Loading...
  • Fatty Acid Synth
  • ATA has the lowest specific activity in comparison with the other enzymes in the system and has been reported as catalyzing the rate-limiting step in the plant fatty acid synthetase (FAS) system: the thioester transfer reaction between acetyl-CoA and acyl carrier protein to form acetyl-ACP. (springer.com)
  • homodimer
  • Accordingly, the ancestral protein may have been a homodimer, and the contemporary form may be considered a covalent heterodimer. (retzepti.ru)
  • synthesis
  • Feedback and allosteric mechanisms ensure that all twenty amino acids are maintained in sufficient amounts for protein synthesis and other processes. (wikipedia.org)
  • lipid
  • Oleaginous microalgae are promising production hosts for the sustainable generation of lipid-based bioproducts and as bioenergy carriers such as biodiesel. (biomedcentral.com)
  • enzymatic
  • The enzymatic steps involved in the elongation process are principally the same as those carried out by FAS, but the four principal successive steps of the elongation are performed by individual proteins, which may be physically associated. (wikipedia.org)
  • Molecular
  • These compounds will be tested by "docking" flexible models of them against 3-D, atomic-scale models of different protein drug targets from the malaria parasite, to predict (a) how tightly these compounds might be able to bind, (b) where these compounds prefer to bind on the molecular target, and (c) what specific interactions are formed between the candidate and the drug target. (scripps.edu)
  • Compounds that can bind tightly to the right regions of particular proteins from the malaria parasite have the potential to "gum up" the parasite's molecular machinery and, thus, help advance the discovery of new types of drugs to cure malaria. (scripps.edu)
  • names
  • section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein. (uniprot.org)
  • Plants
  • In prokaryotes and lower eukaryotes, such as yeast, bacteria, plants, and parasites, FA biosynthesis is accomplished by a series of monofunctional proteins in a dissociated type-II FASN system (FASN II). (aaccjnls.org)
  • target
  • a href='/help/protein_existence' target='_top'>More. (uniprot.org)
  • These calculations will be used to predict the affinity/potency of the compound, the location where it binds on the protein molecule, and the "binding mode" it uses to potentially disable the target. (scripps.edu)
  • Once our collaborators have proven that some of these candidate compounds are definitely able to help kill the malaria parasite, then The Scripps Research Institute and other researchers throughout the world can try to optimize these promising compounds to increase their potency against the target while decreasing their ability to bind to human proteins (since unwanted binding to human proteins can cause toxic side effects). (scripps.edu)
  • Docking is a way of trying to figure out how well a small chemical compound can bind to and block the activity of a target protein. (scripps.edu)
  • These calculations predict how potent the small chemical compound might be at blocking the activity of the target molecule, the location where it binds on the protein target, and the detailed binding mode it uses to potentially disable that target. (scripps.edu)
  • different
  • Barley chloroplasts contain two acyl carrier proteins coded for by different genes. (springer.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • This project will use two different types of "docking" programs to search for new compounds that can bind to and block the activity of protein drug targets from the malaria parasite. (scripps.edu)
  • source
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • role
  • Multicopy clones containing htpG have been obtained as suppressors of a secY mutant strain (208), in particular Hitlers speeches and the three laws, was meant as an homage to the party and as a clear message that the role of the party, the carrier of the anti-Jewish ideological ortho- doxy, was as important as ever. (retzepti.ru)
  • fatty
  • In animals, as well as some fungi such as yeast, these same reactions occur on fatty acid synthase I (FASI), a large dimeric protein that has all of the enzymatic activities required to create a fatty acid. (wikipedia.org)
  • The growing fatty acid chain is carried between these active sites while attached covalently to the phosphopantetheine prosthetic group of an acyl carrier protein (ACP), and is released by the action of a thioesterase (TE) upon reaching a carbon chain length of 16 (palmitic acid). (wikipedia.org)
  • molecule
  • These calculations will be used to predict the affinity/potency of the compound, the location where it binds on the protein molecule, and the "binding mode" it uses to potentially disable the target. (scripps.edu)
  • These calculations predict how potent the small chemical compound might be at blocking the activity of the target molecule, the location where it binds on the protein target, and the detailed binding mode it uses to potentially disable that target. (scripps.edu)
  • Compound
  • Docking is a way of trying to figure out how well a small chemical compound can bind to and block the activity of a target protein. (scripps.edu)
  • Expression
  • Elevated Expression of O-G1cNAc-Modified Proteins and O-GlcNAc Transferase in Corneas of Diabetic Goto-Kakizaki Rats", Investigative Ophthalmology & Visual Science, 44(9):3802-3809, 2003. (freepatentsonline.com)
  • specific
  • These compounds will be tested by "docking" flexible models of them against 3-D, atomic-scale models of different protein drug targets from the malaria parasite, to predict (a) how tightly these compounds might be able to bind, (b) where these compounds prefer to bind on the molecular target, and (c) what specific interactions are formed between the candidate and the drug target. (scripps.edu)
  • particular
  • The present invention is based on the discovery that hexosamine, and in particular the dynamic O-GlcNAcylation of proteins (modification of proteins by the sugar N-acetylglucosamine) both causes insulin-resistance (a hallmark of type II diabetes) and is responsible for glucose toxicity in the disease. (freepatentsonline.com)
  • Compounds that can bind tightly to the right regions of particular proteins from the malaria parasite have the potential to "gum up" the parasite's molecular machinery and, thus, help advance the discovery of new types of drugs to cure malaria. (scripps.edu)
  • high
  • High Glucose and Insulin Promote O-GlcNAc Modification of Proteins, Including Alpha-Tubulin", Am J Physiol Endocrinal Metab, 284:E424-E434, 2003. (freepatentsonline.com)
  • cause
  • Once our collaborators have proven that some of these candidate compounds are definitely able to help kill the malaria parasite, then The Scripps Research Institute and other researchers throughout the world can try to optimize these promising compounds to increase their potency against the target while decreasing their ability to bind to human proteins (since unwanted binding to human proteins can cause toxic side effects). (scripps.edu)
  • Activity
  • This project will use two different types of "docking" programs to search for new compounds that can bind to and block the activity of protein drug targets from the malaria parasite. (scripps.edu)
  • subject
  • Also provided are methods of characterizing hyperglycemia in a subject, methods of identifying a protein as being associated with hyperglycemia, and kits for detecting pre-diabetes or diabetes. (freepatentsonline.com)