• Phosphodiesterase 11A (PDE11A), an enzyme that degrades cyclic nucleotides (cAMP and cGMP), is the only PDE whose mRNA expression in brain is restricted to the hippocampal formation. (frontiersin.org)
  • Given its ability to transport important intra- and intercellular mediators such as cyclic nucleotides and eicosanoids, the physiological repertoire of MRP4 is thought to cover platelet aggregation, cell migration and proliferation, angiogenesis, and cardiomyocyte contraction. (solvobiotech.com)
  • The complete nucleotide sequence of 15,611 bases has been determined, and the gene structures were examined. (embl-heidelberg.de)
  • Sequence homology searches identify PhnC, PhnK, PhnL, and, possibly, PhnN proteins as members of nucleotide-binding proteins of the binding protein-dependent transport systems. (embl-heidelberg.de)
  • Editing involves changing some nucleotides in the pre-mRNA to alter its sequence and function. (stemcelldaily.com)
  • Nucleotide sequence of the PetM gene encoding a 4 kDa subunit of the cytochrome b6f complex from Chlamydomonas reinhardtii. (bio.net)
  • From a series of 20,000 full sequence tests of BRCA1 carried out at Myriad Genetic Laboratories, a total of 314 different missense changes and eight in-frame deletions were observed. (xenbase.org)
  • METHODS: We have used a combination of a multiple sequence alignment of orthologous BRCA1 sequences and a measure of the chemical difference between the amino acids present at individual residues in the sequence alignment to classify missense variants and in-frame deletions detected during mutation screening of BRCA1 . (xenbase.org)
  • The guide RNA complexes with the Cas endonuclease, is transported to the nucleus, and creates a DNA double-strand break (DSB) at a site pre-programmed in the targeting sequence of the guide RNA. (technologynetworks.com)
  • From this cleavage and repair process, sequence insertions or deletions (indels) often cause errors in translation, leading to functional gene, and subsequent protein, knockdown. (technologynetworks.com)
  • Results indicate that AD EVs carry two nucleotide deletions in the sequence located upstream of the γ-secretase cleavage site, which could affect APP processing. (ucf.edu)
  • Nucleotide sequence of 21·8 kbp of variola major virus strain Harvey and comparison with vaccinia virus. (microbiologyresearch.org)
  • Sequence analysis, expression, and deletion of a vaccinia virus gene encoding a homolog of profilin, a eukaryotic actin-binding protein. (microbiologyresearch.org)
  • Generally, the DNA sequences transcribed are known as genes whose nucleotide sequence encodes the information required by the production of either a functional protein or regulatory RNA. (pediaa.com)
  • Here, the genes encoded for proteins are known as the protein-coding genes and their transcription results in the synthesis of mRNA s, later translated into the amino acid sequence of the functional protein. (pediaa.com)
  • Here, based on the effect on the nucleotide sequence, mutations can be divided into two categories: gene-level mutations and chromosomal mutations. (pediaa.com)
  • Furthermore, the main importance of mutated sequences is that they are responsible for the alteration of the nucleotide sequence of genes, altering the gene product or alteration of the structure of the genome, altering the regulation of gene expression. (pediaa.com)
  • Based on the nucleotide sequence information of transcripts, we identified 819 novel transcriptionally active regions (nTARs) and revised 906 incorrectly predicted gene models, including revisions of exon-intron structure, gene orientation and sequencing errors. (biomedcentral.com)
  • The predicted amino acid sequence yields a protein mass of 30,200 Da, but on polyacrylamide gel electrophoresis or size exclusion chromatography it has an apparent molecular mass of 32-38 kDa and by isoelectric focusing a PI of about 3.5 - 4.0 depending on species and technique. (pancreapedia.org)
  • Sequence alignment of the protein encoded by etrA reveal that the four cysteine residues that form the [4Fe-4S] 2+ cluster in Fnr are conserved in EtrA [ 16 ]. (biomedcentral.com)
  • A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordered regions of proteins. (biomedcentral.com)
  • Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
  • The gene level mutations can be either nucleotide substitutions, insertions, deletions or frameshift mutations. (pediaa.com)
  • Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (wikipedia.org)
  • Polymorphisms in this gene are generally found in the form of a single-nucleotide polymorphism (SNP). (wikipedia.org)
  • The ABCC1 gene, the gene that encodes the ABCC1 protein, is found on chromosome 16 within the nucleus. (wikipedia.org)
  • Once a particular gene is shown to be defective in a given condition, the nature of the mutation in a patient can be determined by sequencing the nucleotides of the coding exons and the splice sites. (mhmedical.com)
  • For example, all sickle cell disease is caused by exactly the same change of glutamate to valine at position 6 of beta-globin, and that substitution in turn is due to a change of one nucleotide at the sixth codon in the beta-globin gene. (mhmedical.com)
  • If the sequences of the 10-20 nucleotides at the ends of a region of DNA of interest (such as a portion of a gene) are known, then "primers" complementary to these sequences can be synthesized. (mhmedical.com)
  • The nucleotide and deduced amino acid sequences of the phnA gene showed no significant homology with any data bank accessions. (embl-heidelberg.de)
  • Furthermore, gene overexpression is also frequently associated to antifungal resistance as well as an increase in the activity of proteins that reduce oxidative damage. (intechopen.com)
  • In Library, lysine-10( H3K9) vision gene has required a green protein-protein for visual studies and lacks visually one of the unknown conditions known with acid( Peters et al. (erik-mill.de)
  • In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
  • To acquire an unbiased watch from the multiple, conflicting sometimes, biological actions and signaling systems that are influenced by fucoidans in proliferating cells, this research initially examined the consequences of the well-defined fucoidan remove in the edible macroalga by testing a gene deletion collection. (irjs.info)
  • For this function, the present research utilized a single-gene deletion collection of strains and incubated the gene deletion strains in the lack and existence of fucoidan. (irjs.info)
  • By evaluating the overall development (population thickness) from the gene deletion strains in the lack and existence of fucoidan we could actually unearth genes, and therefore potential hereditary/useful pathways influenced by fucoidan. (irjs.info)
  • We used this experimental approach to address the query of how one type of edible fucoidanfrom gene deletion strains was measured in the absence and presence of 500 g/mL fucoidan, (Table S1). (irjs.info)
  • His fields of research comprise RNA-mediated gene silencing processes with a focus on epigenetic phenomena, including studies on RNA-directed DNA methylation, the characterization of virus silencing suppressor proteins, the development of plant bioreactor platforms and viroid research. (degruyter.com)
  • While direct repeats and imperfectly homologous sequences appear to mediate the formation of mtDNA deletions, the nicotinamide adenine dinucleotide dehydrogenase 5 gene is a hot-spot for these rearrangements. (nih.gov)
  • The pc-1 phenotype of Chlamydomonas reinhardtii results from a deletion mutation in the nuclear gene for NADPH:protochlorophyllide oxidoreductase. (bio.net)
  • The kinesin- homologous protein encoded by the Chlamydomonas FLA10 gene is associated with basal bodies and centrioles. (bio.net)
  • The OCA2 gene (formerly called the P gene) provides instructions for making a protein called the P protein. (medlineplus.gov)
  • Cells with only one copy of the OCA2 gene make a reduced amount of P protein compared with cells with two functional copies of this gene, which affects the coloring of the hair and skin. (medlineplus.gov)
  • In addition to a deletion in chromosome 15 that removes one copy of the OCA2 gene, these individuals have a variant (also known as a mutation) in the OCA2 gene on the other copy of chromosome 15. (medlineplus.gov)
  • The most common OCA2 variant is a large deletion in the gene, which is found in many affected individuals of sub-Saharan African heritage. (medlineplus.gov)
  • Other OCA2 gene variants, including changes in single DNA building blocks (base pairs) and small deletions, are more common in other populations. (medlineplus.gov)
  • Cells missing a copy of the OCA2 gene make less P protein than cells with two functional copies of the gene, which affects the coloring of the hair and skin. (medlineplus.gov)
  • Bittel DC, Kibiryeva N, Talebizadeh Z, Butler MG. Microarray analysis of gene/transcript expression in Prader-Willi syndrome: deletion versus UPD. (medlineplus.gov)
  • In contrast to RNAi, CRISPR-based gene manipulation requires a guide RNA and a programmable Cas endonuclease protein. (technologynetworks.com)
  • Extracellular vaccinia virus formation and cell-to-cell virus transmission are prevented by deletion of the gene encoding the 37,000-Dalton outer envelope protein. (microbiologyresearch.org)
  • They undergo the two sequential steps of protein synthesis: transcription and translation, forming gene products. (pediaa.com)
  • Analysis of the gene space of 5DS suggested an increasing gradient of genes organized in islands towards the telomere, with the highest gene density of 5.17 genes/Mb in the 0.67-0.78 deletion bin, 1.4 to 1.6 times that of all other bins. (biomedcentral.com)
  • In a gene replacement study, etrA of strain MR-1 restored wild type physiology of an E. coli fnr deletion mutant [ 16 ]. (biomedcentral.com)
  • The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • The env gene maintained an ORF coding for a 538-amino acid polypeptide that has all the characteristic features of env proteins and mediates intercellular fusion in vitro [ 11 - 13 ]. (ecancer.org)
  • Here, we review mechanisms of mitochondrial gene expression with a focus on the recent findings in the field of mammalian mtDNA transcription and disease phenotypes caused by defects in proteins involved in this process. (biomed.news)
  • We observe that each gene and its products have a unique set of DNA, RNA or protein motifs that encode a regulatory program to define the logical circuitry that guides the life cycle of these biomolecules, from transcription to degradation. (biomedcentral.com)
  • Motor proteins of the conserved kinesin-14 family have important roles in mitotic spindle organization and chromosome segregation. (elifesciences.org)
  • 3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
  • Ordering of 80 contigs along the deletion bins of chromosome arm 5DS revealed small-scale breaks in syntenic blocks. (biomedcentral.com)
  • The alterations of pyrimidine nucleoside metabolism are hypothesized to cause imbalances of mitochondrial nucleotide pools that, in turn, may cause somatic alterations of mtDNA. (nih.gov)
  • Genomic polymorphism can influence drug transport, metabolism and cellular response, and lead to individual variations in terms of the response and toxicity and even to overall survival [ 8 , 9 ]. (biomedcentral.com)
  • Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)
  • Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive multisystem disorder associated with depletion, multiple deletions and site-specific point mutations of mitochondrial DNA (mtDNA). (nih.gov)
  • Amino acid substitution during functionally constrained divergent evolution of protein sequences. (xenbase.org)
  • The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor. (xenbase.org)
  • The main difference between original and mutated sequences is that original sequences do not have any mutated nucleotides or damages in DNA whereas mutated sequences may either contain nucleotide alterations or DNA damages . (pediaa.com)
  • Furthermore, original sequences are responsible for the production of the regular protein profile of a particular organism while mutated sequences are responsible for the production of novel proteins. (pediaa.com)
  • Original and mutated sequences are two types of nucleotide sequences which can occur in the genome of a particular organism. (pediaa.com)
  • Mutated sequences are the DNA sequences of organisms that have undergone alterations of nucleotides or DNA damages. (pediaa.com)
  • Therefore, mutated sequences are thought to generate novel proteins, bringing altered phenotypes to the organism. (pediaa.com)
  • Moreover, original sequences undergo transcription and translation to produce proteins in the regular proteome while mutated sequences produce novel proteins separated to the proteins in the regular proteome. (pediaa.com)
  • Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
  • Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. (jci.org)
  • To examine the role of protein kinase C as a chronic regulator of proximal tubule Na/H antiporter activity, the effect of phorbol 12-myristate 13-acetate (PMA) on the Na/H antiporter was studied in cultured proximal tubule cells. (jci.org)
  • Short-term activation of protein kinase C by 5 min exposure to PMA caused an acute increase in Na/H antiporter activity that was not prevented by cycloheximide or actinomycin D and did not persist 24 h later. (jci.org)
  • Long-term activation of protein kinase C by 2 h exposure to PMA caused a dose-dependent increase in Na/H antiporter activity 24 h later. (jci.org)
  • This latter effect was due to protein kinase C activation in that it was inhibited by sphingosine and was not seen with 4 alpha-PMA, an inactive analogue. (jci.org)
  • In conclusion, short-term activation of protein kinase C leads to a transient increase in Na/H antiporter activity that is independent of transcription and translation, whereas long-term activation of protein kinase C causes a persistent increase in antiporter activity that is dependent on transcription and translation and is associated with increased mRNANa/H abundance. (jci.org)
  • They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
  • Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
  • This occurs through the downregulation of methylmalonyl coenzyme A epimerase (MCEE), mediated by an extracellular signal-regulated kinase 2-driven transcription factor Sp1/early growth response protein 1 transcriptional switch driven by metastatic signalling at its promoter level. (biomed.news)
  • ABC proteins transport various molecules across extra-and intra-cellular membranes. (wikipedia.org)
  • Due to its presence in the choroid plexus and blood-brain barrier and its ability to transport multiple kinds of molecules out of cells, ABCC1 has been a point of interest in many Alzheimer's disease studies. (wikipedia.org)
  • Molecules can be transported around a cell by so-called motor proteins that move along a network of filaments called microtubules. (elifesciences.org)
  • In most cells, kinesins tend to transport other molecules away from the center and towards the cell edge. (elifesciences.org)
  • Viroids are non-encapsidated, single-stranded (ss), 250-400 nucleotide (nt)-long circular RNA molecules that do not encode proteins (1, 2). (degruyter.com)
  • Within melanocytes, the P protein may transport molecules into and out of structures called melanosomes (where melanin is produced). (medlineplus.gov)
  • The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)
  • Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. (wikipedia.org)
  • RESULTS: In the present analysis we were able to classify an additional 50 missense variants and two in-frame deletions as probably deleterious and 92 missense variants as probably neutral. (xenbase.org)
  • Each RNA polymerase requires the assistance of several other proteins or protein complexes, called general (or basal) transcription factors, which must assemble into a complex on the promoter in order for RNA polymerase to bind and start transcription. (stemcelldaily.com)
  • After translation, where is a protein localised, and what complexes should it join? (biomedcentral.com)
  • CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)
  • To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
  • A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)
  • The protein-protein interactions may help CRYAA carry out multifaceted functions. (molvis.org)
  • To understand the functions of CRYAA and how these are regulated, protein-protein interactions need to be investigated. (molvis.org)
  • Genetic engineering of the processing site of D1 precursor protein of photosystem II reaction center in Chlamydomonas reinhardtii. (bio.net)
  • This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. (wikipedia.org)
  • At the ribosome, the processed mRNA is translated to produce proteins from amino acid units. (cdc.gov)
  • The two nucleotide binding domains have a functional asymmetry that plays a significant role in the ability of ATP to power the transporter. (wikipedia.org)
  • Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)
  • Predicting the functional consequences of non-synonymous single nucleotide polymorphisms: structure-based assessment of amino acid variation. (xenbase.org)
  • As a result, cells make little or no functional P protein. (medlineplus.gov)
  • The term motif denotes a repeated figure or design and, in motif biology, the occurrence of a given class of motif in a set of unrelated biomolecules led to the appropriation of the term to refer to a recurrent pattern of nucleotides or amino acids that corresponds to an autonomous functional module. (biomedcentral.com)
  • This cap protects the mRNA from degradation and facilitates its transport and recognition by the ribosome. (stemcelldaily.com)
  • We have now identified five major forms of mtDNA deletions in the skeletal muscle of MNGIE patients. (nih.gov)
  • A novel aspect of the mtDNA deletions in MNGIE is the presence of microdeletions at the imperfectly homologous breakpoints. (nih.gov)
  • EVs transport pathologically significant biomolecules, like nucleic acids and proteins, across the blood-brain barrier, mediating local and distant cell-to-cell communication. (ucf.edu)
  • The function of the SEDL protein is not known although it is speculated that it may participate in the ER-to-Golgi transport as part of a novel highly conserved multiprotein TRAPP complex. (nature.com)
  • Antibiotics in current use target a surprisingly small number of cellular functions: cell wall, DNA, RNA, and protein biosynthesis. (biomedcentral.com)
  • Here, these proteins are either enzymes, hormones or other structural and transport proteins responsible for the regular functioning of the organism. (pediaa.com)
  • Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
  • In laboratory studies, neither molnupiravir nor N4-hydroxycytidine (NHC, the active moiety of molnupiravir) induced or inhibited major drug metabolising enzymes or major drug transporting systems. (who.int)
  • Hardman et al found that insulin and estrogen increased the level of MNK mRNA and protein levels in the placenta. (medscape.com)
  • We found that TRIM13 mRNA and protein expression was reduced in NSCLC tissues and cell lines in comparison to paired non-cancerous tissues and a human normal bronchial epithelial cell line, respectively. (cancerindex.org)
  • In addition, the protein also contains a third membrane-spanning domain that sets it apart from other transporters within the ATP-binding cassette family of transporters. (wikipedia.org)
  • The protein resides intracellularly on the basolateral side of the plasma membrane which differs from other ATP-binding cassette transporters that are found on the apical side of the membrane. (wikipedia.org)
  • Under normal circumstances, ATP7A transports copper into the secretory pathway of the cell for incorporation into the cuproenzymes and excretion from the cell. (medscape.com)
  • When evaluated by EM immunocytochemistry using antibody raised against purified pancreatic proteins, pancreatic DNase was concentrated in the secretory pathway similar to other pancreatic secretory proteins with the highest amount in the Golgi and zymogen granules (2,14). (pancreapedia.org)
  • This is done by a complex of proteins and RNAs called spliceosome. (stemcelldaily.com)
  • These RNAs are regulatory RNA responsible for the regulation of protein synthesis. (pediaa.com)
  • ABCC1 is a 190 kDa protein that contains two membrane-spanning domains of hydrophobic nature and two nucleotide binding domains. (wikipedia.org)
  • [ 2 ] The MNK protein also became localized toward the basolateral membrane and increased copper transport. (medscape.com)
  • Candidates for other membrane components and regulatory proteins are also identified. (embl-heidelberg.de)
  • Membrane structure and function: Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis, ion channels, active transport, ion pumps, mechanism of sorting and regulation of intracellular transport, electrical properties of membranes. (pathfinderacademy.in)
  • A signature of genomic deletion of introns via NHEJ is the presence of 2-8 bp of micro-homology. (biomedcentral.com)
  • The identified proteins were subjected to subsequent bioinformatics analysis using the DAVID database. (molvis.org)
  • miRNAs are either expressed from independent transcriptional units or derive from introns of protein-coding genes or exons or introns of long ncRNAs. (biomedcentral.com)
  • In this study, we show that the yeast kinesin-14 Kar3 generates processive movement as a heterodimer with the non-motor proteins Cik1 or Vik1. (elifesciences.org)
  • Many motor proteins-including the kinesin family of these proteins-can only move in one direction along a microtubule. (elifesciences.org)
  • Kinesin proteins: A phylum of motors for microtubule-based motility. (bio.net)
  • Fucoidan treatment of HCT-116 colon cancer cells resulted in downregulation of the ER protein 29 (ERp29), and triggered the phosphorylation of eukaryotic initiation element 2 alpha (p-eIF2a)/CCAAT/enhancer binding protein homologous protein (CHOP) pro-apoptotic cascade [14]. (irjs.info)
  • Seven virus-encoded proteins have been identified that are components of IEV, and five of them are present in CEV or EEV. (microbiologyresearch.org)
  • All copper-transporting ATPases have a histidine residue in the large cytoplasmic loop adjacent to the ATP-binding domain. (medscape.com)
  • DNA is composed of alternating sugar and phosphate groups, with the sugar attached to 1 of 4 possible nucleotide bases (adenosine, cytosine, guanine, thymidine). (cdc.gov)
  • Glutathione as a conjugation partner or co-transported substrate plays multiple and partially undefined roles in the transport mechanism of MRPs, especially of MRP2. (solvobiotech.com)
  • This protein family includes an uncharacterised member designated phnA in Escherichia coli, part of a large operon associated with alkylphosphonate uptake and carbon-phosphorus bond cleavage. (embl-heidelberg.de)
  • The PhnA protein family includes the uncharacterised Escherichia coli protein PhnA and its homologues. (embl-heidelberg.de)
  • Deletion analysis demonstrated that at least 13 kilobases of DNA information is required for E. coli to express the phosphonate utilization phenotype (Phn+). (embl-heidelberg.de)
  • ACCESSION AP009048-129 PROTEIN_ID BAB96710.2 SOURCE Escherichia coli str. (nig.ac.jp)
  • A lack of P protein disrupts the production of melanin, leading to the characteristic features of albinism. (medlineplus.gov)
  • Extracellular accumulation of amyloid-beta (Aß), through the abnormal cleavage of the amyloid precursor protein (APP) by ß- and γ-secretases, is one of the hallmarks of AD. (ucf.edu)
  • They undergo transcription and translation to synthesize proteins. (pediaa.com)
  • This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. (wikipedia.org)
  • Cell signaling: Hormones and their receptors, cell surface receptor, signaling through G-protein coupled receptors, signal transduction pathways, second messengers, regulation of signaling pathways, bacterial and plant two-component signaling systems, bacterial chemotaxis and quorum sensing. (pathfinderacademy.in)
  • Given its particular distribution in normal human tissues and its potential roll as an immune modulator and in amino acid transport, tissue tolerance and protection against retroviral infection, syncytin could be a potential target for immune therapy using specific inhibitors. (ecancer.org)
  • Finally, we contrast the regulatory properties of protein motifs and the regulatory elements of DNA and (pre-)mRNAs, advocating that co-regulation, co-operativity, and motif-driven regulatory programs are common mechanisms that emerge from the use of simple, evolutionarily plastic regulatory modules. (biomedcentral.com)
  • Two main mechanisms for intron loss have been proposed, that is reverse transcription (RT)-mediated intron loss and intron deletion triggered by repair of double strand breaks (DSBs) via non-homologous end joining (NHEJ). (biomedcentral.com)
  • The transporter protein has been shown to decrease β-amyloid accumulation by nearly 80 percent when activated, leading researchers to further investigation on its use in future treatments of Alzheimer's and other neurological disorders. (wikipedia.org)