• Degranulation in mast cells is part of an inflammatory response, and substances such as histamine are released. (wikipedia.org)
  • Antigens interact with IgE molecules already bound to high affinity Fc receptors on the surface of mast cells to induce degranulation, via the activation of tyrosine kinases within the cell. (wikipedia.org)
  • Concanavalin A (Con A) covalently linked to Sepharose 4B beads induced localized degranulation of sensitized rat peritoneal mast cells in regions of contact between beads and cells. (rupress.org)
  • This degranulation was Ca2+ dependent and was not seen when sensitized mast cells bound to beads conjugated with a nonstimulating lectin, wheat germ agglutinin, or when unsensitized mast cells bound to Con A-Sepharose. (rupress.org)
  • The results suggest that, if an influx of Ca2+ is the mechanism for initiating mast cell degranulation, then the opening of Ca2+ channels in the plasma membrane of activated mast cells is a localized event and that Ca2+ acts locally within the cell to initiate exocytosis. (rupress.org)
  • Neuropeptide AF induces piecemeal degranulation in murine mucosal mast cells : a new mediator in neuro-immune communication in the intestinal lamina propria? (uantwerpen.be)
  • Which substance is released during the degranulation of mast cells? (proprofs.com)
  • During the degranulation of mast cells, cytokines are released. (proprofs.com)
  • MCs express receptors for both estrogen and progesterone that induce degranulation upon binding. (frontiersin.org)
  • Degranulation in neutrophils can occur in response to infection, and the resulting granules are released in order to protect against tissue damage. (wikipedia.org)
  • Excessive degranulation of neutrophils, sometimes triggered by bacteria, is associated with certain inflammatory disorders, such as asthma and septic shock. (wikipedia.org)
  • Tear neutrophils from dry eye subjects had increased expression of membrane receptor CD66b, a marker associated with secondary granule degranulation. (physiciansweekly.com)
  • The fact that AGP may modulate the degranulation of neutrophils confirms the hypothesis that AGP is heavily involved in the fine tuning of neutrophil activity in the inflammatory environment. (unimi.it)
  • Fig. 7: Radiation-primed neutrophils boost lung metastasis via their degranulation activity. (nature.com)
  • Any process that modulates the frequency, rate or extent of basophil degranulation. (planteome.org)
  • Link to all annotated objects annotated to regulation of basophil degranulation. (planteome.org)
  • Link to all direct and indirect annotations to regulation of basophil degranulation. (planteome.org)
  • Human basophil degranulation triggered by very dilute antiserum against IgE. (thieme-connect.de)
  • Enhanced closed eye neutrophil degranulation in dry eye disease. (physiciansweekly.com)
  • Down-regulatory effect of alpha(1)-acid glycoprotein on bovine neutrophil degranulation / A. Miranda-Ribera, C. Lecchi, V. Bronzo, L.M. Scaccabarozzi, P. Sartorelli, F. Franciosi, F. Ceciliani. (unimi.it)
  • Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis. (liverpool.ac.uk)
  • Because glucocorticoids are a mainstay in the treatment of asthma and other allergic diseases, we tested the effect of various steroid hormones on secretory IgA- and IgG-induced eosinophil degranulation in vitro. (elsevierpure.com)
  • Dexamethasone (10 -9 to 10 -4 mol/L), hydrocortisone (10 -9 to 10 -4 mol/L), estradiol (10 -9 to 10 -7 mol/L), and dihydrotestosterone (10 -9 to 10 -4 mol/L) had no effect on normodense eosinophil degranulation. (elsevierpure.com)
  • rIL-5 enhanced immunoglobulin-induced eosinophil degranulation, but this effect of rIL-5 was not blocked by any of the steroids tested. (elsevierpure.com)
  • These results suggest that eosinophil degranulation and rIL-5-mediated eosinophil activation are not direct targets of glucocorticoids and that the beneficial effects of glucocorticoids on allergic inflammation in vivo are not likely due to direct effects on eosinophil degranulation. (elsevierpure.com)
  • Elevated F‐EDN correlates with mucosal eosinophil degranulation in patients with IBS-A possible association with microbiota? (qub.ac.uk)
  • Dive into the research topics of 'Elevated F‐EDN correlates with mucosal eosinophil degranulation in patients with IBS-A possible association with microbiota? (qub.ac.uk)
  • Eosinophil degranulation may lead to fibroblast activation. (medscape.com)
  • The repercussions of murine allergic asthma on brain and behavior are IgE-dependent, mediated by mast cell degranulation, and do not require a pulmonary inflammatory infiltrate, suggesting that the early phase of this immediate allergic response suffices for the brain activation associated with avoidance behavior towards exposure to the allergen. (fapesp.br)
  • Chloroquine phosphate (CP) is an antimalarial medication that, upon injection subcutaneously, promotes a robust itch response thought to be primarily due to triggering mast cell degranulation and a subsequent elevation of inflammatory cytokines as well as other itch-producing mediators (Aghahowa et al. (gasyblog.com)
  • BMMCs were found to express MrgprA4 and A1, and functional analysis of the effects of NPAF by means of a beta-hexosaminidase assay, mMCP-1 ELISA, electron microscopy and live cell calcium imaging revealed a piecemeal degranulation induced by NPAF. (uantwerpen.be)
  • The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
  • Electron microscopy reveals mast cell and eosinophilic degranulation. (cdc.gov)
  • The experiments described here were designed to determine the role of anaphylactic antibodies, mast cell degranulation, and lung inflammation in the neural and behavioral correlates of an experimental murine asthma-like response. (fapesp.br)
  • Eosinophils were incubated with various steroids, including dexamethasone, hydrocortisone, methylprednisolone, estradiol, or dihydrotestosterone at concentrations from 10 -9 to 10 -4 mol/L. Sepharose 4B beads coupled to ovalbumin, secretory IgA, or IgG were added as targets of degranulation and incubated at 37 ° C for 4 hours. (elsevierpure.com)
  • Methylprednisolone, 10 -5 mol/L, inhibited degranulation of normodense eosinophils up to 20%, whereas 10 -4 mol/L inhibited degranulation of hypodense eosinophils, up to 30%, Overall, no difference in inhibition by steroids was observed between normodense and hypodense eosinophils. (elsevierpure.com)
  • Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some cells. (wikipedia.org)
  • Indeed, our experiments showed significantly decreased degranulation capacity of primary NK cells from CLL patients expressing low levels of SLAMF1 and SLAMF7. (nature.com)
  • Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation", JOURNAL OF EXPERIMENTAL MEDICINE , vol. 196, 2002, pp. 493-503. (uni-bielefeld.de)
  • By preventing neutrophil-dependent Notch activation, via blocking degranulation, we were able to significantly offset the radiation-enhanced metastases. (nature.com)
  • Secretory vesicles are the most likely to release their contents by degranulation, followed by gelatinase granules, specific granules, and azurophil granules. (wikipedia.org)
  • A comprehensive pathway analysis revealed a potent activation of neutrophil and platelet mediated defenses including neutrophil and platelet degranulation, and NET formation at both time points. (liverpool.ac.uk)
  • Localized mast cell degranulation induced by concanavalin A-sepharose beads. (rupress.org)
  • In the present study we investigated the effect of the mast cell degranulation in neutrophil migration failure observed in diabetic mice after polymicrobial sepsis induced by cecal ligation and puncture (CLP). (biomedcentral.com)
  • Role of mast cell degranulation in the neural corr. (fapesp.br)
  • Mast cell degranulation was inhibited by cromolyn. (fapesp.br)
  • This downregulatory effect is much more evident when degranulation is challenged with Zymosan activated serum (ZAS). (unimi.it)
  • Many animal venoms contain components that can induce mast cell degranulation, and this has been thought to contribute to the pathology and mortality caused by envenomation. (jci.org)
  • The aim of this study was to evaluate if somatostatin could contribute to the reduction of intestinal mucosal mast cell degranulation. (uab.cat)
  • Saavedra, Y & Vergara, P 2003, ' Somatostatin inhibits intestinal mucosal mast cell degranulation in normal conditions and during mast cell hyperplasia ', Regulatory Peptides , vol. 111, pp. 67-75. (uab.cat)
  • Veterinarians prescribe Benadryl for dogs with mast cell tumors to help mitigate the effects of the massive histamine release caused by mast cell degranulation. (akc.org)
  • In present study, we measured flowcytometry based assay (FCA) and RT-CES based NK cytotoxicity and analyzed degranulation activity (CD107a) and cytokine production. (hindawi.com)
  • Lytic granule release was quantified by CD107a degranulation assay. (bsz-bw.de)
  • While γδ T cell killing is dominated by degranulation, the availability of lytic molecules appears tightly regulated in time and space. (nature.com)
  • The purpose of the present study was to investigate the effects of a lower temperature on the proliferation and degranulation of rat mast cells. (edu.hk)
  • ET-1 induced dose-dependent alterations in the haemodynamic and morphological parameters, and caused significant mast cell degranulation. (portlandpress.com)
  • Moreover, in the cluster headache group exclusively, adventitial mast cells show profound morphological modifications suggesting progressive degranulation. (clusterheadachewarriors.org)
  • Cloxacillin-induced cholestasis was diagnosed with the help of the macrophage inhibition factor and mast-cell degranulation tests. (nih.gov)
  • Recent findings on the mechanisms of neutrophil stimulation of goblet cell degranulation are discussed. (nih.gov)
  • Degranulation Diamond Burs are Designed with extra-large diamond grit to remove soft tissue, root/bone fragments left from tooth extractions. (dentalree.com)
  • Primary NKp44+NK cells exhibited significantly higher degranulation in response to plate-bound HLA-DPA1*02:01-DPB1*01:01 compared with control HLA-DP molecules, which were inhibited by anti-NKp44-blocking. (bmj.com)