For example, we observed increased platelet aggregation that plays a key role in the blood viscosity value in blood vessels with low shear rates. (annaly-nevrologii.com)
Increased erythrocyte aggregation, decreased erythrocyte deformation, changed hematocrit and plasma viscosity leads to a blockage of capillaries, a slowed down blood flow and develops a capillary stasis. (rheology.biz)
Pentoxifylline administration has been shown to produce dose-related hemorrheologic effects, lowering blood viscosity, and improving erythrocyte flexibility. (drugs.com)
Danshen can affect hemostasis in several ways, including inhibition of platelet aggregation, interference with the extrinsic blood coagulation, Antithrombin III (ATIII) - like activity, and promotion of fibrinolytic activity. (bfsumastore.com)
Hematocrit2
The erythrocyte deformability is determined by measurement of passage time (reciprocal of deformability) of erythrocyte suspension in phosphate buffered saline at hematocrit 6% through cellulose … membranes. (iospress.com)
The shape of erythrocytes change from biconcave discoid to an ellipsoid due shear flow in microcapillaries that provides a larger specific surface area-to-volume ratio for optimal microvascular perfusion and tissue oxygenation establishing the importance not only of total hematocrit but also of the capacity for large deformations in physiology. (cfidsresearch.com)
Membrane7
It measures, among others, RBC deformability and aggregation and is used in the diagnosis and treatment of malaria, sickle cell disease, and RBC membrane disorders. (sabaindomedika.com)
2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)
Erythrocytes must be able to rapidly deform while also maintaining membrane stability when exposed to varying shear stresses. (hemorheology.com)
The role of membrane organization is prominently reflected in red blood cell deformation and aggregation. (frontiersin.org)
The observations suggest that deformability and aggregation share at least one common, membrane-related molecular mechanism. (frontiersin.org)
Together with data obtained after treatment with various agents known to affect membrane organization in vitro , our findings suggest that a phosphorylation-controlled interaction between the cytoskeleton and the integral membrane protein band 3 is part of the membrane-centered mechanism that plays a role in deformability as well as aggregation. (frontiersin.org)
Hemodynamic2
Ebrahimi S, Bagchi P. A computational study of red blood cell deformability effect on hemodynamic alteration in capillary vessel networks. (hemorheology.com)
Laviocard+" promotes improvement rheological blood properties as well as the condition of erythrocytes, improves its deformability and hemodynamic characteristics. (ametis.ru)
Hemorheological1
The hemorheological parameters, erythrocyte aggregation and deformability are determined in jaundice patients and are compared with that of healthy subjects. (iospress.com)
Inhibit1
Pentoxifylline has been shown to increase leukocyte deformability and to inhibit neutrophil adhesion and activation. (drugs.com)
Parameters4
The analysed data is represented by aggregation parameters-aggregate size index, aggregate sedimentation time index, total number of fluctuations, time required for completion of process, effective number of cells and effective cellular sedimentation duration. (iospress.com)
However, no significant difference was observed in the osmotic deformability parameters of HV. (semcs.net)
To address the potential interdependence of these two parameters, we measured deformation and aggregation in a variety of physiological as well as pathological conditions. (frontiersin.org)
As a first step, we correlated a number of deformability and aggregation parameters in red blood cells from healthy donors, which we obtained in the course of our studies on red blood cell homeostasis in health and disease. (frontiersin.org)
Osmotic1
RBC deformability and deformability under an osmotic gradient were significantly reduced in COVID-19 patients. (dshs-koeln.de)
Oxidative2
Impaired RBC deformability might also be related to morphological changes and/or increased oxidative state. (dshs-koeln.de)
Erythrocytes are potent scavengers of oxidative stress, and their shape changes appreciably in response to oxidative stress and certain inflammatory conditions including obesity and diabetes. (cfidsresearch.com)
However, higher shear rates were necessary to balance the aggregation-disaggregation in COVID-19 patients which might be, among others, related to morphological changes. (dshs-koeln.de)
RBCs1
We tested the deformability of RBCs using a high-throughput microfluidic device which mimics blood flow through microcapillaries. (cfidsresearch.com)
Velocity2
In these reports image processing algorithms and techniques for the assessment of red blood cell aggregation, whole blood coagulation and RBC velocity (for the ESR index) are presented. (cut.ac.cy)
In these cells its loss led to a slightly slower aggregation velocity which seems to be compensated by an increased number of platelets. (biomedcentral.com)
Sedimentation2
RR Mechatronics is the world leader in automated Erythrocyte Sedimentation Rate (ESR) instruments. (sabaindomedika.com)
While routine blood tests for humans indirectly measure inflammation through RBC sedimentation induced by RBC aggregation, hemorheology is not commonly incorporated into veterinary medicine. (hemorheology.com)
Characteristics2
Effects of erythrocyte aggregation, haematocrit and deformability in the flow characteristics of blood, flowing in a TiO2 coated microfluidic channel. (cut.ac.cy)
Tissue oxygenation depends on hemoglobin as much as on red blood cell (RBC) characteristics such as metabolism, communication with the immune system, deformability and aggregation behavior. (frontiersin.org)
Therefore, the pathological changes in elastic properties of the erythrocyte membranes in stroke are not corrected by ongoing standard therapy. (annaly-nevrologii.com)
Annexin A7 is a Ca 2+ - and phospholipid-binding protein, which was isolated as the agent that mediated aggregation of chromaffin granules and fusion of phospholipid membranes in the presence of Ca 2+ . (biomedcentral.com)
Observations1
The observations show that the aggregation process in jaundice starts earlier, form compact structures which move faster initially and thus reducing the effective number of cells in the observation volume at all time intervals compared to that of normal suspensions. (iospress.com)
Patients2
BACKGROUND: Thalassemia patients have reduced red cell deformability and decreased plasma zinc levels in their blood. (semcs.net)
We measure hundreds of cells from each patient, so, because of this, even though the number of patients is low, we get a very statistically significant distinction between patient and healthy cells' deformability. (cfidsresearch.com)
Significantly1
The rheologic properties of blood - aggregability , deformability and elasticity - significantly impact vascular flow resistance, particularly in the microcirculation. (hemorheology.com)
Effects2
These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats. (scialert.net)
l Trilinolein, isolated from the traditional Chinese herb Sanchi (Panax notoginseng), has been shown to have various beneficial effects including reducing thrombogenicity, erythrocyte deformability and arrhythmias. (bfsumastore.com)
Disease1
1 There are a number of conditions associated with poor RBC deformability, such as poor circulatory health, diabetes, cardiovascular disease, sepsis, sickle cell disease, and various other blood disorders. (hemorheology.com)
Rats2
The increased levels of oxidants and decreased levels of enzymatic, nonenzymatic antioxidants, glycoproteins and ATPases were observed in erythrocytes of aged rats. (scialert.net)
Effect of total glucosides of paeony and Tripterygium wilfordii polyglycosides on erythrocyte methotrexate polyglutamates in rats, analysed using ultra-high-performance liquid chromatography-tandem mass spectrometry. (academic-accelerator.com)
Effect1
OBJECTIVES The aim of the study was to explore the effect of total glucosides of paeony (TGP) and Tripterygium wilfordii polyglycosides (TWP) on erythrocyte methotrexate polyglutamates (MTXPGs), the metabolites of methotrexate (MTX). (academic-accelerator.com)
High1
In this study, a novel high-performance liquid chromatography-tandem mass spectrometry method was developed and validated to simultaneously determine erythrocyte methotrexate polyglutamates using stable isotope-labeled internal standards. (academic-accelerator.com)
Assess1
Besides the formalism of both many and torpedo injection quantization Poets, a primary tracking erythrocyte, used on MM5-CAMx diffusion, was studied to assess the accuracy and solve( such and hydrodynamic) of the able graphs and its problems. (taido-hannover.de)
Scales1
With Fishers scales the shop henri cartier can describe the aggregation of speed-up per molecular, the advantage of each photon, the particle desktop and with some computations Delayed Start( from a mercury to 365 flows). (taido-hannover.de)
RBC aggregation index remained unaffected. (dshs-koeln.de)
Method1
Simultaneous determination of erythrocyte methotrexate polyglutamates by a novel and simple HPLC-MS/MS method with stable isotope-labeled internal standards. (academic-accelerator.com)
Importance1
Erythrocyte aggregation: basic aspects and clinical importance. (hemorheology.com)