While tiapride preferentially targets the limbic system over the striatum, its moderate antagonistic effect on striatal dopamine receptors makes it effective in treating motor deficits that involve this area, such as tardive dyskinesia and chorea. (wikipedia.org)
It has also been suggested that histamine plays a role in sensory gating via the H1 and H3 receptors. (epiphanyasd.com)
Induces also bronchial relaxation and increases heart rate and contractility by stimulating beta-adrenergic receptors. (medscape.com)
Inhibits2
Western blotting data further reveals that neflamapimod inhibits LPS-induced phosphorylation of p38 MAPKα and the activation of NF-κB signaling in ECs. (bvsalud.org)
They compete with histamine for histamine receptor type 1 (H1) receptor sites in the blood vessels, GI tract, and respiratory tract, which, in turn, inhibits physiologic effects that histamine normally induces at the H1 receptor sites. (medscape.com)
Cognitive2
The novel ketone diet, therefore, improved physical performance and cognitive function in rats, and its energy-sparing properties suggest that it may help to treat a range of human conditions with metabolic abnormalities. (epiphanyasd.com)
Clinically, when GMP-level plasminogen was administered to 6 AD patients for 1-2 weeks, their average scores on the Minimum Mental State Examination (MMSE), which is a standard scoring system used to measure the memory loss and cognitive deficits, were extremely significantly improved by 4.2 +/- 2.23 points, e.g., an average increase from 15.5 +/- 8.22 before treatment to 19.7 +/- 7.09 after treatment. (inra.fr)
Significantly1
Consistent with vascular inflammation, LPS-treated rat arteries exhibit significantly diminished vasodilation response to acetylcholine, however, arteries from rats treated with neflamapimod maintain their vasodilation capacity, demonstrating its ability to limit LPS-induced vascular inflammation. (bvsalud.org)
Mechanisms1
Inhalation of agents in the workplace can induce asthma in a mechanisms involved in asthma. (cdc.gov)
Effects3
A derivative of benzamide, tiapride is chemically and functionally similar to other benzamide antipsychotics such as sulpiride and amisulpride known for their dopamine antagonist effects. (wikipedia.org)
Antipsychotic drugs are the most common treatment for these symptoms, but often come with a host of side-effects including orthostatic hypotension and deficits in vigilance and attention. (wikipedia.org)
Using ex vivo, in vivo and clinical approaches, we investigated the functional effects of plasminogen on the widely used FAD, Abeta42 oligomer or Tau intracranial injection-induced AD mouse model and explored its therapeutic effects on patients with AD. (inra.fr)
Clinical1
Syringomyelia is a condition characterised by fluid filed cavities (syrinxes or syringes) within the central spinal cord and the resulting damage produces clinical signs of pain and neurological deficits. (marysfamilymedicine.org)
Recent1
A recent study of diet-induced obesity in rats provides some confirmation of this idea. (bmj.com)
Diet3
5 Rats fed a diet high in fats and sugar were injected intraperitoneally with bilirubin or vehicle for 14 days. (bmj.com)
We found that blood ketone levels can be increased and cholesterol and triglycerides decreased by feeding rats a novel ketone ester diet: chow that is supplemented with ( R) -3-hydroxybutyl ( R )-3-hydroxybutyrate as 30% of calories. (epiphanyasd.com)
Isolated, perfused hearts from rats that were fed the ketone diet had greater free energy available from ATP hydrolysis during increased work than did hearts from rats on the other diets as shown by using [ 31 P]-NMR spectroscopy. (epiphanyasd.com)
Treatment1
Our results demonstrate that LPS treatment of cultured ECs and rats leads to significant upregulation of adhesion molecules, both in vitro and in vivo, which can be effectively inhibited by neflamapimod treatment. (bvsalud.org)