• Hippocampal pathology is central to Alzheimer's disease (AD) and other forms of dementia such as frontotemporal lobar degeneration (FTLD). (nih.gov)
  • Is granulovacuolar degeneration an essential pathological component of Alzheimer's disease? (nih.gov)
  • Granulovacuolar degeneration (GVD) is a histopathological feature of Alzheimer's disease (AD) and some non-Alzheimer neurodegenerative diseases. (nih.gov)
  • Degeneration of human orexinergic neurons across Braak stages of Alzheimer's disease: Implication for pathogenesis, sleep dysfunction, and therapy. (ucsf.edu)
  • The presentation of degenerative disease in focal areas of the cerebral cortex is the hallmark of the family of diseases referred to as frontotemporal dementia (also termed frontotemporal lobar degeneration). (medscape.com)
  • In Alzheimer disease both extracellular amyloid deposits and intracellular amyloid β protein may activate caspases, leading to cleavage of nuclear and cytoskeletal proteins, including tau protein. (elsevierpure.com)
  • Thus, pericyte degeneration as seen in neurological disorders such as Alzheimer's disease may contribute to neurovascular dysfunction and neurodegeneration associated with human disease. (nature.com)
  • BrightFocus funds research in an effort to discover cures for Alzheimer's disease, macular degeneration and glaucoma, and provides information and free English and Spanish resources to increase awareness about these diseases. (wikipedia.org)
  • Through its research programs - Alzheimer's Disease Research, National Glaucoma Research, and Macular Degeneration Research - the Foundation has awarded nearly $290 million in research funding. (wikipedia.org)
  • BrightFocus provides free public education and free printed brochures and publications on brain and eye diseases in English and Spanish, including Alzheimer's disease, macular degeneration, and glaucoma. (wikipedia.org)
  • Our work further identifies cerebrospinal fluid neurofilament light and plasma neurofilament light as biomarkers of axonal degeneration in patients with mild cognitive impairment and Alzheimer's disease. (imrpress.com)
  • article{Benussi2021, abstract = {Dysfunctions in the endo-lysosomal system have been hypothesized to underlie neurodegeneration in major neurocognitive disorders due to Alzheimer's disease (AD), Frontotemporal Lobar Degeneration (FTLD), and Lewy body disease (DLB). (dissem.in)
  • Macular degeneration is an eye disease that causes a person's central vision to blur. (medicalnewstoday.com)
  • Age-related macular degeneration (AMD) is a progressive eye disease that damages the macula - the small area of the retina that is needed for sharp, central vision. (medicalnewstoday.com)
  • Lecanemab-irmb is the first amyloid beta-directed antibody to be converted from an accelerated approval to a traditional approval for the treatment of Alzheimer disease. (pharmacytimes.com)
  • The FDA has converted the accelerated approval of lecanemab-irmb (Leqembi) to a full traditional approval for the treatment of Alzheimer disease (AD) in patients with mild cognitive impairment or mild dementia state of disease. (pharmacytimes.com)
  • Braak Alafuzoff I, Arzberger T et al (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. (springer.com)
  • A new paper in Innovation in Aging shows that a great deal of media coverage of the actor Bruce Willis' condition, frontotemporal degeneration, was inaccurate, revealing the public's limited knowledge of the disease. (medicalxpress.com)
  • White matter (WM) degeneration is a critical component of early Alzheimer's disease (AD) pathophysiology. (wisc.edu)
  • Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. (cshlpress.com)
  • Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. (cshlpress.com)
  • Contributors discuss the biochemistry and cell biology of amyloid β-protein precursor (APP), tau, presenilin, β-secretase, and apolipoprotein E and their involvement in Alzheimer disease. (cshlpress.com)
  • Anyone following the primary literature on Alzheimer s disease research knows that keeping abreast of this rapidly evolving field has become a Herculean task. (cshlpress.com)
  • Introduction: Synaptic dysfunction and degeneration is one of the earliest events in Alzheimer's disease (AD) and the best correlate of cognitive decline. (lu.se)
  • Alzheimer disease causes progressive cognitive deterioration and is characterized by beta-amyloid deposits and neurofibrillary tangles in the cerebral cortex and subcortical gray matter. (msdmanuals.com)
  • laboratory and imaging tests are usually done to look for specific findings that suggest Alzheimer disease and to identify other treatable causes of dementia. (msdmanuals.com)
  • In the US, an estimated 10% of people ≥ 65 have Alzheimer disease. (msdmanuals.com)
  • Most cases of Alzheimer disease are sporadic, with late onset ( ≥ 65 years) and unclear etiology. (msdmanuals.com)
  • Mutations in genes for the amyloid precursor protein, presenilin I, and presenilin II may lead to autosomal dominant forms of Alzheimer disease, typically with early onset. (msdmanuals.com)
  • Risk of Alzheimer disease is substantially increased in people with two epsilon-4 alleles and may be decreased in those who have the epsilon-2 allele. (msdmanuals.com)
  • For people with two epsilon-4 alleles, risk of developing Alzheimer disease by age 75 is about 10 to 30 times that for people without the allele. (msdmanuals.com)
  • Alzheimer disease (AD) is an acquired disorder of cognitive and behavioral impairment that markedly interferes with social and occupational functioning. (medscape.com)
  • Coronal T1-weighted magnetic resonance imaging (MRI) scan in a patient with moderate Alzheimer disease. (medscape.com)
  • It consists of residues K 254 -F 378 of 3R tau, while other taupathies (including Alzheimer's disease, progressive supranuclear palsy, and corticobasal ganglionic degeneration) either have 4Rtau or a combination of 3R and 4Rtau. (medscape.com)
  • Language comprehension profiles in Alzheimer's disease, multi-infarct dementia, and frontotemporal degeneration. (bvsalud.org)
  • APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort. (cdc.gov)
  • Unlike Alzheimer disease, which typically presents with impairment of recent memory associated with entorhinal cortex and hippocampal dysfunction, Pick disease typically affects the frontal and/or anterolateral temporal lobes. (medscape.com)
  • First described in 1892, with the defining pathologic characteristics first reported by Alois Alzheimer in 1911, Pick disease is now considered by some to be part of a complex of neurodegenerative disorders with similar or related histopathologic and clinical features. (medscape.com)
  • Primary progressive aphasia is a focal atrophy syndrome that may be associated with Pick disease, Alzheimer disease, or other pathology. (medscape.com)
  • The condition described in the North American literature as primary progressive aphasia and that described in the European literature as frontal dementia have been combined under the term frontotemporal lobe dementia (FTD) or frontotemporal lobar degeneration (FTLD). (medscape.com)
  • An alternate term, frontotemporal lobar degeneration, relates to pathologies associated with the frontotemporal lobe dementia syndromes. (medscape.com)
  • Frontotemporal Degeneration, Alzheimer's, and Dementia are diseases with no cure, minimal treatments, and have a deep impact on families and caretakers. (brightfunds.org)
  • Proteolysis of tau may be critical to neurofibrillary degeneration, which correlates with dementia (see the related article beginning on page 121). (elsevierpure.com)
  • BrightFocus Foundation offers free monthly low-vision audio podcast programs with medical experts on Glaucoma and Macular Degeneration and a free expert Alzheimer's video series called "Zoom in On Alzheimer's and Dementia" with medical doctors. (wikipedia.org)
  • Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: Cause or effect? (elsevierpure.com)
  • Dive into the research topics of 'Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: Cause or effect? (elsevierpure.com)
  • Macular Degeneration Research Program, currently funding 58 research projects. (wikipedia.org)
  • Granulovacuolar degeneration bodies (GVDs) are double membrane vacuoles present in neurons, having an immunohistochemical signature that suggests that they derive from the autophagic system [ 22 ]. (biomedcentral.com)
  • The features of GRN -related frontotemporal lobar degeneration result from the gradual loss of neurons in regions near the front of the brain called the frontal and temporal lobes . (medlineplus.gov)
  • However, it is unclear why the loss of neurons occurs in the frontal and temporal lobes more often than other brain regions in people with GRN -related frontotemporal lobar degeneration. (medlineplus.gov)
  • Using primary neuron-enriched and neuron/glia cultures from the rat mesencephalon, we discovered an extraordinary feature for rotenone-induced degeneration of cultured dopaminergic neurons. (jneurosci.org)
  • This is the first report demonstrating that microglia play a pivotal role in rotenone-induced degeneration of dopaminergic neurons. (jneurosci.org)
  • Los agregados anatomopatológicos de las proteínas tau se asocian con mutación del gen tau en el cromosoma 17 en pacientes con ENFERMEDAD DE ALZHEIMER, DEMENCIA, TRASTORNOS PARKINSONIANOS, PARÁLISIS SUPRANUCLEAR PROGRESIVA y degeneración corticobasal. (bvsalud.org)
  • granulovacuolar degeneration. (nih.gov)
  • Immunohistochemical analyses using isoform-selective antibodies demonstrated that MARK4 in a phosphorylated form colocalizes with p-tau Ser 262 in granulovacuolar degeneration bodies (GVDs) that progressively accumulate in AD. (biomedcentral.com)
  • However, a standardized clinical evaluation of asymmetric neuronal degeneration and its impact on clinical findings has only sporadically been investigated for F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). (uni-muenchen.de)
  • This study aimed to evaluate the impact of lateralized neuronal degeneration on the detection of AD by detailed clinical testing. (uni-muenchen.de)
  • Furthermore, we compared associations between clinical evaluation and lateralized neuronal degeneration between FDG-PET hypometabolism and hippocampal atrophy. (uni-muenchen.de)
  • Finally, we investigated if specific subtests show associations with lateralized neuronal degeneration. (uni-muenchen.de)
  • For assessment of neuronal degeneration, FDG-PET hypometabolism in brain regions typically affected in AD were graded by visual (3D-surface projections) and semiquantitative analysis. (uni-muenchen.de)
  • Measures of asymmetry were calculated to quantify lateralized neuronal degeneration and asymmetry scores were subsequently correlated with CERAD. (uni-muenchen.de)
  • Direct comparison of CERAD-PET associations in cases with right- and left-lateralized neuronal degeneration estimated a detection gap of 2.7 years for right-lateralized cases. (uni-muenchen.de)
  • 0.001) and constructional praxis (semiquantitative: β = 0.292, p = 0.008) showed significant associations with right-hemispheric neuronal degeneration. (uni-muenchen.de)
  • Conclusions: Asymmetry of deteriorated cerebral glucose metabolism has a significant impact on the coupling between neuronal degeneration and cognitive function. (uni-muenchen.de)
  • Right dominant neuronal degeneration shows a delayed detection by global CERAD testing and requires evaluation of specific subdomains of cognitive testing. (uni-muenchen.de)
  • Blockade of N-methyl-D-aspartate (NMDA) glutamate receptors by MK-801 induces neuronal degeneration in the posterior cingulate/retrosplenial cortex and other corticolimbic regions although damage in the latter has not been adequately characterized. (wustl.edu)
  • We found that MK-801 triggers neuronal degeneration in a widespread pattern similar to that induced by phencyclidine and that females showed more damage than males. (wustl.edu)
  • b]Terminal/Primary diagnosis[/b] Can senile degeneration of the brain (G31.1) be a terminal/primary dx for Hospice Medicare? (aapc.com)
  • A clinical study evaluating biomarkers of immunosenescence in the progression of Age-Related Macular Degeneration. (southampton.ac.uk)
  • Discussion - Our results suggest that WM degeneration may be more pervasive in AD than is commonly appreciated and that innovative DWI models such as MAP‐MRI may provide clinically viable biomarkers of AD‐related neurodegeneration in the earliest stages of AD progression. (wisc.edu)
  • Thus, identification and validation of biomarkers reflecting synaptic degeneration to be used as prognostic biomarkers are greatly needed. (lu.se)
  • In SAMP8 mice , the expression level of upregulated miRNAs were the highest in the brainstem , wherein age-related brain degeneration occurs early. (bvsalud.org)
  • It was demonstrated that the order of specific miRNA expression levels corresponded to the progression order of age-related brain degeneration. (bvsalud.org)
  • Specifically, they examined glial cells because microglial dysfunction is known to lead to neural degeneration. (scitechdaily.com)
  • It is this gene that is responsible for the degeneration in Alzheimer's patients. (scienceblogs.com)
  • Ultrastructural evaluation revealed that a major feature of the neurotoxic action involves degeneration of dendritic spines which entails loss of synaptic complexes. (wustl.edu)
  • I am currently leading a UK multi-centre clinical trial evaluating photodynamic laser treatment for central serous chorioretinopathy funded by the NIHR and an international research project funded by the Wellcome Trust evaluating machine learning as a tool to better understand age related macular degeneration (AMD). (southampton.ac.uk)
  • However, recent human clinical research in Italy and Australia has discovered a non-pharmaceutical approach that proved efficacious for improving eyesight with macular degeneration sufferers safely. (naturalnews.com)
  • Alzheimer Europe's database on research projects was developed as part of the 2020 Work Plan which received funding under an operating grant from the European Union's Health Programme (2014-2020). (alzheimer-europe.org)
  • Using loss-of-function pericyte-deficient mice, here we show that pericyte degeneration diminishes global and individual capillary CBF responses to neuronal stimuli, resulting in neurovascular uncoupling, reduced oxygen supply to the brain and metabolic stress. (nature.com)
  • Wet macular degeneration does involve retina capillary leakage. (naturalnews.com)
  • Foram analisados 70 pacientes (entre 57 à 91 anos) com Doença Alzheimer e Doença Parkinson, por meio de avaliação de prontuários neurológicos e exame clinico oral. (bvsalud.org)
  • Macular degeneration mostly affects central vision, forcing people to rely more on less distinct peripheral vision to recognize objects and faces. (naturalnews.com)
  • Age-related brainstem degeneration through microRNA modulation in mice. (bvsalud.org)