Delivery of therapeutic localization anticancer drugs or radiation. Medical search. Frequent questions

The emerging technology known as targeted therapy facilitates selective delivery of chemotherapeutic agents involving therapeutic genes and drugs to tumor sites, which enhances the therapeutic efficacy and reduces side effects 2 . (nature.com)
It enables in situ delivery of the produced bioactive molecules to tumor site, which improves the therapeutic efficacy. (nature.com)
Bio-degradable polymers investigated for the preparation of nanocarriers for the entrapment of drugs and to enhance the efficacy through improved adherence of tissue in the eye, sustained release measures, enhanced bioavailability, lower toxicity, and targeted delivery is applicable. (bvsalud.org)
The TAPUR Study aims to describe the safety and efficacy of Food and Drug Administration (FDA)-approved, targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has a potentially actionable genomic alteration. (facingourrisk.org)
To gain FDA approval as anti-cancer drugs, the agents need to pass two criteria, safety and efficacy, besides the product qualification validation. (fordating.club)
Interindividual UGT variability likely plays an important role in drug efficacy and xenobiotic toxicity, as well as in hormonal regulation and certain diseases, which in some cases may be amenable to therapeutic manipulations including gene therapy. (aspetjournals.org)
While tumor imaging and radiotherapy strategies are crucial for tumor identification and treatment, the presence of metastasis and radiation resistance has reduced the efficacy of treatment in cancer patients. (biomedcentral.com)
He serves as Associate Director for Liver Tumor, Kidney Tumor, Germ Cell, and Neuroblastoma Targeted Therapies, and is currently the Sponsor and Study Principal Investigator the CaboMain trial, a Phase 2 study evaluating the efficacy of the oral anticancer agent cabozantinib as a maintenance therapy for ultra-high-risk solid tumors. (spotify.com)
However, the therapeutic safety and efficacy must be further optimized and balanced to ensure the superior safe and efficient OVT in clinics, and reasonable combination therapy strategies are also important challenges worthy to be explored. (biomedcentral.com)
With increasingly high therapeutic efficacy being achieved recent years and owing to the unique features such as specific tumor tropism, low cytotoxicity against normal cells, OVT has been inviting a great attention as an ideal weapon against cancers. (biomedcentral.com)

These nanocapsules are made of a PLGA-polymer matrix coated with Fe/FeO core-shell nanocrystals and co-loaded with chemotherapy drug and photothermal agent. (nature.com)
Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. (wikipedia.org)
It is also common to combine radiation therapy with surgery, chemotherapy, hormone therapy, immunotherapy or some mixture of the four. (wikipedia.org)
Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
This study is looking at how well the drug elimusertib (a type of targeted therapy known as an ATR inhibitor) works when combined with chemotherapy for treating people with advanced cancers, including urothelial, ovarian, gastric, endometrial, triple-negative breast cancer and others. (facingourrisk.org)
Despite the current aggressive treatment strategies with chemotherapy, radiation therapy and surgery, oral cancer remains the third most lethal cancer, accounting for 18% of all cancer deaths and a 5-year survival of less than 50% [ 1 , 2 ]. (oncotarget.com)
Tumor growth is initially reduced by radiation, surgery, or hormone therapy and later, by pairing them with chemotherapy for advanced cancer. (mdpi.com)
Drug resistance is a main obstacle for curative cancer chemotherapy. (hindawi.com)

Overall, this study proposes a new strategy for the bacteria-mediated delivery of therapeutic proteins to tumors. (nature.com)
Smartly engineered nanocapsules can not only shrink and decompose into small-sized nanodrugs upon drug release but also can regulate the TME to overproduce reactive oxygen species for enhanced synergistic therapy in tumors. (nature.com)
Therapeutic vaccination has the major advantage that the induced immune response selectively attacks tumors while leaving the healthy cells untouched. (universiteitleiden.nl)
Greish, K.: Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines, J Drug Target, 15, 457 (2007). (dergipark.org.tr)

Photoabsorbing agents such as nanoparticles need to reach the tumor site at therapeutic concentrations, crossing the blood-brain barrier upon systemic administration. (frontiersin.org)
Delivery strategies include drugs encapsulated into liposomes, polymeric micelles of drugs, solid lipid nanoparticles, nanostructured lipid carriers, nano emulsions, and Nanosuspension used to improve penetrating properties, bioavailability, and residence time of the drugs as examples available in the literature. (bvsalud.org)
Biotinylated LLY13, in complex with streptavidin-alexa488 was taken up by live oral cancer cells, thus rendering it as an excellent candidate vehicle for efficient delivery of drug loaded-nanoparticles. (oncotarget.com)
Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. (researchgate.net)
Strategies have been advised that nanoparticles can be used to deliver drug/gene to targeted tissues [ 4 ]. (hindawi.com)

For example, most chemotherapeutic drugs work by impairing mitosis (cell division), effectively targeting fast-dividing cells. (justia.com)

One of the possible reasons for the failure of the present therapeutic regimens is the existence of a relatively rare cell population known as cancer stem cells (CSCs) that are resistant to or not targeted by present therapeutic modalities. (docksci.com)
It is envisaged that understanding of the embryo-endometrial dialogue leading to the "selector" activity, aids in development of appropriate therapeutic modalities for infertility related disorders and miscarriages. (brjnmims.org)

Human sodium/iodide symporter (hNIS) is considered as one of the most prevalent nuclear imaging reporter transgenes that provides precise information regarding the kinetics of gene expression, viral biodistribution, toxicity, and therapeutic outcomes using the accumulation of radiotracers at the site of transgene expression. (biomedcentral.com)

Our investigations are ongoing in biomarkers of resistance and potential new targets for therapeutic intervention in colorectal cancer, melanoma and Merkel cell carcinoma. (massgeneral.org)
CrossTalk is an interdisciplinary study that utilises the state-of-the-art technologies in order to identify novel opportunities for targeted therapeutic intervention and improved patient stratification. (dcu.ie)
Only if you reach this level, rational intervention, like needed in drug discovery, is possible. (infn.it)
Acupuncture as a therapeutic intervention is widely practiced in the United States. (meridianhealthnc.com)

METHODS: The development of nanotechnology for anticancer drug delivery has developed several potentials as nanocarriers, which may boost the pharmacokinetic and pharmacodynamic effects of the drug product and substantially reduce the side effects. (bvsalud.org)
With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. (hindawi.com)

It is estimated that half of the US' 1.2M invasive cancer cases diagnosed in 2022 received radiation therapy in their treatment program. (wikipedia.org)

Ultrasonic drug and gene delivery from nanocarriers have tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly noninvasive means [ 7 ]. (hindawi.com)

The biodistribution of drug carriers is monitored by imaging, so that the optimal timing for the application of external stimuli can be achieved [ 2 ]. (hindawi.com)

The goal is to develop a better method for immunotherapy drug delivery since systemic exposure is often associated with significant negative side effects. (uclahealth.org)

Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body, and have not spread to other parts. (wikipedia.org)
It may also be used as palliative treatment (where cure is not possible and the aim is for local disease control or symptomatic relief) or as therapeutic treatment (where the therapy has survival benefit and can be curative). (wikipedia.org)
The precise treatment intent (curative, adjuvant, neoadjuvant therapeutic, or palliative) will depend on the tumor type, location, and stage, as well as the general health of the patient. (wikipedia.org)
They can pass through blood capillary walls and cell membrane walls to deliver drugs [ 8 ], thereby reducing the side effect and enhancing the curative effect of cancer therapy [ 9 ]. (hindawi.com)

Thermo-responsive Fibrinogen Nanogels: a Viable Thermo-responsive Drug Delivery Agent for Breast Cancer Therapy? (amrita.edu)
Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the field of theranostics. (nature.com)
Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a treatment using ionizing radiation, generally provided as part of cancer therapy to either kill or control the growth of malignant cells. (wikipedia.org)
Most common cancer types can be treated with radiation therapy in some way. (wikipedia.org)
The response of a cancer to radiation is described by its radiosensitivity. (wikipedia.org)
Highly radiosensitive cancer cells are rapidly killed by modest doses of radiation. (wikipedia.org)
Renal cell cancer and melanoma are generally considered to be radioresistant but radiation therapy is still a palliative option for many patients with metastatic melanoma. (wikipedia.org)
It is important to distinguish the radiosensitivity of a particular tumor, which to some extent is a laboratory measure, from the radiation "curability" of a cancer in actual clinical practice. (wikipedia.org)
This study is comparing safety and effectiveness of a new drug called giredestrant compared to standard hormone therapy in people with early-stage, ER-positive breast cancer. (facingourrisk.org)
Patients still deal with cancer itself, as well as radiation therapy. (fordating.club)
Background Antibody-drug conjugates are an exceptional and useful therapeutic tool for multiple diseases, particularly for cancer treatment. (bmj.com)
Nanomaterials for targeted drug delivery to cancer stem cells. (docksci.com)
Immunotherapy has established a firm position in the battle against cancer next to theclassical chemo- and radiation therapies. (universiteitleiden.nl)
In 2016 the Leiden University Translational Drug Discovery & Development "Molecule to Man" Award was received with the aim to develop Personalized Cancer Immunotherapy. (universiteitleiden.nl)
Recent innovations have helped to develop prescription drugs against certain prostate cancer types, showing gene alterations that prevent the repair of damaged DNA or activate the body's anti-cancer natural immune defense. (mdpi.com)
In recent years, tumor-targeted therapy has been appearing as a promising therapeutic choice for cancer treatment. (hindawi.com)
Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)
In this review article, we will focus on a broad range of cannabinoids, their receptor dependent and receptor independent functional roles against various cancer types with respect to growth, metastasis, energy metabolism, immune environment, stemness and future perspectives in exploring new possible therapeutic opportunities. (oncotarget.com)

Moreover, according to the requirements of US Food and Drug Administration (FDA), theranostic agents should be completely cleared from the body within a reasonable period of time. (nature.com)
Additionally, GBM is characterized by high inter-tumor and intra-tumor heterogeneity at a cellular, molecular, histological, and clinical level leading to very different responses to therapeutic agents and failure of targeted therapies ( 9 , 10 ). (frontiersin.org)
Additionally, CPP has become another strategy to overcome some of the current therapeutic agents' limitations. (bvsalud.org)
Such studies should also aid in the design of molecular probes to assess the capacity of individuals to metabolize specific drugs and toxins, before exposure to these agents. (aspetjournals.org)

Combining radiation therapy with immunotherapy is an active area of investigation and has shown some promise for melanoma and other cancers. (wikipedia.org)

Current advancements in drug carrier systems, i.e., nanocarriers, have shown promise for improving the retention time, drug permeation and prolonging the duration of release of the drug in the ocular site. (bvsalud.org)
This review covers the introduction of various nanocarriers and polymers for ocular drug delivery with the purpose of enhancing the absorption, retention and bioavailability of medications in the eye. (bvsalud.org)
Nanocarriers, with the properties of smaller particle size, and long circulation time, would be advantageous in diagnostic and therapeutic applications. (hindawi.com)
Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. (hindawi.com)
In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers. (hindawi.com)
Furthermore, as targeted delivery carriers, gene/drug-loaded nanocarriers can release their associated payload upon insonation. (hindawi.com)
Besides, nanocarriers decorated with targeting moiety can adhere to targeted tissues, which can promote intracellular uptake of drug delivery vehicles. (hindawi.com)
Although the system of ultrasound-mediated drug delivery with nanocarriers has many advantages, there are still many challenges. (hindawi.com)

Secondly, the central nervous system (CNS) has a unique microenvironment and is protected by the blood-brain barrier (BBB), which limits the access of systemically delivered drugs to the brain reducing the therapeutic options available for GBM. (frontiersin.org)

Brachytherapy, in which a radioactive source is placed inside or next to the area requiring treatment, is another form of radiation therapy that minimizes exposure to healthy tissue during procedures to treat cancers of the breast, prostate, and other organs. (wikipedia.org)
The use of radiation therapy in non-malignant conditions is limited partly by worries about the risk of radiation-induced cancers. (wikipedia.org)
Different cancers respond to radiation therapy in different ways. (wikipedia.org)
The majority of epithelial cancers are only moderately radiosensitive, and require a significantly higher dose of radiation (60-70 Gy) to achieve a radical cure. (wikipedia.org)
In this role, he works to identify new uses of currently available anticancer treatments, including drugs originally developed for use against cancers in adults. (spotify.com)
Amazing combination of therapeutic strategies of OVs and immune cells confers immense potential for managing cancers. (biomedcentral.com)

Apparently, there is a pressing need to rationally design delivery systems for tumor therapy. (nature.com)
Photothermal therapy may be a promising strategy for the treatment of GBM, as it allows the destruction of the tumor using heat as a non-chemical treatment for disease bypassing the GBM heterogeneity limitations, conventional drug resistance mechanisms and side effects on peripheral healthy tissues. (frontiersin.org)
Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. (wikipedia.org)
Radiation may be prescribed by a radiation oncologist with intent to cure or for adjuvant therapy. (wikipedia.org)
Total body irradiation (TBI) is a radiation therapy technique used to prepare the body to receive a bone marrow transplant. (wikipedia.org)
Radiation therapy has several applications in non-malignant conditions, such as the treatment of trigeminal neuralgia, acoustic neuromas, severe thyroid eye disease, pterygium, pigmented villonodular synovitis, and prevention of keloid scar growth, vascular restenosis, and heterotopic ossification. (wikipedia.org)
For example, leukemias are not generally curable with radiation therapy, because they are disseminated through the body. (wikipedia.org)
These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)

A physician who practices in this subspecialty is a radiation oncologist. (wikipedia.org)
Treatment decisions are best made by a team approach, including input from the involved neurosurgeon, radiation oncologist, and medical oncologist or neurologist, as well as the patient and/or their family. (medscape.com)

Ionizing radiation works by damaging the DNA of cancerous tissue leading to cellular death. (wikipedia.org)
The cellular membrane hinders the effective delivery of therapeutics to targeted sites. (bvsalud.org)
In this review, we mainly discuss the cellpenetrating peptide as the delivery vehicle, the cellular uptake mechanism of CPPs, their design, and some strategies to synthesize the CPP complex via some linkers such as disulfide bond, oxime, etc. (bvsalud.org)
The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is the key component of the non-homologous end-joining (NHEJ) pathway for DNA double-strand break (DSB) repair and is required for cellular resistance to ionizing radiation (IR) ( 1 , 2 ). (amegroups.org)
These isozymes synthesise different sizes of HA polymers, which are differentially regulated at the transcriptional, translational, and post-translational levels, which include epigenetic processes, sub-cellular localization, and alternative splicing. (biotechnolabs.com)
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. (stemcellslab.net)

Recently, various innovative approaches have been explored to overcome the therapeutic resistance caused by hypoxia. (nature.com)
Existing approaches to the production of calcium phosphate cements as drugs are analyzed. (encyclopedia.pub)
He also consults on patients for precision oncology, partnering with the Institute for Genomic Medicine to identify therapeutic approaches based on patient tumor and germline genomics. (spotify.com)

With our recent discovery of the molecule HB-EGF in resistance pathways, we worked with collaborators in Japan to bring a new drug to the clinic that targets this specific pathway. (massgeneral.org)
Identifying these changes can help us understand how diseases such as epilepsy affect these cells and may represent viable therapeutic targets. (dcu.ie)

Besides the tumour itself, the radiation fields may also include the draining lymph nodes if they are clinically or radiologically involved with the tumor, or if there is thought to be a risk of subclinical malignant spread. (wikipedia.org)

Microbubbles are commonly used as intravascular ultrasound imaging probes and are becoming increasingly popular tools for targeted drug delivery. (hindawi.com)

The subspecialty of oncology concerned with radiotherapy is called radiation oncology. (wikipedia.org)
Radiation oncology is the medical specialty concerned with prescribing radiation, and is distinct from radiology, the use of radiation in medical imaging and diagnosis. (wikipedia.org)
Benjamin P.C. Chen, PhD. Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 2201 Inwood Rd., Rm. (amegroups.org)

On the contrary, small size NPs with a diameter of 4-20 nm easily penetrate into deep tumor tissues, but they are more prone to rapid clearance and insufficient drug retention. (nature.com)

In this context LEAPS will organize 14-19 May, 2023 the second LEAPS Conference aiming at bringing together the latest achievements from the Life Sciences user community with those from synchrotron radiation source development and instrumentation. (infn.it)
Conversely, it might also benefit the development of anti-implantation drugs for contraception. (brjnmims.org)

Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)

To spare normal tissues (such as skin or organs which radiation must pass through to treat the tumor), shaped radiation beams are aimed from several angles of exposure to intersect at the tumor, providing a much larger absorbed dose there than in the surrounding healthy tissue. (wikipedia.org)
Histopathological analysis of tissues from treated mice did not demonstrate any specific drug-related changes. (bmj.com)

We previously showed that the fusion of the serine protease granzyme B (GrB), the effector molecule or T and B cells, to a binding domain allows the controlled and effective delivery of the cytotoxic payload into the target cell. (bmj.com)
As these drugs cause damage to cells they are termed cytotoxic. (justia.com)

The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. (aspetjournals.org)

However, developing SDDSs with early diagnostic capability, enhanced drug delivery and efficient biodegradability still remains a scientific challenge. (nature.com)

The focus of the second LEAPS Conference will be the opportunities emerging from the Life Sciences R&D. This conference will showcase where today and future synchrotron radiation contributes to the advancements in Life Sciences. (infn.it)

However, there are still many challenges in developing TME-sensitive SDDSs to overcome the anaerobic problem and improve the therapeutic effect. (nature.com)
Ultrasound is a noninvasive and visual theranostic modality that can be used to track drug carriers, trigger drug release, and improve local drug sediment with high spatial precision [ 5 , 6 ]. (hindawi.com)
Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)

Our synthetic strategy provides a platform for next generation smart nanocapsules with enhanced permeability and retention effect, multimodal anticancer theranostics, and biodegradability. (nature.com)

Recent advances in our biological understanding of gliomas have led to important and substantive changes in their classification, in the identification of prognostic and predictive molecular markers, and in the therapeutic management of newly diagnosed glioma. (cancernetwork.com)

Radiation Research Radiation Research, 186(5): 520-530 (2016). (usherbrooke.ca)
Radiation Physics and Chemistry 128, 36-43 (2016). (usherbrooke.ca)
Invest New Drugs 34, 269-276 (2016). (usherbrooke.ca)

In vivo experiments demonstrate that these nanocapsules can target to tumor sites through fluorescence/magnetic resonance imaging and offer remarkable therapeutic results. (nature.com)
Another hallmark of epileptic tissue is astrocyte dysfunction which has not received much attention as a therapeutic target. (dcu.ie)

All 18 patients received external beam radiation at the time of their initial diagnosis after surgical resection of the original tumor. (ajnr.org)

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