Loading...
  • Inhibition
  • A variant BEAS-2B-R1 cell line, which is partially resistant to RA, remains responsive to 4HPR and CDDO with respect to inhibition of cell growth and promotion of G 1 cyclin degradation. (aacrjournals.org)
  • Cells in differentiating tissues with compromised PP2A retain high Cdk2 activity when they should be quiescent, and genetic epistasis tests demonstrate that ectopic Cyclin E/Cdk2 activity is responsible for the extra cell cycles caused by PP2A inhibition. (biologists.org)
  • CDK4
  • Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. (uniprot.org)
  • Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). (uniprot.org)
  • Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. (uniprot.org)
  • Phase
  • Cyclin E1 is expressed at the G 1/S phase transition of the cell cycle to drive the initiation of DNA replication and is degraded during S/G2M. (garvan.org.au)
  • We identify that in cancer cells, unlike normal cells, the closely related protein cyclin E2 is expressed predominantly in S phase, concurrent with DNA replication. (garvan.org.au)
  • the APC/C is proposed to auto-inhibit by targeting its associated E2 ubiquitin conjugating enzyme UbcH10 for destruction in late G1, allowing essential cell cycle regulators such as cyclin A to accumulate during S phase ( Rape and Kirschner, 2004 ). (biologists.org)
  • CDK5
  • In contrast to MEF2A and MEF2D, MEF2C is not phosphorylated by Cdk5 after glutamate exposure and, therefore, resistant to neurotoxin-induced caspase-dependent degradation. (jneurosci.org)
  • implications
  • The distinct cell cycle expression of the two E-type cyclins in cancer cells has implications for their roles in genomic instability and proliferation and may explain their associations with different signatures of disease. (garvan.org.au)
  • Activity
  • This suggests that mechanisms regulating Cyclin/Cdk2 activity during the final cell cycle in vivo could impact the timing and robustness of cell cycle exit in tissues. (biologists.org)
  • suggests
  • None of these changes occurred in the presence of nondegradable cyclin B. Modeling suggests that they depend on the establishment of a spatial gradient of MT plus-end catastrophe frequencies, decreasing toward the equator. (rupress.org)
  • cancer
  • Deregulation of its periodic degradation is observed in cancer and is associated with increased proliferation and genomic instability. (garvan.org.au)
  • activation
  • The positive feedback loops in the model account for thresholds and time lags in cyclin-induced and MPF-induced activation of MPF, and the model can be fitted quantitatively to these experimental observations. (ebi.ac.uk)
  • paper
  • Please note that active MPF and cyclin concentrations in the paper are given relative to total cdc2 concentration (100nM). (ebi.ac.uk)