• MicroRNAs (miRNAs) are a class of short non-coding RNAs that primarily regulate protein synthesis through reversible translational repression or mRNA degradation. (uzh.ch)
  • We show that, similar to metazoan steady-state systems, endogenous miRNAs in Chlamydomonas can regulate gene expression both by destabilization of the mRNA and by translational repression. (freethoughtblogs.com)
  • MicroRNA (miR) is a small, non-coding RNA that negatively regulates gene expression mainly via translational repression. (biomedcentral.com)
  • MicroRNAs (miRs) are small, non-coding RNAs that negatively regulate gene expression via translational repression or messenger RNA degradation. (biomedcentral.com)
  • Mature microRNAs (miRNAs) are 21 to 23 nucleotide noncoding RNA molecules that can downregulate multiple gene expression by mRNA degradation or translational repression. (oncotarget.com)
  • miRNAs binding to 3′-untranslated region (UTR) of the targeted mRNA leads to its degradation or translational repression [ 4 ]. (oncotarget.com)
  • miRNAs are considered post-transcriptional gene regulators enabling translational repression, mRNA degradation and gene silencing thus playing a major role in gene expression. (athena-innovation.gr)
  • mir-279 is a short RNA molecule found in Drosophila melanogaster that belongs to a class of molecules known as microRNAs. (wikipedia.org)
  • MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. (gene-quantification.com)
  • MicroRNAs are small, non-coding RNA molecules that can complementarily bind to the mRNA 3'-UTR region to regulate the gene expression by transcriptional repression or induction of mRNA degradation. (gene-quantification.com)
  • many studies have shown that small RNA molecules called microRNAs circulate in the blood in cell-free mode. (gene-quantification.com)
  • miRNAs exert their function via base pairing with complementary mRNA molecules, resulting in gene silencing via transcriptional repression or target degradation. (biogenex.com)
  • MicroRNAs (miRNAs/miRs) are endogenous, single-stranded, small (approximately 22 nucleotides in length) noncoding RNA molecules that play an important and ubiquitous role in regulating genes expression. (spandidos-publications.com)
  • MicroRNAs (miRNAs) are approximately 22 nucleotide single-stranded RNA molecules that originate from hairpin precursors and regulate gene expression at the posttranscriptional level by basepairing with target messenger RNA and blocking its translation or inducing its degradation. (knaw.nl)
  • Evolutionarily conserved, these 17-22 nucleotide long molecules regulate gene expression at post-transcriptional level generally by repressing translation or increasing degradation of messenger RNAs (mRNAs). (biomedcentral.com)
  • Chemical modifications to provide drug-like properties to RNA molecules are used in the synthesis of both siRNAs and antimicroRNAs (antimiRs). (genengnews.com)
  • MicroRNAs (miRNAs) are 21-23 nucleotide RNA molecules that modulate the stability or translational efficiency of target messenger RNAs [ 1 , 2 ]. (oncotarget.com)
  • binding to Polycomb repressive complexes and even interacting with miRNA molecules and regulate gene expression. (athena-innovation.gr)
  • MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate the expression of target genes by either mRNA degradation or translational inhibition. (biomedcentral.com)
  • MicroRNAs (miRNAs) are endogenous noncoding RNAs that act as post-transcriptional regulators of gene expression by binding to the 3′-untranslated region (UTR) of target mRNAs. (nature.com)
  • miRNAs exert their effects by suppressing the translation and often inducing the degradation of their target mRNAs. (nature.com)
  • MicroRNAs (miRNAs) are a class of short, endogenous primed non-coding RNAs (18-25 nucleotides) that regulate gene expression through pairing with 3′-untranslated region (3′-UTR) bases to mediate translation inhibition or degradation of homologous mRNAs [ 7 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs) play crucial regulatory roles in repressing mRNA translation or mediating mRNA degradation by targeting mRNAs in a sequence-specific manner [ 1 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs) are short (21-24 nucleotides) sequences of RNA that reduce gene expression by promoting the breakdown of messenger RNAs (mRNAs) and by repressing translation of mRNAs into proteins. (freethoughtblogs.com)
  • miRNAs regulate proteins expressions by arresting or degrading the mRNAs. (cancerindex.org)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
  • It's been suggested that miRNAs regulate up to 50% of all mRNAs in the human genome. (genengnews.com)
  • Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
  • microRNAs are ~22nt-long non-coding RNAs that post-transcriptionally regulate the expression of genes, often by binding to the 3' untranslated region of mRNA, targeting the transcript for degradation. (wikipedia.org)
  • This observation highlights how microRNAs regulate pleiotropic neural genes, determining the divergence of sensory systems. (wikipedia.org)
  • Given this phenotype, one might expect miR-279 to directly regulate clock genes within the core-clock neurons. (wikipedia.org)
  • MicroRNAs (miRNAs) are noncoding RNAs of approximately 20 nucleotides in length that block gene expression at the posttranscriptional level by partial complementary binding to the 3′-untranslated region (3′-UTR) of mRNA of target genes in animals, resulting in mRNA degradation or translation inhibition [ 3 ]. (hindawi.com)
  • In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
  • We conclude that duplicated paralogous genes that often changed their function, also diverse in their tendency to be miRNA regulated. (frontiersin.org)
  • MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
  • This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
  • We knock down the gene expression using nanoparticle-mediated RNA interference, which targets the γ-glutamyl-cysteine synthetase and thioredoxin reductase genes of microsporidia. (bvsalud.org)
  • Identification of miRNA-regulated targeting genes is important for understanding their specific biological functions [ 11 ]. (degruyter.com)
  • One of the challenges to understand miRNA-mediated regulation is to identify co-regulating miRNAs that simultaneously regulate their target genes in a network perspective. (biomedcentral.com)
  • Pathway enrichment analysis of target genes in the cooperatively regulating miRNAs revealed the mutually exclusive functional landscape of miRNA cooperativity. (biomedcentral.com)
  • We evaluate the miRNAs modules determined to be significantly cooperative by assessing the functional coherence of target genes co-regulated by the miRNA modules. (biomedcentral.com)
  • Thus, gene expression must be tightly regulated so that only appropriate genes are expressed in a particular cell type. (ernolaszlo.com)
  • Use of the microarray analysis is often restricted by the known gene sequences arrayed on the chip, whereas RNA sequencing is not dependent on pre-existing databases of expressed genes and, therefore, provides an unbiased and more complete view of gene expression profiles [ 17 ], including lncRNA. (biomedcentral.com)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
  • miR-279 fine-tunes JAK/STAT signaling in the ovary by negatively regulating stat (unlike the neurons, where it is reported to regulate upd). (wikipedia.org)
  • miRNAs are small, evolutionarily conserved, noncoding RNAs that negatively regulate gene expression and have fundamental roles in cancer growth and metastasis. (biogenex.com)
  • Based on the findings, the inhibition of miR-543 was found to play a tumor suppressive role in PA through the down-regulation of Wnt/β-catenin pathway by negatively regulating Smad7. (cancerindex.org)
  • Small noncoding RNAs called microRNAs (miRNA) negatively regulate gene expression by sequence-specific targeting of protein-coding transcripts [ 6 ]. (researchsquare.com)
  • MiRNAs typically bind to the 3′ untranslated region (UTR) of their mRNA targets and downregulate gene expression via mRNA degradation or translational inhibition ( 8 - 10 ). (spandidos-publications.com)
  • MicroRNAs (miRNAs) are short non-coding RNAs, typically 21-23 nucleotides long, that function in post-transcriptional gene regulation typically through translation inhibition and/or mRNA degradation ( 1 ). (amegroups.org)
  • Binding of a miRNA to a complementary sequence in a target mRNA is mediated by Argonaute proteins leading to degradation of the mRNA or translational inhibition, thereby lowering protein levels in cells [ 7 ]. (researchsquare.com)
  • As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)
  • When a signal is sent to express a specific gene, the DNA sequence encoding that gene is used as a template to produce single-stranded RNA in a process called transcription. (ernolaszlo.com)
  • These naturally occurring, noncoding, single-stranded RNAs (21-25 nucleotides long) base-pair with their target mRNA within the RISC (RNA-induced silencing complex). (genengnews.com)
  • MicroRNAs are a class of small, single-stranded, noncoding RNA (~21-24 nt in length) that occur in the genomes of plants and animals. (biomedcentral.com)
  • MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
  • While most membranous and disease related proteins are regulated by miRNAs, the G-protein coupled receptor (GPCR) family is an exception, being mostly unregulated by miRNAs. (frontiersin.org)
  • MicroRNAs display exquisite stability in serum or plasma because they are packaged in membrane-encapsulated vesicles or protected by RNA-binding proteins. (gene-quantification.com)
  • After transcription, the pre-mRNA transcript is spliced, joining coding exons together while excising introns and generating messenger RNA (mRNA), which is exported from the nucleus and read by ribosomes to produce polypeptides that fold into the final 3-dimensional structure of proteins ( Figure 1.1) . (ernolaszlo.com)
  • Here, we attempted to verify the endocrine role of EV production and their contents, such as RNAs and bioactive proteins, from the regulation of biogenesis, secretion, and action mechanisms while discussing the current technical limitations. (molcells.org)
  • Neuropeptides also play important roles in the physiology and behaviours of animals. (nature.com)
  • Increasingly evidences suggest that long intergenic ncRNAs (lincRNAs) are developmentally regulated and play important roles in development and stress responses of plants. (biomedcentral.com)
  • miRNAs are considered to play important roles in cell proliferation, apoptosis, and differentiation during mammalian development. (oncotarget.com)
  • Oxidative stress and neuroinflammation play important roles in the pathogenesis of AD. (nature.com)
  • The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)
  • Mechanistically, PTTG3P upregulated the expression of miR-383 targets Cyclin D1 (CCND1) and poly ADP-ribose polymerase 2 (PARP2) by sponging miR-383, acting as a competing endogenous RNA (ceRNA). (biomedcentral.com)
  • A series of studies indicate that lncRNAs serve as competing endogenous RNAs (ceRNA) by sponging miRNAs, and modulate the targets of miRNAs [ 15 , 16 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
  • miRNAs are a class of short (∼22 nucleotide) noncoding RNAs (ncRNAs). (frontiersin.org)
  • Post-transcriptional regulation in multicellular organisms is mediated by microRNAs. (frontiersin.org)
  • The rapid pace of studies on microRNA regulation and function necessitates the development of suitable techniques for measuring and modulating microRNAs in different model systems. (gene-quantification.com)
  • MicroRNAs (miRNAs) are short non-coding RNAs that have been termed "master regulators of the genome" given their significance in post-transcriptional gene regulation, and roles in a multitude of normal and disease processes. (amegroups.org)
  • MicroRNAs (miRNAs) are key components in post-transcriptional gene regulation in multicellular organisms. (biomedcentral.com)
  • The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA's influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. (cshlpress.com)
  • We have only known that microRNAs even existed since the early 1990's, and their importance in gene regulation and development wasn't appreciated until the 2000's. (freethoughtblogs.com)
  • MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
  • MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. (researchsquare.com)
  • MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
  • MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
  • Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)
  • More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)
  • While long noncoding RNAs (lncRNAs) are important i. (researchgate.net)
  • While long noncoding RNAs (lncRNAs) are important in cardiac development and disease, their role in physiol. (researchgate.net)
  • Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • The SFRPs inhibit Wnt receptor binding to down-regulate pathway signaling during development [ 8 ]. (biomedcentral.com)
  • J147 played these roles mainly by activating the extracellular signal-regulated protein kinase (ERK) pathway. (frontiersin.org)
  • Here, we used RNAseq to identify a novel class of cardiac lncRNAs that are dynamically regulated by exercise. (researchgate.net)
  • In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
  • Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). (biomedcentral.com)
  • Pseudogene, a subclass of long non-coding RNAs (lncRNAs), are considered as genomic loci that resemble real gene, but lost some functionality because they are lack of protein-coding ability because of disabling mutation, lack of transcription, or their inability to encode RNA [ 3 ]. (biomedcentral.com)
  • However, few reports on genome-wide lncRNAs are available in bread wheat using high-throughput RNA sequencing. (biomedcentral.com)
  • They bind on their target usually by partial or complete base pairing on specific miRNA recognition elements (MREs) on mRNA as well as other non-coding RNA sequences such as lncRNAs. (athena-innovation.gr)
  • This review summarizes recent data exemplifying the known roles of miRNAs in memory formation in different model organisms, and describes how neuronal plasticity regulates miRNA biogenesis, activity and degradation. (uzh.ch)
  • MiRNAs that regulate components of pathways required for learning and memory further modulate the influence of epigenetics on cognition in the normal and diseased brain. (uzh.ch)
  • Skeletal muscle regeneration is regulated by coordinated activation of multiple signaling pathways. (elifesciences.org)
  • Multiple signaling pathways participate in pigmentation by regulating the expression level of MITF. (frontiersin.org)
  • The arsenal of DIANA Tools ranges from target prediction algorithms (microT v4 and microT-CDS), databases of experimentally verified miRNA targets on coding and non-coding RNAs (TarBase v7.0 and LncBase) to software capable of identifying potentially altered molecular pathways by the expression of a single or multiple miRNAs (mirPath). (athena-innovation.gr)
  • Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis. (shengsci.com)
  • Synovial fluid represents a potential source of disease-specific small non-coding RNAs (sncRNAs) that could aid in the understanding of the pathogenesis of osteoarthritis. (biomedcentral.com)
  • The biological processes they regulate may play an important role in understanding early osteoarthritis pathogenesis. (biomedcentral.com)
  • Understanding the roles of Asthma is a worldwide problem, the prevalence of miRNAs in asthma pathogenesis may also aid to asthma ranged from 1% to 18% of the population in explore new therapeutic targets. (cdc.gov)
  • MicroRNAs (miRNAs) are essential regulators of gene expression in humans and can control pathogenesis and host-virus interactions. (cdc.gov)
  • MicroRNAs (miRNAs) regulate many physiological processes including body growth. (nature.com)
  • However, their roles in exercise-induced physiological hypertrophy are unclear. (researchgate.net)
  • This review covers some of the most striking microRNA functions involved in morphine tolerance and presents limitations on our knowledge of their physiological roles. (hindawi.com)
  • MicroRNAs also survive in unfavorable physiological conditions, such as repeated freeze-thawing, and long-term storage at room temperature. (gene-quantification.com)
  • MicroRNAs (miRNAs) are master regulators involved in multiple physiological and pathological processes. (genengnews.com)
  • The varied roles of mir-279, both in the developing and adult fly, highlight the utility of microRNAs in regulating unique biological processes. (wikipedia.org)
  • Bioinformatic analysis was performed in order to identify putative targets of the differentially expressed microRNAs and to explore potential associations with specific biological processes. (biomedcentral.com)
  • Originally identified as moderate biological modifiers, microRNAs have recently emerged as powerful regulators of diverse cellular processes with especially important roles in disease and tissue remodeling. (gene-quantification.com)
  • MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators involved in various biological and pathological processes of cells, but their association with tumor chemoresistance has not been fully understood. (biomedcentral.com)
  • The pleiotropic transcription factor Prospero regulates miR-279 expression, and this appears to indirectly restrict CO2 neuron formation. (wikipedia.org)
  • Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). (cshlpress.com)
  • Second, we aimed to assess the phylogenetic diversity, host specificity and to explore the evolutionary history that may explain the diversity of gammarid-infecting Nosema lineages by performing a phylogenetic reconstruction based on RNA polymerase II subunit B1 (RPB1) gene sequences. (bvsalud.org)
  • NGS analysis predicted forty-two RNA sequences as possible miRNAs based on computational algorithms. (cdc.gov)
  • Recent studies have suggested that eukaryotic genomes encode a large number of functional transcripts of non-coding RNAs (ncRNAs), including housekeeping and regulatory RNAs [ 1 - 3 ]. (biomedcentral.com)
  • Recent studies have unveiled the numerous roles of non-coding RNAs (ncRNAs) highlighting the biological significance of these previously 'overlooked' RNA species. (athena-innovation.gr)
  • We identified 160 differentially expressed miRNAs using RNA-Seq data from the GEO database. (biomedcentral.com)
  • Here, we provide a comprehensive global analysis of the evolutionarily distant unicellular green alga Chlamydomonas reinhardtii to quantify the effects of miRNA on protein synthesis and RNA abundance. (freethoughtblogs.com)
  • Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
  • In the search for molecular biomarkers that could reveal pre-clinical phases of the disease, scientists have focused much of their attention on microRNAs (miRNAs), the best characterised family of small non-coding RNAs. (biomedcentral.com)
  • Because miR-279 regulates upd, which is downstream of the circadian-activated Pigment-Dispersing Factor Receptor, miR-279 indirectly regulates JAK/STAT signaling. (wikipedia.org)
  • Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. (cancerindex.org)
  • Identification of several targets of miRNAs associated with cancer suggests that networks of miRNAs linked to oncogenes or tumor suppressors play pivotal roles in cancer development. (genengnews.com)
  • MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
  • However, the role of microRNA in mammalian tissue development and differentiation is still quite uncharacterized. (mdpi.com)
  • miRNAs are essential for brain development and function, with multiple miRNAs enriched in specific cell types where they regulate differentiation, structure and neurophysiological properties [ 9 , 10 ]. (researchsquare.com)
  • Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)
  • Deregulated miRNAs may function as tumor suppressors such as miR-205 and let-7 [ 6 , 7 ], or oncogenes such as miR-17-92 cluster and miR-214 [ 8 , 9 ], depending on the regulated targets. (oncotarget.com)
  • I am molecular and cellular biologist with expertise in virus and microRNAs. (researchgate.net)
  • miRNAs play key roles in a broad range of cellular processes and the response to changes in the environment ( Leung and Sharp, 2010 ). (frontiersin.org)
  • Sequencing as well as functional studies using antisense oligonucleotides, indicate important roles for microRNAs during the development of epilepsy through targeting transcripts involved in neuronal structure, gliosis and inflammation. (researchsquare.com)
  • miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. (shengsci.com)
  • Luciferase reporter assay and RNA pull-down assay were carried out to detect the interaction between miR-383 and LncRNA PTTG3P. (biomedcentral.com)
  • The binding sites of miR-128-3p and TGFBR2 were predicted by Targetscan online software and confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. (degruyter.com)
  • The engineered S. alvi induces RNA interference and represses parasite gene expression, thereby inhibits the parasitism significantly. (bvsalud.org)
  • Some of the same strategies already developed for delivery of siRNA for RNA interference (RNAi) also are being applied to miRNA. (genengnews.com)
  • Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)
  • With the maturation of deep sequencing methodologies for small RNA identification, the number of reported mature miRNAs has drastically increased. (frontiersin.org)
  • microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. (shengsci.com)
  • Small RNA sequencing was performed using synovial fluid from the metacarpophalangeal joints of both control and early osteoarthritic horses. (biomedcentral.com)
  • Small interfering RNA-mediated RKIP knockdown revealed similar effects as that of ectopic miR-27a expression, while overexpression of RKIP attenuated the function of miR-27a in lung adenocarcinoma cells. (biomedcentral.com)
  • Next we explored the roles of miR-27a and its target Raf Kinase Inhibitory Protein (RKIP) in regulating cisplatin resistance and metastasis in lung adenocarcinoma. (biomedcentral.com)
  • Berezikov, E. / Expression pattern analysis of microRNAs in Caenorhabditis elegans . (knaw.nl)
  • Isik, M & Berezikov, E 2013, ' Expression pattern analysis of microRNAs in Caenorhabditis elegans ', Methods in Molecular Biology , vol. 936, pp. 129-141. (knaw.nl)
  • MicroRNAs (miRNAs) are involved in the prognosis of nasopharyngeal carcinoma (NPC). (biomedcentral.com)
  • Taken together, our findings indicate that the lincRNA of wheat responded to Bgt and Pst stress and played important roles in splicesome and inter-regulating with miRNA. (biomedcentral.com)
  • It will also be important to discuss how blood EV concentrations are regulated as if EVs are humoral endocrine machinery. (molcells.org)
  • Since the insulin and growth phenotypes are rescued by expression of sNPFR1, we propose that the conserved miR-9a/miR-9 regulates body growth by modulating insulin signalling through its conserved sNPFR1/NPY2R target in both Drosophila and mammals. (nature.com)
  • Increasing evidence suggests a new mechanism by which miRNAs may regulate target gene expression by binding in promoter and amino acid coding regions. (gene-quantification.com)
  • Bong I, Ng CC, Baharuddin P, Zakaria Z: MicroRNA expression patterns and target prediction in multiple myeloma development and malignancy. (karger.com)
  • miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
  • This degenerative, age-related joint disease is characterised by a progressive degradation of articular cartilage and concomitant structural and functional change of all joint constituents, including the synovial membrane, the subchondral bone and periarticular tissues [ 4 ]. (biomedcentral.com)
  • Although they are structurally similar, plant and animal microRNAs repress gene expression through very different mechanisms. (freethoughtblogs.com)
  • At different transcriptional, posttranscriptional, and epigenetic levels, MOR levels may be regulated, and miRNAs mainly regulate MOR levels at the posttranscriptional level [ 13 ]. (hindawi.com)
  • Individual miRNAs are capable of regulating gene networks by interacting with multiple targets or by suppressing transcriptional controllers [ 6 , 8 ]. (researchsquare.com)