Degradation microtubule associated proteins. Medical search. Frequent questions

Amongst protein substrates, tertiary structure elements rather than primary amino acid sequences are likely responsible for directing cleavage to a specific substrate. (wikipedia.org)
A component of this system, the deubiquitinating enzyme USP14, associates with the proteasome where it can rescue substrates from degradation by removal of the ubiquitin tag. (cornell.edu)
We previously found that a small-molecule inhibitor of USP14, known as IU1, can increase the rate of degradation of a subset of proteasome substrates. (cornell.edu)
Among the diverse signaling outcomes associated with ubiquitination, the most well-established is the targeted degradation of substrates via the proteasome. (intechopen.com)

thus it is used as an indicator of autophagic degradation [ 6 ]. (biomedcentral.com)
We further show that Sert suppresses tauopathy by promoting the autophagic degradation of MAPT (microtubule associated protein tau) protein via inducing autophagy. (elsevierpure.com)

Under these physiological conditions, a transient and localized influx of calcium into the cell activates a small local population of calpains (for example, those close to Ca2+ channels), which then advance the signal transduction pathway by catalyzing the controlled proteolysis of its target proteins. (wikipedia.org)
Despite the well-understood process of CUL3-mediated protein ubiquitination and degradation 12 , its target proteins in the developing central nervous system and its role in brain development remain utterly understudied. (nature.com)
CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)

The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice. (ironmagazine.com)
One of the first known mechanisms is the accumulation of proteins: α-synuclein (Parkinson's disease), Tau (Alzheimer's disease) and β-amyloid (Alzheimer's disease and Parkinson's disease) proteins. (encyclopedia.pub)
Protein accumulation is related to a disruption of mitochondrial activity associated with cell death and oxidative stress. (encyclopedia.pub)
The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)

Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)

E3 ubiquitin ligases regulate cellular protein composition by providing target recognition and specificity to the ubiquitin-dependent proteasomal degradation pathway 12 . (nature.com)
The aggresome is juxtanuclear inclusion body containing heat-shock proteins and components of the ubiquitin-proteasome system ( Olzmann et al, 2008 ). (biorxiv.org)
The ubiquitin-proteasome system (UPS) is a well-characterized protein degradation system in cells whose dysfunction is implicated in many diseases, including neurodegeneration and cancer 1,2 . (cytoskeleton.com)
Activation of the UPS begins with attachment of an 8 kDa ubiquitin protein to a target protein by a three step cascade carried out by Ub ligases. (cytoskeleton.com)
Conjugation of the Atg8 (autophagy related 8) family of ubiquitin-like proteins to phospholipids of the phagophore is a hallmark of macroautophagy/autophagy. (babraham.ac.uk)
The ubiquitin-proteasome system (UPS) is responsible for most selective protein degradation in eukaryotes and regulates numerous cellular processes, including cell cycle control and protein quality control. (cornell.edu)
The small protein ubiquitin plays a vital role in virtually all aspects of cellular life. (intechopen.com)
In particular, ubiquitin-mediated degradation is critically important at transition points where it provides directionality and irreversibility to the cell cycle, which is essential for maintaining genome integrity. (intechopen.com)

Spinal plasticity, a key process mediating neuropathic pain development, requires ubiquitination-dependent protein turnover. (jneurosci.org)
Nevertheless, the mechanism for ubiquitination-regulated turnover of presynaptic active zone proteins in the progression of spinal plasticity-associated neuropathic pain remains unclear. (jneurosci.org)
That is, RIM1α-facilitated Ca V 2.2 expression plays a role in the downstream signaling of Fbxo3-dependent Fbxl2 ubiquitination/degradation to promote spinal plasticity underlying the progression of nociceptive hypersensitivity following neuropathic injury. (jneurosci.org)
SIGNIFICANCE STATEMENT Ubiquitination is a well known process required for protein degradation. (jneurosci.org)
Studies investigating pain pathology have demonstrated that ubiquitination contributes to chronic pain by regulating the turnover of synaptic proteins. (jneurosci.org)
In addition, Fbxo3 modifies this pathway by inhibiting Fbxl2-mediated RIM1α ubiquitination, suggesting that presynaptic protein ubiquitination makes a crucial contribution to the development of neuropathic pain. (jneurosci.org)
Ub itself can be ubiquitinated, leading to poly-ubiquitination, a marker for proteasomal recognition and ultimately degradation (Fig. 1). (cytoskeleton.com)
Due to the prevalence of UPS dysfunction in disease and an increased molecular understanding of how ubiquitination degrades protein, interest in targeting the UPS for therapeutic intervention has grown substantially. (cytoskeleton.com)

Autophagy is a highly conserved and lysosome-dependent bulk degradation process. (hindawi.com)
Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. (arigobio.com)

Here, we focus on functional interactions between podosomes and microtubules, and on the delivery of regulatory factors through microtubule-based motor proteins to podosomes. (daniel-walz.de)

Protein aggregates are the pathogenic hallmarks of many different neurodegenerative diseases and include the Lewy bodies found in Parkinson's disease. (biorxiv.org)
Hsp70, Hsp90, and their co-chaperones are crucial members of the proteostasis network that are able to recognize misfolded proteins, aberrant condensates and protein aggregates, triaging proteins for refolding or degradation. (encyclopedia.pub)

Additionally, phosphorylation by protein kinase A and dephosphorylation by alkaline phosphatase have been found to positively regulate the activity of μ-calpains by increasing random coils and decreasing β-sheets in its structure. (wikipedia.org)
Phosphorylation of Hsp70 and Hsp90 C-terminal tails dictate the binding of CHIP, promoting substrate degradation [ 10 ] . (encyclopedia.pub)
Wegmann S , Biernat J, Mandelkow E . A current view on Tau protein phosphorylation in Alzheimer's disease. (neurotree.org)

Western blot was used for analysis of protein levels, Boyden chamber assays for analyses of cell migration and co-immunoprecipitation (CoIP) followed by western blot, PCR or qPCR for analysis of protein-protein and protein-mRNA interactions. (biomedcentral.com)
It disrupted the AR translational MID1 regulator complex leading to release of the associated AR mRNA and subsequently to downregulation of AR protein in AR positive cell lines. (biomedcentral.com)
The dissociation of GRP78 allows IRE1 dimerisation and activation of C-terminal endoribonuclease activity, which non-canonically splices a 26-base pair intron from the X-box binding protein 1 (XBP1) mRNA to produce the spliced form of XBP1 (sXBP1). (distantreader.org)
Circular RNAs (circRNAs) are closed, long, non-coding RNAs that are formed via direct reverse splicing of precursor mRNA that function by regulating RNA transcription and protein production, as well as sponging miRNAs ( 4 ). (spandidos-publications.com)
QuickPrep micro mRNA protein citation( Amersham Pharmacia Biotech, Sweden) for the general wild-type of poly-A+ RNA from original adaptors in kinesin. (swcomsvc.com)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)

Given the proteasome's role in regulated degradation of poly-ubiquitinated proteins and its dysfunction in cancer, researchers posited that inhibition of the proteasome may be effective for treating cancer cachexia (wasting syndrome) 4 . (cytoskeleton.com)
We also report that a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome. (cornell.edu)

Autophagy is the "self-eating" process of degrading damaged proteins and organelles, as well as recycling intracellular energy to maintain cellular homeostasis under stress conditions. (hindawi.com)
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
Lysosomes were previously believed to be the sites of the degradation of intracellular and extracellular substances. (biomedcentral.com)

Fusion Proteins offer an important biological assay for direct protein-to-protein interactions. (thermofisher.com)

Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)
In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
This spliced form of XBP1 then translates into a transcription factor, which further translocates into the nucleus where it induces expression of a wide variety of genes including ER-associated chaperones and protein folding enzymes to increase ER size and folding capacity. (distantreader.org)
Situs inversus has a familial pattern and has been associated with a number of genes related to microtubule-associated proteins. (lookformedical.com)

CUL3 is a conserved protein of the Cullin family, comprising eight members, which contain a conserved cullin homology domain, named after its ability to select cellular proteins for degradation. (nature.com)
Mechanistically, Sert potentially binds to and antagonizes the mitochondrial VDAC1 (voltage dependent anion channel 1), resulting in reduced cellular ATP (adenosine triphosphate) level, activation of AMP-activated protein kinase (AMPK) and inhibition of its downstream, MTOR (mechanistic target of rapamycin kinase)-RPS6KB1 (ribosomal protein S6 kinase B1) signaling pathway. (elsevierpure.com)
Aggregated misfolded proteins in the ER cause cellular stress, which if unresolved can lead to cell death. (distantreader.org)
Aggresomes are closely-related cellular accumulations of misfolded proteins. (biorxiv.org)
Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)

They develop in a juxtanuclear position, adjacent to the centrosome, the microtubule organizing centre of the cell, and share some protein components. (biorxiv.org)
Despite the long-standing observation that aggresomes/Lewy bodies and the centrosome sit side-by-side in the cell, no studies have been done to see whether these protein accumulations impede the organelle function. (biorxiv.org)
We investigated whether the formation of aggresomes affected key centrosome functions: its ability to organize the microtubule network and to promote cilia formation. (biorxiv.org)
The juxtanuclear location of the aggresome is shared by the centrosome, the microtubule organising centre of the cell. (biorxiv.org)

ARA55, ARA54, ARA70, BRCA1, and heat-shock proteins) may allow cells to become independent of androgens (intrinsic activation). (aacrjournals.org)

Experimental research found a markedly decreased expression of autophagy-related proteins such as Beclin-1, Atg12-Atg5, and LC3-II in a diabetic mouse model and in a high glucose-induced podocyte injury model [ 4 ]. (hindawi.com)
Autophagy is a fundamental catabolic process coordinated by a network of autophagy-related (ATG) proteins. (babraham.ac.uk)

Interestingly, these variable regions determine the differential effects of Hsp70 isoforms on the aggregation or degradation of the Alzheimer's-disease-related protein tau [ 16 ] . (encyclopedia.pub)
Alzheimer's disease (AD) and the toxicity and mechanisms of amyloid protein aggregation will be emphasized in this review. (hyperthermicwellness.com)
Protein aggregation connected with dysfunctional protein degradation systems, mitochondrial perturbation related with cell death and oxidative stress were identified as mechanisms common to the two most-frequent neurodegenerative diseases in humans : Parkinson's and Alzheimer's disease. (encyclopedia.pub)
In Parkinson's and Alzheimer's disease, protein aggregation concerns α-synuclein, Tau and β-amyloid proteins, respectively, although β-amyloid proteins are equally present in Parkinson's disease. (encyclopedia.pub)

LC3B is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. (arigobio.com)
We find that when aggresomes are present, neuronal cells are unable to organise their microtubule network. (biorxiv.org)
Using primary neuronal cultures, IU1-47 was found to accelerate the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant. (cornell.edu)

To date, at least 28 different proteins have been identified as amyloids in humans [ 3 , 5 - 7 ]. (hyperthermicwellness.com)

Three scaffolds with inhibitory activity against the heat shock protein 70 (Hsp70) family of chaperones have been found to enhance the degradation of the microtubule associated protein tau in cells, neurons, and brain tissue. (usf.edu)
Indeed, Hsp70, Hsp90 and their co-chaperones are increasingly recognized as therapeutic targets for the development of treatments against prevalent protein misfolding diseases. (encyclopedia.pub)
Hsp40/DNAJ proteins interact differently with Hsp70 chaperones [ 13 ] . (encyclopedia.pub)

CUL3 ASD-associated genetic variants are most often de novo missense or loss of function (loF) mutations, dispersed throughout the entire gene and affecting distinct protein domains. (nature.com)
Cell-to-cell movement of Potato mop-top virus (PMTV) is mediated by three virus-encoded 'triple gene block' (TGB) proteins termed TGBp1, TGBp2 and TGBp3. (benthamopen.com)
Adenomatous polyposis coli protein is a protein in humans that is encoded by APC gene. (cusabio.com)

GST (Glutathione S-transferase) is a 26kDa protein, present in eukaryotes and in prokaryotes, where they catalyze a variety of reactions. (thermofisher.com)

It mainly forms the catalytic subunits of two protein complexes, including mTOR complex 1 (mTOR complex1, mTORC1) and mTOR complex 2 (mTOR complex2, mTORC2). (hindawi.com)

A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)
This GST-fusion protein can then be purified from cells via its high affinity for glutathione. (thermofisher.com)

These ATG proteins also perform an important parallel role in 'noncanonical' autophagy, a lysosome-associated signaling pathway with key functions in immunity, inflammation, cancer, and neurodegeneration. (babraham.ac.uk)

At the molecular level, Cul3 regulates cytoskeletal and adhesion protein abundance in mouse embryos. (nature.com)
The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment. (babraham.ac.uk)

Amyloidosis is a large group of pathologic conditions in which a particular type of protein, called amyloid, is abnormally deposited in various tissues or organs. (hyperthermicwellness.com)
Generally, amyloid refers to misfolded peptides or proteins that demonstrate a stable, cross-beta super-secondary structure that renders it insoluble, fibrous-like, and resistant to proteolysis. (hyperthermicwellness.com)
Each type of amyloidosis is classified according to clinical signs and the main peptide or protein that constitutes the amyloid fibrils. (hyperthermicwellness.com)

Kaniyappan S , Balaji V, Wang Y, Mandelkow E . Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease. (neurotree.org)

Src was the first oncogene to be discovered, and the first protein tyrosine kinase, and dissecting the mechanisms of Src transformation, regulation, substrate selection and function has proved to be a powerful research paradigm to understand tumorigenesis. (daniel-walz.de)

3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
Hop (Hsp-organizing protein) promotes the transfer of the substrate from the Hsp70 machinery to Hsp90. (encyclopedia.pub)

used in the n't chemical historians in Molecular Biology period link, levels are weeks to their small enthusiasts, mutations of the Other microtubules and terms, stage, experimentally total serum macromolecules, and properties on site and following removed themes. (swcomsvc.com)

The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)

EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. (wikipedia.org)
Recent work published in The EMBO Journal and EMBO Reports reveals a novel role for the protein TECPR1 as a sensor for stressed membranes and regulator of lysosomal membrane repair. (babraham.ac.uk)

As a soluble, zinc-coordinated homotrimeric protein, it has emerged as a promising candidate for cancer therapy through its capacity to trigger apoptosis in many types of cancers without causing significant toxicity to normal cells [ 7 , 8 ]. (biomedcentral.com)
Taken together, these results suggest that endosomes made up of GzmB and perforin fuse with autophagosomes upon activation of Mouse monoclonal to CHK1 autophagy in hypoxic cells, leading to the specific degradation of GzmB. (cancerhugs.com)
New microtubules are not nucleated and extended, and the cells fail to respond to polarity cues. (biorxiv.org)
The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)
They found fifty percent less fat [triglycerides] in these cells in the BCAA mice, and much greater activity in the molecules that are involved in fat burning, such as the fat sensor PPAR-alpha, the enzyme COT-1 and the uncoupling proteins 2 and 3. (ironmagazine.com)
uncoupling proteins boost the heat production in cells. (ironmagazine.com)
The capacity of this compound, IU1-47, to enhance protein degradation in cells was tested using as a reporter the microtubule-associated protein tau, which has been implicated in many neurodegenerative diseases. (cornell.edu)
Normally, dividing cells form a single metaphase plate of paired chromosomes which are pulled apart by opposing microtubule spi. (ucsd.edu)

The inhibitory effect of metformin was mimicked by disruption of the MID1-α4/PP2A protein complex by siRNA knockdown of MID1 or α4 whereas AMPK activation was not required. (biomedcentral.com)

GRP78 has a high affinity for misfolded and unfolded proteins: when luminal load of misfolded protein increases, GRP78 is released from the ER stress sensors, which are then free to initiate downstream signalling outside the ER. (distantreader.org)

Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid. (lookformedical.com)

Hochmair J, Exner C, Betzel C, Mandelkow E , Wegmann S . Light Microscopy and Dynamic Light Scattering to Study Liquid-Liquid Phase Separation of Tau Proteins In Vitro. (neurotree.org)

The selectivity of GzmB degradation Pomalidomide-PEG4-C-COOH by autophagy was further supported by our data demonstrating that inhibition of the autophagy cargo protein p62 restores GzmB level in hypoxic targets (Fig. S3). (cancerhugs.com)

clinical name, dulanermin) belongs to a small subset of pro-apoptotic protein ligands in the tumor necrosis factor (TNF) superfamily. (biomedcentral.com)

Macroautophagy/autophagy (hereafter autophagy), the process of mass degradation of unnecessary elements within the cell, is often dysregulated in many diseases such as cancer, atherosclerosis, and neurodegenerative diseases. (elsevierpure.com)

Autophagy is a self degradation process that can mediate cell death as well as survival [ 1 ]. (biomedcentral.com)
Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)
If dietary( being current introductions), pdf protein onto human method of materiality so Remains even cause particular and at the available cell. (swcomsvc.com)
Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. (cusabio.com)
It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. (cusabio.com)

To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
The protein-protein interactions may help CRYAA carry out multifaceted functions. (molvis.org)
To understand the functions of CRYAA and how these are regulated, protein-protein interactions need to be investigated. (molvis.org)

However, the Atg8 family of proteins are not found solely attached to double-membrane autophagosomes. (babraham.ac.uk)
In non-canonical Atg8-family protein lipidation they become conjugated to single membranes. (babraham.ac.uk)
We have shown that this process is triggered by recruitment of ATG16L1 by the vacuolar-type H-translocating ATPase (V-ATPase) proton pump, suggesting a role for pH sensing in recruitment of Atg8-family proteins to single membranes. (babraham.ac.uk)

Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB. (thermofisher.com)

As a result, the ER has evolved a regulatory network, known as the unfolded protein response (UPR), to control the protein folding process. (distantreader.org)

When the sequence of this enzyme became known, it was given the name "calpain", to recognize its common properties with two well-known proteins at the time, the calcium-regulated signalling protein, calmodulin, and the cysteine protease of papaya, papain. (wikipedia.org)

Despite the stringent regulation around protein folding and redundancy within the chaperone-assisted folding process, both endogenous and exogenous triggers can disrupt the ER homeostasis and increase protein misfolding. (distantreader.org)

Finally, we study the mechanisms of podosome-dependent matrix degradation through delivery and regulation of matrix-degrading enzymes. (daniel-walz.de)
Hasnain, Sumaira Z title: Immune regulation of the unfolded protein response at the mucosal barrier in viral infection date: 2018-04-03 journal: Clin Transl Immunology DOI: 10.1002/cti2.1014 sha: 6a80b22e84d2692545c6f11d7cb4c96602a25c39 doc_id: 3122 cord_uid: 07dlf3zw Protein folding in the endoplasmic reticulum (ER) is subject to stringent quality control. (distantreader.org)

The black medium of this situ presents five distance book with secondary microtubules of nineteenth layerline, interface protein in E. The First marker of this degradation links 11 fossils following records of methods of recovery of vacuum and Health relocating in protective antiquities and rushed help branches affected from kinesin-like-proteins. (swcomsvc.com)

Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. (cusabio.com)

Deletion analysis also revealed a correlation between TGBp1 microtubule association and plasmodesmata targeting. (benthamopen.com)

The UPR activation involves three major downstream effects including reduction in protein synthesis to reduce ER load, enhancement of ER protein folding capacity and upregulation of ER-associated protein degradation (ERAD). (distantreader.org)

Upon autophagy induction microtubule-associated protein light chain 3 (LC3) can specifically target autophagic membranes to form autophagosomes [12]. (crispr-reagents.com)

Here, we found that the spinal presynaptic active zone protein Rab3-interactive molecule-1α (RIM1α) participates in neuropathic pain development by binding to and upregulating the expression of Ca V 2.2. (jneurosci.org)

To analyze subcellular localization and transport of TGBp1 we used a single binary vector for agrobacterium-mediated co-expression of PMTV TGBp1 fused to green fluorescent protein and TGBp2/TGBp3. (benthamopen.com)

We propose that TGBp1 interaction with MTs may be important for the formation of vRNP bodies destined for the transport to plasmodesmata as well as degradation of the excessive TGBp1. (benthamopen.com)

Anatomy43

Organisms18

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes63

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science4

Health Care2

Substrates4

Autophagic degradation2

Target proteins3

Accumulation4

Binding Proteins3

Ubiquitin8

Ubiquitination8

Bulk degradation2

Motor proteins1

Aggregates2

Phosphorylation3

MRNA6

Proteasome2

Intracellular3

Fusion Proteins1

Genes4

Cellular5

Centrosome4

Heat-shock pr1

Autophagy-related2

Aggregation4

Neuronal3

Different proteins1

Chaperones3

Gene3

Eukaryotes1

Complexes1

Glutathione2

Pathway1

Regulates2

Amyloid3

Alzheimer's1

Kinase1

Substrate2

Molecular1

Subunits1

Lysosomal2

Cells8

Inhibitory1

High affinity1

Lipid1

Phase separation1

Inhibition1

Subset1

Neurodegenerative diseases1

Cell5

Interactions3

ATG83

Membrane1

Regulatory1

Calmodulin1

Homeostasis1

Regulation2

Marker1

Promotes1

Targeting1

Downstream1

Induction1

Participates1

Expression1

Interaction1