UbiquitinUbiquitin-Protein LigasesUbiquitinsUbiquitinationProteasome Endopeptidase ComplexUbiquitin ThiolesteraseUbiquitin-Conjugating EnzymesCullin ProteinsPolyubiquitinProteolysisSKP Cullin F-Box Protein LigasesLigasesUbiquitin-Protein Ligase ComplexesF-Box ProteinsMolecular Sequence DataEndosomal Sorting Complexes Required for TransportCysteine EndopeptidasesAmino Acid SequenceUbiquitin-Activating EnzymesProtein BindingUbiquitin CMultienzyme ComplexesProtein Structure, TertiaryCell LineMutationAnaphase-Promoting Complex-CyclosomeRING Finger DomainsBiodegradation, EnvironmentalProtein Processing, Post-TranslationalS-Phase Kinase-Associated ProteinsSaccharomyces cerevisiae ProteinsProteasome InhibitorsUbiquitinated ProteinsHeLa CellsHEK293 Cellsbeta-Transducin Repeat-Containing ProteinsEndopeptidasesLysineSignal TransductionSaccharomyces cerevisiaeCarrier ProteinsCell Cycle ProteinsPeptide HydrolasesProto-Oncogene Proteins c-cblEndoplasmic Reticulum-Associated DegradationProtein StabilityProtein TransportSubstrate SpecificityUbiquitin-Specific ProteasesAmino Acid MotifsNuclear ProteinsModels, BiologicalProteinsHydrolysisRecombinant Fusion ProteinsImmunoprecipitationCells, CulturedEndoplasmic ReticulumKineticsCysteine Proteinase InhibitorsPhosphorylationCarbon-Nitrogen LyasesSequence Homology, Amino AcidDNA-Binding ProteinsProto-Oncogene Proteins c-mdm2RNA, MessengerCell Line, TumorBase SequenceBlotting, WesternRNA InterferenceModels, MolecularBinding SitesRNA, Small InterferingEndocytosisAutophagyTwo-Hybrid System TechniquesMultiprotein ComplexesSUMO-1 ProteinTranscription FactorsDown-RegulationRecombinant ProteinsProtein FoldingImmunoblottingAdaptor Proteins, Signal TransducingMembrane ProteinsProtease InhibitorsGene Expression RegulationRepressor ProteinsSmall Ubiquitin-Related Modifier ProteinsLeupeptinsReceptors, Autocrine Motility FactorCell NucleusTime FactorsCOS CellsRNA StabilityTumor Suppressor Protein p53Protein Interaction Domains and MotifsTranscription, GeneticCell CycleSumoylation