Tumor Suppressor Protein p53Tumor Suppressor ProteinsGenes, Tumor SuppressorVon Hippel-Lindau Tumor Suppressor ProteinTumor Suppressor Protein p14ARFCell Line, TumorRetinoblastoma ProteinMolecular Sequence DataPhosphorylationProto-Oncogene Proteins c-mdm2Cell LineMutationProtein BindingAmino Acid SequenceNuclear ProteinsApoptosisDNA-Binding ProteinsTransfectionProtein-Serine-Threonine KinasesTranscription FactorsSerineSignal TransductionUbiquitin-Protein LigasesProto-Oncogene ProteinsCell CycleGenes, p53Cell Cycle ProteinsGene Expression Regulation, NeoplasticTumor Cells, CulturedBase SequenceBlotting, WesternNeurofibromin 2Cells, CulturedPhosphoproteinsProtein Structure, TertiaryAdenomatous Polyposis Coli ProteinProteinsProteasome Endopeptidase ComplexCell ProliferationPromoter Regions, GeneticTranscription, GeneticBinding SitesPTEN PhosphohydrolaseRNA, MessengerCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Cell DivisionDNA DamageDown-RegulationCell Transformation, NeoplasticEnzyme ActivationHeLa CellsGenes, SuppressorProtein KinasesCarrier ProteinsRecombinant Fusion ProteinsTranscriptional ActivationLigasesNeoplasm ProteinsCyclinsRepressor ProteinsRNA, Small InterferingUbiquitinFibroblastsGene Expression RegulationCell NucleusNeoplasmsRecombinant ProteinsRNA InterferenceModels, BiologicalIntracellular Signaling Peptides and ProteinsE2F Transcription FactorsPhosphoserineTrans-ActivatorsMembrane ProteinsImmunoblottingPrecipitin TestsTyrosineReverse Transcriptase Polymerase Chain ReactionImmunoprecipitationGene SilencingUbiquitinationEnzyme InhibitorsTumor Markers, BiologicalSuppressor of Cytokine Signaling ProteinsProtein Processing, Post-TranslationalProto-Oncogene Proteins c-aktDNA PrimersAdaptor Proteins, Signal TransducingE2F1 Transcription FactorCyclin-Dependent KinasesGene DeletionMice, KnockoutCOS CellsTime FactorsThreonineTumor Necrosis Factor-alphaOncogene Proteins, ViralKineticsImmunohistochemistry