Considerable published evidence suggests that alpha-subunits of the cloned channel sqKv1A compose the "delayed rectifier" in the squid giant axon system, but discrepancies regarding inactivation properties of cloned versus native channels exist. (nih.gov)
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (nih.gov)
These channels, which transport positively charged potassium atoms (ions) into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals. (medlineplus.gov)
These channels are active in the inner ear and in heart (cardiac) muscle, where they transport potassiumions out of cells. (medlineplus.gov)
An altered KCNE1 protein cannot regulate the flow of potassiumions through channels in the inner ear and cardiac muscle. (medlineplus.gov)
This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. (nih.gov)
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
3. Stuhmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, and Pongs O (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. (aspetjournals.org)
4. Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T, and Numa S (1989) Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells: primary structure and functional expression from cDNAs. (aspetjournals.org)
As expected, both delayed rectifier K\(^+\) channels shortened AP duration significantly. (uni-wuerzburg.de)
Potassium channels of T lymphocytes take center stage in the fight against cancer. (uc.edu)
Only few studies have focused on QT heterogeneity or ion channel physiology, and it seems that all volatile anesthetics-including isoflurane-interact directly with cardiac delayed rectifier potassium channels. (asahq.org)
The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al. (antibodiesinc.com)
1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra. (antibodiesinc.com)
Lymphocytes predominantly express delayed rectifier K + -channels (Kv1.3) in their plasma membranes, and the channels play crucial roles in the lymphocyte activation and proliferation. (elsevierpure.com)
The KCNQ family of channel proteins (also known as Kv7) form K + -selective, voltage-gated channels ( Hille, 2001 ) that are slowly activating delayed rectifier K + ( I Ks ) channels. (molcells.org)
Previous studies have shown that inhibition of multiple potassium channels, including inwardly rectifying potassium current ( I k1 ), transient outward potassium current ( I to ), and delayed outward rectifier potassium current ( I k ) with similar potency, as well as prolongation of action potential duration (APD), are the major mechanisms of the antiarrhythmic effects of artemisinin [5]. (fortunepublish.com)
This is followed by the flow of outward current through the slowly activating (iKs) and rapidly activating (iKr) delayed rectifier Kþ channels. (diseasesdic.com)
Currents6
An increase in the density of the voltage-dependent potassium currents and the H current is required to account for the decrease in input resistance. (cellml.org)
The delayed cellular repolarization in LQTS represents either impaired rapid or slow delayed rectifier potassium currents (i Kr or i Ks ) or inappropriately inactivated sodium currents (i Na ). (asahq.org)
In addition, SP induced a significant reduction of the delayed rectifier K+ currents (I-k) in about 42% of the patched neurons, when these were evoked with depolarizing potential steps. (torvergata.it)
Our computational study focused on the conditions that could provide the generation of endogenous bursting activity in single pacemaker neurons and neural populations and on the specific roles of voltage-gated potassium and persistent sodium currents in triggering or suppression of endogenous population oscillations in the pBC. (northwestern.edu)
Nitroprusside inhibited L-type calcium currents, transient outward currents and transient inward current, but increased delayed rectified potassium currents. (biomedcentral.com)
Activating delayed rectifier potassium current1
In guinea-pig ventricular myocytes, in which the deactivation of slowly activating delayed rectifier potassium current (IKs) is slow, IKs can be increased by rapid pacing as a result of incomplete deactivation and subsequent current accumulation. (ku.dk)
Cardiac4
8. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, and Clapham DE (1991) Cloning and expression of a rat cardiac delayed rectifier potassium channel. (aspetjournals.org)
Pre-clinical electrophysiological studies have shown that ketoconazole inhibits the rapidly activating component of the cardiac delayed rectifier potassium current, prolongs the action potential duration, and may prolong the QT c interval. (nih.gov)
The slowly activating delayed rectifier K + ( I Ks ) channel is a cardiac K + channel composed of KCNQ1 and KCNE1 subunits. (molcells.org)
Interestingly, the nrp1b knockout significantly delayed heart regeneration and impaired cardiac function in the adult zebrafish after cryoinjury, demonstrated by reduced heart rate, ejection fractions, and fractional shortening. (bvsalud.org)
Conductance2
In contrast, pharmacologically blocking the delayed rectifier potassium, voltage-gated calcium or Ih, conductance had little effect on dendritic action potential propagation. (yale.edu)
The best-fit model included a non-uniform sodium channel distribution with decreasing conductance with distance from the soma, together with a non-uniform (increasing) A-type potassium conductance. (yale.edu)
Current7
Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. (ox.ac.uk)
IKr mediates the rapid component of the delayed rectifier potassium current. (acc.org)
Therefore, although current guidelines suggest that outpatient initiation of sotalol remains a reasonable approach in those without obvious risk factors and a baseline QT less than 450ms (6) , this case reflects the importance of continued vigilance due to delayed risk of proarrhythmia, particularly in women and those with renal dysfunction or bradycardia. (acc.org)
This is followed by a rapid, transient outward potassium current (Ito), while the influx rate of positive ions (Na + , Ca ++ ) declines. (medscape.com)
The deep endocardial region and midmyocardial layer (composed of M cells) of the ventricle are more prone to prolongation of repolarization and EADs because they have a less-rapid delayed rectifier potassium current (IKr), while other regions might have short or normal cycles. (medscape.com)
In the current study, we have evaluated the ability of substance P (SP) and other neurokinin I receptor (NK1) agonists to protect, in a dose-and time-dependent manner, primary cultures of rat cerebellar granule cells (CGCs) from serum and potassium deprivation-induced cell death (S-K5). (torvergata.it)
Recent research has shown the ability of artemisinin to attenuate the voltage-gated Na + ( I Na ) and delayed-rectifier K + current (I K(DR) ) in endocrine or neuroendocrine cells [7]. (fortunepublish.com)
This leads to a further delay in repolarization and causes early afterdepolarization (EAD), the triggering event for torsade. (medscape.com)
As stated in the introduction, patients with LQTS often show a "delayed cellular repolarization and heterogeneity in dispersion of repolarization, which … can lead to early after-depolarization, further dispersion of repolarization, and the formation of reentry circuits. (asahq.org)
Subfamily4
This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. (nih.gov)
Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene. (wikipedia.org)
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (wikipedia.org)
This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. (antikoerper-online.de)
Channel genes2
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (nih.gov)
5. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, and Gutman GA (1990) A family of three mouse potassium channel genes with intronless coding regions. (aspetjournals.org)
Genes1
2. Kamb A, Weir M, Rudy B, Varmus H, and Kenyon C (1989) Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. (aspetjournals.org)
Subunit1
Ehmke H. Physiological functions of the regulatory potassium channel subunit KCNE1. (medlineplus.gov)
Kv2.11
The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration. (nih.gov)
Oscillations1
We show that by deceasing the inertia of the delayed rectifier potassium channel, a transition to 40 Hz oscillations can be achieved. (modeldb.science)
Magnesium3
BMI = 42]), potassium 3.7 mmol/L and magnesium 1.7 mmol/L. She was admitted for initiation of Sotalol and cardioversion. (acc.org)
Her estimated creatinine clearance was unchanged and her potassium and magnesium levels remained within normal range. (acc.org)
Torsades de pointes with prolonged QT interval (12-lead ECG of torsades de pointes (TdP) in a 56-year-old white female with low blood potassium (2.4 mmol/L) and low blood magnesium (1.6 mg/dL). (medscape.com)
Membrane1
Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. (nih.gov)
Cloning1
7. Roberds SL and Tamkun MM (1991) Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. (aspetjournals.org)
Slow1
A very slow opening and closing voltage-gated potassium channel that is expressed in NEURONS and is commonly mutated in BENIGN FAMILIAL NEONATAL CONVULSIONS. (wakehealth.edu)
Voltage1
Predicted to be part of voltage-gated potassium channel complex. (mcw.edu)
Activity3
This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. (nih.gov)
Predicted to enable delayed rectifier potassium channel activity. (mcw.edu)
This graph shows the total number of publications written about "KCNQ2 Potassium Channel" by people in this website by year, and whether "KCNQ2 Potassium Channel" was a major or minor topic of these publications. (wakehealth.edu)
Beta1
Sotalol is a class III antiarrhythmic agent that blocks beta- adrenergic receptors and the IKr potassium channel. (acc.org)
Transport2
Predicted to be involved in potassium ion transmembrane transport. (mcw.edu)
A new technique has been presented that results in an acceleration of delayed primary healing with full thickness skin and subcutaneous tissue coverage. (who.int)