free energy profiles have also been compared with those obtained from simpler models which treat the dendrimer molecule as a rigid sphere showing that such simplification is acceptable in poor solvent but not in good solvent where the flexibility of the dendrimer molecule plays a major role in its stability at the interface. (rsc.org)
  • Ferrocene-containing dendrimers are of interest for their ability to do multielectron-transfers and they have been synthesized by convergent and divergent approaches. (wikipedia.org)
  • Their tree-like architecture and step-wise growth with repeating self-similar units results in dendrimers containing cavities, hollow objects with controllable design. (innovations-report.com)
  • Synthetic processes can also precisely control the size and number of branches on the dendrimer. (wikipedia.org)
  • These findings compare well with simulation results obtained from atomistic simulations performed on polyaminoamide dendrimer at the air-water interface. (rsc.org)
  • The effect of back-folding is enhanced upon addition of salt in the solution, whereby flexible dendrimers undergo significant shrinking, becoming compact objects with no hollow spaces in their interior. (innovations-report.com)
  • There are many potential applications for ferrocene containing dendrimers. (wikipedia.org)
  • The aim of this book is to be the reference book about dendrimers applications. (wiley.com)
  • In addition to drug delivery, which is the key application area, some other potential applications of dendrimers being actively pursued in research include disease diagnosis, targeted therapy, MRI imaging, tissue regeneration, cell repair and vaccine development. (marketresearch.com)
  • Very large (G-7 and greater) dendrimers can be thought of more like solid particles with very dense surfaces due to the structure of their outer shell. (wikipedia.org)
  • Dendrimers can be considered to have three major portions: a core, an inner shell, and an outer shell. (wikipedia.org)
  • In a paper, 'Dendrimer-fullerenol soft-condensed nanoassembly,' reported in The Journal of Physical Chemistry C, researchers from Clemson University and their collaborators have demonstrated the way of using dendrimer, a soft nanomaterial, to protect the environment against potentially toxic nanomaterials. (azonano.com)
  • This idea brought together researchers from various interdisciplinary fields who have been investigating dendrimers as promising candidates for creating such nano-carriers. (innovations-report.com)
  • One important property of dendrimers is "polyvalency" or the presence of multiple active groups on the surface of the dendrimer. (starpharma.com)
  • Many such surface modifications have been carried out to improve the delivery potential of small interfering RNA (siRNA) modified dendrimers compared to simple plain dendrimers. (eurekaselect.com)
  • The objective of this manuscript is to provide different approaches currently available for surface modifications of dendrimers and their overall effect on transfection ability of siRNA to target tissues. (eurekaselect.com)