Cation Transport ProteinsHepcidinsAntimicrobial Cationic PeptidesIronIron Metabolism DisordersIron OverloadHemochromatosisApoferritinsRNA, NuclearFerritinsCeruloplasminEnterocytesReceptors, TransferrinDuodenumIron-Regulatory ProteinsIron, DietaryProteasome Endopeptidase ComplexHomeostasisTransferrinIron Regulatory Protein 2Cell LineUbiquitinationProteolysisMacrophagesMutationNitrilotriacetic AcidUbiquitinIron Regulatory Protein 1Biodegradation, EnvironmentalAnemia, Iron-DeficiencyIron-Binding ProteinsCaco-2 CellsProtein TransportRNA, MessengerMembrane ProteinsLiverFerric CompoundsMononuclear Phagocyte SystemUbiquitin-Protein LigasesEndocytosisMolecular Sequence DataIntestinal AbsorptionPolycythemiaGene Expression RegulationProtein BindingAmino Acid SequenceFilipinBlotting, WesternProtein Processing, Post-TranslationalCysteine EndopeptidasesIron RadioisotopesCells, CulturedUbiquitinsMutant ProteinsHEK293 CellsMultienzyme ComplexesDown-RegulationEndoplasmic Reticulum-Associated DegradationReverse Transcriptase Polymerase Chain ReactionMice, Inbred C57BLAmino Acid SubstitutionCell MembraneBiological TransportMice, KnockoutErythropoiesisModels, BiologicalHistocompatibility Antigens Class IHeLa CellsCell Line, TumorHeme Oxygenase-1Base SequenceHydrolysisHepatocytesIntestinesKineticsRecombinant Fusion ProteinsHemeProtein Interaction Domains and MotifsAnemiaHemoglobinsGenes, DominantMutation, MissenseTranscription, GeneticRNA StabilityPhenotypePeptide HydrolasesEndoplasmic ReticulumProtoporphyrinsGPI-Linked ProteinsGene ExpressionProteasome InhibitorsF-Box ProteinsCysteine Proteinase InhibitorsAutophagyUp-RegulationSignal TransductionBinding SitesJanus Kinase 2Protein Structure, TertiaryPhosphorylation