Degradation i kappa b proteins. Medical search. Frequent questions

Activation of membrane receptors leads to NFKBI phosphorylation and ubiquitination, and its subsequent proteasomal degradation. (frontiersin.org)
However, binding of TNF alpha to its cognate receptor phosphorylates IKK which in turn phosphorylates I kB allowing proteasomal degradation of I kB. (thermofisher.com)
Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. (abcam.cn)
Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. (nih.gov)
Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. (nih.gov)
Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. (nih.gov)
The Nrf2-signaling pathway mediates multiple avenues of cytoprotection by activating the transcription of more than 200 genes that are crucial in the metabolism of drugs and toxins, protection against oxidative stress and inflammation, as well as playing an integral role in stability of proteins and in the removal of damaged proteins via proteasomal degradation or autophagy. (dundee.ac.uk)
proteasomal degradation. (healthweeks.com)
The N-terminal baculovirus IAP repeat (BIR) domains of IAP family members have been demonstrated to bind to Smac/DIABLO (second mitochondrion-derived activator of caspase) protein which induces rapid proteasomal degradation of cIAPs [27 28 In addition cIAP1/2 also contain an ubiquitin-associated (UBA) domain that binds to polyubiquitin chains [29] and a less well characterized caspase-recruitment domain (CARD) which was found to be an intrinsic inhibitory domain. (healthweeks.com)

Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. (nih.gov)
However, unlike the canonical regulation of β-catenin via glycogen synthase kinase 3β (GSK3β)-dependent degradation, GSK3β expression and phosphorylation were unaltered during hyperammonemia, and depletion of GSK3β did not prevent ammonia-induced degradation of β-catenin. (nih.gov)
Overexpression of GSK3β-resistant variants, genetic depletion of IκB kinase β (IKKβ) (activated during hyperammonemia), protein interactions, and in vitro kinase assays showed that IKKβ phosphorylated β-catenin directly. (nih.gov)
Effects of EGCG on mitogen-activated protein kinase (MAPK) phosphorylation were determined by cell-based enzyme-linked immunosorbent assay (ELISA) and western blotting. (molvis.org)
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. (nih.gov)
AURK significantly promotes activation of IκBα at serine 32, but not serine 36 residues, unlike IκB kinase (IKK) family proteins activate both IκBα serine residues. (researchsquare.com)
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. (cusabio.com)
In addition, pretreatment using isodojaponin D substantially attenuated LPS-induced mitogen-activated proteins kinase (MAPK) initial. (4egi-1inhibitor.com)
This gene encodes a member of the serine/threonine protein kinase family. (sitoolsbiotech.com)

Here we identify the tumor suppressor Protein tyrosine phosphatase receptor-type kappa (Ptprk), as a Wnt inhibitor of the Spemann organizer. (elifesciences.org)
We show that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt signaling promoting Wnt receptor degradation, which is also expressed in the organizer. (elifesciences.org)
These include RANKL (Receptor activator of nuclear factor kappa-B ligand), osteoprotegerin , and sclerostin . (saveourbones.com)
Western blot analysis was used to detect the protein expression of ATP binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor α (PPARα), peroxisome proliferator-activated receptor Î³ coactivator-1α (PGC-1α) and nuclear factor κB p-p65 (NF-κB p-p65). (bvsalud.org)
they are improvement of disease launch from contaminated cells (26 41 47 50 and degradation from the HIV receptor Compact disc4 proteins in the endoplasmic reticulum (ER) (53). (cancer-pictures.org)
MAM is an acronym derived from meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu. (embl.de)
TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)

Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. (wikipedia.org)
In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. (hmdb.ca)
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. (oncotarget.com)
Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. (cusabio.com)
In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. (cusabio.com)
The results demonstrate that the inhibition of miR-16 renders resistance to paclitaxel in vitro and in vivo by targeting IKBKB via NF-kappa B signaling pathway. (cusabio.com)
The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. (sitoolsbiotech.com)
Further mechanistic studies indicated that PF suppressed the production of these pro-inflammatory cytokines by regulating the nuclear factor-kappa B (NF-kappa B) pathway. (gnu.ac.kr)

We also show that the TNF signaling reduces the level of inhibitory nuclear factor kappa B protein subtype A (NFKBIA), leading to the nuclear translocation of two NFKB dimers, p50/p50, and p50/RelA. (frontiersin.org)
Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. (cusabio.com)

This was consistent with IkappaBalpha phosphorylation and degradation, yet TNF-alpha-induced NF-kappaB DNA binding was only 30-40% greater than for IL-1beta. (nih.gov)

NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. (hmdb.ca)
NF-kB P65 is also known as RelA (v-rel avian reticuloendotheliosis viral oncogene homolog A) and belongs to the Rel family of proteins. (thermofisher.com)
The first subfamily of proteins (c-Rel, RelB, p65/RelA) contains a C-terminal transactivation domain. (oncotarget.com)
NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. (nih.gov)
The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. (nih.gov)

Controlled by sequential serine-phosphorylation, ubiquitination and degradation. (lu.se)
We showed that HAX1 promotes auto-ubiquitination and degradation of cIAPs by facilitating the intermolecular homodimerization of RING finger domain. (healthweeks.com)

The stable association of Vpu with βTrCP also affects the latter's cellular functions, one of which is to direct the proteosomal degradation of inhibitor of kappa B (IκB) [ 14 ]. (biomedcentral.com)

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (hmdb.ca)
May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. (lu.se)
NF-κB ( Nuclear Factor kappa B ) is a ubiquitous family of transcription factors involved in biological processes such as inflammation, immunity, proliferation and apoptosis [ 1 - 3 ]. (oncotarget.com)
In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. (cusabio.com)
Inhibitor of apoptosis (IAP) protein family is an endogenous and negative regulator of apoptosis through the direct inhibition of caspases and/or the suppression of apoptotic signaling pathways [10-12]. (healthweeks.com)
This family includes X-linked inhibitor Eteplirsen of apoptosis protein (XIAP) cellular inhibitor of apoptosis 1 and 2 (cIAP1 cIAP2) melanoma inhibitor of apoptosis (ML-IAP) and survivin [10]. (healthweeks.com)

Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. (cusabio.com)
Next activated IKKα phosphorylates p100/NF-κB2 and induces partial degradation of p100 to p52 [26]. (healthweeks.com)

These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. (cusabio.com)

NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. (hmdb.ca)

In response to diverse stimuli, IkBs are rapidly phosphorylated, ubiquitinated and undergo degradation via 26S proteasome. (dtic.mil)
NF-κB is usually activated by the release from cytoplasmic IκB proteins and subsequently translocates into the nucleus (3 5 34 Activation is usually brought on by signal-induced phosphorylation of IκB which targets the inhibitor for rapid degradation by the proteasome (49). (bibf1120.com)
Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by blocking the formation of phosphorylated STAT1 and promoting ubiquitin-mediated proteasome-dependent degradation of STAT1 (PubMed:23799612) (By similarity). (proteopedia.org)

The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. (hmdb.ca)
Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
However, platonin inhibited Oxidized low-density lipoprotein (ox-LDL)-induced MCP-1 production, possibly through the at-tenuation of Activator protein 1 (AP-1) binding activity and C-Jun N-terminal kinases 1 2 (JNK1/2) phosphorylation. (tmu.edu.tw)

This was not explained by degradation of IkappaBbeta, IkappaBepsilon, or p105 nor nuclear translocation of NF-kappaB. (nih.gov)
During resting conditions, NFKB inhibitory protein (NFKBI) binds to NFKB dimers, impairing their nuclear translocation ( O'Neill and Kaltschmidt, 1997 ). (frontiersin.org)

Collagen degradation products are a class of bone resorption marker generated when the collagen in bones is broken down during the resorption process. (saveourbones.com)
Markers of bone resorption include collagen degradation products, non-collagenous proteins, osteoclastic enzymes, and osteocyte activity markers. (saveourbones.com)
One such target for aging reversal is collagen degradation or turnover. (dovepress.com)

The reduction in salivary flow and changes in the concentration of salivary proteins were associated with the development of MRONJ. (frontiersin.org)
The association between caries experience/activity and the electrophoretic profiles of salivary proteins lactoferrin and lysozyme was evaluated. (bvsalud.org)

IκBα inhibits the NF-κB by keeping them in a state isolated from the inactive cytoplasmic mask and the nuclear localization signal of NF-κB proteins. (researchsquare.com)

These protein kinases are currently seen as a target of choice to specifically inhibit NF- kB activity. (dtic.mil)
The second subfamily of proteins (p105 and p100) has a C-terminal region that contains multiple copies of ankyrin repeats, instead of a transactivation domain, and can bind to and inhibit Rel proteins. (oncotarget.com)
thus, highly expressed Cdt1 protein would mask PCNA to inhibit the repair process. (rawveronica.com)
Saliva contains both specific and non-specific protective factors of the immune system, such as antimicrobial proteins, which can inhibit the adhesion and viability of cariogenic microorganisms. (bvsalud.org)
Most of these proteins can inhibit the metabolism, adherence and cariogenic viability of microorganisms in vitro (1-3). (bvsalud.org)

p100 and p105 can however undergo limited proteolysis to generate p52 and p50, respectively, which can form heterodimers with Rel proteins to form transcriptional activators [ 5 ]. (oncotarget.com)

The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. (hmdb.ca)
p50 binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. (hmdb.ca)
Free NFKB dimers translocate to the nucleus, bind to the kappa B element of gene promoters and induce or repress the transcription of target genes. (frontiersin.org)
Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. (nih.gov)
Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)

NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. (hmdb.ca)

Pig zonadhesin, a protein that binds in a species-specific manner to the zona pellucida of the egg. (embl.de)
A pig sperm protein that binds to the extracellular matrix of the egg in a species-specific manner was recently identified and named zonadhesin (Hardy, D. M., and Garbers, D. L. (1995) J. Biol. (embl.de)

Has E3 ubiquitin-protein ligase activity. (abcam.cn)
Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. (nih.gov)

Osteoclastic enzymes are secreted by osteoclasts to break down bone matrix proteins. (saveourbones.com)
However, PF elevated the protein expression of inhibitor kappa B-alpha and those of A beta degrading enzymes, insulin degrading enzyme and neprilysin. (gnu.ac.kr)
CONCLUSIONS: These findings indicate that PF exerts protective effects against A beta-mediated neuroinflammation by inhibiting NF-kappa B signaling, and these effects were associated with the enhanced activity of A beta degradation enzymes. (gnu.ac.kr)

The domain has been shown to play a role in homodimerization of protein-tyrosine phosphatase mu [ ( PUBMED:7782276 ) ] and appears to help determine the specificity of these interactions. (embl.de)

Similarly, bioactive peptides, which are specific protein fragments that are thought to have physiological health benefits, are good candidates for cosmeceutical components that provide enzyme-modulating activity. (dovepress.com)

Our findings demonstrate that UV irradiation induces multiple repair pathways that activate CRL4Cdt2 to degrade its target proteins in the G1 phase of the cell cycle, leading to efficient repair of DNA damage. (rawveronica.com)

One of the central anti-apoptotic pathways in cells is mediated by NF-kB nuclear factor kappa-B transcription factors. (dtic.mil)
its steady association with Vpu impacts the Wnt and nuclear element kappa B (NF-κB) signaling pathways (1 5 In HIV-infected cells Vpu can be synthesized from a bicistronic mRNA that also rules for the viral envelope (Env) proteins gp160. (cancer-pictures.org)
Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)
Our data uncovered that multiple pathways are involved in Cdt1 degradation after UV irradiation. (rawveronica.com)

This family of proteins comprises two subfamilies that share a DNA-binding and dimerization domain called the Rel homology domain (RHD) [ 4 ] and form homo- or hetero- dimers. (oncotarget.com)

Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NF-kappa-B activation, and activates AP-1 (By similarity). (proteopedia.org)
Vertebrate enteropeptidase ( EC 3.4.21.9 ), a type II membrane protein of the intestinal brush border, which activates trypsinogen. (embl.de)

This leads to IkappaBalpha degradation and release of NF-kappaB. (nih.gov)
IkappaBalpha complexes or degradation-independent release of NF-kappaB. (nih.gov)
These data reveal an imprecise relationship between IKK activation, IkappaBalpha degradation, and NF-kappaB DNA binding, suggesting the existence of additional mechanisms that regulate NF-kappaB activation. (nih.gov)

URG4/URGCP protein and mRNA expression were significantly upregulated in HCC cell lines. (biomedcentral.com)
Expression of mouse zonadhesin mRNA is evident only within the testis, and the protein is found exclusively on the apical region of the sperm head. (embl.de)
[ 16 ] In one study, arecoline was found to elevate the mRNA and protein expression of cystatin C, a nonglycosylated basic protein consistently up-regulated in a variety of fibrotic diseases, in a dose-dependent manner in persons with oral submucous fibrosis. (medscape.com)

This antibody detects the 53 kDa human XIAP protein. (abcam.cn)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AE Binding Protein 1 (AEBP1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human AE Binding Protein 1 (AEBP1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)

Nrf2 interacts with other important cell regulators such as tumor suppressor protein 53 (p53) and nuclear factor-kappa beta (NF-kappa B) and through their combined interactions is the guardian of healthspan, protecting against many age-related diseases including cancer and neurodegeneration. (dundee.ac.uk)

Transcriptome analyses, real-time PCR, and immunoblotting showed consistent reductions in the expression of the large and small ribosomal protein subunits (RPL and RPS, respectively) in hyperammonemic murine skeletal myotubes, HEK cells, and skeletal muscle from hyperammonemic rats and human cirrhotics. (nih.gov)
The five different subunits of NFKB express REL homology domains, which are responsible for binding to the DNA kappa B element. (frontiersin.org)
It is one of the two subunits of NF-kB (Nuclear factor kappa-light-chain-enhancer of activated B cells) that heterodimerizes with the other subunits p50 or p52. (thermofisher.com)

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. (wikipedia.org)

The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. (wikipedia.org)
NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. (hmdb.ca)

Several IkB kinases IKKs which trigger IkB degradation and NF-kB activation were discovered in 1997-2000 Zandi et al. (dtic.mil)

Therefore the Vpu proteins also plays a part in viral persistence by attenuating immune system reactions during HIV disease. (cancer-pictures.org)

Although these findings may represent a dominant unfavorable effect of ectopic expression of PIP-degron peptide proteins, it is probable that CRL4Cdt2-mediated quick degradation of Cdt1 and other targets facilitates DNA repair. (rawveronica.com)

Protein level and Gene expression were tested by Western blotting analysis and by the Applied Biosystems® Tagman® Array Plates, respectively. (longdom.org)
VEGFC protein expression was analyzed using an ELISA. (biomedcentral.com)
The expression of microtubule-associated protein LC3II and SQSTM1/p62 in the colon tissues was detected by immunohistochemistry. (hindawi.com)
Whether Vpu is a viral pathogenesis factor remains to be established, but compared to HIV-1, closely related retroviruses such as HIV-2 and SIV that lack expression of a fully functional Vpu protein also cause less severe disease outcomes. (biomedcentral.com)
The human being immunodeficiency virus type 1 (HIV-1) Vpu accessory protein is a transmembrane protein that down regulates CD4 expression and promotes the discharge of new virions. (cancer-pictures.org)
Whether Vpu can be a virulence element remains to become established but in comparison to HIV-1 carefully related retroviruses such as for example PHA-848125 HIV-2 and SIV that absence expression of a completely functional Vpu proteins also cause much less severe disease results. (cancer-pictures.org)
Pretreatment with platonin suppressed the expression of inducible nitric oxide synthetase and mature interleukin-1β but not that of monocyte chemoattractant protein-1 (MCP-1) in VSMCs stimulated by a combination of lipopolysaccharide and interferon-γ (LPS/IFN-γ). (tmu.edu.tw)
When ZK-261991 Cdt1 degradation was attenuated by high Cdt1 expression, repair synthesis at the damaged sites was inhibited. (rawveronica.com)

In addition, bisphosphonates, denosumab, and other bone-modifying agents showed a significantly higher risk of developing MRONJ owing to the changes in salivary microbiome profiles, cytokine profiles, interleukins, hypotaurine, and binding proteins. (frontiersin.org)

We show that hyperammonemia, which occurs in diverse chronic disorders, impairs protein synthesis as a result of decreased ribosomal content and translational capacity. (nih.gov)

Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage (PubMed:14602201). (proteopedia.org)

Using Vpu proteins from a primary subtype C and the pNL4-3 subtype B isolates of HIV-1, we show oligomerization of the full-length protein as well as its transmembrane (TM) domain by genetic, biochemical and biophysical methods. (biomedcentral.com)

The key to NF-kB regulation is the inhibitory kB IkB proteins which retain NF-kB in an inactive form in the cytoplasm. (dtic.mil)

It specifically plays a key role in transcription of immunoglobulin k (kappa) gene in mature B-lymphoid cells. (thermofisher.com)
A luciferase reporter assay was used to examine the transcriptional activity of nuclear factor kappa - light - chain - enhancer of activated B cells (NF-κB). (biomedcentral.com)
Early research showed that manifestation of Vpu could improve the launch of varied retroviral contaminants from human being cells whether those retroviruses normally bring a Vpu protein (17). (cancer-pictures.org)
Furthermore, platonin inhibited LPS/IFN-γ-induced Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation though the direct reduction of p65 Ser536 phosphorylation but not the restoration of Inhibitor of nuclear factor kappa B (IκBα) degradation in VSMCs. (tmu.edu.tw)
We predict that this noncanonical MMR responds to such UV-induced lesions in the G1 phase, leading to the formation of a single-strand space to weight PCNA in G0/G1-phase cells, or that PCNA was first recruited to the lesion sites through direct conversation with Msh2-Msh6, because Msh6 has a PIP-box, and thus CRL4Cdt2 is usually activated for Cdt1 degradation. (rawveronica.com)

The HIV-1 Vpu protein is an oligomeric integral membrane protein essential for particle release, viral load and CD4 degradation. (biomedcentral.com)
One such protein is viral protein U (Vpu) that is encoded by HIV-1 but not HIV-2 or the simian immunodeficiency virus (SIV) [ 2 ]. (biomedcentral.com)
Though distinct from its CD4 degradation function, it is not clear whether Vpu enhances virus release through modification of the cellular environment or specific interactions with cellular or viral factors. (biomedcentral.com)
Participates in the viral particle production as a result of its interaction with the non-structural protein 5A (By similarity). (proteopedia.org)

Treatment of HCEpiC with 1 ng/ml IL-1β for 18 h significantly increased release of the cytokines/chemokines granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1), while hyperosmolarity-induced release of IL-6 and MCP-1. (molvis.org)
Furthermore, LPS-induced pro-inflammatory cytokines, which includes IL-1 'beta', IL-6, and also TNF-alpha, were furthermore diminished by simply pretreatment using isodojaponin D. This influence has been along with a decline in translocations of Nuclear Factor-KappaB (NF-kappa W) p50 as well as p65 through the cytoplasm on the nucleus and also by home loan business 1 kappaB (My partner and i kappa N) degradation. (4egi-1inhibitor.com)

Background: The phosphorylation of NF-kappaB inhibitor alpha (IκBα) protein is pivotal to the regulation of NF-κB transcription factor activity in the cell. (researchsquare.com)
Nuclear factor kappa B (NF-κB) has been implicated in the regulation of cell proliferation transformation and tumor development. (bibf1120.com)

Apical endosomal glycoprotein from rat, a protein probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. (embl.de)

INTRODUCTION HS-1-associated protein X-1(HAX1) is a ubiquitously expressed multifaceted protein with multiple protein-protein interaction domains Eteplirsen [1]. (healthweeks.com)

While Cdt1 destruction after the initiation of DNA replication is usually important to prevent re-replication, the physiologic functions of Cdt1 degradation after DNA damage are not well known. (rawveronica.com)

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. (nih.gov)

Tonsoku-like, DNA repair protein is a protein that in humans is encoded by the TONSL gene. (wikipedia.org)

Furthermore, the mechanism underlying the effect of PF on inflammatory responses and A beta degradation was determined by Western blot. (gnu.ac.kr)

Consistently, co-immunoprecipitation of Cdt2C3FLAG with Msh2 and Msh6 proteins was detected after UV irradiation. (rawveronica.com)

Description: A sandwich ELISA kit for detection of AE Binding Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (kits-elisa.com)

Anatomy16

Organisms7

Diseases1

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes39

Information Science3

Health Care1

Proteasomal degradation9

Kinase9

Receptor7

Pathway8

NFKBIA2

Phosphorylation and degradation1

RELA5

Ubiquitination2

Inhibitor of kappa1

Apoptosis6

Phosphorylates2

Inhibitors1

NFKB11

Proteasome3

Activator3

Translocation2

Collagen degradation3

Salivary proteins2

Cytoplasmic1

Inhibit5

P1051

Genes5

Transcriptional activators1

Binds2

Ubiquitin-protei2

Enzymes3

Tyrosine phosphatase1

Peptides1

Target proteins1

Pathways4

Family of proteins1

Activates2

IkappaBalpha3

MRNA3

Antibody3

Tumor suppressor1

Subunits3

Negative regulator1

Complexes2

IKKs1

Immune1

Targets1

Expression8

Interleukins1

Ribosomal1

Metabolism1

Subtype1

Inhibitory1

Cells5

Viral4

Cytokines2

Regulation2

Glycoprotein1

Interaction1

Physiologic1

Ubiquitous1

Humans1

Inflammatory responses1

Consistently1

ELISA Kit1