• Loss of sex and recombination is generally assumed to impede the effectiveness of purifying selection and to result in the accumulation of slightly deleterious mutations. (nih.gov)
  • We analyse the accumulation of slightly deleterious nonsynonymous and synonymous point mutations in 99 single copy orthologue protein-coding loci shared among the investigated taxa. (nih.gov)
  • In the alternative Buffering model, Wolbachia protects bam from deleterious mutations during an infection and thereby allows such mutations to accumulate and even fix in the population. (biorxiv.org)
  • Two novel deleterious mutations and one novel missense mutation were identified from this study, with the prevalence of about 3. (academic-accelerator.com)
  • For germline de novo mutations, we find significant enrichment of loss-of-function mutations in constrained genes (corrected- P = 0.0410) and deleterious mutations in presynaptic active zone genes (FDR = 0.0415). (nature.com)
  • An analysis integrating single-cell RNA-sequencing data identifies a subset of excitatory neurons preferentially expressing the genes hit by deleterious mutations, which are also characterized by high expression of developmental disorder genes. (nature.com)
  • In the analysis of postzygotic mutations, we observe significant enrichment of deleterious ones in developmental disorder genes ( P = 0.00135), including the SRCAP gene mutated in two unrelated probands. (nature.com)
  • This project aims to employ different cutting-edge bioinformatics techniques to predict deleterious scores of mutations across a comprehensive dataset of avian genomes, representing a broad swath of the avian phylogenetic tree, and compare their accuracy. (lu.se)
  • Strikingly diverse functional abnormalities have been identified for disease-linked ATP1A2 mutations which frequently lead to changes in the enzyme's voltage-dependent properties, kinetics, or apparent cation affinities, but some mutations are truly deleterious for enzyme function and thus cause full haploinsufficiency. (frontiersin.org)
  • Helicobacter pylori infection causes both protective and deleterious effects in human health and disease. (annakmiller.info)
  • The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice. (bvsalud.org)
  • Conclusion: It can be concluded that is extremely important an early diagnosis and multidisciplinary work for possible removal of deleterious oral habits and their consequences. (bvsalud.org)
  • Product released under bond for removal of deleterious substances. (nih.gov)
  • Regarding your recent post, "Compact Fluorescent Lights: Deadly Mercury & Deleterious Vibrational Effects" I would like to add that when these mercury lightbulbs radiate light with the wavelength and frequency of the mercury within them, that energy excites the mercury in our bodies, increasing the energy levels, making it more reactive and toxic as well. (educate-yourself.org)
  • The biological effects of near-infrared have both beneficial applications and deleterious effects. (scirp.org)
  • Y. Tanaka and L. Gale, "Beneficial Applications and Deleterious Effects of Near-Infrared from Biological and Medical Perspectives," Optics and Photonics Journal , Vol. 3 No. 4A, 2013, pp. 31-39. (scirp.org)
  • Ritodrine-induced cardiac and pulmonary side effects may be associated with deleterious genetic variants in ciliary and pharmacokinetic genes. (nih.gov)
  • 1) Special tax treatment for health benefits has several deleterious effects. (english-dictionary.help)
  • 3) The resulting instability often has deleterious effects on the children of the relationship. (english-dictionary.help)
  • 5) Moreover, scientific studies on choking reveal no deleterious after effects. (english-dictionary.help)
  • 7) So what can be done to wind back the deleterious effects of confidentiality agreements on public safety? (english-dictionary.help)
  • 10) This type of genetic shuffling may have unpredictable, often deleterious effects. (english-dictionary.help)
  • 11) It is currently unknown whether the deleterious effects of fats are limited to specific fatty acids. (english-dictionary.help)
  • 13) The virus causes about 1 million deaths a year due to its deleterious effects on the liver. (english-dictionary.help)
  • 15) Some deleterious effects ascribed to lead may include contributions from other metals. (english-dictionary.help)
  • These models demonstrated that aberrant expression of either Msi1 or Msi2 has deleterious effects on normal spermatogenesis, with Msi2 overexpression resulting in male sterility. (edu.au)
  • Background Alcohol make use of in excessive amounts has deleterious effects on brain structure and behavior in adults and during periods of quick neurodevelopment such as prenatally. (conferencedequebec.org)
  • Despite H. pylori infection being the primary causative agent for gastric cancer, H. pylori infection can also cause other effects, detrimental or beneficial, throughout an individual's life, with the beneficial effects often being seen in childhood and the deleterious effects in adulthood. (annakmiller.info)
  • In contrast, budesonide had significant but greatly diminished deleterious effects in noncolitic mice or in mice with lymphocyte transfer colitis . (bvsalud.org)
  • Figure 5: Potential deleterious effects of senescent cells. (nature.com)
  • Since prolonged pain relief is presumed to result from a reduction in an inflammatory process, it is also reasonable to assume that during the period of this analgesia, the afflicted nerve roots were relatively protected from the deleterious effects of inflammation. (medscape.com)
  • Research has documented the deleterious effects of poor staffing levels and conditions. (who.int)
  • For physicians to intervene, however, they must be adequately trained to identify victims and potential victims of abuse, help them receive treatment, understand the deleterious effects of violence, teach patients about violence prevention, and become comfortable with their role as collaborators with professionals from other disciplines who deal with violence. (cdc.gov)
  • Viruses, bacteria, and the selfing nematode Caenorhabditis elegans have been shown to be capable of rapid recovery from the fixation of novel deleterious mutation, however the potential for fitness recovery from fixation of segregating variation under inbreeding in outcrossing organisms is poorly understood. (academic-accelerator.com)
  • Therefore, the sequence of CYP21A2 gene must be analyzed carefully in case rare or novel deleterious variants exist. (academic-accelerator.com)
  • Among the rest of 174 samples, five were found carrying novel deleterious LGRs in BRCA1 which are exon5-7dup (1 patient), exon13-14dup (2 patients), and exon1-22del (2 patients). (academic-accelerator.com)
  • Results: Both brothers were found to have novel deleterious mutation in MYO7A (c. (academic-accelerator.com)
  • What is/are Novel Deleterious? (academic-accelerator.com)
  • Novel Deleterious - Finally, we identified a novel deleterious splice-acceptor site mutation of chr5:5186164 G>T (chromosome 5p15) encoding the gene, ADAMTS16, in the invasive component. (academic-accelerator.com)
  • In three of four families, novel deleterious variants have been identified in three different genes, including ZDHHC9 ( p. (biomedcentral.com)
  • This study investigated four families with severe XLID to identify deleterious variants for possible diagnostics and prevention aims. (biomedcentral.com)
  • The deleterious impact of nonsynonymous substitutions for all genes was computed and compared between cases (n = 13) and controls (n = 30). (nih.gov)
  • The study of deleterious variation, or genetic load, in natural populations has become increasingly important in conservation genomics, particularly with the advent of novel bioinformatics tools (see our related work in Bertorelle et al. (lu.se)
  • The most deleterious force for America and for conservatism has been Fox News leading people astray," Ann Coulter told Breitbart News. (breitbart.com)
  • 2023). Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. (upenn.edu)
  • In this rat model of intraabdominal sepsis, postoperative hypothermia was deleterious. (asahq.org)
  • Second, we construct a more comprehensive list of gDNMs in 354 BD trios and analyze the properties of the genes hit by deleterious gDNMs. (nature.com)
  • Third, we investigate genes recurrently hit by deleterious gDNMs in BD or a broad spectrum of neuropsychiatric/developmental disorders (DDs), including BD. (nature.com)
  • Also, our analysis of the genes hit by deleterious gDNMs or pzDNMs in BD provides insights into its neurobiology, including biological pathways related to BD and neuronal cell types possibly playing a critical role in the disease etiology. (nature.com)
  • Objective: The aim of this study was to review the current literature about the deleterious oral habits and their consequences in Pediatric Dentistry. (bvsalud.org)
  • 2) Any move is likely to have a deleterious effect on their health and will certainly adversely affect the quality of their life. (english-dictionary.help)
  • 4) Nor do they show evidence of any long-term deleterious effect in children attending day-care from an early age. (english-dictionary.help)
  • 6) As for carbon dioxide emission - if this does have a deleterious effect, how should we deal with the problem? (english-dictionary.help)
  • 8) I think, to that degree, it may have had a deleterious effect upon the medium since then. (english-dictionary.help)
  • 9) In fact, the war itself would have had a deleterious effect on tourism, one would have thought. (english-dictionary.help)
  • 12) We should vigorously oppose such a show, which can only have a deleterious effect on the moral and spiritual climate of our city. (english-dictionary.help)
  • 14) The deleterious effect is that there can be no public scrutiny and comment on the conduct of the police investigation. (english-dictionary.help)
  • 16) And finally, it examines the deleterious effect that this might have on the performer and the people around them. (english-dictionary.help)
  • Therefore, their deleterious effect between charts makes sense. (angelfire.com)
  • The workplace can have a deleterious effect on cardiovascular health. (cdc.gov)
  • The notion that ingesting alcohol kills the virus is a myth and will only have a deleterious effect on health, including death3. (who.int)
  • The work reported here demonstrates that well-fertilized tobacco plants have a substantial degree of flexibility in protein metabolism and can accommodate considerable levels of some recombinant proteins without exhibiting deleterious mutant phenotypes. (biomedcentral.com)
  • What deleterious means in Lithuanian, deleterious meaning in Lithuanian, deleterious definition, examples and pronunciation of deleterious in Lithuanian language. (english-dictionary.help)
  • The authors conclude that for the parameters selected the impact noise was more deleterious to hearing than continuous noise with the same acoustic power spectrum. (cdc.gov)
  • Promptly freeze at -70°C. Repeated freeze/thaw cycles are deleterious to virus. (cdc.gov)
  • Ample evidence argues that these observed bubble-induced responses would be deleterious VAE bubbles in blood flow pass across the surface of the ECs providing a shear stimulus in the ESL connection that we cannot reproduce completely with this experimental model. (abt-888.net)
  • Assessing deleterious ecosystem-level effects of environmental pollutants as a means of avoiding evolutionary consequences. (nih.gov)
  • Notice that NIDA's "Synthetic Psychoactive Drugs and Strategic Approaches to Counteract Their Deleterious Effects" Funding Opportunity Announcements Have Been Reposted as PARs. (nih.gov)
  • Since prolonged pain relief is presumed to result from a reduction in an inflammatory process, it is also reasonable to assume that during the period of this analgesia, the afflicted nerve roots were relatively protected from the deleterious effects of inflammation. (medscape.com)
  • Have corrupt societies deleterious effects on health? (glabor.org)
  • This paper examines whether living in a corrupt society has deleterious effects on health. (glabor.org)
  • Deleterious effects of formalin-fixation and delays to fixation on RNA and miRNA-Seq profiles. (nih.gov)
  • The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice. (bvsalud.org)
  • In contrast, budesonide had significant but greatly diminished deleterious effects in noncolitic mice or in mice with lymphocyte transfer colitis . (bvsalud.org)
  • Objective: The aim of this study was to review the current literature about the deleterious oral habits and their consequences in Pediatric Dentistry. (bvsalud.org)
  • These results suggest that general anesthetics preferring γ-aminobutyric acid receptor type A may have deleterious consequences when used in the presence of persistent inflammation. (silverchair.com)
  • It has been shown that low carbohydrate ketogenic diet is effective in the amelioration of many of the deleterious consequences of diabetes [ 11 ]. (hindawi.com)
  • For comprehensive sequencing, results fall into three major categories: (1) deleterious mutation, (2) genetic variant of unknown clinical significance, and (3) no abnormality detected. (cdc.gov)
  • includes genetic variants for which the available evi dence indicates a likelihood, but not proof, that the mutation is deleterious. (cdc.gov)
  • A genetic variant of uncertain signifi cance in either MLH1 or MSH2 is considered to be less likely to be deleterious if it has been observed in one or more individuals with a known deleterious mutation in the same gene. (cdc.gov)
  • The mutation landscape revealed several unappreciated deleterious variants in BRCA1/2 and other HRR genes reported previously. (frontiersin.org)
  • Of note, KMT2C has a deleterious mutation hotspot. (nih.gov)
  • This inviability is thought to result from unmasked deleterious alleles on the clonally transmitted R genomes. (bioone.org)
  • These populations are three-way admixed between European, African, and Native American ancestries and provide an opportunity to study the distribution of deleterious alleles partitioned by local ancestry and ROH. (biorxiv.org)
  • Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant. (nih.gov)
  • HBV infection may play a deleterious role in radiographic and clinical outcomes in patients with RA, and HBV reactivation should be paid close attention during immunosuppressive therapy. (biomedcentral.com)
  • We have previously shown that ROH, and especially long ROH that are likely the result of recent parental relatedness, are enriched for homozygous deleterious coding variation in a worldwide sample of outbred individuals. (biorxiv.org)
  • We re-capitulate previous findings that long ROH are enriched for deleterious variation genome-wide. (biorxiv.org)
  • These results suggest that, while ROH on any haplotype background are associated with an inflation of deleterious homozygous variation, African haplotype backgrounds may play a particularly important role in the genetic architecture of complex diseases for admixed individuals, highlighting the need for further study of these populations. (biorxiv.org)
  • The study of deleterious variation, or genetic load, in natural populations has become increasingly important in conservation genomics, particularly with the advent of novel bioinformatics tools (see our related work in Bertorelle et al. (lu.se)
  • However, the distribution of ROH in admixed populations and their relationship to deleterious homozygous genotypes is understudied. (biorxiv.org)
  • Smartapp deleterious content test app is built to follow the standard test methodology and reporting of test results. (smartapp.com)
  • Deleterious experiences in first 18 years of life. (nih.gov)
  • Eventually after trying multiple ways to kill senescent cells remembered that they survived despite the fact that the deleterious senescent cells kill cells around them, which lead us to hypothesise that they must have pathways that defend them against the things they're using to kill the cells around them. (foresight.org)
  • Natural Medicines Comprehensive Database (La Base Exhaustiva de Datos de Medicamentos Naturales) clasifica la eficacia, basada en evidencia científica, de acuerdo a la siguiente escala: Eficaz, Probablemente Eficaz, Posiblemente Eficaz, Posiblemente Ineficaz, Probablemente Ineficaz, Ineficaz, e Insuficiente Evidencia para Hacer una Determinación. (medlineplus.gov)