LysosomesProteolysisUbiquitinationProteasome Endopeptidase ComplexAutophagyUbiquitinEndosomesEndocytosisEndosomal Sorting Complexes Required for TransportUbiquitin-Protein LigasesProtein TransportChloroquineCell LineProto-Oncogene Proteins c-cblLysosomal-Associated Membrane Protein 2Cysteine EndopeptidasesSphingolipid Activator ProteinsBiodegradation, EnvironmentalHEK293 CellsUbiquitinsSaposinsMolecular Sequence DataFetuinsProtein BindingCells, CulturedPhagosomesProtein Processing, Post-TranslationalLeupeptinsAmino Acid SequenceDown-RegulationMultivesicular BodiesSignal TransductionHeLa CellsMutationMultienzyme ComplexesG(M2) Activator ProteinAsialoglycoproteinsUbiquitin ThiolesteraseCysteine Proteinase InhibitorsProtein Structure, TertiaryKineticsModels, BiologicalLysosome-Associated Membrane GlycoproteinsProteasome InhibitorsMembrane ProteinsCell MembraneRNA, Small InterferingCell Line, TumorFibroblastsEndoplasmic ReticulumPhosphorylationEndoplasmic Reticulum-Associated DegradationRecombinant Fusion ProteinsRNA InterferenceEndopeptidasesVesicular Transport ProteinsHSC70 Heat-Shock ProteinsCathepsinsCarrier ProteinsProteinsClathrinAmmonium ChlorideBlotting, WesternVacuolesRNA, Messengerrab GTP-Binding ProteinsHydrolysisTime FactorsAcetylcysteineGreen Fluorescent ProteinsImmunoprecipitationImmunoblottingHalf-LifeCOS CellsMicroscopy, ConfocalGene Knockdown TechniquesCathepsin DAmino Acid MotifsGangliosidosesDynaminsGene Expression RegulationHydrogen-Ion ConcentrationMicroscopy, FluorescenceTransport VesiclesCricetinaeMicrotubule-Associated ProteinsAdaptor Proteins, Signal TransducingLiverCytoplasmElectrophoresis, Polyacrylamide GelMacrolidesRNA StabilityBiological TransportPeptide Hydrolasesrab5 GTP-Binding ProteinsGolgi ApparatusApoptosisRecombinant ProteinsLeucineSubcellular Fractions