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  • kcns3
  • Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). (uniprot.org)
  • properties
  • Here, we examined the localization, native interactions, and functional properties of K V 8.2-containing channels in mouse, macaque, and human photoreceptors of either sex. (jneurosci.org)
  • Retinal K V 2.1 was less phosphorylated than cortical K V 2.1, a difference expected to alter the biophysical properties of these channels. (jneurosci.org)
  • human
  • Our data indicate a role for K V 2/K V 8.2 channels in human photoreceptor function and suggest that the visual deficits in patients with KCNV2 mutations arise from inadequate resting activation of K V channels in rod and cone inner segments. (jneurosci.org)
  • Response
  • Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. (uniprot.org)
  • The metabotropic taurine response was insensitive to the Cl(-) channel blockers, picrotoxin and strychnine, but it was inhibited by a specific serotonin 5-HT(2A) receptor antagonist, MDL11939. (biomedsearch.com)
  • evidence
  • Using voltage-clamp recordings and pharmacology, we provide functional evidence for Kv2-containing channels in primate rods and cones. (jneurosci.org)