Proteasome Endopeptidase ComplexProteolysisUbiquitinBiodegradation, EnvironmentalUbiquitinationUbiquitin-Protein LigasesMolecular Sequence DataCysteine EndopeptidasesUbiquitinsMultienzyme ComplexesAmino Acid SequenceCell LineEndoplasmic Reticulum-Associated DegradationMutationProtein BindingHydrolysisKineticsCells, CulturedProtein Processing, Post-TranslationalRNA, MessengerPeptide HydrolasesRNA StabilityEndoplasmic ReticulumProteasome InhibitorsF-Box ProteinsSignal TransductionCysteine Proteinase InhibitorsAutophagyProtein Structure, TertiaryBase SequencePhosphorylationProtein TransportProtein StabilityHeLa CellsModels, BiologicalTime FactorsEndopeptidasesProteinsSubstrate SpecificityProtease InhibitorsCell Line, Tumorbeta-Transducin Repeat-Containing ProteinsBlotting, WesternI-kappa B ProteinsHEK293 CellsCullin ProteinsPolyubiquitinSKP Cullin F-Box Protein LigasesSaccharomyces cerevisiae ProteinsDown-RegulationEndocytosisSaccharomyces cerevisiaeLigasesRecombinant ProteinsUbiquitin-Protein Ligase ComplexesCarrier ProteinsRecombinant Fusion ProteinsElectrophoresis, Polyacrylamide GelUbiquitin-Conjugating EnzymesFibroblastsChromatography, High Pressure LiquidMembrane ProteinsBacterial ProteinsEscherichia coliCell Cycle ProteinsRNA, Small InterferingHalf-LifeRNA InterferenceNuclear ProteinsDNA-Binding ProteinsEndopeptidase ClpGene Expression RegulationTranscription, GeneticImmunoprecipitationApoptosisCell NucleusCalpainImmunoblottingNF-kappa BTemperatureOxidation-ReductionTranscription FactorsBinding SitesPeptide FragmentsPlasmidsExoribonucleasesProtein FoldingMolecular ChaperonesProto-Oncogene Proteins c-mdm2Hydrogen-Ion ConcentrationCattleCytoplasmS-Phase Kinase-Associated ProteinsPseudomonasProtein BiosynthesisSequence Homology, Amino AcidLiverOxygenasesMolecular WeightPeptides