• Polymer Degradation and Stability deals with the degradation reactions and their control which are a major preoccupation of practitioners of the many and diverse aspects of modern polymer technology . (elsevier.com)
  • For example, photodegradable plastics are now available, the recycling of polymeric products will become increasingly important, degradation and combustion studies are involved in the definition of the fire hazards which are associated with polymeric materials and the microelectronics industry is vitally dependent upon polymer degradation in the manufacture of its circuitry. (elsevier.com)
  • Publication date: Available online 22 October 2019Source: Polymer Degradation and StabilityAuthor(s): Weiguo Sun, Yi Zhang, Jia Fu, Zhanwen Zhang, Weidong Wu, Yongjian TangAbstractA difference algebraic converging method for rate problem (DACMr) is proposed to study the rate function of a simple chemical reaction that is the function of activation energy and rate constant. (medworm.com)
  • Publication date: Available online 23 October 2019Source: Polymer Degradation and StabilityAuthor(s): C. Arribas, M.G. Prolongo, M. Sánchez-cabezudo, R. Moriche, S.G. ProlongoAbstractThe hydrothermal ageing of hybrid nanocomposites formed by carbon nanotubes (CNTs) and graphene nanoplatelets (GNPs) incorporated into an epoxy matrix was studied. (medworm.com)
  • Publication date: Available online 18 October 2019Source: Polymer Degradation and StabilityAuthor(s): A. Bardin, P.Y. Le Gac, Stéphane Cérantola, Gaëlle Simon, Hervé Bindi, B. FayolleAbstractA hydrolytic kinetic model predicting chains scissions of a polyurethane elastomer (TPU) containing an anti-hydrolysis agent (stabilization via carbodiimide) was developed. (medworm.com)
  • Polymer Degradation and Stability provides a forum for the publication of their work. (materialstoday.com)
  • Rose also demonstrated that ubiquitin-mediated protein degradation helps control a number of other critical biochemical processes, including cell division, the repair of defects in DNA, and gene transcription, the process in which genes use their coded instructions to manufacture a protein. (britannica.com)
  • The ubiquitin system for protein degradation. (nih.gov)
  • Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted protein degradation by the ubiquitin-proteasome system represent a new therapeutic modality and are the focus of great interest, owing to potential advantages over traditional occupancy-based inhibitors with respect to dosing, side effects, drug resistance and modulating 'undruggable' targets. (nature.com)
  • Importantly, fewer than 10 of the more than 600 E3 ubiquitin ligases have so far been exploited for targeted protein degradation, and expansion of knowledge in this area is a key opportunity. (nature.com)
  • Here, we briefly discuss lessons learned about targeted protein degradation in chemical biology and drug discovery and systematically review the expression profile, domain architecture and chemical tractability of human E3 ligases that could expand the toolbox for PROTAC discovery. (nature.com)
  • Fig. 1: Substrate recruitment in targeted protein degradation. (nature.com)
  • Fig. 2: Structures of ternary complexes formed during targeted protein degradation. (nature.com)
  • Itoh, Y., Ishikawa, M., Naito, M. & Hashimoto, Y. Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins. (nature.com)
  • Fisher, S. L. & Phillips, A. J. Targeted protein degradation and the enzymology of degraders. (nature.com)
  • Proteasomal protein degradation in Mycobacteria is dependent upon a prokaryotic ubiquitin-like protein. (nature.com)
  • Protein degradation has been identified as a centerpiece of regulation of cell functions. (springer.com)
  • This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. (springer.com)
  • Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated. (springer.com)
  • At the University of Cincinnati her research focused on the identification and cytotoxicity of chemical warfare agent degradation products and protein phosphorylation studies on cerebral spinal fluid, a study that may help in the development of drugs for patients diseased with a hemorrhagic stroke. (wiley.com)
  • These results and the results obtained in the presence of a normal motA gene suggest that gene 61.5 protein functions to discriminate mRNAs for degradation in a stage-dependent manner. (genetics.org)
  • Biochemical and genetic data reveal that TCDD incudes ubiquitination of AhR and shortening of the half-life of the protein through the 26S-proteasome mediated protein degradation. (cdc.gov)
  • Our findings provide new insights into the control of the activity of agonist activated AhR through a regulated, proteasomal protein degradation pathway. (cdc.gov)
  • Rates and Deadlines listed below are for the 2020-X8 "Targeted Protein Degradation" conference only. (keystonesymposia.org)
  • Here's an example in the protein degradation field: a team at Promega (well-known vendors of assay reagents and kits) report a new system to evaluate the extent and time course of protein degradation compounds. (sciencemag.org)
  • For targeted degradation, you assemble a molecule (often rather odd-looking by the time you're finished) that has a ligand for your desired marked-for-destruction protein at one end, a linker group, and a ligand for one of the ligase enzymes at the other. (sciencemag.org)
  • As it stands now, protein degradation seems to have rather too high a Voodoo Quotient. (sciencemag.org)
  • What you see are that (1) the more degrader molecule you add, the more BRD protein degradation you get, but only up to a saturation point, (2) BRD2 and BRD4 degrade much more quickly than BRD3 if you're using MZ1, but not if you're using dBET1, and (3) the time needed to reach maximum degradation varies quite a bit depending on the protein and degrader. (sciencemag.org)
  • In particular our research focuses on oncogenic protein degradation in relation to biology of cancer. (ki.se)
  • Through a genetic screening in fruit flies, and later verification in rodents, the team used both in vitro and in vivo system to demonstrate that overexpressing Vps4 protein could delay the degradation of damaged nerves by up to three days. (chinadaily.com.cn)
  • We showed that palmitic acid-induced oxidative stress caused conjugation of the ubiquitin-like NEDD8 protein to SRSF3 and proteasome-mediated degradation. (jci.org)
  • describe a mechanism by which the ARTS protein promotes proteasome-mediated degradation of Bcl-2 and thereby stimulates cell death. (mendeley.com)
  • NEW YORK (GenomeWeb) - Evotec said today that it has entered into a drug-discovery alliance with biotech firm Celgene that will focus on targeted protein degradation. (genomeweb.com)
  • Fibrin degradation products (FDPs) are the substances left behind when clots dissolve in the blood. (medlineplus.gov)
  • Fibrinogen breakdown products (fibrin degradation products, FDP) - blood. (medlineplus.gov)
  • Fibrin Degradation Products (FDP) that occur are very heterogeneous and include products derived from fibrin, soluble complexes, degradation products from fibrinogen, and from nonstabilized fibrin. (labcorp.com)
  • Little is known about lignin degradation in complex ecosystems, such as insect guts, where a consortium of microbes may be involved in degradation rather than just a single species. (pnas.org)
  • The international community is working to halt and reverse land degradation, restore degraded ecosystems and sustainably manage our resources through a commitment to land degradation neutrality (LDN). (thegef.org)
  • Feb. 1, 2013 - A study published in Conservation Letters this week found that freshwater ecosystems in the Amazon are highly vulnerable to environmental degradation. (cbd.int)
  • Until recently, companies had no systematic way of understanding the threats and opportunities stemming from one part of this growing natural resource supply constraint - the degradation of ecosystems and the benefits or "ecosystem services" they provide. (wri.org)
  • Sustainable land use can help to reduce the impacts of agriculture and livestock, preventing soil degradation and erosion and the loss of valuable land to desertification. (worldwildlife.org)
  • Effects include land degradation, soil erosion and sterility, and a loss of biodiversity, with huge economic costs for nations where deserts are growing. (worldwildlife.org)
  • Loss of soil organic carbon is one of the principal signs of land degradation, and land degradation is one of the leading challenges for sustainable development, biodiversity conservation, and mitigating and adapting to climate change. (iucn.org)
  • When land is degraded, soil carbon can be released into the atmosphere, along with nitrous oxide, making land degradation one of the biggest contributors to climate change. (iucn.org)
  • Reversing land degradation and increasing soil organic carbon provides one of the surest and lowest-cost multiple-wins: climate change mitigation and adaptation, conservation of biodiversity, and increased food production. (iucn.org)
  • Amongst such enclosed seas the Mediterranean Sea and its adjacent basin, the Black Sea, experience the severe impact of human activities, due to the population expansion of the last 50 years, urban growth, tourism, intensive agriculture and pollution, eutrophication, soil degradation, disposal of industrial and domestic waste and desertification. (innovations-report.com)
  • There is an acute need for systematic analysis and georeferencing of the various forms of multiple land use in dryland areas, including aspects such as inputs, labour requirements, local redistribution of soil fertility, as a prerequisite for any well integrated intervention to halt land degradation and rehabilitate rural livelihood systems. (fao.org)
  • Deforestation is the main cause of soil degradation in South America (41%), in Asia (40%) and also in Europe (38%), particularly in Central and Oriental European countries. (goodplanet.info)
  • The World Resources Institute published an article which highlighted the importance of soil ecosystem management especially in the search for solutions to fight desertification and certain forms of soil degradation. (goodplanet.info)
  • This is what these authors suggested for the risks linked to soil degradation to be managed better. (goodplanet.info)
  • Human activity is the main cause of soil degradation. (goodplanet.info)
  • Agriculture plays a large part in soil degradation, especially clearing, irrigation, the spreading of chemical fertilisers and pesticides, overgrazing and even the passage of heavy farming equipment. (goodplanet.info)
  • By threatening the productive capacity and/or reproduction of vegetation, overgrazing strips soils thus making them more vulnerable to hydraulic erosion (this is the case for 56% of soil degradation) and wind erosion (28% of cases). (goodplanet.info)
  • In drylands, land degradation is known as desertification. (iucn.org)
  • Recent estimates of the global loss of ecosystem services due to land degradation and desertification are between US$ 6.3 and 10.6 trillion annually. (iucn.org)
  • In 2015, the 12th session of the Conference of the Parties to the United Nations Convention to Combat Desertification (UNCCD COP 12) adopted 35 decisions related to desertification, land degradation and drought. (thegef.org)
  • This reflects the importance of GEF support for the implementation of the Convention and for mobilizing additional sustainable financing and responsible and sustainable investments that address desertification, land degradation, and drought issues. (thegef.org)
  • Land degradation, however, constrains the supply of these ecosystem services and negatively impacts household income and consumption in many parts of the world, worsening poverty and widening inequalities. (unccd.int)
  • A review of methods, data, and models to assess changes in the value of ecosystem services from land degradation and restoration ," Ecological Modelling , Elsevier, vol. 319(C), pages 190-207. (repec.org)
  • The films were characterized at different degradation times by differential scanning calorimetry (DSC), Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). (chemweb.com)
  • When this gene is mutated, both degradation and specific cleavage of late-gene mRNA is induced after a delay, as exemplified by soc mRNA. (genetics.org)
  • This is attributable to an activity of gene 61.5 specific for degradation of middle-gene mRNA. (genetics.org)
  • The degradation of middle-gene mRNA in the presence of a normal gene 61.5 appears in parallel with the degradation of late-gene mRNA in its absence. (genetics.org)
  • Moreover, ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines and transcription inhibitors. (nih.gov)
  • Contaminants Affecting the Formation of Soft Particles in Bio-Based Diesel Fuels during Degradation," SAE Technical Paper 2019-01-0016, 2019, https://doi.org/10.4271/2019-01-0016 . (sae.org)
  • An accurate analysis of deforestation and forest degradation requires that clear distinctions be made between these two terms, between the factors and underlying causes of these processes and between direct (e.g. the different forms of agriculture) and indirect (e.g. the development of logging road infrastructure)factors. (fao.org)
  • It is important at the outset to carefully distinguish between the underlying causes of deforestation and forest degradation, about which there might be divergent views, and the actual factors, which could be part of the area of objective observation. (fao.org)
  • The confusion that reigns between the two notions of deforestation and forest degradation has all too often been kept alive, or unconsciously made. (fao.org)
  • From the end of the 1940s to the beginning of the 1990s, over 90% of the degradation of productive land was due to overgrazing, deforestation and inappropriate agricultural practices. (goodplanet.info)
  • However, these biocompatible and biodegradable aromatic polyanhydrides have radical or aliphatic bonds resulting in compounds with slow degradation times as well as relatively insoluble degradation products unless incorporated into a copolymer containing a more hydrophilic monomer, such as sebacic acid. (google.com)
  • Degradation of Hazardous organic compounds by rhizosphere microbial communities (T.A. Anderson, D.C. White, B.T. Walton). (elsevier.com)
  • Methods to preserve and prevent further degradation, include a dry environment, because the presence of water and moisture encourage the growth of bacteria and further damage. (news-medical.net)
  • The experimental results show that the molecular weight or intrinsic viscosity of polymer melts decreased with ultrasonic irradiation time and approached a limiting value, below which no further degradation took place. (chemweb.com)
  • Hence, our aim is to understand the complexity of various degradation systems and its explicit interactions and mechanisms, that might provide a foundation for the development of diagnostic strategies and major conceptual advance to uncover novel therapeutic drug targets in malignancies as well as in other human disorders. (ki.se)
  • covering the various degradation mechanisms through scientific research. (coursera.org)
  • The selective degradation of superfluous or damaged peroxisomes is facilitated by several tightly regulated pathways. (hindawi.com)
  • Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. (nature.com)
  • Lessons in PROTAC design from selective degradation with a promiscuous warhead. (nature.com)
  • Several PHB depolymerases have been purified from some microorganisms and their properties have been characterised.11-13 Enzymatic degradation depends on (cristallinity) spherulite size and chemical composition of PHAs. (redorbit.com)
  • The enzymatic degradation of PHB films was investigated using an extracellular PHB depolymerase from Alcaligenes faecalis T1. (redorbit.com)
  • Thermogravimetric analysis indicates that this series of polymers is stable through fusion, and consequently these new poly(ester amide)s can be easily processed from the melt.Hydrolytic and enzymatic degradation studies, where weight losses, intrinsic viscosity changes, NMR spectra and calorimetric data of degraded samples were evaluated, have also been undertaken. (chemweb.com)
  • Chauhan A, Chakraborti AK, Jain RK (2000) Plasmid-encoded degradation of p-nitrophenol and 4-nitrocatechol by Arthrobacter protophormiae . (springer.com)
  • Yet land degradation is putting the health, livelihoods and security of an estimated 3.2 billion people at risk. (thegef.org)
  • However, the impact of land degradation is especially severe on livelihoods of the poor who heavily depend on natural resources. (ifpri.org)
  • Microbial metabolism of CNAs has been studied, and several metabolic pathways for degradation of CNAs have been proposed. (springer.com)
  • Metabolic pathways of purine (red) and pyrimidine (green) nucleotide degradation, via the nucleoside and base to the respective metabolic end products (blue), indicating the enzymes (pink) deficient in genetic disorders affecting these pathways. (els.net)
  • This book describes nerve agents and vesicants, their decomposition and their degradation products' chemistry as well as their toxicity including a list of detection techniques of nerve agents and their degradation products. (wiley.com)
  • The Marker degradation is a three-step synthetic route in steroid chemistry developed by American chemist Russell Earl Marker in 1938-40. (wikipedia.org)
  • As with much steroid chemistry, the Marker degradation relies heavily on kinetic control to degrade the sapogenin side chain while leaving similar functional groups on the steroid nucleus (relatively) unaffected. (wikipedia.org)
  • Productivity impacts of land degradation are due to a decline in land quality on site where degradation occurs (e.g. erosion) and off site where sediments are deposited. (bartleby.com)
  • range of degradation hazards, including erosion by water and wind, sandblasting of crops and emerging seedlings on arable land and rangeland, deposition of windblown sand, plant nutrient depletion in the soils, surface sealing or crusting, salinization in some areas. (fao.org)
  • The degradation process can take different forms: hydraulic erosion, wind erosion, changes in the soil's composition, physical degradation. (goodplanet.info)
  • Nucleotide degradation is an integrated process in all human cells that is intimately linked with the pathways of nucleotide synthesis and salvage. (els.net)
  • Synthesis and degradation of dimethyl nitrosamine in the natural environment and in humans (T. Yoshinari). (elsevier.com)
  • Heightened expression of epsins induced by ROS facilitates epsin binding to VEGFR3 in the Golgi, promotes newly synthesized VEGFR3 degradation, and progressively decreases availability of VEGFR3 at the cell surface. (jci.org)
  • Hydrolytic degradation of PHAs is not evident as shown on poly(3- hydroxyoctanoate) (PHO) and is depending on the structure of the polyester and more particularly on the nature of the side chains. (redorbit.com)
  • Forest area changes in industrialized countries, generally positive, have been less the subject of study, contrary to what has been the case of forest degradation resulting from air pollution, fires, insects and diseases. (fao.org)
  • Bangladesh pays a high price from environment degradation and pollution in its urban areas. (worldbank.org)
  • The FDP Plasma kit provides reagents for the detection and semi-quantitation of fibrin/fibrinogen degradation products (FDP) in plasma by the use of latex particles coated with monoclonal antibodies to FDP. (labcorp.com)
  • Considering that Nand C- terminal peptide carrying PEST motifs form disordered loops in the globular proteins after caspase cleavage, it is postulated here that these exposed termini serve as unstructured initiation site, coupling caspase cleavage and ubiquitinproteasome dependent and independent degradation of short-lived proteins. (ingentaconnect.com)
  • The Fenton process utilizes iron catalysts with H 2 O 2 to create powerful, oxidizing hydroxides for the degradation of organic pollutants such as sewage and sludge as well as dyes. (wikipedia.org)
  • Beunink J, Rehm HJ (1990) Coupled reductive and oxidative degradation of 4-chloro-2-nitrophenol by a co-immobilized mixed culture system. (springer.com)
  • Oxidative degradation of adhesives based on silane terminated polypropylene oxide and polypropylene oxide (PPO) was studied. (diva-portal.org)
  • The combination of rapeseed oil and PPO as plasticizer in the parquet adhesive gave rise to oxidative degradation in contact with screeds of certain minerals. (diva-portal.org)