Deficient mice. Medical search. Frequent questions

Male C57BL/6j (lean) and ob/ob mice (leptin-deficient mice exhibiting obese phenotype) were subjected to SF or control conditions for 24 h using an automated SF chamber. (peerj.com)
Decreased body weight in leptin-deficient mice protects against bone loss. (ijbs.com)

Here, we describe an MTO1-deficient mouse model generated by gene trap mutagenesis that mirrors the human phenotype remarkably well. (uni-koeln.de)
We have previously showed that genetic polymorphisms in glucose transporter 10 (GLUT10) gene are associated with a T2DM intermediate phenotype in non-diabetic population, and GLUT10 G128E mice (carrying human orthologous GLUT10 G128E variant) are highly sensitive to HFD-induced metabolic dysregulation. (researchsquare.com)
By contrast, the phenotype of the BlAJ/NRG mice was milder in each case. (plos.org)
Mutations at the Atrn locus in the mouse result in the mahogany phenotype where, despite normal levels of the agouti protein that acts as an antagonist of α-melanocyte stimulating hormone (α-MSH), the agouti protein does not appear to be appropriately presented to the Melanocortin-1 receptor (Mc1R) and black/brown eumelanin synthesis persists rather than that of the lighter yellowish phaeomelanin [ 2 ]. (biomedcentral.com)
Since Atrn mutations are recessive, homozygous Atrn mg−3J/mg−3J mice were mated with heterozygous Atrn +/mg−3J mice resulting in litters where half the mice were wild-type phenotype and half the mice were recessive Atrn mutants. (biomedcentral.com)
Methods: Gem-deficient mice were generated and their metabolic phenotype characterised by in vivo testing of glucose tolerance, insulin tolerance and insulin secretion. (edu.au)

Immune-deficient mouse kinds of liver damage allow examination of human being stem cell migration to sites of damage and subsequent contribution to repair and survival. (woofahs.com)
We possess proven that, although rare relatively, cell blend will can be found in between transplanted individual control cells and receiver immune-deficient mouse hepatocytes vivo, ending in individual albumin-expressing cells [19]. (woofahs.com)
To facilitate gene and cell therapy experiments, we created severely immune-deficient mouse models of Duchenne muscular dystrophy (DMD), limb girdle muscular dystrophy 2B (LGMD2B), and limb girdle muscular dystrophy 2D (LGMD2D) by crossing mdx 4Cv , Bl/AJ, and Sgca-null mice with NRG immune-deficient mice. (plos.org)
These novel immune-deficient mouse models of DMD, LGMD2B, and LGMD2D will be useful for long-term gene and cell therapy studies involving transfer of foreign genes and cells. (plos.org)

Yamada, Y. & Mori, H. Multistep carcinogenesis of the colon in Apc Min /+ ) mouse. (nature.com)

Repair of the fracture in MMP-13 deficient (MMP-13 -/- ) mice was significantly delayed and characterized by a retarded cartilage resorption in the fracture callus. (elsevierpure.com)

Slp65-deficient mice spontaneously develop pre-B-cell leukemia, expressing high levels of the pre-BCR on their cell surface. (eur.nl)
We show here that virtually all CD47-deficient nonobese diabetic (NOD) mice spontaneously develop severe lethal autoimmune hemolytic anemia (AIHA) at 180 to 280 days of age, whereas none of the control CD47 + NOD mice develop lethal AIHA at least during the first year of life. (ashpublications.org)

In addition to confirming previous works regarding mRNA expression in Mecp2 -deficient animals, the current study identified hundreds of novel protein targets. (biomedcentral.com)

SFARI Investigators Vikaas Sohal and John Rubenstein addressed this question by studying network-level physiology and behavior in Pogz heterozygous mice. (sfari.org)
Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)

This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity. (diabetesjournals.org)
To elucidate the role of T1 in vivo, we generated T1-deficient mice and a T1-transgenic strain which secretes soluble T1-Fc fusion protein into the serum. (gla.ac.uk)
Because of their monoallelic genetic basis, the addition of genes or cells that could provide the DMD, SGCA, or DYSF protein that is deficient in these disorders has the potential to be an effective treatment. (plos.org)
Histological and histochemical analysis to detect glycosylated protein identified a severe loss in attractin-deficient mice of extracellular proteoglycan between kidney tubules in addition to a loss of glycosylated material within the intratubular brush border. (biomedcentral.com)
Genetic disruption of multidrug resistance-associated protein 1 improves endothelial function and attenuates atherosclerosis in MRP1-/- LDL-/- double knockout mice. (escardio.org)

cells engraft in beige/nude/xid immune-deficient mice and their progeny can be recovered from the murine bone marrow for as long as 18?months posttransplantation [28, 29]. (woofahs.com)
T1D susceptibility is restored to normally resistant NOD.β2m -/- mice transgenically expressing human disease-associated HLA-A ∗ 02:01 or HLA-B ∗ 39:06 class I molecules in place of their murine counterparts. (elsevierpure.com)

In support of this hypothesis, adoptively transferred TACI-deficient peritoneal or adipose tissue Mϕs, but not B cells, can improve glucose metabolism in the obese host. (nih.gov)
At the age of twenty weeks the obese mice were almost twice as heavy as the lean mice. (ijbs.com)
High weight-bearing insignificantly improved all trabecular bone parameters in the obese mice. (ijbs.com)

Materials and methods: 40 C57BL/ 6J ob/ob-mice in the age of 20 weeks have been devided into two groups with an ad-libitum-diet and with reduced diet. (ijbs.com)
Similarly, CD47 −/− C57BL/6 mice were much more sensitive than their wild-type counterparts to experimental passive AIHA induced by anti-RBC monoclonal antibodies. (ashpublications.org)
C57BL/6J mice were sensitized by sc injection and challenged on 3 occasions by inhalation of the chemical. (cdc.gov)

We previously reported that tumor growth and tumor angiogenesis were augmented in VASH1 (-/-) mice. (elsevierpure.com)
Histological analyses revealed that vessels of the footpad tumor in VASH1 (-/-) mice were more immature, having fewer mural cells. (elsevierpure.com)
Mice deficient in tumor necrosis factor (TNF) activity, i.e. (cdc.gov)

We show that despite a profound defect in glucose-stimulated insulin secretion, diabetic Hnf-1α −/− mice have a robust glibenclamide-induced insulin secretory response. (diabetesjournals.org)
Methods: Aortic plaque deposition was assessed in streptozotocin-induced diabetic apolipoprotein E (Apoe) knockout (KO) and At 2 r (also known as Agtr2)/Apoe double-KO (DKO) mice. (monash.edu)
Control and diabetic Apoe-KO mice received an AT 2 R antagonist PD123319 (5 mg kg -1 day -1 ) via osmotic minipump for 20 weeks (n = 7-8 per group). (monash.edu)

We found that the ratio of the concentrations of glibenclamide and its metabolites was moderately increased in livers of Hnf-1α −/− mice, suggesting that hepatic glibenclamide metabolism was not impaired in animals with Hnf-1α deficiency. (diabetesjournals.org)

In addition, the mutant mice showed a marked worsening of arrhythmias during induction and reversal of anaesthesia. (uni-koeln.de)
Previously we reported that increased lateral deviation while ambulating and slips while traversing a narrow beam of ataxic Kcnc3 -null mice were corrected by restoration of Kv3.3 channels specifically to Purkinje cells, whereas Kcnc3 -mutant mice additionally lacking one Kcnc1 allele were partially rescued. (jneurosci.org)
As Kcnc1 , but not Kcnc3 , alleles are lost, mutant mice exhibit increasing gait ataxia accompanied by spike broadening and deceleration in DCN neurons, suggesting the facet of coordination rescued by Purkinje-cell-restricted Kv3.3 restoration in mice lacking just Kcnc3 is hypermetria, while gait ataxia emerges when additionally Kcnc1 alleles are lost. (jneurosci.org)
The resulting mdx 4Cv /NRG, BlAJ/NRG, and Sgca/NRG mice demonstrated the presence of the appropriate mutant alleles at Dmd , Dysf , Sgca , Rag1 , and Il2 rγ by genotyping PCR. (plos.org)
These results are consistent with a generalized defect in extracellular proteoglycan deposition in Atrn -mutant mice and support previous reports suggesting a role for attractin in the secretory vesicle pathway. (biomedcentral.com)
In any experiment, only control and mutant siblings from the same mating were compared (aged 3-3.5 months), and comparisons examined mice with no gender preference. (biomedcentral.com)
To test these hypotheses we generated and characterized utrophin-deficient mutant mice. (wustl.edu)
These mutant mice were normal in appearance and behavior and showed no obvious defects in muscle or nonmuscle tissue. (wustl.edu)

After 24 hours, we found that eNOS-/-mice were protected against the LPS mediated increase in inflammatory cell infiltration, inflammatory cytokine production, and lung injury. (nih.gov)
Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)
FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. (ozgene.com)
The Lrch4-null mouse will be tested in a wide array of pro-inflammatory and host defense model exposures. (nih.gov)

Therefore, the focus of this study was to determine whether mice deficient in endothelial NOS (eNOS-/-) are protected against ALI. (nih.gov)
Consistent with the observations, the chondrocyte pellets cultured from the MMP13 -/- mice exhibited diminished angiogenic activities when the pellets were co-cultured with endothelial cells. (elsevierpure.com)

Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
Although Th2 cytokine production by lymph node cells was similar in all groups of N. brasiliensis-infected mice, a decrease in IL-5 production by lung lymphocytes was detected in both T1-deficient and T1-Fc-transgenic mice compared to control littermates. (gla.ac.uk)
This difference in IL-5 production did not influence blood eosinophilia, but recruitment of eosinophils into lung tissue, especially in T1-Fc-transgenic mice was slightly decreased. (gla.ac.uk)
However, induction of all other immune parameters was normal and both T1-deficient and T1-Fc-transgenic mice were able to clear the parasite infection within 12 days with kinetics similar to those in control mice. (gla.ac.uk)

Insulin secretion from islets of Hnf-1α −/− mice is blunted in response to glucose and other glycolytic stimuli but normal in response to non-nutrient secretagogues such as potassium ( 5 ). (diabetesjournals.org)
Furthermore, the expression of GLUT2 and the glycolytic enzymes glucokinase and liver pyruvate kinase are reduced in pancreatic islets of Hnf-1α −/− mice compared with wild-type mice ( 6 ). (diabetesjournals.org)
Furthermore, the islets of Gem-deficient mice exhibited decreased free calcium responses to glucose and the calcium oscillations seen upon glucose stimulation were smaller in amplitude and had a reduced frequency. (edu.au)

The aim of this study was to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodeling in a mouse model of MI. (springer.com)
Consequently, a greater post-MI monocyte-derived myocardial macrophage infiltration was noted in Hmox1-deficient individuals. (springer.com)
In this manner mild reactivity of wild-type RBCs with macrophage phagocytic receptors is tolerated, whereas otherwise identical CD47-deficient RBCs are rapidly eliminated. (ashpublications.org)

Detailed analysis, however, revealed that the density of acetylcholine receptors and the number of junctional folds were reduced at the neuromuscular junctions in utrophin- deficient skeletal muscle. (wustl.edu)

Thus, the adoptive transfer experiments offer a model where TACI-deficient Mϕs accumulate in VAT and protect against metaflammation and obesity-associated dysregulation of glucose metabolism. (nih.gov)
To study the pharmacogenetic mechanism(s), we have investigated glibenclamide-induced insulin secretion, glibenclamide clearance from the blood, and glibenclamide metabolism in wild-type and Hnf-1α-deficient mice. (diabetesjournals.org)
Therefore, we first used a genetically predisposed mouse model to investigate whether AA effects on metabolism might be influenced by particular genetic and diet. (researchsquare.com)
In this study, we examined AA effects on metabolism in wild-type (WT) mice and GLUT10 G128E mice fed with a normal diet (CD) or HFD, as we previously showed that GLUT10 G128E mice are highly sensitive to HFD-induced T2DM 9 . (researchsquare.com)

Resistance to HFD-induced metabolic changes in TACI-deficient mice does not involve TACI-mediated adipogenesis. (nih.gov)
We investigated the impacts of AA on high-fat diet (HFD)-induced metabolic dysregulation in wild type (WT) and GLUT10 G128E mice. (researchsquare.com)
Here we show that AA has greater metabolic impacts on HFD-fed GLUT10 G128E mice than HFD-fed WT mice. (researchsquare.com)
Furthermore, AA attenuates the predisposition of GLUT10 G128E mice to HFD-triggered eWAT inflammation, adipokine dysregulation, ectopic fatty acid accumulation, metabolic dysregulation and body weight gain, as compared with WT mice. (researchsquare.com)
AA plays an important role in improving WAT development and HFD-induced metabolic dysregulation in GLUT10 G128E mice. (researchsquare.com)

Transgenic expression of HLA-A2 or-B39 restored pathogenic CD8 + T-cell development and T1D susceptibility to NOD-cMHCI -/- mice. (elsevierpure.com)
Loss of IKK activity results in deficient NF-kB activity and increased susceptibility to apoptosis. (medscape.com)

In both wild-type and eNOS-/- mice, ALI was induced by the intratracheal instillation of LPS (2 mg/kg). (nih.gov)
Hmox1 knockout (Hmox1 −/− ) and wild-type (WT, Hmox1 +/+ ) mice were subjected to a permanent ligation of the left anterior descending coronary artery. (springer.com)
We demonstrate that the half-life ( t 1/2 ) of glibenclamide in the blood is increased in Hnf-1α −/− mice compared with wild-type littermates (3.9 ± 1.3 vs. 1.5 ± 1.8 min, P ≤ 0.05). (diabetesjournals.org)
Ob/ob mice exhibited elevated cytokine gene expression in liver (TNF-α, TGF-β1), heart (TGF-β1), fat (TNF-α), and brain (hippocampus, hypothalamus, prefrontal cortex: IL-1β, TNF-α) compared with wild-type mice. (peerj.com)
SF significantly increased IL-1β and TNF-α gene expression in fat and TGF-β1 expression in spleen relative to controls, but only in wild-type mice. (peerj.com)
ABSTRACT: BACKGROUND: Benzo[a]pyrene (B[a]P) exposure induces DNA adducts at all stages of spermatogenesis and in testis, and removal of these lesions is less efficient in nucleotide excision repair deficient Xpc-/- mice than in wild type mice. (maastrichtuniversity.nl)
RESULTS: Two-Way ANOVA revealed only 4 genes differentially expressed between wild type and Xpc-/- mice, and 984 genes between testes of B[a]P treated and untreated mice irrespective of the mouse genotype. (maastrichtuniversity.nl)
CONCLUSIONS: Gene expression in testis of untreated Xpc-/- and wild type mice were very similar, with only 4 genes differentially expressed. (maastrichtuniversity.nl)
Methods and Results - ApoE-deficient (apoE-/-), wild-type (WT), and transgenic apoE-/- mice (secreting apoE at different levels from adrenal glands) underwent femoral artery injury. (mssm.edu)
However, when LLC cells were injected into a tail vein, the extent of lung metastasis was unchanged between wild-type mice and VASH1 (-/-) mice. (elsevierpure.com)

In order to facilitate more physiologic in vivo investigations of the function and disease-relevant roles of Lrch4, we produced a Lrch4 ene-deleted mouse. (nih.gov)

Neurodegeneration and hair pigmentation alterations in mice occur consequent to aberrations at the Atrn locus coding for the transmembrane form of attractin. (biomedcentral.com)

Immunohistochemistry indicated severe defects in vascular penetration and chondroclast recruitment to the fracture callus in MMP-13 -/- mice. (elsevierpure.com)
The severe insulin-deficient diabetes (SIDD) subgroup is characterised by non-autoimmune impaired insulin secretion and was previously hidden in the type 2 diabetes group. (lu.se)

Significantly lower incidence of left ventricle (LV) free wall rupture was noted between 3rd and 5th day after MI in Hmox1 −/− mice resulting in their better overall survival. (springer.com)
Results: Animals with an ad-libitum-diet were found to increase body weight significantly at the age of six weeks in comparison with lean mice. (ijbs.com)

In conclusion, we have established a mouse model that combines hyperglycemia with diet-induced hyperlipidemia in LDL-RD mice and studied its effect on atherosclerosis progression. (diabetesjournals.org)

Here we show that co-administration of phosphorodiamidate morpholino oligomers (PMOs) with glucose enhances exon-skipping activity in Duchenne muscular dystrophy (DMD) mdx mice. (ox.ac.uk)

As leukemic Slp65-deficient pre-B cells express the recombination activating genes (Rag)1 and Rag2, and manifest ongoing immunoglobulin (Ig) light-chain rearrangement, it has been hypothesized that deregulated recombinase activity contributes to malignant transformation. (eur.nl)
Trisomy for orthologues of about half of the genes on chromosome 21 (Hsa21) in Ts65Dn mice or just 33 of these genes in Ts1Rhr mice resulted in a significant reduction in the number of intestinal tumours. (nature.com)
However, the level in which these B[a]P regulated genes are expressed differs between Wt and Xpc-/- mice (p = 0.000000141), and were predominantly involved in the regulation of cell cycle, translation, chromatin structure and spermatogenesis, indicating a general stress response. (maastrichtuniversity.nl)
Exposure to benzo(a)pyrene affected the expression of genes that are involved in cell cycle regulation in both genotypes, indicating that the presence of unrepaired DNA damage in testis blocks cell proliferation to protect DNA integrity in both DNA repair proficient and deficient animals. (maastrichtuniversity.nl)

In addition, FcR-gamma chain-deficient mice were found to express partially functional FcgammaRI. (ozgene.com)

Insulin signaling experiments revealed that IL-10 secreted by TACI-deficient Mϕs is responsible for maintaining adipocyte insulin sensitivity. (nih.gov)
Mice lacking the Hnf-1α gene ( 3 , 4 ) also have a dramatic reduction in insulin secretory response to glucose. (diabetesjournals.org)
Results: Gem-deficient mice were glucose intolerant and had impaired glucose stimulated insulin secretion. (edu.au)
Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. (lu.se)

1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)

Exon 8 of the mouse α 6 subunit gene was disrupted by homologous recombination. (jneurosci.org)
Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice. (ox.ac.uk)

In contrast, neurological examination was largely normal in Mto1-deficient mice. (uni-koeln.de)

A translational consequence of this mouse model may be to caution against anaesthesia-related cardiac arrhythmias which may be fatal in patients. (uni-koeln.de)
We have characterized AEP-deficient mice as a disease model of human hemomphagocytic syndrome, which developed hemophagocytosis especially in bone marrow. (nii.ac.jp)
We have conducted further examinations so as to characterize AEP-deficient mice as a new model of lysosomal disease. (nii.ac.jp)
In the current study, we established a model combining hyperglycemia with hyperlipidemia in LDL receptor-deficient (LDL-RD) mice and assessed its possible influences on lipid profile, HSP60/65, and atherogenesis. (diabetesjournals.org)
We therefore performed the first comprehensive transcriptome-proteome comparison in a RTT mouse model to elucidate RTT pathophysiology, identify potential therapeutic targets, and further our understanding of MeCP2 function. (biomedcentral.com)
A mouse model for Down Syndrome exhibits learning and behaviour deficits. (nature.com)
A mouse artery injury model was used to examine whether apoE exhibits beneficial lipid-independent effects on neointimal formation. (mssm.edu)
Conclusions - Similar to its effects on atherosclerosis progression, in a mouse model of restenosis, a subphysiological level of apoE was associated with beneficial effects on lesion size/composition. (mssm.edu)
We performed centronucleation, Evans blue dye, hydroxyproline, and treadmill assays on the disease model mice versus NRG controls to evaluate muscle histology and function. (plos.org)

Here, we demonstrate that TACI-deficient mice subjected to high-fat diet (HFD) are protected from weight gain and dysregulated glucose homeostasis. (nih.gov)
Plasma glucose, cholesterol, and triglyceride levels were elevated in mice injected with streptozotocin compared with control mice. (diabetesjournals.org)

These studies demonstrated that the mdx 4Cv /NRG and Sgca/NRG mice showed significant deficits in muscle structure and function in all the assays and were similar to each other. (plos.org)

The X-linked gene Rlim plays major roles in female mouse development and reproduction, where it is crucial for the maintenance of imprinted X chromosome inactivation in extraembryonic tissues of embryos. (umass.edu)
Here we examined kidney and liver, both heavily dependent upon proteoglycan, of attractin-deficient mice to determine whether abnormalities were observed in these tissues. (biomedcentral.com)

We used mouse models of Down's syndrome and of cancer in a biological approach to investigate the relationship between trisomy and the incidence of intestinal tumours. (nature.com)
Genetic identification of Mom-1 , a major modifier locus affecting Min -induced intestinal neoplasia in the mouse. (nature.com)

The clearance of glibenclamide from the blood during the first hours after intravenous administration was reduced approximately fourfold in Hnf-1α −/− mice compared with Hnf-1α +/+ littermates. (diabetesjournals.org)

When reisolated from the marrow of beige/nude/xid mice, the human cells were lacking of CD34 expression absolutely. (woofahs.com)
A slightly higher induction of average gene expression was observed at the G2-M checkpoint in Xpc-/- mice, but this did not reach statistical significance (P=0.086). (maastrichtuniversity.nl)
NOD-cMHCI -/- mice retained nonclassical MHC I molecule expression and FcRn activity. (elsevierpure.com)
We also identified that RDH gene expression is regulated by forkhead box O (FOXO) transcription factors, which are inactivated by hyperactive Akt in the Pten -deficient mouse RPE. (molcells.org)
In addition, we have a Lrch4 mouse line with a B-galactosidase construct in the Lrch4 locus Lrch4 Tn1/+, which can be used for expression profiling of Lrch4. (nih.gov)
1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)

Improved mouse models for type 1 diabetes (T1D) therapy development are needed. (elsevierpure.com)

When challenged with HSP65 in vitro, splenocytes from streptozotocin-injected mice favored the production of the T-helper (TH)-1 cytokine gamma-interferon. (diabetesjournals.org)

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. (bvsalud.org)

The inactivation of the mouse high-affinity IgG Fc receptor FcgammaRI resulted in a wide range of defects in antibody Fc-dependent functions. (ozgene.com)
1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)

In this report, we investigated whether Rag-induced DNA damage is involved in oncogenic transformation of Slp65-deficient B cells. (eur.nl)
The most successful liver repopulation with bone-marrow-derived cells was observed in mice with fumarylacetoacetate hydrolase (FAH? (woofahs.com)
cells after CCL4-mediated liver organ damage had been probed with both individual (in nuclei) and mouse (… 87976-03-2 supplier Solitude of hematopoietic control cells for liver organ fix using phenotypic vs .. useful guns Methods to determine the most old fashioned hematopoietic come cells (HSC) are constantly wanted. (woofahs.com)
cells in immune-deficient mice after 1?year and that the reisolated human CD34? (woofahs.com)
NOD.β2m -/- -A2.1 mice were previously used to identify β-cell autoantigens presented by this human class I variant to pathogenic CD8 + T cells and for testing therapies to attenuate such effectors. (elsevierpure.com)
When Lewis lung carcinoma (LLC) cells were inoculated in the footpad to observe spontaneous metastasis, a significant increase in lung metastasis together with inguinal lymph node metastasis was evident in the VASH1 (-/-) mice. (elsevierpure.com)
If healthy muscle progenitor cells were introduced and could fuse to existing deficient fibers, as well as form new muscle fibers, regeneration of muscle might occur 11 , 12 . (plos.org)
Cells that retain IKK activity may produce additional cytokines that trigger apoptosis in neighboring IKK-deficient cells, thus creating an amplification loop that eventually results in the death of all of the IKK-deficient cells. (medscape.com)
Reconstitution of whole body irradiated mice with IL-1Ra-producing bone marrow cells is associated with neuroprotection and recruitment of IL-1Ra-producing leukocytes after stroke. (lu.se)

Fig.?1 FISH analysis for individual and mouse centromeres in liver sections. (woofahs.com)
Liver organ areas from a mouse that acquired been transplanted with ALDHhiLin? (woofahs.com)
Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)
or each of these agents, carcinogenicity in rats and/or mice, els, differences in exposure con- there was sufficient evidence of car- for example for the liver (aflatoxins, ditions between studies in animals cinogenicity from studies in rats and/ trichloroethylene [TCE], and vinyl and in humans, or limitations in Part 1 · Chapter 1. (who.int)

0.05 versus apoE-/- mice). (mssm.edu)

Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions. (nature.com)

LDL-RD mice were injected either with streptozotocin to induce hyperglycemia or with citrate buffer (control). (diabetesjournals.org)

Our data demonstrate that high serum glibenclamide concentrations and an increased t 1/2 of glibenclamide in the blood of Hnf-1α −/− mice are caused by a defect in hepatic uptake of glibenclamide. (diabetesjournals.org)

Here, we report mice lacking all Kcnc1 and Kcnc3 alleles exhibit no such rescue. (jneurosci.org)
To define which electrophysiological changes could most plausibly account for the ataxia, we examined intrinsic spiking of DCN neurons in mice lacking Kcnc3 as well as Kcnc1 alleles. (jneurosci.org)

In this study, we investigated by using microarray technology whether compromised DNA repair in Xpc-/- mice may lead to a transcriptional reaction of the testis to cope with increased levels of B[a]P induced DNA damage. (maastrichtuniversity.nl)

Objective - Apolipoprotein E (apoE) reduces mouse atherosclerosis progression independent of plasma cholesterol level effects. (mssm.edu)

Using a synergistic analytical approach, it was possible to trace the effect that changes in the remodelling regime have on the bone mineral chemistry and structure in normal and mineral-deficient (hypophosphatemic) mice. (iucr.org)
The results indicate that hypophosphatemic mice have increased bone remodelling, increased carbonate content and decreased crystallinity of the bone mineral, as well as increased misalignment of crystallites within the bone tissue. (iucr.org)
The aim of this study was to investigate and measure the different effects of weight-bearing on trabecular bone formation in mice without the stimulation of leptin and with or without osteoarthritis. (ijbs.com)

Anatomy46

Organisms15

Diseases26

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Psychiatry and Psychology3

Phenomena and Processes43

Disciplines and Occupations1

Information Science2

Leptin-deficient mice2

Phenotype6

Immune-deficient mouse4

Carcinogenesis1

Delayed and characterized1

Spontaneously develop2

MRNA expression1

Heterozygous2

Protein6

Murine2

Obese3

C57BL3

Tumor3

Diabetic3

Deficiency1

Mutant8

Inflammatory5

Endothelial2

Transgenic mice4

Islets3

Macrophage3

Skeletal1

Metabolism4

Metabolic5

Susceptibility2

Wild-type10

Vivo1

Alterations1

Severe2

Significantly2

Diet-induced1

Duchenne1

Genes4

Partially1

Insulin4

Adverse1

Exon2

Contrast1

Model9

Glucose2

Deficits1

Tissues2

Intestinal2

Littermates1

Expression6

Diabetes1

Cytokine1

Checkpoint1

Receptor2

Cells9

Liver4

0.051

Orthologous1

Hyperglycemia1

Defect1

Alleles2

Microarray1

Atherosclerosis progression1

Bone3