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HepcidinsAntimicrobial Cationic PeptidesCation Transport ProteinsIronIron OverloadHemochromatosisFerritinsIron Metabolism DisordersReceptors, TransferrinAnemia, Iron-DeficiencyIron, DietaryBone Morphogenetic Protein 6TransferrinApoferritinsHomeostasisDuodenumAnemiaErythropoiesisIron-Regulatory ProteinsLiverMembrane ProteinsRNA, NuclearEnterocytesCeruloplasminHepatocytesGene Expression RegulationRNA, MessengerHistocompatibility Antigens Class IMacrophagesProteasome Endopeptidase ComplexIntestinal AbsorptionCell LineMutationIron-Binding ProteinsGPI-Linked ProteinsIron IsotopesPolycythemiabeta-ThalassemiaSmad8 ProteinIron Regulatory Protein 2ProteolysisHemoglobinsMice, Inbred C57BLIron CompoundsUbiquitinationInterleukin-6Bone Morphogenetic ProteinsMononuclear Phagocyte SystemHep G2 CellsMice, KnockoutReverse Transcriptase Polymerase Chain ReactionCaco-2 CellsInflammationMolecular Sequence DataProtein TransportNitrilotriacetic AcidUbiquitinFerric CompoundsIron Regulatory Protein 1Blotting, WesternDown-RegulationGrowth Differentiation Factor 15Biodegradation, EnvironmentalAmino Acid SequenceCells, CulturedProtein BindingPhlebotomyErythropoietinEndocytosisFursultiaminSmad ProteinsProtein Processing, Post-TranslationalSignal TransductionUbiquitin-Protein LigasesGrowth Differentiation Factor 2Cell Line, TumorSmad5 ProteinSerine EndopeptidasesAmino Acid SubstitutionBiological TransportSpleenPhenylhydrazinesCytophagocytosisFilipinHEK293 CellsGrowth Differentiation FactorsBlood TransfusionBase SequencePromoter Regions, GeneticModels, BiologicalCell MembraneSTAT3 Transcription FactorUp-RegulationDisease Models, AnimalCysteine EndopeptidasesLeprosy, MultibacillaryMutation, MissenseIron RadioisotopesGene ExpressionUbiquitins

HemochromatosisMacrophagesDeficiencyLiverProteinIronExpression

Hemochromatosis2

• Hepcidin has been suggested to act as a modifier gene in genetic hemochromatosis. (wjgnet.com)
• However, ferroportin-related hemochromatosis is transmitted in an autosomal dominant manner. (nih.gov)

Macrophages2

• An additional function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the basolateral membrane of enterocytes and cell membrane of macrophages for degradation resulting in decreased iron uptake from food and decreased iron release from recycled red blood cells in the MPS (mononuclear phagocyte system) respectively. (wikipedia.org)
• Hepcidin inhibits iron entry into plasma by binding to and inactivating the iron exporter ferroportin in target cells, such as duodenal enterocytes and tissue macrophages. (nih.gov)

Deficiency1

• Inactivating mutations in components of this pathway cause hepcidin deficiency, which allows inappropriately increased iron absorption and efflux into the bloodstream. (nih.gov)

Liver4

• Hepcidin is a circulatory antimicrobial peptide synthesized by the liver. (wjgnet.com)
• The role of gender in the regulation of human hepcidin gene expression in the liver is unknown. (wjgnet.com)
• However, hepcidin may play a role in gender-based differences in iron metabolism and liver diseases. (wjgnet.com)
• Dietary iron absorption and systemic iron traffic are tightly controlled by hepcidin, a liver-derived peptide hormone. (nih.gov)

Protein2

• [ 10 ] Transcription of integrated HIV-1 proviral DNA is induced by HIV-1 Tat protein that relieves RNA polymerase II pausing by recruiting positive transcription elongation factor b (P-TEFb), which contains CDK9/cyclin T1 and other transcriptional regulatory factors, to the HIV-1 long terminal repeat. (medscape.com)
• Recent studies from the authors' laboratory have shown that HIV-1 transcription is inhibited by iron chelators that inhibit the enzymatic activity of CDK2, [ 12 , 13 ] and by the expression of the iron export protein, ferroportin. (medscape.com)

Iron1

• Hepcidin is induced in response to increased body iron stores to inhibit further iron absorption and prevent iron overload. (nih.gov)

Expression1

• Sex and genetic background have also been shown to modulate hepcidin expression in mice. (wjgnet.com)